Treatment schedule with an immunoglobulin preparation against fever in granulocytopenic patients with hematological malignancies
Patients with hematological malignancies, who were clinically suspected of having sepsis after developing granulocytopenia and a fever of 38°C or higher following anti-cancer chemotherapy, were divided into Group A and Group B by an envelope method. Group A received antibacterial agents (piperacilli...
Saved in:
| Published in | Japanese Journal of Chemotherapy Vol. 44; no. 11; pp. 853 - 857 |
|---|---|
| Main Authors | , , , , , , , , , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
Japanese Society of Chemotherapy
1996
公益社団法人 日本化学療法学会 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1340-7007 1884-5886 |
| DOI | 10.11250/chemotherapy1995.44.853 |
Cover
| Abstract | Patients with hematological malignancies, who were clinically suspected of having sepsis after developing granulocytopenia and a fever of 38°C or higher following anti-cancer chemotherapy, were divided into Group A and Group B by an envelope method. Group A received antibacterial agents (piperacillin: PIPC+isepamicin: ISP) and an immunoglobulin preparation (Polyglobin N®) simultaneously. Group B received antibacterial agents (PIPC+ISP) first and an immunoglobulin preparation 4 days later. The clinical courses of both groups were compared. There were no significant differences between Group A (10 cases) and Group B (11 cases) in underlying diseases and leukocyte count, granulocyte count, CRP or use of CSF preparations at the fever onset. In Group A, decline of fever and improvement of CRP were significantly quicker compared to those in Group B. Recovery of the leukocyte count was also significantly faster in Group A than in Group B. The treatment period with the antibacterial agents was significantly shortened in Group A compared with Group B. Though GOT and GPT were elevated slightly in one case of Group A, no severe adverse reaction was seen in both groups. These results demonstrate the possibility that an early injection of immunoglobulin preparations is effective for the treatment of granulocytopenic infections in patients with hematological malignancies. |
|---|---|
| AbstractList | Patients with hematological malignancies, who were clinically suspected of having sepsis after developing granulocytopenia and a fever of 38°C or higher following anti-cancer chemotherapy, were divided into Group A and Group B by an envelope method. Group A received antibacterial agents (piperacillin: PIPC+isepamicin: ISP) and an immunoglobulin preparation (Polyglobin N®) simultaneously. Group B received antibacterial agents (PIPC+ISP) first and an immunoglobulin preparation 4 days later. The clinical courses of both groups were compared. There were no significant differences between Group A (10 cases) and Group B (11 cases) in underlying diseases and leukocyte count, granulocyte count, CRP or use of CSF preparations at the fever onset. In Group A, decline