臓器移植におけるLiquid Biopsy（ドナー由来遊離DNA断片測定）
臓器移植後の長期グラフト機能維持は今後の移植医療の重要課題である．近年，グラフト障害を低侵襲かつ高感度にモニタリング可能な血清バイオマーカーとして，ドナー由来遊離DNA断片（donor-derived cell-free DNA）が注目され, 急性拒絶反応の早期診断，治療効果判定，侵襲を伴う検査の減少，外来レベルでの安全なモニタリング等における有用性が報告されている．さらには，既存のバイオマーカーとの組み合わせでグラフトの長期生存率向上に寄与することも期待される．...
Saved in:
| Published in | Organ Biology Vol. 31; no. 1; pp. 017 - 023 |
|---|---|
| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
一般社団法人 日本臓器保存生物医学会
2024
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 1340-5152 2188-0204 |
| DOI | 10.11378/organbio.31.017 |
Cover
| Abstract | 臓器移植後の長期グラフト機能維持は今後の移植医療の重要課題である．近年，グラフト障害を低侵襲かつ高感度にモニタリング可能な血清バイオマーカーとして，ドナー由来遊離DNA断片（donor-derived cell-free DNA）が注目され, 急性拒絶反応の早期診断，治療効果判定，侵襲を伴う検査の減少，外来レベルでの安全なモニタリング等における有用性が報告されている．さらには，既存のバイオマーカーとの組み合わせでグラフトの長期生存率向上に寄与することも期待される． |
|---|---|
| AbstractList | 臓器移植後の長期グラフト機能維持は今後の移植医療の重要課題である．近年，グラフト障害を低侵襲かつ高感度にモニタリング可能な血清バイオマーカーとして，ドナー由来遊離DNA断片（donor-derived cell-free DNA）が注目され, 急性拒絶反応の早期診断，治療効果判定，侵襲を伴う検査の減少，外来レベルでの安全なモニタリング等における有用性が報告されている．さらには，既存のバイオマーカーとの組み合わせでグラフトの長期生存率向上に寄与することも期待される． |
| Author | 金森, 洋樹 篠田, 昌宏 西郷, 健一 長谷川, 康 北川, 雄光 山田, 洋平 藤野, 明浩 井ノ上, 逸朗 尾原, 秀明 光永, 滋樹 |
| Author_xml | – sequence: 1 fullname: 尾原, 秀明 organization: 慶應義塾大学医学部 外科学（一般・消化器） – sequence: 1 fullname: 長谷川, 康 organization: 慶應義塾大学医学部 外科学（一般・消化器） – sequence: 1 fullname: 篠田, 昌宏 organization: 国立遺伝学研究所人類遺伝研究室 – sequence: 1 fullname: 山田, 洋平 organization: 慶應義塾大学医学部 外科学（小児） – sequence: 1 fullname: 西郷, 健一 organization: 独立行政法人地域医療機能推進機構千葉病院移植外科 – sequence: 1 fullname: 藤野, 明浩 organization: 慶應義塾大学医学部 外科学（小児） – sequence: 1 fullname: 北川, 雄光 organization: 慶應義塾大学医学部 外科学（一般・消化器） – sequence: 1 fullname: 井ノ上, 逸朗 organization: 国立遺伝学研究所人類遺伝研究室 – sequence: 1 fullname: 金森, 洋樹 organization: 慶應義塾大学医学部 外科学（小児） – sequence: 1 fullname: 光永, 滋樹 organization: 国立遺伝学研究所人類遺伝研究室 |
| BookMark | eNo9kD1Lw0AAhg-pYFvdHf0DqfeRy13GtmoVil10DpdLribUpiZ16Bg71FYcRBFUXERR8APcBPtvQlM79S-o-LE87_DAOzw5kGkGTReARQQLCBHGl4OwLpq2FxQIKkDEZkAWI841iKGeAVlEdKhRRPEcyEWRDyHlOjKzoPbROx1dPIzv39Pb4yR-TOJBEp8kB0dVb2_fc5ZKXtCKOtPhYdLtJ91B0h2Oz17T67tJPJhc3axsFtPz53G_l749jV4up8P-PJhVohG5C7-bB9trq1vlda1aq2yUi1XNRxwLDQtbGdiQJjOxDZlSuim54VDGlE6o0DEzuS0MSAWTAhomolBJx-FSSe4i6ZA8KP38-lFb1F2rFXq7IuxYImx7suFafzUsgiz0ja8k_1LuiNDyBfkEu811Kg |
| ContentType | Journal Article |
| Copyright | 2023 日本臓器保存生物医学会 |
| Copyright_xml | – notice: 2023 日本臓器保存生物医学会 |
| DOI | 10.11378/organbio.31.017 |
| DatabaseTitleList | |
| DeliveryMethod | fulltext_linktorsrc |
| EISSN | 2188-0204 |
| EndPage | 023 |
| ExternalDocumentID | article_organbio_31_1_31_017_article_char_ja |
| GroupedDBID | ABDBF ABJNI ALMA_UNASSIGNED_HOLDINGS JMI JSF JSH KQ8 MOJWN RJT RZJ |
| ID | FETCH-LOGICAL-j182a-2abf626c9792b07ff49c86d577f435a42798ba605a7ca069150fcdd8cfc8e1cd3 |
| ISSN | 1340-5152 |
| IngestDate | Wed Sep 03 06:31:24 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | false |
| IsScholarly | false |
| Issue | 1 |
| Language | Japanese |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-j182a-2abf626c9792b07ff49c86d577f435a42798ba605a7ca069150fcdd8cfc8e1cd3 |
| OpenAccessLink | https://www.jstage.jst.go.jp/article/organbio/31/1/31_017/_article/-char/ja |
| PageCount | 7 |
| ParticipantIDs | jstage_primary_article_organbio_31_1_31_017_article_char_ja |
