4)病態からみえてきた炎症性腸疾患治療―現在そして未来にむけて

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Published in日本内科学会雑誌 Vol. 109; no. 9; pp. 1759 - 1763
Main Author 仲瀬, 裕志
Format Journal Article
LanguageJapanese
Published 一般社団法人 日本内科学会 10.09.2020
Subjects
Online AccessGet full text
ISSN0021-5384
1883-2083
DOI10.2169/naika.109.1759

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Author 仲瀬, 裕志
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References 9) Nakase H, et al: Significance of measurement of serum trough level and anti-drug antibody of adalimumab as personalised pharmacokinetics in patients with Crohn's disease: a subanalysis of the DIAMOND trial. Aliment Pharmacol Ther 46: 873-882, 2017.
7) Forkel M, et al: Distinct alterations in the composition of mucosal innate lymphoid cells in newly diagnosed and established Crohn's disease and ulcerative colitis. J Crohns Colitis 13: 67-78, 2019.
2) Cooney R, et al: NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation. Nat Med 16: 90-97, 2010.
11) Yoshino T, et al: Immunosuppressive effects of tacrolimus on macrophages ameliorate experimental colitis. Inflamm Bowel Dis 16: 2022-33, 2010.
4) Smith PD, et al: Intestinal macrophages: unique effector cells of the innate immune system. Immunol Rev 206: 149-159, 2005.
13) Sandborn WJ, et al: Tofacitinib as induction and maintenance therapy for ulcerative colitis. N Engl J Med 376: 1723-1736, 2017.
17) Vermeire S, et al: The mucosal addressin cell adhesion molecule antibody PF-00547,659 in ulcerative colitis: a randomised study. Gut 60: 1068-1075, 2011.
1) Fritz T, et al: Crohn's disease: NOD2, autophagy and ER stress converge. Gut 60: 1580-1588, 2011.
5) Denning TL, et al: Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17-producing T cell responses. Nat Immunol 8: 1086-1094, 2007.
15) Christensen B, et al: Safety and efficacy of combination treatment with calcineurin inhibitors and vedolizumab in patients with refractory inflammatory bowel disease. Clin Gastroenterol Hepatol 17: 486-493, 2019.
12) Vijayakrishnan L, et al: Treating inflammation with the Janus kinase inhibitor CP-690,550. Trends Pharmacol Sci 32: 25-34, 2011.
3) Smythies LE, et al: Human intestinal macrophages display profound inflammatory anergy despite avid phagocytic and bacteriocidal activity. J Clin Invest 115: 66-75, 2005.
10) Arseneau KO, Cominelli F: Targeting leukocyte trafficking for the treatment of inflammatory bowel disease. Clin Pharmacol Ther 97: 22-28, 2015.
16) Danese S, Panés J: Development of drugs to target interactions between leukocytes and endothelial cells and treatment algorithms for inflammatory bowel diseases. Gastroenterology 147: 981-989, 2014.
14) Scribano ML: Vedolizumab for inflammatory bowel disease: from randomized controlled trials to real-life evidence. World J Gastroenterol 24: 2457-2467, 2018.
8) Yamada S, et al: Long-term efficacy of infliximab for refractory ulcerative colitis: results from a single center experience. BMC Gastroenterol 14: 80, 2014.
18) Sandborn WJ, et al: Ozanimod induction and maintenance treatment for ulcerative colitis. N Engl J Med 374: 1754-1762, 2016.
6) Kamada N, et al: Unique CD14 intestinal macrophages contribute to the pathogenesis of Crohn disease via IL-23/IFN-gamma axis. J Clin Invest 118: 2269-2280, 2008.
References_xml – reference: 7) Forkel M, et al: Distinct alterations in the composition of mucosal innate lymphoid cells in newly diagnosed and established Crohn's disease and ulcerative colitis. J Crohns Colitis 13: 67-78, 2019.
– reference: 3) Smythies LE, et al: Human intestinal macrophages display profound inflammatory anergy despite avid phagocytic and bacteriocidal activity. J Clin Invest 115: 66-75, 2005.
– reference: 5) Denning TL, et al: Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17-producing T cell responses. Nat Immunol 8: 1086-1094, 2007.
– reference: 15) Christensen B, et al: Safety and efficacy of combination treatment with calcineurin inhibitors and vedolizumab in patients with refractory inflammatory bowel disease. Clin Gastroenterol Hepatol 17: 486-493, 2019.
– reference: 1) Fritz T, et al: Crohn's disease: NOD2, autophagy and ER stress converge. Gut 60: 1580-1588, 2011.
– reference: 8) Yamada S, et al: Long-term efficacy of infliximab for refractory ulcerative colitis: results from a single center experience. BMC Gastroenterol 14: 80, 2014.
– reference: 14) Scribano ML: Vedolizumab for inflammatory bowel disease: from randomized controlled trials to real-life evidence. World J Gastroenterol 24: 2457-2467, 2018.
– reference: 2) Cooney R, et al: NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation. Nat Med 16: 90-97, 2010.
– reference: 6) Kamada N, et al: Unique CD14 intestinal macrophages contribute to the pathogenesis of Crohn disease via IL-23/IFN-gamma axis. J Clin Invest 118: 2269-2280, 2008.
– reference: 12) Vijayakrishnan L, et al: Treating inflammation with the Janus kinase inhibitor CP-690,550. Trends Pharmacol Sci 32: 25-34, 2011.
– reference: 4) Smith PD, et al: Intestinal macrophages: unique effector cells of the innate immune system. Immunol Rev 206: 149-159, 2005.
– reference: 16) Danese S, Panés J: Development of drugs to target interactions between leukocytes and endothelial cells and treatment algorithms for inflammatory bowel diseases. Gastroenterology 147: 981-989, 2014.
– reference: 18) Sandborn WJ, et al: Ozanimod induction and maintenance treatment for ulcerative colitis. N Engl J Med 374: 1754-1762, 2016.
– reference: 10) Arseneau KO, Cominelli F: Targeting leukocyte trafficking for the treatment of inflammatory bowel disease. Clin Pharmacol Ther 97: 22-28, 2015.
– reference: 11) Yoshino T, et al: Immunosuppressive effects of tacrolimus on macrophages ameliorate experimental colitis. Inflamm Bowel Dis 16: 2022-33, 2010.
– reference: 9) Nakase H, et al: Significance of measurement of serum trough level and anti-drug antibody of adalimumab as personalised pharmacokinetics in patients with Crohn's disease: a subanalysis of the DIAMOND trial. Aliment Pharmacol Ther 46: 873-882, 2017.
– reference: 13) Sandborn WJ, et al: Tofacitinib as induction and maintenance therapy for ulcerative colitis. N Engl J Med 376: 1723-1736, 2017.
– reference: 17) Vermeire S, et al: The mucosal addressin cell adhesion molecule antibody PF-00547,659 in ulcerative colitis: a randomised study. Gut 60: 1068-1075, 2011.
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SubjectTerms 獲得免疫
生物学的製剤
自然免疫
Title 4)病態からみえてきた炎症性腸疾患治療―現在そして未来にむけて
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