C 型肝炎ウイルス感染による大脳皮質の形態的変化 Surface-based Morphometry を用いた検討
C 型肝炎ウイルス (HCV) は，慢性肝炎や肝硬変などの肝疾患の起因としてよく知られているが，その他 30 以上のウイルス関連性の肝外疾患が存在する．最近では，HCV 感染による中枢神経系への直接的・間接的障害が注目されている．本研究では，慢性 C 型肝炎患者を対象として，頭部 MRI 画像を用いた大脳皮質の形態的変化を検討した．疾患群は慢性 C 型肝炎患者 11 人，対照群は 18 人であった．頭部 MRI 画像を元に，Surfacebasedmorphometry (SBM) の一つである FreeSurfer で大脳皮質表面を再構築し，Query, Design, Estimate,...
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| Published in | 日大医学雑誌 Vol. 77; no. 4; pp. 261 - 266 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
日本大学医学会
01.08.2018
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0029-0424 1884-0779 |
| DOI | 10.4264/numa.77.4_261 |
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| Abstract | C 型肝炎ウイルス (HCV) は，慢性肝炎や肝硬変などの肝疾患の起因としてよく知られているが，その他 30 以上のウイルス関連性の肝外疾患が存在する．最近では，HCV 感染による中枢神経系への直接的・間接的障害が注目されている．本研究では，慢性 C 型肝炎患者を対象として，頭部 MRI 画像を用いた大脳皮質の形態的変化を検討した．疾患群は慢性 C 型肝炎患者 11 人，対照群は 18 人であった．頭部 MRI 画像を元に，Surfacebasedmorphometry (SBM) の一つである FreeSurfer で大脳皮質表面を再構築し，Query, Design, Estimate, and Contrast(QDEC) 解析法を用いて大脳皮質を疾患群と対照群との間で比較した．その結果，疾患群では対照群と比較して，左中側頭回，左上側頭回，左上前頭回，右中心後回に皮質表面積の有意な低下 (P < 0.001)，右下頭頂小葉に皮質厚の有意な増加を認めた (P < 0.001)．従って，慢性 C 型肝炎患者において言語領域を主体とした大脳皮質の形態的変化が認められ，HCV 感染によって惹起された中枢神経障害を示唆するものと考えられた． |
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| AbstractList | C 型肝炎ウイルス (HCV) は，慢性肝炎や肝硬変などの肝疾患の起因としてよく知られているが，その他 30 以上のウイルス関連性の肝外疾患が存在する．最近では，HCV 感染による中枢神経系への直接的・間接的障害が注目されている．本研究では，慢性 C 型肝炎患者を対象として，頭部 MRI 画像を用いた大脳皮質の形態的変化を検討した．疾患群は慢性 C 型肝炎患者 11 人，対照群は 18 人であった．頭部 MRI 画像を元に，Surfacebasedmorphometry (SBM) の一つである FreeSurfer で大脳皮質表面を再構築し，Query, Design, Estimate, and Contrast(QDEC) 解析法を用いて大脳皮質を疾患群と対照群との間で比較した．その結果，疾患群では対照群と比較して，左中側頭回，左上側頭回，左上前頭回，右中心後回に皮質表面積の有意な低下 (P < 0.001)，右下頭頂小葉に皮質厚の有意な増加を認めた (P < 0.001)．従って，慢性 C 型肝炎患者において言語領域を主体とした大脳皮質の形態的変化が認められ，HCV 感染によって惹起された中枢神経障害を示唆するものと考えられた． |
| Author | 浅井, 聰 菊田, 潤子 西田, 弥生 髙橋, 泰夫 天野, 康雄 阿部, 修 原留, 弘樹 和田, 昭彦 |
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| References | Gautam P, Anstey KJ, Wen W, et al. Cortical gyrification andits relationships with cortical volume, cortical thickness, andcognitive performance in healthy mid-life adults. BehaviouralBrain Research 2015; 287: 331–339. Kramer L, Bauer E, Funk G, et al. Subclinical impairmentof brain function in chronic hepatits C infection. Journal ofHepatology 2002; 37: 349–354. Rakic P. Evolution of the neocortex: a perspective from developmentalbiology. Nat Rev Neurosci 2009; 10: 724–735. Wisco JJ, Kuperberg G, Manoach D, et al. Abnormal corticalfolding patterns within Broca's area in schizophrenia: evidencefrom structural MRI. Schizophr Res 2007; 94: 317–327. Singh-Curry V, Husain M. The functional role of the inferiorparietal lobe in the dorsal and ventral stream dichotomy. Neuropsychologia2009; 47: 1434–1448. 入戸野宏．P300 応用：認知科学の立場から．臨床神経生理 2015; 41(2): 86–92. Yun JY, Kim JC, Ku J, et al. The left middle temporal gyrusin the middle of an impaired social-affective communicationnetwork in social anxiety disorder. J Affect Disord. 