18F-AV45（Florbetapir）を用いた脳アミロイドイメージング
Alzheimer 病（AD）において脳内に蓄積したアミロイドの描出を18F-AV45（Florbetapir）を用いたPET で評価し，軽度認知機能障害（MCI），前頭側頭葉変性症（FTLD）および正常対照（HC）と比較検討を行った．前頭葉，側頭葉，頭頂葉，後頭葉および被殻，視床，橋に関心領域を設定し小脳を対照としたstandardized uptake value ratio（SUVR）を測定し，AD と各疾患で比較した．SUVR は大脳皮質全般でAD において最も高く，MCI はADとHC の中間であった．FTLD では低値であった．HC では白質の集積がやや高かった．18F-AV45...
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| Published in | 脳循環代謝（日本脳循環代謝学会機関誌） Vol. 25; no. 2; pp. 91 - 96 |
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| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
日本脳循環代謝学会
2014
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0915-9401 2188-7519 |
| DOI | 10.16977/cbfm.25.2_91 |
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| Abstract | Alzheimer 病（AD）において脳内に蓄積したアミロイドの描出を18F-AV45（Florbetapir）を用いたPET で評価し，軽度認知機能障害（MCI），前頭側頭葉変性症（FTLD）および正常対照（HC）と比較検討を行った．前頭葉，側頭葉，頭頂葉，後頭葉および被殻，視床，橋に関心領域を設定し小脳を対照としたstandardized uptake value ratio（SUVR）を測定し，AD と各疾患で比較した．SUVR は大脳皮質全般でAD において最も高く，MCI はADとHC の中間であった．FTLD では低値であった．HC では白質の集積がやや高かった．18F-AV45 を用いることで優れたアミロイドイメージングが得られ，またAD とMCI，FTLD，HC の鑑別にSUVR を用いた半定量法ではアミロイド沈着の評価においてこれまでの報告と同様の結果が得られた．今後症例数を増やした統計学的な検討が必要と考えられた． |
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| AbstractList | Alzheimer 病（AD）において脳内に蓄積したアミロイドの描出を18F-AV45（Florbetapir）を用いたPET で評価し，軽度認知機能障害（MCI），前頭側頭葉変性症（FTLD）および正常対照（HC）と比較検討を行った．前頭葉，側頭葉，頭頂葉，後頭葉および被殻，視床，橋に関心領域を設定し小脳を対照としたstandardized uptake value ratio（SUVR）を測定し，AD と各疾患で比較した．SUVR は大脳皮質全般でAD において最も高く，MCI はADとHC の中間であった．FTLD では低値であった．HC では白質の集積がやや高かった．18F-AV45 を用いることで優れたアミロイドイメージングが得られ，またAD とMCI，FTLD，HC の鑑別にSUVR を用いた半定量法ではアミロイド沈着の評価においてこれまでの報告と同様の結果が得られた．今後症例数を増やした統計学的な検討が必要と考えられた． |
| Author | 世良, 耕一郎 柴田, 俊秀 高橋, 純子 米澤, 久司 小原, 智子 佐々木, 敏秋 寺崎, 一典 寺山, 靖夫 工藤, 雅子 |
| Author_xml | – sequence: 1 fullname: 小原, 智子 organization: 岩手医科大学内科学講座神経内科・老年科分野 – sequence: 1 fullname: 柴田, 俊秀 organization: 岩手医科大学内科学講座神経内科・老年科分野 – sequence: 1 fullname: 佐々木, 敏秋 organization: 岩手医科大学サイクロトロンセンター – sequence: 1 fullname: 寺崎, 一典 organization: 岩手医科大学サイクロトロンセンター – sequence: 1 fullname: 工藤, 雅子 organization: 岩手医科大学内科学講座神経内科・老年科分野 – sequence: 1 fullname: 世良, 耕一郎 organization: 岩手医科大学サイクロトロンセンター – sequence: 1 fullname: 高橋, 純子 organization: 岩手医科大学内科学講座神経内科・老年科分野 – sequence: 1 fullname: 寺山, 靖夫 organization: 岩手医科大学内科学講座神経内科・老年科分野 – sequence: 1 fullname: 米澤, 久司 organization: 岩手医科大学内科学講座神経内科・老年科分野 |
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| References | 2) Clark CM, Schneider JA, Bedell BJ, Beach TG, Bilker WB, Mintun MA, Pontecorvo MJ, Hefti F, Carpenter AP, Flitter ML, Krautkramer MJ, Kung HF, Coleman RE, Doraiswamy PM, Fleisher AS, Sabbagh MN, Sadowsky CH, Reiman EP, Reiman PE, Zehntner SP, Skovronsky DM; AV45-A07 Study Group: Use of florbetapir-PET for imaging beta-amyloid pathology. JAMA 305: 275–283, 2011 7) Petersen RC, Smith GE, Waring SC, Ivnik RJ, Tangalos EG, Kokmen E: Mild cognitive impairment: clinical characterization and outcome. Arch Neurol 56: 303–308, 1999 10) Jack CR, Lowe VJ, Senjem ML, Weigand SD, Kemp BJ, Shiung MM, Knopman DS, Boeve BF, Klunk WE, Mathis CA, Petersen RC: 11C PiB and structural MRI provide complementary information in imaging of Alzheimer’s disease and amnestic mild cognitive impairment. Brain 131: 665–680, 2008 8) Braak H, Braak E: Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol 82: 239–259, 1991 5) McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM: Clinical diagnosis of Alzheimer’s disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer’s Disease. Neurology 34: 939–944, 1984 9) Joachim CL, Morris JH, Selkoe DJ: Diffuse senile plaques occur commonly in the cerebellum