PERSONALIZE TREATMENT FOR LONGITUDINAL DATA USING UNSPECIFIED RANDOM-EFFECTS MODEL

• Published in: Statistica Sinica Vol. 27; no. 1; pp. 187 - 206
• Main Authors: Cho, Hyunkeun, Wang, Peng, Qu, Annie
• Format: Journal Article
• Language: English
• Published: Institute of Statistical Science, Academia Sinica and International Chinese Statistical Association 01.01.2017
• ISSN: 1017-0405; 1996-8507
• DOI: 10.5705/ss.202015.0120

We develop new modeling for personalized treatment for longitudinal studies involving high heterogeneity of treatment effects. Incorporating subjectspecific information into the treatment assignment is crucial since different individuals can react to the same treatment very differently. We estimate unobserved subject-specific treatment effects through conditional random-effects modeling, and apply the random forest algorithm to allocate effective treatments for individuals. The advantage of our approach is that random-effects estimation does not rely on the normality assumption. In theory, we show that the proposed random-effect estimator is consistent and more efficient than the random-effect estimator that ignores correlation information from longitudinal data. Simulation studies and a data example from an HIV clinical trial also confirm that the proposed method can efficiently identify the best treatments for individual patients.