4）肥満症の新たな視点―細胞内ストレス応答系を活用した治療法開発
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| Published in | 日本内科学会雑誌 Vol. 105; no. 9; pp. 1739 - 1745 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
一般社団法人 日本内科学会
2016
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 0021-5384 1883-2083 |
| DOI | 10.2169/naika.105.1739 |
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| Author | 甲斐, 広文 近藤, 龍也 荒木, 栄一 |
|---|---|
| Author_xml | – sequence: 1 fullname: 甲斐, 広文 organization: 熊本大学大学院生命科学研究部代謝内科学分野 – sequence: 1 fullname: 近藤, 龍也 organization: 熊本大学大学院生命科学研究部代謝内科学分野 – sequence: 1 fullname: 荒木, 栄一 organization: 熊本大学大学院生命科学研究部代謝内科学分野 |
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| References | 10) Morino, S, et al: Mild electrical stimulation with heat shock ameliorates insulin resistance via enhanced insulin signaling. PLoS One 3: e4068, 2008. 2) Hirosumi J, et al: A central role for JNK in obesity and insulin resistance. Nature 420: 333-336, 2002. 6) Biro S, et al: Clinical implications of thermal therapy in lifestyle-related diseases. Exp Biol Med (Maywood) 228: 1245-1249, 2003. 15) Kurucz I, et al: Decreased expression of heat shock protein 72 in skeletal muscle of patients with type 2 diabetes correlates with insulin resistance. Diabetes 51: 1102-1109, 2002. 1) Romeo GR, et al: Metabolic syndrome, insulin resistance, and roles of inflammation-mechanisms and therapeutic targets. Arterioscler Thromb Vasc Biol 32: 1771-1776, 2012. 5) Hooper PL: Hot-tub therapy for type 2 diabetes mellitus. N Engl J Med 341: 924-925, 1999. 3) Morimoto RI, et al: The heat-shock response: regulation and function of heat-shock proteins and molecular chaperones. Essays Biochem 32: 17-29, 1997. 8) Morino-Koga S, et al: Insulin receptor activation through its accumulation in lipid rafts by mild electrical stress. J Cell Physiol 228: 439-446, 2013. 11) Kondo, T, et al: Hyperthermia with mild electrical stimulation protects pancreatic beta-cells from cell stresses and apoptosis. Diabetes 61: 838-847, 2012. 4) Morimoto RI: Cells in stress: Transcriptional activation of heat shock genes. Science 259: 1409-1410, 1993. 13) Kondo, T, et al: Heat shock treatment with mild electrical stimulation safely reduced inflammatory markers in healthy male subjects. Obes Res Clin Pract 4: e83-162, 2010. 14) Kondo T, et al: Mild Electrical Stimulation with Heat Shock Reduces Visceral Adiposity and Improves Metabolic Abnormalities in Subjects with Metabolic Syndrome or Type 2 Diabetes: Randomized Crossover Trials. EBioMedicine 1: 80-89, 2014. 12) Adachi H, et al: An acylic polyisoprenoid derivative, geranylgeranylacetone protects against visceral adiposity and insulin resistance in high fat fed mice. Am J Physiol Endocrinol Metab 299: E764-771, 2010. 7) Yano S, et al: Glucose uptake in rat skeletal muscle L6 cells is increased by low-intensity electrical current through the activation of the phosphatidylinositol-3-OH kinase (PI-3K) /Akt pathway. J Pharmacol Sci 115: 94-98, 2011. 16) Hooper, PL, et al: The importance of the cellular stress response in the pathogenesis and treatment of type 2 diabetes. Cell Stress Chaperones 19: 447-464, 2014. 17) Moran MM, et al: Transient receptor potential channels as therapeutic targets. Nat Rev Drug Discov 10: 601-620, 2011. 9) Morino S, et al: Mild electrical stimulation increases ubiquitinated proteins and Hsp72 in A549 cells via attenuation of proteasomal degradation. J Pharmacol Sci 108: 222-226, 2008. |
| References_xml | – reference: 15) Kurucz I, et al: Decreased expression of heat shock protein 72 in skeletal muscle of patients with type 2 diabetes correlates with insulin resistance. Diabetes 51: 1102-1109, 2002. – reference: 6) Biro S, et al: Clinical implications of thermal therapy in lifestyle-related diseases. Exp Biol Med (Maywood) 228: 1245-1249, 2003. – reference: 2) Hirosumi J, et al: A central role for JNK in obesity and insulin resistance. Nature 420: 333-336, 2002. – reference: 14) Kondo T, et al: Mild Electrical Stimulation with Heat Shock Reduces Visceral Adiposity and Improves Metabolic Abnormalities in Subjects with Metabolic Syndrome or Type 2 Diabetes: Randomized Crossover Trials. EBioMedicine 1: 80-89, 2014. – reference: 7) Yano S, et al: Glucose uptake in rat skeletal muscle L6 cells is increased by low-intensity electrical current through the activation of the phosphatidylinositol-3-OH kinase (PI-3K) /Akt pathway. J Pharmacol Sci 115: 94-98, 2011. – reference: 13) Kondo, T, et al: Heat shock treatment with mild electrical stimulation safely reduced inflammatory markers in healthy male subjects. Obes Res Clin Pract 4: e83-162, 2010. – reference: 16) Hooper, PL, et al: The importance of the cellular stress response in the pathogenesis and treatment of type 2 diabetes. Cell Stress Chaperones 19: 447-464, 2014. – reference: 17) Moran MM, et al: Transient receptor potential channels as therapeutic targets. Nat Rev Drug Discov 10: 601-620, 2011. – reference: 3) Morimoto RI, et al: The heat-shock response: regulation and function of heat-shock proteins and molecular chaperones. Essays Biochem 32: 17-29, 1997. – reference: 4) Morimoto RI: Cells in stress: Transcriptional activation of heat shock genes. Science 259: 1409-1410, 1993. – reference: 9) Morino S, et al: Mild electrical stimulation increases ubiquitinated proteins and Hsp72 in A549 cells via attenuation of proteasomal degradation. J Pharmacol Sci 108: 222-226, 2008. – reference: 10) Morino, S, et al: Mild electrical stimulation with heat shock ameliorates insulin resistance via enhanced insulin signaling. PLoS One 3: e4068, 2008. – reference: 12) Adachi H, et al: An acylic polyisoprenoid derivative, geranylgeranylacetone protects against visceral adiposity and insulin resistance in high fat fed mice. Am J Physiol Endocrinol Metab 299: E764-771, 2010. – reference: 5) Hooper PL: Hot-tub therapy for type 2 diabetes mellitus. N Engl J Med 341: 924-925, 1999. – reference: 11) Kondo, T, et al: Hyperthermia with mild electrical stimulation protects pancreatic beta-cells from cell stresses and apoptosis. Diabetes 61: 838-847, 2012. – reference: 8) Morino-Koga S, et al: Insulin receptor activation through its accumulation in lipid rafts by mild electrical stress. J Cell Physiol 228: 439-446, 2013. – reference: 1) Romeo GR, et al: Metabolic syndrome, insulin resistance, and roles of inflammation-mechanisms and therapeutic targets. Arterioscler Thromb Vasc Biol 32: 1771-1776, 2012. |
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| SubjectTerms | インスリン抵抗性 ヒートショック蛋白 メタボリックシンドローム 慢性炎症 糖尿病 |
| Title | 4）肥満症の新たな視点―細胞内ストレス応答系を活用した治療法開発 |
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