in Alzheimer’s disease. Am J Pathol 135: 309–319, 1989 4) Wong DF, Rosenberg PB, Zhou Y, Kumar A, Raymont V, Ravert HT, Dannals RF, Nandi A, Brasić JR, Ye W, Hilton J, Lyketsos C, Kung HF, Joshi AD, Skovronsky DM, Pontecorvo MJ: In vivo imaging of amyloid deposition in Alzheimer disease using the radioligand 18F-AV-45 (flor-betapir [corrected] F 18). J Nucl Med 51: 913–920, 2010 1) Choi SR, Golding G, Zhuang Z, Zhang W, Lim N, Hefti F, Benedum TE, Kilbourn MR, Skovronsky D, Kung HF: Preclinical properties of 18F-AV-45: a PET agent for Abeta plaques in the brain. J Nucl Med 50: 1887–1894, 2009 3) Fleisher AS, Chen K, Liu X, Roontiva A, Thiyyagura P, Ayutyanont N, Joshi AD, Clark CM, Mintun MA, Pontecorvo MJ, Doraiswamy PM, Johnson KA, Skovronsky DM, Reiman EM: Using positron emission tomography and florbetapir F18 to image cortical amyloid in patients with mild cognitive impairment or dementia due to Alzheimer disease. Arch Neurol 68: 1404–1411, 2011 6) Petersen RC: Mild cognitive impairment as a diagnostic entity. J Intern Med 256: 183–194, 2004 |
| References_xml | – reference: 2) Clark CM, Schneider JA, Bedell BJ, Beach TG, Bilker WB, Mintun MA, Pontecorvo MJ, Hefti F, Carpenter AP, Flitter ML, Krautkramer MJ, Kung HF, Coleman RE, Doraiswamy PM, Fleisher AS, Sabbagh MN, Sadowsky CH, Reiman EP, Reiman PE, Zehntner SP, Skovronsky DM; AV45-A07 Study Group: Use of florbetapir-PET for imaging beta-amyloid pathology. JAMA 305: 275–283, 2011 – reference: 5) McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM: Clinical diagnosis of Alzheimer’s disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer’s Disease. Neurology 34: 939–944, 1984 – reference: 9) Joachim CL, Morris JH, Selkoe DJ: Diffuse senile plaques occur commonly in the cerebellum in Alzheimer’s disease. Am J Pathol 135: 309–319, 1989 – reference: 4) Wong DF, Rosenberg PB, Zhou Y, Kumar A, Raymont V, Ravert HT, Dannals RF, Nandi A, Brasić JR, Ye W, Hilton J, Lyketsos C, Kung HF, Joshi AD, Skovronsky DM, Pontecorvo MJ: In vivo imaging of amyloid deposition in Alzheimer disease using the radioligand 18F-AV-45 (flor-betapir [corrected] F 18). J Nucl Med 51: 913–920, 2010 – reference: 6) Petersen RC: Mild cognitive impairment as a diagnostic entity. J Intern Med 256: 183–194, 2004 – reference: 3) Fleisher AS, Chen K, Liu X, Roontiva A, Thiyyagura P, Ayutyanont N, Joshi AD, Clark CM, Mintun MA, Pontecorvo MJ, Doraiswamy PM, Johnson KA, Skovronsky DM, Reiman EM: Using positron emission tomography and florbetapir F18 to image cortical amyloid in patients with mild cognitive impairment or dementia due to Alzheimer disease. Arch Neurol 68: 1404–1411, 2011 – reference: 7) Petersen RC, Smith GE, Waring SC, Ivnik RJ, Tangalos EG, Kokmen E: Mild cognitive impairment: clinical characterization and outcome. Arch Neurol 56: 303–308, 1999 – reference: 10) Jack CR, Lowe VJ, Senjem ML, Weigand SD, Kemp BJ, Shiung MM, Knopman DS, Boeve BF, Klunk WE, Mathis CA, Petersen RC: 11C PiB and structural MRI provide complementary information in imaging of Alzheimer’s disease and amnestic mild cognitive impairment. Brain 131: 665–680, 2008 – reference: 1) Choi SR, Golding G, Zhuang Z, Zhang W, Lim N, Hefti F, Benedum TE, Kilbourn MR, Skovronsky D, Kung HF: Preclinical properties of 18F-AV-45: a PET agent for Abeta plaques in the brain. J Nucl Med 50: 1887–1894, 2009 – reference: 8) Braak H, Braak E: Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol 82: 239–259, 1991 |
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| Title | 18F-AV45（Florbetapir）を用いた脳アミロイドイメージング |
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