of fever and improvement of CRP were significantly quicker compared to those in Group B. Recovery of the leukocyte count was also significantly faster in Group A than in Group B. The treatment period with the antibacterial agents was significantly shortened in Group A compared with Group B. Though GOT and GPT were elevated slightly in one case of Group A, no severe adverse reaction was seen in both groups. These results demonstrate the possibility that an early injection of immunoglobulin preparations is effective for the treatment of granulocytopenic infections in patients with hematological malignancies. Patients with hematological malignancies, who were clinically suspected of having sepsis after developing granulocytopenia and a fever of 38°C or higher following anti-cancer chemotherapy, were divided into Group A and Group B by an envelope method. Group A received antibacterial agents (piperacillin: PIPC+isepamicin: ISP) and an immunoglobulin preparation (Polyglobin N®) simultaneously. Group B received antibacterial agents (PIPC+ISP) first and an immunoglobulin preparation 4 days later. The clinical courses of both groups were compared. There were no significant differences between Group A (10 cases) and Group B (11 cases) in underlying diseases and leukocyte count, granulocyte count, CRP or use of CSF preparations at the fever onset. In Group A, decline of fever and improvement of CRP were significantly quicker compared to those in Group B. Recovery of the leukocyte count was also significantly faster in Group A than in Group B. The treatment period with the antibacterial agents was significantly shortened in Group A compared with Group B. Though GOT and GPT were elevated slightly in one case of Group A, no severe adverse reaction was seen in both groups. These results demonstrate the possibility that an early injection of immunoglobulin preparations is effective for the treatment of granulocytopenic infections in patients with hematological malignancies. 血液悪性疾患の抗癌化学療法後の顆粒球減少時に38℃ 以上の発熱を認め, Boneによる敗血症の診断基準を満たし, 臨床的に敗血症を疑った症例を抗菌薬 (piperacillin: PIPC+isepamicin: ISP) と同時に免疫グロプリン製剤 (ポリグロビンN®) を投与する群 (A群) と抗菌薬 (PIPC+ISP) 投与後4日目から免疫グロブリン製剤を投与する群 (B群) とに封筒法で分け, 臨床経過を比較検討した。A群 (10例) とB群 (11例) とには基礎疾患, 発熱時の白血球数・顆粒球数・CRP・colony-stimulating factor (CSF) 製剤の使用に有意差はなかった。A群ではB群に比較し, 解熱・CRPの改善と白血球数の回復とが有意に早く, 抗菌薬の投与期間が有意に短縮した。A群の1例でGOT・GPTの軽度上昇を認めたが, 重篤な副作用は両群ともなかった。以上から血液悪性疾患では顆粒球減少時の感染症治療上免疫グロプリン製剤を早期から投与することが有用である可能性が示唆された。 |
| Author | Sakamoto, Masahiro Mori, Kei Sawaki, Masayoshi Narita, Nobuhiro Tsujimoto, Masayuki Nishikawa, Kiyoshi Imae, Norihisa Yamanaka, Takayo Maeda, Koichi Konishi, Mitsuru Hamada, Kaoru Teramoto, Shoji Mikasa, Keiichi |
| Author_FL | 前田 光一 山中 貴世 井前 徳久 三笠 桂一 森 啓 成田 亘啓 坂本 正洋 濱田 薫 西川 潔 澤木 政好 寺本 正治 辻本 正之 古西 満 |
| Author_FL_xml | – sequence: 1 fullname: 古西 満 – sequence: 2 fullname: 井前 徳久 – sequence: 3 fullname: 森 啓 – sequence: 4 fullname: 寺本 正治 – sequence: 5 fullname: 坂本 正洋 – sequence: 6 fullname: 辻本 正之 – sequence: 7 fullname: 山中 貴世 – sequence: 8 fullname: 前田 光一 – sequence: 9 fullname: 濱田 薫 – sequence: 10 fullname: 三笠 桂一 – sequence: 11 fullname: 西川 潔 – sequence: 12 fullname: 澤木 政好 – sequence: 13 fullname: 成田 亘啓 |