2017; 214:53–59. Csernansky JG, Gillespie SK, Dierker DL, et al. Symmetricabnormalities in sulcal patterning in schizophrenia. Neuroimage2008; 43: 440–446. Montoliu C, Gonzalez-Escamilla G, Atienza M, et al. Focalcortical damage parallels cognitive impairment in minimalhepatic encephalopathy. Neuroimage 2012; 61: 1165–1175. Boisgueheneuc F, Levy R, Volle E, et al. Functions of the leftsuperior frontal gyrus in humans: a lesion study. Brain 2006;129: 3315–3328. Wallace GL, Robustelli B, Dankner N, et al. Increased gyrification,but comparable surface area in adolescents with autismspectrum disorders. Brain 2013; 136: 1956–1967. Richman DP, Stewart RM, Hutchinson JW et al. Mechanicalmodel of brain convolutional development. Science 1975; 189(4196): 18–21. Forton DM, Allsop JM, Main J, et al. Evidence for a cerebraleffect of the hepatitis C virus. The Lancet 2001; 358(9275):38–39. Thames AD, Castellon SA, Singer EJ, et al. Neuroimagingabnormalities, neurocognitive function, and fatigue in patientswith hepatitis C. Neurol Neuroimmunol Neuroinflamm 2015; 2:e59. Cacciarelli TV, Martinez OM, Gish RG, et al. ImmunoregulatoryCytokines in Chronic Hepatitis C Virus Infection: PreandPosttreatment With Interferon Alfa. Hepatology 1996;24(1): 6–9. Pagonabarraga J, Corcuera-Solano I, Vives-Gilabert Y, et al.Pattern of regional cortical thinning associated with cognitivedeterioration in Parkinson's disease. PLoS One 2013; 8:e54980. Ogino Y, Nemoto H, Goto F. Somatotopy in human primarysomatosensory cortex in pain system. Anesthesiology 2005;103: 821–827. Tomasz L, Marek R, Debra M, et al. Emerging evidence ofhepatitis C virus neuroinvasion. AIDS 2005; 19(3): 140–144. Monaco S, Ferrari S, Gajofatto A, et al. HCV-related nervoussystem disorders. Clin Dev Immunol 2012; 236148. Worker A, Blain C, Jarosz J, et al. Cortical thickness, surfacearea and volume measures in Parkinson’s disease, multiplesystem atrophy and progressive supranuclear palsy. PLoS One2014; 9: e114167. Dale AM, Fischl B, Sereno MI. Cortical surface-based analysisI: Segmetation and surface reconstruction. Neuroimage1999; 9(2): 179–194. Van Essen DC. A tension-based theory of morphogenesis andcompact wiring in the central nervous system. Nature 1997;385(6614): 313–318. Kriegstein A, Noctor S, Cerdeno VM. Patterns of neural stemand progenitor cell division may underlie evolutionary corticalexpansion. Nuroscience 2006; 7: 883–890. Sarma MK, Nagarajan R, Hinkin CH, et al. Voxel-BasedMorphometric Analysis of Brain Volumetry and Diffusivity inHepatitis C. Proc Intl Soc Mag Reson Med 2010; 18: 2426. Hilgetag CC, Barbas H. Role of mechanical factors in themorphology of the primate cerebral cortex. PLoS Comput Biol2006; 2: e22. Yarlott L, Heald E, Forton D. Hepatitis C virus infection, andneurological and psychiatric disorders – A review. J Adv Res2017; 8: 139–148. Riccelli R, Toschi N, Nigro S, et al. Surface-based morphometryreveals the neuroanatomical basis of the five-factor modelof personality. Soc Cogn Affect Neurosci 2017; 12(4): 671–684. Fischl B, Dale AM. Measuring the thickness of the humancerebral cortex from magnetic resonance images. Proc NatlAcad Sci USA 2000; 97: 11050–11055. Leff AP, Schofield TM, Crinion JT, et al. The left superiortemporal gyrus is a shared substrate for auditory short-termmemory and speech comprehension: evidence from 210 patientswith stroke. Brain 2009; 132: 3401–3410. Fischl B, Sereno MI, Dale AM. Cortical surface-based analysisII: Inflation, Flattening, and a surfaced-based coordinatesystem. Neuroimage 1999; 9: 195–207. Marsland AL, Gianaros PJ, Kuan DC, et al. Brain morphologylinks systemic inflammation to cognitive function in midlifeadults. Brain Behav Immun 2015; 48: 195–204. Bladowska J, Zimny A, Knysz B, et al. Evaluation of early cerebral metabolic, perfusion and microstructural changes inHCV-positive patients: A pilot study. Journal of Hepatology2013; 59: 651–657. Reynolds S, Carrey N, Jaworska, et al. Cortical thickness inyouth with major depressive disorder. BMC Psychiatry 2014;14: 83. Heeren M, Weissenborn