| PublicationCentury | 2000 |
| PublicationDate | 2024 |
| PublicationDateYYYYMMDD | 2024-01-01 |
| PublicationDate_xml | – year: 2024 text: 2024 |
| PublicationDecade | 2020 |
| PublicationTitle | Organ Biology |
| PublicationTitleAlternate | Organ Biology |
| PublicationYear | 2024 |
| Publisher | 一般社団法人 日本臓器保存生物医学会 |
| Publisher_xml | – name: 一般社団法人 日本臓器保存生物医学会 |
| References | 5) Fernández-Galán E, Badenas C, Fondevila C, et al. Monitoring of Donor-Derived Cell- Free DNA by Short Tandem Repeats: Concentration of Total Cell-Free DNA and Fragment Size for Acute Rejection Risk Assessment in Liver Transplantation. Liver Transpl 2022;28: 257-268 12) Tanaka S, Sugimoto S, Toyooka S, et al. Donor-derived cell-free DNA is associated with acute rejection and decreased oxygenation in primary graft dysfunction after living donor-lobar lung transplantation. Sci Rep 2018;8:15366 8) De Vlaminck I, Martin L, Kertesz M, et al. Noninvasive monitoring of infection and rejection after lung transplantation. Proc Natl Acad Sci USA 2015;112:13336-13341 3) Knight SR, Thorne A, Lo Faro ML. Donor-specific Cell-free DNA as a Biomarker in Solid Organ Transplantation. A Systematic Review. Transplantation 2019;103:273-283 20) Levitsky J, Kandpal M, Guo K, Kleiboeker S, Sinha R, Abecassis M. Donor-derived cell-free DNA levels predict graft injury in liver transplant recipients. Am J Transplant 2022;22:532-540 13) Beck J, Bierau S, Balzer S, et al. Digital droplet PCR for rapid quantification of donor DNA in the circulation of transplant recipients as a potential universal biomarker of graft injury. Clin Chem 2013;59:1732-1741 15) Zhang J, Tong KL, Li PK, et al. Presence of donor- and recipient-derived DNA in cell-free urine samples of renal transplantation recipients: urinary DNA chimerism. Clin Chem 1999;45:1741-1746 1) Fact Book 2022 on Organ Transplantation in Japan. http://www.asas.or.jp/jst/pdf/factbook/factbook2022.pdf 9) Schutz E, Fischer A, Beck J, et al. Graft-derived cell-free DNA, a noninvasive early rejection and graft damage marker in liver transplantation: A prospective, observational, multicenter cohort study. PLoS Med 2017;14:e1002286 16) Bloom RD, Bromberg JS, Poggio ED, et al. Cell-free DNA and active rejection in kidney allografts. J Am Soc Nephrol 2017;28(7):2221-2232 23) Michael K, Rohan M, Sean AE, et al. Comparison of donor-derived cell-free DNA between single versus double lung transplant recipients. Am J Transplant 2022;22:2451-2457 2) Lo YM, Tein MS, Pang CC, et al. Presence of donor-specific DNA in plasma of kidney and liver-transplant recipients. Lancet 1998;351:1329-1330 4) Verhoeven J, Boer K, Van Schaik RHN, et al. Liquid Biopsies to Monitor Solid Organ Transplant Function: A Review of New Biomarkers. Ther Drug Monit 2018;40: 515-25. 7) De Vlaminck I, Valantine HA, Snyder TM, et al.Circulating cell-free DNA enables noninvasive diagnosis of heart transplant rejection. Sci Transl Med 2014;6:241ra77 22) Michael K, Cedric M, Sean AE, et al. Biological Variation of Donor-Derived Cell-Free DNA in Stable Lung Transplant Recipients. J Appl Lab Med 2022;30:901-909 10) Bloom R, Bromberg J, Poggio E, et al. Donor-derived cell-free DNA correlates with antibody-mediated rejection in kidney allografts. 