VIII．HTLV-1関連疾患に対する新規治療法の展望
ヒトT細胞白血病ウイルス1型（human T-cell leukemia virus type 1：HTLV-1）は，数万年前に類人猿からヒトに伝播され，特徴的なT細胞腫瘍と炎症性疾患を人類にもたらしてきた．本ウイルスの病原性発見の契機となった成人T細胞白血病（adult T-cell leukemia：ATL）やHTLV-1関連脊髄症（HTLV-1-associated myelopathy：HAM）は，未だに有効な治療法に乏しい難治性疾患であるが，近年の我が国における抗CCケモカイン受容体4（CC-motif chemokine receptor 4：CCR4）抗体，Taxワクチン（Tax...
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| Published in | 日本内科学会雑誌 Vol. 106; no. 7; pp. 1417 - 1422 |
|---|---|
| Main Authors | , |
| Format | Journal Article |
| Language | Japanese |
| Published |
一般社団法人 日本内科学会
10.07.2017
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0021-5384 1883-2083 |
| DOI | 10.2169/naika.106.1417 |
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| Abstract | ヒトT細胞白血病ウイルス1型（human T-cell leukemia virus type 1：HTLV-1）は，数万年前に類人猿からヒトに伝播され，特徴的なT細胞腫瘍と炎症性疾患を人類にもたらしてきた．本ウイルスの病原性発見の契機となった成人T細胞白血病（adult T-cell leukemia：ATL）やHTLV-1関連脊髄症（HTLV-1-associated myelopathy：HAM）は，未だに有効な治療法に乏しい難治性疾患であるが，近年の我が国における抗CCケモカイン受容体4（CC-motif chemokine receptor 4：CCR4）抗体，Taxワクチン（Tax抗原を標的とする樹状細胞ワクチン）等の開発は，HTLV-1関連疾患の治療パラダイムを変革しつつある．今後はHTLV-1感染T細胞の増殖を効果的に抑制するための新規免疫療法の開発に大きな期待が寄せられている． |
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| AbstractList | ヒトT細胞白血病ウイルス1型（human T-cell leukemia virus type 1：HTLV-1）は，数万年前に類人猿からヒトに伝播され，特徴的なT細胞腫瘍と炎症性疾患を人類にもたらしてきた．本ウイルスの病原性発見の契機となった成人T細胞白血病（adult T-cell leukemia：ATL）やHTLV-1関連脊髄症（HTLV-1-associated myelopathy：HAM）は，未だに有効な治療法に乏しい難治性疾患であるが，近年の我が国における抗CCケモカイン受容体4（CC-motif chemokine receptor 4：CCR4）抗体，Taxワクチン（Tax抗原を標的とする樹状細胞ワクチン）等の開発は，HTLV-1関連疾患の治療パラダイムを変革しつつある．今後はHTLV-1感染T細胞の増殖を効果的に抑制するための新規免疫療法の開発に大きな期待が寄せられている． |
| Author | 一戸, 辰夫 福島, 伯泰 |
| Author_xml | – sequence: 1 fullname: 福島, 伯泰 organization: 広島大学原爆放射線医科学研究所血液・腫瘍内科研究分野 – sequence: 1 fullname: 一戸, 辰夫 organization: 広島大学原爆放射線医科学研究所血液・腫瘍内科研究分野 |
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| Copyright | 2017 一般社団法人 日本内科学会 |
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| References | 7) Kanda J, et al: Impact of graft-versus-host disease on outcomes after allogeneic hematopoietic cell transplantation for adult T-cell leukemia: a retrospective cohort study. Blood 119: 2141-2148, 2012. 2) Ishida T, et al: Dose-intensified chemotherapy alone or in combination with mogamulizumab in newly diagnosed aggressive adult T-cell leukaemia-lymphoma: a randomized phase II study. Br J Haematol 169: 672-682, 2015. 3) Ureshino H, et al: Effector regulatory T cells reflect the equilibrium between antitumor immunity and autoimmunity in adult T-cell leukemia. Cancer Immunol Res 4: 644-649, 2016. 5) Ishida T, et al: Multicenter phase II study of lenalidomide in relapsed or recurrent adult T-cell leukemia/lymphoma: ATLL-002. J Clin Oncol 34: 4086-4093, 2016. 9) 末廣陽子: HTLV-1を標的とする免疫療法. 臨床血液 57: 2250-2258, 2016. 10) Sugata K, et al: Protective effect of cytotoxic T lymphocytes targeting HTLV-1 bZIP factor. Blood 126: 1095-1105, 2015. 1) Ishida T, et al: Defucosylated anti-CCR4 monoclonal antibody (KW-0761) for relapsed adult T-cell leukemia-lymphoma: a multicenter phase II study. J Clin Oncol 30: 837-842, 2012. 4) Ito T, et al: Identification of a primary target of thalidomide teratogenicity. Science 327: 1345-1350, 2010. 6) Hishizawa M, et al: Transplantation of allogeneic hematopoietic stem cells for adult T-cell leukemia: a nationwide retrospective study. Blood 116: 1369-1376, 2010. 8) Nishikawa H, et al: Cancer/testis antigens are novel targets of immunotherapy for adult T-cell leukemia/lymphoma. Blood 119: 3097-3104, 2012. |
| References_xml | – reference: 2) Ishida T, et al: Dose-intensified chemotherapy alone or in combination with mogamulizumab in newly diagnosed aggressive adult T-cell leukaemia-lymphoma: a randomized phase II study. Br J Haematol 169: 672-682, 2015. – reference: 10) Sugata K, et al: Protective effect of cytotoxic T lymphocytes targeting HTLV-1 bZIP factor. Blood 126: 1095-1105, 2015. – reference: 5) Ishida T, et al: Multicenter phase II study of lenalidomide in relapsed or recurrent adult T-cell leukemia/lymphoma: ATLL-002. J Clin Oncol 34: 4086-4093, 2016. – reference: 4) Ito T, et al: Identification of a primary target of thalidomide teratogenicity. Science 327: 1345-1350, 2010. – reference: 9) 末廣陽子: HTLV-1を標的とする免疫療法. 臨床血液 57: 2250-2258, 2016. – reference: 8) Nishikawa H, et al: Cancer/testis antigens are novel targets of immunotherapy for adult T-cell leukemia/lymphoma. Blood 119: 3097-3104, 2012. – reference: 3) Ureshino H, et al: Effector regulatory T cells reflect the equilibrium between antitumor immunity and autoimmunity in adult T-cell leukemia. Cancer Immunol Res 4: 644-649, 2016. – reference: 6) Hishizawa M, et al: Transplantation of allogeneic hematopoietic stem cells for adult T-cell leukemia: a nationwide retrospective study. Blood 116: 1369-1376, 2010. – reference: 1) Ishida T, et al: Defucosylated anti-CCR4 monoclonal antibody (KW-0761) for relapsed adult T-cell leukemia-lymphoma: a multicenter phase II study. J Clin Oncol 30: 837-842, 2012. – reference: 7) Kanda J, et al: Impact of graft-versus-host disease on outcomes after allogeneic hematopoietic cell transplantation for adult T-cell leukemia: a retrospective cohort study. Blood 119: 2141-2148, 2012. |
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| Snippet | ヒトT細胞白血病ウイルス1型（human T-cell leukemia virus type 1：HTLV-1）は，数万年前に類人猿からヒトに伝播され，特徴的なT細胞腫瘍と炎症性疾患を人... |
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| SubjectTerms | レナリドミド 免疫療法 同種造血幹細胞移植 抗CCR4抗体 |
| Title | VIII．HTLV-1関連疾患に対する新規治療法の展望 |
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