K, Arvanitis D, et al. Cerebral glucoseutilisation in hepatitis C virus infection-associated encephalopathy.J Cereb Blood Flow Metab 2011; 31: 2199–2208. Kamei S, Morita A, Tanaka N, et al. Relationships betweenQuantitative Electroencephalographic Alterations and theSeverity of Hepatitis C Based on Liver Biopsy in Interferon-αTreated Patients. Internal Medicine 2009; 48: 975–980. Voets NL, Hough MG, Douaud G, et al. Evidence for abnormalitiesof cortical development in adolescent-onset schizophrenia.Neuroimage 2008; 43: 665–675. |
| References_xml | – reference: Rakic P. Evolution of the neocortex: a perspective from developmentalbiology. Nat Rev Neurosci 2009; 10: 724–735. – reference: Leff AP, Schofield TM, Crinion JT, et al. The left superiortemporal gyrus is a shared substrate for auditory short-termmemory and speech comprehension: evidence from 210 patientswith stroke. Brain 2009; 132: 3401–3410. – reference: Van Essen DC. A tension-based theory of morphogenesis andcompact wiring in the central nervous system. Nature 1997;385(6614): 313–318. – reference: Dale AM, Fischl B, Sereno MI. Cortical surface-based analysisI: Segmetation and surface reconstruction. Neuroimage1999; 9(2): 179–194. – reference: Singh-Curry V, Husain M. The functional role of the inferiorparietal lobe in the dorsal and ventral stream dichotomy. Neuropsychologia2009; 47: 1434–1448. – reference: Cacciarelli TV, Martinez OM, Gish RG, et al. ImmunoregulatoryCytokines in Chronic Hepatitis C Virus Infection: PreandPosttreatment With Interferon Alfa. Hepatology 1996;24(1): 6–9. – reference: Hilgetag CC, Barbas H. Role of mechanical factors in themorphology of the primate cerebral cortex. PLoS Comput Biol2006; 2: e22. – reference: Wisco JJ, Kuperberg G, Manoach D, et al. Abnormal corticalfolding patterns within Broca's area in schizophrenia: evidencefrom structural MRI. Schizophr Res 2007; 94: 317–327. – reference: Reynolds S, Carrey N, Jaworska, et al. Cortical thickness inyouth with major depressive disorder. BMC Psychiatry 2014;14: 83. – reference: Montoliu C, Gonzalez-Escamilla G, Atienza M, et al. Focalcortical damage parallels cognitive impairment in minimalhepatic encephalopathy. Neuroimage 2012; 61: 1165–1175. – reference: Pagonabarraga J, Corcuera-Solano I, Vives-Gilabert Y, et al.Pattern of regional cortical thinning associated with cognitivedeterioration in Parkinson's disease. PLoS One 2013; 8:e54980. – reference: Marsland AL, Gianaros PJ, Kuan DC, et al. Brain morphologylinks systemic inflammation to cognitive function in midlifeadults. Brain Behav Immun 2015; 48: 195–204. – reference: Voets NL, Hough MG, Douaud G, et al. Evidence for abnormalitiesof cortical development in adolescent-onset schizophrenia.Neuroimage 2008; 43: 665–675. – reference: Worker A, Blain C, Jarosz J, et al. Cortical thickness, surfacearea and volume measures in Parkinson’s disease, multiplesystem atrophy and progressive supranuclear palsy. PLoS One2014; 9: e114167. – reference: Kriegstein A, Noctor S, Cerdeno VM. Patterns of neural stemand progenitor cell division may underlie evolutionary corticalexpansion. Nuroscience 2006; 7: 883–890. – reference: Kramer L, Bauer E, Funk G, et al. Subclinical impairmentof brain function in chronic hepatits C infection. Journal ofHepatology 2002; 37: 349–354. – reference: Wallace GL, Robustelli B, Dankner N, et al. Increased gyrification,but comparable surface area in adolescents with autismspectrum disorders. Brain 2013; 136: 1956–1967. – reference: Thames AD, Castellon SA, Singer EJ, et al. Neuroimagingabnormalities, neurocognitive function, and fatigue in patientswith hepatitis C. Neurol Neuroimmunol Neuroinflamm 2015; 2:e59. – reference: Yun JY, Kim JC, Ku J, et al. The left middle temporal gyrusin the middle of an impaired social-affective communicationnetwork in social anxiety disorder. J Affect Disord. 