2017 American Transplant Congress (Abstract No.397) https://atcmeetingabstracts.com/abstract/donor-derived-cell-free-dna-correlates-with-antibody-mediated-rejection-in-kidney-allografts/ (accessed on 2023/11/04 19) Kanamori H, Yamada Y, Kuroda T et al. Noninvasive graft monitoring using donor-derived cell-free DNA in Japanese liver transplantation. Hepatol Res 2023 Oct 18. DOI: 10.1111/hepr.13978. https://onlinelibrary.wiley.com/doi/epdf/10.1111/hepr.13978 14) Lee H, Park YM, We YM, et al. Evaluation of digital PCR as a technique for monitoring acute rejection in kidney transplantation. Genomics Inform 2017;15:2-10 21) Sean AE, Palak S, Hannah AV, et al. Cell-Free DNA to Detect Heart Allograft Acute Rejection. Circulation 2021;143:1184-1197 6) Dengu F. Next-generation sequencing methods to detect donor-derived cell-free DNA after transplantation. Transplant Rev (Orlando) 2020;34:100542 18) Sigdel TK, Vitalone MJ, Tran TQ, et al. A rapid noninvasive assay for the detection of renal transplant injury. Transplantation 2013;96:97-101 11) U.S. National Library of Medicine. ClinicalTrials.gov, https://classic.clinicaltrials.gov/ct2/home searched by "cfDNA, transplant" (accessed on 2023/11/04 17) Jordan SC, Bunnapradist S, Bromberg JS, et al. Donor-derived Cell-free DNA Identifies Antibody-mediated Rejection in Donor Specific Antibody Positive Kidney Transplant Recipients. Am J Transplant 2018;18(Suppl 4):254 |
| References_xml | – reference: 7) De Vlaminck I, Valantine HA, Snyder TM, et al.Circulating cell-free DNA enables noninvasive diagnosis of heart transplant rejection. Sci Transl Med 2014;6:241ra77 – reference: 10) Bloom R, Bromberg J, Poggio E, et al. Donor-derived cell-free DNA correlates with antibody-mediated rejection in kidney allografts. 2017 American Transplant Congress (Abstract No.397) https://atcmeetingabstracts.com/abstract/donor-derived-cell-free-dna-correlates-with-antibody-mediated-rejection-in-kidney-allografts/ (accessed on 2023/11/04) – reference: 6) Dengu F. Next-generation sequencing methods to detect donor-derived cell-free DNA after transplantation. Transplant Rev (Orlando) 2020;34:100542 – reference: 5) Fernández-Galán E, Badenas C, Fondevila C, et al. Monitoring of Donor-Derived Cell- Free DNA by Short Tandem Repeats: Concentration of Total Cell-Free DNA and Fragment Size for Acute Rejection Risk Assessment in Liver Transplantation. Liver Transpl 2022;28: 257-268 – reference: 14) Lee H, Park YM, We YM, et al. Evaluation of digital PCR as a technique for monitoring acute rejection in kidney transplantation. Genomics Inform 2017;15:2-10 – reference: 16) Bloom RD, Bromberg JS, Poggio ED, et al. Cell-free DNA and active rejection in kidney allografts. J Am Soc Nephrol 2017;28(7):2221-2232 – reference: 18) Sigdel TK, Vitalone MJ, Tran TQ, et al. A rapid noninvasive assay for the detection of renal transplant injury. Transplantation 2013;96:97-101 – reference: 21) Sean AE, Palak S, Hannah AV, et al. Cell-Free DNA to Detect Heart Allograft Acute Rejection. Circulation 2021;143:1184-1197 – reference: 3) Knight SR, Thorne A, Lo Faro ML. Donor-specific Cell-free