| Author_xml | – sequence: 1 fullname: Mori, Kei organization: Second Department of Internal Medicine, Nara Medical University – sequence: 1 fullname: Hamada, Kaoru organization: Second Department of Internal Medicine, Nara Medical University – sequence: 1 fullname: Imae, Norihisa organization: Second Department of Internal Medicine, Nara Medical University – sequence: 1 fullname: Mikasa, Keiichi organization: Second Department of Internal Medicine, Nara Medical University – sequence: 1 fullname: Sakamoto, Masahiro organization: Second Department of Internal Medicine, Nara Medical University – sequence: 1 fullname: Teramoto, Shoji organization: Second Department of Internal Medicine, Nara Medical University – sequence: 1 fullname: Yamanaka, Takayo organization: Second Department of Internal Medicine, Nara Medical University – sequence: 1 fullname: Tsujimoto, Masayuki organization: Second Department of Internal Medicine, Nara Medical University – sequence: 1 fullname: Maeda, Koichi organization: Second Department of Internal Medicine, Nara Medical University – sequence: 1 fullname: Nishikawa, Kiyoshi organization: Second Department of Internal Medicine, Nara Medical University – sequence: 1 fullname: Sawaki, Masayoshi organization: Second Department of Internal Medicine, Nara Medical University – sequence: 1 fullname: Narita, Nobuhiro organization: Second Department of Internal Medicine, Nara Medical University – sequence: 1 fullname: Konishi, Mitsuru organization: Second Department of Internal Medicine, Nara Medical University |
| BackLink | https://cir.nii.ac.jp/crid/1390001206286266240$$DView record in CiNii |
| BookMark | eNpdkMtKAzEUhoMoqLXvkIXbqckkc8lSxBsU3dT1cHKZaUomGTKp0p2PbqRdiJv_HDgfH4f_Gp374A1CmJIVpWVF7tTWjCFtTYTpQIWoVpyv2oqdoSvatryo2rY-zzvjpGgIaS7Rcp6tJIRSUjMqrtD3JhpIo_EJz1mm987gL5u2GDy247j3YXBB7p31eIpmggjJBo9hAOvnhHvzaSLOxyGC37ugDilMxluFpwxm63y05TchBRcGq8DhEZwdPHhlzXyDLnpws1me5gJ9PD1uHl6K9fvz68P9utjRqiEFa3QvgJSyhKZtNNVcyVpDL4XkveYMoDK8ZyBkW3MNWirWMyl6VTWq0UKyBbo9er21nbK_SZkguYqS1GVbl3VdcpKxtyO2mxMMppuiHSEeOojJKme6_4V3nHeUnjI3_weE2BnPfgDVq4eb |
| ContentType | Journal Article |
| Copyright | Japanese Society of Chemotherapy |
| Copyright_xml | – notice: Japanese Society of Chemotherapy |
| DBID | RYH |
| DOI | 10.11250/chemotherapy1995.44.853 |
| DatabaseName | CiNii Complete |
| DatabaseTitleList | |
| DeliveryMethod | fulltext_linktorsrc |
| DocumentTitleAlternate | 血液悪性疾患でのか粒球減少時の発熱に対する免疫グロブリン製剤投与時期に関する検討 |
| DocumentTitle_FL | 血液悪性疾患でのか粒球減少時の発熱に対する免疫グロブリン製剤投与時期に関する検討 |
| EISSN | 1884-5886 |
| EndPage | 857 |
| ExternalDocumentID | 130004297612 article_chemotherapy1995_44_11_44_11_853_article_char_en |
| GroupedDBID | 5GY ALMA_UNASSIGNED_HOLDINGS DIK JSF KQ8 P2P RJT RYH |
| ID | FETCH-LOGICAL-j1570-37df9a02b2a787d1d4cb6dafb9b4fd43aa5e4f3a9b864dadbc3f3b9fc57c7d9b3 |
