B型肝炎ウイルスと肝発がん

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Published inウイルス Vol. 44; no. 1; pp. 86 - 90
Main Author 小池, 克郎
Format Journal Article
LanguageJapanese
Published 日本ウイルス学会 01.06.1994
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ISSN0042-6857
1884-3433
DOI10.2222/jsv.44.86

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Author 小池, 克郎
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References 18) Mahe, Y., Mukaida N., Kuno, K., Akiyama, M., Ikeda, N., Matsushima, K. and Murakami, S. Hepatitis b virus X protein transactivates human interleukin-8 genethrough acting on nuclear fatter kB and CCAAT/Enhancerbinding protein-like cis-elements J. Biol. Chem. 266: 13759-13763, 1991.
11) Shirakata, Y., Kawada, M., Fujiki, Y., Sano, H., Oda, M., Yaginuma, K., Kobayashi, M., Koike, K. The X gene of hepatitis B virus induced growth stimulationand tumorigenic trans-formation of mouse NIH3T3 cells. Jpn. J. Cancer. Res. 80: 617-621, 1989.
15) Chisari, F. V., Klopchin, K., Moriyama, T., Pasquinelli, C., Dunsford, H. A., Sell, S., Pinkert, C. A., Brinster, R. L. and Palmiter, R. D. Molecular pathogenesis of hepatocellular carcinoma in hepatitis B virus transgenic mice. Cell 59: 1145-1156, 1989.
24) Takada, S. and Koike, K. Trans-activation function of 3′ truncated X gene-cell fusion product from integrated hepatitis B virus DNA in chronic hepatitis tussues. Proc. Natl. Acad. Sci. USA. 87: 5628-5632. 1990.
3) Koike, K., Shirakata, Y., Yaginuma, K., Nakamura, I., Hayashi, Y., Kawada, M., Kobayashi, M. Oncogenic potential of hepatitis B virus. Mol. Biol. Med. 6: 151-160, 1989.
10) Carman, W. F. Mutation preventing formation of hepatitis B e antigen in thepatients with chronic hepatitis B infection. Lancet ii: 588-591, 1989.
7) Seto, E., Yen, T. S. B., Peterlin, B. M., Ou, J. Trans-activation of the human immnodeficiency virus long terminal repeat by the hepatitis B virus X protein. Proc. Natl. Acad. Sci. USA. 85: 8286-8290, 1988.
14) Cova, L., Trepo, C.: 私信
27) Emi, M., Fujiwara, Y., Ohta, H., Tsuda, H., Hirohashi, S., Koike, M., Miyaki, K., Monden, M. and Nakamura, Y. Allelic loss at chromosome band 8p21. 3-p. 22 is associated with progression of hepatocellular carcinoma. Genes, Chromosomes & Cancer 7: 152-157, 1993.
8) Yaginuma, K., Shirakata, Y., Kobayashi, M., and Koike, K. Hepatitis B virus (HBV) particles are produced in a cell culture system by transient expression of transfected HBV DNA. Proc. Natl. Acad. Sci. USA 84: 2678-2682, 1987.
13) Kim, C., Koike, K.. Saito, I.. Miyamura, T., and Gilbert, J. HBx gene of hepatitis B virus induces liver cancer in transgenic mice. Nature 351: 317-320, 1991.
23) Takada, S. and Koike, K. 投稿中
5) Spandau, D. F. and Lee, C. Trans-Activation of viral enhancers by the hepatitis B virus X protein. J. Virol. 62: 427-434, 1988.
21) Takada, S. and Koike, K. X protein of hepatitis B virus resembles a serineprotease inhibitor. Jpn. J. Cancer. Res. 81: 1191-1194, 1990.
25) Takada, S. and Koike, K. B型肝炎ウイルスと肝発癌. 蛋・核・酵. 35: 2089-2099, 1990.
16) Zahm, P., Hofschneider, P. H. and Koshy, R. The HBV X-ORF encodes a transactivator: a potential factor in viral hepatocarcinogenesis. Oncogene 3: 169-177, 1988.
12) Hohne, M., Schaefer, S., Scifer, M., Feitelson, M. A., Paul, D., Gerlich, W. H. Malignant transformation of immortalized transgenic hepatocyte after transfection with hepatitis B virus DNA. Embo J. 9: 1137-1145, 1990.
29) Takada, S., Mori, T., Kido, H., Nakamura, I., Yaginuma, K., Tsuchida, K., and Koike, K. Contribution of HBV X gene expression to hepatic carcinogenesis. In Viral Hepatitis and Liver Diseases, Springer-Verlag, Tokyo, pp. 753-756, 1994.