DNA as a Biomarker in Solid Organ Transplantation. A Systematic Review. Transplantation 2019;103:273-283 – reference: 20) Levitsky J, Kandpal M, Guo K, Kleiboeker S, Sinha R, Abecassis M. Donor-derived cell-free DNA levels predict graft injury in liver transplant recipients. Am J Transplant 2022;22:532-540 – reference: 1) Fact Book 2022 on Organ Transplantation in Japan. http://www.asas.or.jp/jst/pdf/factbook/factbook2022.pdf – reference: 23) Michael K, Rohan M, Sean AE, et al. Comparison of donor-derived cell-free DNA between single versus double lung transplant recipients. Am J Transplant 2022;22:2451-2457 – reference: 2) Lo YM, Tein MS, Pang CC, et al. Presence of donor-specific DNA in plasma of kidney and liver-transplant recipients. Lancet 1998;351:1329-1330 – reference: 11) U.S. National Library of Medicine. ClinicalTrials.gov, https://classic.clinicaltrials.gov/ct2/home searched by "cfDNA, transplant" (accessed on 2023/11/04) – reference: 8) De Vlaminck I, Martin L, Kertesz M, et al. Noninvasive monitoring of infection and rejection after lung transplantation. Proc Natl Acad Sci USA 2015;112:13336-13341 – reference: 12) Tanaka S, Sugimoto S, Toyooka S, et al. Donor-derived cell-free DNA is associated with acute rejection and decreased oxygenation in primary graft dysfunction after living donor-lobar lung transplantation. Sci Rep 2018;8:15366 – reference: 17) Jordan SC, Bunnapradist S, Bromberg JS, et al. Donor-derived Cell-free DNA Identifies Antibody-mediated Rejection in Donor Specific Antibody Positive Kidney Transplant Recipients. Am J Transplant 2018;18(Suppl 4):254 – reference: 19) Kanamori H, Yamada Y, Kuroda T et al. Noninvasive graft monitoring using donor-derived cell-free DNA in Japanese liver transplantation. Hepatol Res 2023 Oct 18. DOI: 10.1111/hepr.13978. https://onlinelibrary.wiley.com/doi/epdf/10.1111/hepr.13978 – reference: 22) Michael K, Cedric M, Sean AE, et al. Biological Variation of Donor-Derived Cell-Free DNA in Stable Lung Transplant Recipients. J Appl Lab Med 2022;30:901-909 – reference: 4) Verhoeven J, Boer K, Van Schaik RHN, et al. Liquid Biopsies to Monitor Solid Organ Transplant Function: A Review of New Biomarkers. Ther Drug Monit 2018;40: 515-25. – reference: 13) Beck J, Bierau S, Balzer S, et al. Digital droplet PCR for rapid quantification of donor DNA in the circulation of transplant recipients as a potential universal biomarker of graft injury. Clin Chem 2013;59:1732-1741 – reference: 9) Schutz E, Fischer A, Beck J, et al. Graft-derived cell-free DNA, a noninvasive early rejection and graft damage marker in liver transplantation: A prospective, observational, multicenter cohort study. PLoS Med 2017;14:e1002286 – reference: 15) Zhang J, Tong KL, Li PK, et al. Presence of donor- and recipient-derived DNA in cell-free urine samples of renal transplantation recipients: urinary DNA chimerism. Clin Chem 1999;45:1741-1746 |
| SSID | ssj0058419 |
| Score | 1.9619431 |
| Snippet | 臓器移植後の長期グラフト機能維持は今後の移植医療の重要課題である．近年，グラフト障害を低侵襲かつ高感度にモニタリング可能な血清バイオマーカーとして，ドナー由来... |
| SourceID | jstage |
| SourceType | Publisher |
| StartPage | 017 |
| SubjectTerms | グラフト障害 ドナー由来cell free DNA リキッドバイオプシー 臓器移植 |
| Title | 臓器移植におけるLiquid Biopsy（ドナー由来遊離DNA断片測定） |