2017; 214:53–59. – reference: Ogino Y, Nemoto H, Goto F. Somatotopy in human primarysomatosensory cortex in pain system. Anesthesiology 2005;103: 821–827. – reference: Yarlott L, Heald E, Forton D. Hepatitis C virus infection, andneurological and psychiatric disorders – A review. J Adv Res2017; 8: 139–148. – reference: Kamei S, Morita A, Tanaka N, et al. Relationships betweenQuantitative Electroencephalographic Alterations and theSeverity of Hepatitis C Based on Liver Biopsy in Interferon-αTreated Patients. Internal Medicine 2009; 48: 975–980. – reference: Boisgueheneuc F, Levy R, Volle E, et al. Functions of the leftsuperior frontal gyrus in humans: a lesion study. Brain 2006;129: 3315–3328. – reference: Bladowska J, Zimny A, Knysz B, et al. Evaluation of early cerebral metabolic, perfusion and microstructural changes inHCV-positive patients: A pilot study. Journal of Hepatology2013; 59: 651–657. – reference: Forton DM, Allsop JM, Main J, et al. Evidence for a cerebraleffect of the hepatitis C virus. The Lancet 2001; 358(9275):38–39. – reference: Heeren M, Weissenborn K, Arvanitis D, et al. Cerebral glucoseutilisation in hepatitis C virus infection-associated encephalopathy.J Cereb Blood Flow Metab 2011; 31: 2199–2208. – reference: 入戸野宏．P300 応用：認知科学の立場から．臨床神経生理 2015; 41(2): 86–92. – reference: Richman DP, Stewart RM, Hutchinson JW et al. Mechanicalmodel of brain convolutional development. Science 1975; 189(4196): 18–21. – reference: Fischl B, Sereno MI, Dale AM. Cortical surface-based analysisII: Inflation, Flattening, and a surfaced-based coordinatesystem. Neuroimage 1999; 9: 195–207. – reference: Monaco S, Ferrari S, Gajofatto A, et al. HCV-related nervoussystem disorders. Clin Dev Immunol 2012; 236148. – reference: Sarma MK, Nagarajan R, Hinkin CH, et al. Voxel-BasedMorphometric Analysis of Brain Volumetry and Diffusivity inHepatitis C. Proc Intl Soc Mag Reson Med 2010; 18: 2426. – reference: Gautam P, Anstey KJ, Wen W, et al. Cortical gyrification andits relationships with cortical volume, cortical thickness, andcognitive performance in healthy mid-life adults. BehaviouralBrain Research 2015; 287: 331–339. – reference: Fischl B, Dale AM. Measuring the thickness of the humancerebral cortex from magnetic resonance images. Proc NatlAcad Sci USA 2000; 97: 11050–11055. – reference: Tomasz L, Marek R, Debra M, et al. Emerging evidence ofhepatitis C virus neuroinvasion. AIDS 2005; 19(3): 140–144. – reference: Riccelli R, Toschi N, Nigro S, et al. Surface-based morphometryreveals the neuroanatomical basis of the five-factor modelof personality. Soc Cogn Affect Neurosci 2017; 12(4): 671–684. – reference: Csernansky JG, Gillespie SK, Dierker DL, et al. Symmetricabnormalities in sulcal patterning in schizophrenia. Neuroimage2008; 43: 440–446. |
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| Snippet | C 型肝炎ウイルス (HCV) は，慢性肝炎や肝硬変などの肝疾患の起因としてよく知られているが，その他 30 以上のウイルス関連性の肝外疾患が存在する．最近では，HCV 感... |
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| SubjectTerms | C 型肝炎ウイルス surface-based morphometry 中枢神経障害 大脳皮質 |
| Subtitle | Surface-based Morphometry を用いた検討 |
| Title | C 型肝炎ウイルス感染による大脳皮質の形態的変化 |
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