1) Beasley, R. P., Lin, C-C., Hwang, L-Y., Chien, C. S. Hepatocellular carcinoma and hepatitis B virus. Lancet ii: 1129-1133, 1981.
4) Wang, G. H. and Seeger, C. The reverse transcriptase of hepatitis B virus acts as a protein primer for viral DNA synthesis. Cell 71: 663-670, 1992.
17) Aufiero, B., and Schneider, R. J. The hepatitis B virus X-gene product tansactivates both RNA polymerase II and III promoters. EMBO. J. 9: 497-504, 1990.
9) Bulla, G. A. and Siddiqui, A. The hepatitis B virus enhancer modulates transcription of the hepatitis B virus surface antigen gene from an internal location. J. Virol. 62: 1437-1441, 1988.
22) Takada, S., Kido, H., Fukutomi, A. Mori, T. and Koike, K. Interaction of hepatitis B virus X protein with a serine protease, trptase TL2 as an inhibitor. Oncogene 9: 341-348, 1994.
19) Siddiqui, A., Gaynor, R., Srinivasan, A., Mapoles, J. and Farr, R. W. Trans-activation of viral enhancers including long terminal repeat of the human immunodeficiency virus by the hepatitis B virus X protein. Virology 169: 479-484, 1989.
20) Faktor, O. and Shaul, Y. The identification of hepatitis B virus X gene responsive elements reveals functional similarity of X and HTLV-1 tax. Oncogene 5: 867-872, 1990.
26) Wollersheim, M., Debelka, U., Hofschneider, P. H. A transactivating function encoded in the hepatitis B virus X gene is conserved in the integrated state. Oncogene 3: 545-552, 1988.
6) Twu, J. S. and Schloemer, R. H. Transcriptional trans-activating function of hepatitis B virus. J. Virol. 61: 3448-3453, 1987.
28) Bressae, B., Galivin, K. M, and Liang, T. J. Abnormal structure and expression of p53 gene in human hepatocellular carcinoma. Proc. Natl. Acad. Sci. USA 87: 1973-1977, 1990.
2) Kobayashi, M. and Koike, K. Complete nucleotide sequence of hepatitis B virus DNA of subtype adr and its conserved gene organization. Gene 30: 227-232, 1984.
References_xml – reference: 18) Mahe, Y., Mukaida N., Kuno, K., Akiyama, M., Ikeda, N., Matsushima, K. and Murakami, S. Hepatitis b virus X protein transactivates human interleukin-8 genethrough acting on nuclear fatter kB and CCAAT/Enhancerbinding protein-like cis-elements J. Biol. Chem. 266: 13759-13763, 1991.
– reference: 27) Emi, M., Fujiwara, Y., Ohta, H., Tsuda, H., Hirohashi, S., Koike, M., Miyaki, K., Monden, M. and Nakamura, Y. Allelic loss at chromosome band 8p21. 3-p. 22 is associated with progression of hepatocellular carcinoma. Genes, Chromosomes & Cancer 7: 152-157, 1993.
– reference: 8) Yaginuma, K., Shirakata, Y., Kobayashi, M., and Koike, K. Hepatitis B virus (HBV) particles are produced in a cell culture system by transient expression of transfected HBV DNA. Proc. Natl. Acad. Sci. USA 84: 2678-2682, 1987.
– reference: 19) Siddiqui, A., Gaynor, R., Srinivasan, A., Mapoles, J. and Farr, R. W. Trans-activation of viral enhancers including long terminal repeat of the human immunodeficiency virus by the hepatitis B virus X protein. Virology 169: 479-484, 1989.
– reference: 4) Wang, G. H. and Seeger, C. The reverse transcriptase of hepatitis B virus acts as a protein primer for viral DNA synthesis. Cell 71: 663-670, 1992.
– reference: 29) Takada, S., Mori, T., Kido, H., Nakamura, I., Yaginuma, K., Tsuchida, K., and Koike, K. Contribution of HBV X gene expression to hepatic carcinogenesis. In Viral Hepatitis and Liver Diseases, Springer-Verlag, Tokyo, pp. 753-756, 1994.
– reference: 3) Koike, K., Shirakata, Y., Yaginuma, K., Nakamura, I., Hayashi, Y., Kawada, M., Kobayashi, M. Oncogenic potential of hepatitis B virus. Mol. Biol. Med. 6: 151-160, 1989.
– reference: 20) Faktor, O. and Shaul, Y. The identification of hepatitis B virus X gene responsive elements reveals functional similarity of X and HTLV-1 tax. Oncogene 5: 867-872, 1990.