| URI | https://www.jstage.jst.go.jp/article/organbio/31/1/31_017/_article/-char/ja |
| Volume | 31 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| ispartofPNX | Organ Biology, 2024, Vol.31(1), pp.017-023 |
| journalDatabaseRights | – providerCode: PRVAFT databaseName: Open Access Digital Library customDbUrl: eissn: 2188-0204 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0058419 issn: 1340-5152 databaseCode: KQ8 dateStart: 20110101 isFulltext: true titleUrlDefault: http://grweb.coalliance.org/oadl/oadl.html providerName: Colorado Alliance of Research Libraries – providerCode: PRVEBS databaseName: EBSCOhost Academic Search Ultimate customDbUrl: https://search.ebscohost.com/login.aspx?authtype=ip,shib&custid=s3936755&profile=ehost&defaultdb=asn eissn: 2188-0204 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0058419 issn: 1340-5152 databaseCode: ABDBF dateStart: 20230901 isFulltext: true titleUrlDefault: https://search.ebscohost.com/direct.asp?db=asn providerName: EBSCOhost |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpR1Na9VAMNT24kUUFb_pwT2mJtkku4un3fcSimi9tNBbSPIS6Du0VduD3p491FY8iCKoeBFFwQ_wJvj-TeirPfXk3Znd5PW19WAVQphkZ2bnI8vOLDtZy7pK_SALmevaoQghQSl4aIusEHbqwdzCKHfKEgucb82E03P-jflgfuzYr5FdS6sr2VT-4I91Jf_iVXgHfsUq2SN4dsgUXgAM_oU7eBjuf-VjEnECybygJAqIEERyEjEiGVGKRCGRECe2SUQhWiRS1QCXNSBcDXiEq5sLd1YXOngu5fK9-ySKiWoRznUzXKIBZA1AK3QjfKJc7Ea0iQxIJBrugghFpNeekboV5GgjPvABWeGN4kS2UGIZESGb7sRomKwrROtzModr_kiiHKIiBDjQxvh91BpzR3cG9oj28EESIGFoJiRkmgNDgTUhPEh43sMHTjGRTqOdY9AM20ZiHu-Tx9VGOICvwPBKNwui6OjCire3pEoiH02BgnO0ttRWBZ8ZBdGGVDOjqAUiS7zQBU6jLtOWB6ClyQ9_DUAVo74oexv1MKKC6YxHpNDGbOkvRuPIUFO1wDUjExb1HRtiUjOjFfodRG3cxqLn0VmunmtHR7OZshxTO1tHP46p_j48sVKG1SL6qLFsYWmKulNDwn2_K68HQ9JgJtRNXLwBetI0YkVh0oW0ZsLDZbRxa0KqtoqbEAqCYn0iz1C5Zn8BCHHtgAgQOXYhj2r2YOqwcPakdaLO5yal6fKUNdZNT1u3f64_23r5cfvDj8G7J1XvU9XbrHpPq4ePzUCbNANtt_-oWtuo1jartf7282-DN-93eps7r9_CwBm8-LK9sT74_nnr66vd_sYZay6OZlvTdn1yid2FfD21vTQrQy_MBRNe5rCy9EXOw07AWAnpSep7TPAsDZ0gZXnqhAKysjLvdHhe5rxw8w49a40vLi0W56xJx-9kQYabESn3izTLaAEsaejnjJdB7p-3rhv9k2Xze5rkKB648F_UF63jOHDMiuQla3zl7mpxGWL0lexK7dHfm9jA7w |
| linkProvider | EBSCOhost |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=%E8%87%93%E5%99%A8%E7%A7%BB%E6%A4%8D%E3%81%AB%E3%81%8A%E3%81%91%E3%82%8BLiquid+Biopsy%EF%BC%88%E3%83%89%E3%83%8A%E3%83%BC%E7%94%B1%E6%9D%A5%E9%81%8A%E9%9B%A2DNA%E6%96%AD%E7%89%87%E6%B8%AC%E5%AE%9A%EF%BC%89&rft.jtitle=Organ+Biology&rft.au=%E5%B0%BE%E5%8E%9F%2C+%E7%A7%80%E6%98%8E&rft.au=%E9%95%B7%E8%B0%B7%E5%B7%9D%2C+%E5%BA%B7&rft.au=%E7%AF%A0%E7%94%B0%2C+%E6%98%8C%E5%AE%8F&rft.au=%E5%B1%B1%E7%94%B0%2C+%E6%B4%8B%E5%B9%B3&rft.date=2024&rft.pub=%E4%B8%80%E8%88%AC%E7%A4%BE%E5%9B%A3%E6%B3%95%E4%BA%BA%E3%80%80%E6%97%A5%E6%9C%AC%E8%87%93%E5%99%A8%E4%BF%9D%E5%AD%98%E7%94%9F%E7%89%A9%E5%8C%BB%E5%AD%A6%E4%BC%9A&rft.issn=1340-5152&rft.eissn=2188-0204&rft.volume=31&rft.issue=1&rft.spage=017&rft.epage=023&rft_id=info:doi/10.11378%2Forganbio.31.017&rft.externalDocID=article_organbio_31_1_31_017_article_char_ja |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1340-5152&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1340-5152&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1340-5152&client=summon |