| ISSN | 1340-7007 |
| IngestDate | Thu Jun 26 23:05:45 EDT 2025 Wed Sep 03 06:28:59 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 11 |
| Language | Japanese |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-j1570-37df9a02b2a787d1d4cb6dafb9b4fd43aa5e4f3a9b864dadbc3f3b9fc57c7d9b3 |
| OpenAccessLink | https://www.jstage.jst.go.jp/article/chemotherapy1995/44/11/44_11_853/_article/-char/en |
| PageCount | 5 |
| ParticipantIDs | nii_cinii_1390001206286266240 jstage_primary_article_chemotherapy1995_44_11_44_11_853_article_char_en |
| PublicationCentury | 1900 |
| PublicationDate | 1996 |
| PublicationDateYYYYMMDD | 1996-01-01 |
| PublicationDate_xml | – year: 1996 text: 1996 |
| PublicationDecade | 1990 |
| PublicationTitle | Japanese Journal of Chemotherapy |
| PublicationTitleAlternate | Jpn. J. Chemother. |
| PublicationTitle_FL | Jpn. J. Chemother 日化療会誌 日本化学療法学会雑誌 |
| PublicationYear | 1996 |
| Publisher | Japanese Society of Chemotherapy 公益社団法人 日本化学療法学会 |
| Publisher_xml | – name: Japanese Society of Chemotherapy – name: 公益社団法人 日本化学療法学会 |
| References | 7) Bone R C, Fein A M, Balk R A, Knaus W A, Cerra F B, Schein R M H, Dellinger R P, Sibbld W J: Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Chest 101: 1644-1655, 1992 2) 佐々木安津子, 塚口真知子: 造血器疾患患者の死因について-特に敗血症と真菌感染について. 現代医療25 (増刊): 3007-3011, 1993 1) 金森平和, 他: 血液疾患に合併した敗血症の検討. 臨床血液30: 158-163, 1989 5) 高橋弘, 草剪博昭, 中澤省三: 脳神経外科領域の重症感染症における免疫グロブリン製剤と抗生物質との併用効果-投与スケジュールの違いによる効果の比較検討-. 感染症誌68: 767-774, 1994 8) 長部誠志: 造血器腫瘍における敗血症の実態-監視培養の有用性と危険因子解析-. Chemotherapy 43: 539-546, 1995 4) 北村聖, 溝口秀昭, 平嶋邦猛, 浅野茂隆, 外山圭助, 池田康夫, 高久史麿: 内科領域の重症感染症に対する人免疫グロブリン, 抗生剤とG-SCFとの併用効果. 感染症誌69: 684-695, 1995 6) Harper T E, Christensen R D, Rothstein G, Hill H R: Effect of intravenous immunoglobulin G on neutrophil kinetics during experimental Group G Streptococcul infection in neonatal rats. Rev Infect Dis 8: S 401-S 408, 1986 3) 北村聖, 高久史麿, 宮崎保, 涌井昭, 溝口秀昭, 内野治人, 正岡徹, 永井清保, 仁保喜之: 内科領域の重症感染症に対する静注用液状人免疫グロブリン製剤C-425の抗生剤との併用効果. 感染症誌64: 19-33, 1990 |
| References_xml | – reference: 3) 北村聖, 高久史麿, 宮崎保, 涌井昭, 溝口秀昭, 内野治人, 正岡徹, 永井清保, 仁保喜之: 内科領域の重症感染症に対する静注用液状人免疫グロブリン製剤C-425の抗生剤との併用効果. 感染症誌64: 19-33, 1990 – reference: 5) 高橋弘, 草剪博昭, 中澤省三: 脳神経外科領域の重症感染症における免疫グロブリン製剤と抗生物質との併用効果-投与スケジュールの違いによる効果の比較検討-. 感染症誌68: 767-774, 1994 – reference: 8) 長部誠志: 造血器腫瘍における敗血症の実態-監視培養の有用性と危険因子解析-. Chemotherapy 43: 539-546, 1995 – reference: 6) Harper T E, Christensen R D, Rothstein G, Hill H R: Effect of intravenous immunoglobulin G on neutrophil kinetics during experimental Group G Streptococcul infection in neonatal rats. Rev Infect Dis 8: S 401-S 408, 1986 – reference: 2) 佐々木安津子, 塚口真知子: 造血器疾患患者の死因について-特に敗血症と真菌感染について. 現代医療25 (増刊): 3007-3011, 1993 – reference: 4) 北村聖, 溝口秀昭, 平嶋邦猛, 浅野茂隆, 外山圭助, 池田康夫, 高久史麿: 内科領域の重症感染症に対する人免疫グロブリン, 抗生剤とG-SCFとの併用効果. 感染症誌69: 684-695, 1995 – reference: 7) Bone R C, Fein A M, Balk R A, Knaus W A, Cerra F B, Schein R M H, Dellinger R P, Sibbld W J: Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Chest 101: 1644-1655, 1992 – reference: 1) 金森平和, 他: 血液疾患に合併した敗血症の検討. 臨床血液30: 158-163, 1989 |