– reference: 28) Bressae, B., Galivin, K. M, and Liang, T. J. Abnormal structure and expression of p53 gene in human hepatocellular carcinoma. Proc. Natl. Acad. Sci. USA 87: 1973-1977, 1990.
– reference: 7) Seto, E., Yen, T. S. B., Peterlin, B. M., Ou, J. Trans-activation of the human immnodeficiency virus long terminal repeat by the hepatitis B virus X protein. Proc. Natl. Acad. Sci. USA. 85: 8286-8290, 1988.
– reference: 26) Wollersheim, M., Debelka, U., Hofschneider, P. H. A transactivating function encoded in the hepatitis B virus X gene is conserved in the integrated state. Oncogene 3: 545-552, 1988.
– reference: 2) Kobayashi, M. and Koike, K. Complete nucleotide sequence of hepatitis B virus DNA of subtype adr and its conserved gene organization. Gene 30: 227-232, 1984.
– reference: 23) Takada, S. and Koike, K. 投稿中
– reference: 6) Twu, J. S. and Schloemer, R. H. Transcriptional trans-activating function of hepatitis B virus. J. Virol. 61: 3448-3453, 1987.
– reference: 11) Shirakata, Y., Kawada, M., Fujiki, Y., Sano, H., Oda, M., Yaginuma, K., Kobayashi, M., Koike, K. The X gene of hepatitis B virus induced growth stimulationand tumorigenic trans-formation of mouse NIH3T3 cells. Jpn. J. Cancer. Res. 80: 617-621, 1989.
– reference: 13) Kim, C., Koike, K.. Saito, I.. Miyamura, T., and Gilbert, J. HBx gene of hepatitis B virus induces liver cancer in transgenic mice. Nature 351: 317-320, 1991.
– reference: 14) Cova, L., Trepo, C.: 私信
– reference: 24) Takada, S. and Koike, K. Trans-activation function of 3′ truncated X gene-cell fusion product from integrated hepatitis B virus DNA in chronic hepatitis tussues. Proc. Natl. Acad. Sci. USA. 87: 5628-5632. 1990.
– reference: 1) Beasley, R. P., Lin, C-C., Hwang, L-Y., Chien, C. S. Hepatocellular carcinoma and hepatitis B virus. Lancet ii: 1129-1133, 1981.
– reference: 25) Takada, S. and Koike, K. B型肝炎ウイルスと肝発癌. 蛋・核・酵. 35: 2089-2099, 1990.
– reference: 10) Carman, W. F. Mutation preventing formation of hepatitis B e antigen in thepatients with chronic hepatitis B infection. Lancet ii: 588-591, 1989.
– reference: 5) Spandau, D. F. and Lee, C. Trans-Activation of viral enhancers by the hepatitis B virus X protein. J. Virol. 62: 427-434, 1988.
– reference: 17) Aufiero, B., and Schneider, R. J. The hepatitis B virus X-gene product tansactivates both RNA polymerase II and III promoters. EMBO. J. 9: 497-504, 1990.
– reference: 21) Takada, S. and Koike, K. X protein of hepatitis B virus resembles a serineprotease inhibitor. Jpn. J. Cancer. Res. 81: 1191-1194, 1990.
– reference: 12) Hohne, M., Schaefer, S., Scifer, M., Feitelson, M. A., Paul, D., Gerlich, W. H. Malignant transformation of immortalized transgenic hepatocyte after transfection with hepatitis B virus DNA. Embo J. 9: 1137-1145, 1990.
– reference: 15) Chisari, F. V., Klopchin, K., Moriyama, T., Pasquinelli, C., Dunsford, H. A., Sell, S., Pinkert, C. A., Brinster, R. L. and Palmiter, R. D. Molecular pathogenesis of hepatocellular carcinoma in hepatitis B virus transgenic mice. Cell 59: 1145-1156, 1989.
– reference: 9) Bulla, G. A. and Siddiqui, A. The hepatitis B virus enhancer modulates transcription of the hepatitis B virus surface antigen gene from an internal location. J. Virol. 62: 1437-1441, 1988.
– reference: 16) Zahm, P., Hofschneider, P. H. and Koshy, R. The HBV X-ORF encodes a transactivator: a potential factor in viral hepatocarcinogenesis. Oncogene 3: 169-177, 1988.
– reference: 22) Takada, S., Kido, H., Fukutomi, A. Mori, T. and Koike, K. Interaction of hepatitis B virus X protein with a serine protease, trptase TL2 as an inhibitor. Oncogene 9: 341-348, 1994.
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