| SSID | ssib001106319 ssib050995465 ssib000940262 ssib001168255 ssib038076210 ssib002822060 ssib002670600 ssib058493824 ssj0003212010 |
| Score | 1.45818 |
| Snippet | Patients with hematological malignancies, who were clinically suspected of having sepsis after developing granulocytopenia and a fever of 38°C or higher... |
| SourceID | nii jstage |
| SourceType | Publisher |
| StartPage | 853 |
| SubjectTerms | グロブリン製剤 投与時期 敗血症 血液悪性疾患 顆粒球減少 |
| Title | Treatment schedule with an immunoglobulin preparation against fever in granulocytopenic patients with hematological malignancies |
| URI | https://www.jstage.jst.go.jp/article/chemotherapy1995/44/11/44_11_853/_article/-char/en https://cir.nii.ac.jp/crid/1390001206286266240 |
| Volume | 44 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| ispartofPNX | Japanese Journal of Chemotherapy, 1996/11/25, Vol.44(11), pp.853-857 |
| journalDatabaseRights | – providerCode: PRVAFT databaseName: Open Access Digital Library customDbUrl: eissn: 1884-5886 dateEnd: 20081231 omitProxy: true ssIdentifier: ssj0003212010 issn: 1340-7007 databaseCode: KQ8 dateStart: 19950101 isFulltext: true titleUrlDefault: http://grweb.coalliance.org/oadl/oadl.html providerName: Colorado Alliance of Research Libraries – providerCode: PRVBFR databaseName: Free Medical Journals customDbUrl: eissn: 1884-5886 dateEnd: 20081231 omitProxy: true ssIdentifier: ssj0003212010 issn: 1340-7007 databaseCode: DIK dateStart: 19950101 isFulltext: true titleUrlDefault: http://www.freemedicaljournals.com providerName: Flying Publisher |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1LbxMxELbScuGCQIAopcgHbtGGza734SNCQKEqp1bqbeVn6kCTKo8DnPi7_Atm1t5dpxQJKi5W4mSdjWfG84135jMhr0qepWXGVFJYU0CAIngiEcjJmmubGawFxSe6p5_L43P26aK4GI1-RllL242cqO-31pXcRarQB3LFKtl_kGw_KHTAa5AvtCBhaP9Oxn2WOMSo4DO-mq5Wbeyw7mOJdB9tqvn1yniSb0w-ngkHoHBsDfxh3O-Ygb_aglP7tsGztJzqyFZD5VtL69qvkVcA3Gf-TN_1DrIFr4unWY4jiItsBKHCa0g2Xvra9hPjot1zoUNp2nK17bX1SpjwaMldunXvP07dF7EWYQynLt2wc4HJzoM_6e6oy0y97Y78epxjwmPqD8adGN9X1ywp6sCgHRZxTyLZKes0WpJrT0bceXdPh_274wAoCOJW0V1g8fqEsUk_wA4tdxB6c_OKhjGIqkILlzbDF8UKlHaP3Mtw6wjx-8eTCOlCIB8xNwIqK_OYaW9aQiwfIdsSaY8i5AZALx0iXTxGoMwGZAewkOOx9_37mvG8DoVBCFpygDCp5-7oprzLe4OZef2HeQHYNocgBtkp9hbORcjs7CF5EPSNvvEz8IiM5uIx-dHbBu1sg6I2U7Ggu7ZBI9ugwTZoaxsUPrxpG7SzDT_ajm3Q2DaekPP3787eHifhtJFkPi0qACOVtlykmcwEODE91UzJUgsruWRWs1yIwjCbCy7rkmmhpcptLrlVRaUqzWX-lOwvlgvzjFBpuUkrUwMUt0wqJZlAYjkhJdOmyqsD8sFPW3PtKWWau2rTATmCeW-UwxaCuXZjGcuiSwDeANaf_7dfOiT3fcEC7j6-IPub1dYcAR7fyJetJv8CmS_kZw |
| linkProvider | Flying Publisher |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Treatment+schedule+with+an+immunoglobulin+preparation+against+fever+in+granulocytopenic+patients+with+hematological+malignancies&rft.jtitle=Japanese+Journal+of+Chemotherapy&rft.au=Mori%2C+Kei&rft.au=Hamada%2C+Kaoru&rft.au=Imae%2C+Norihisa&rft.au=Mikasa%2C+Keiichi&rft.date=1996&rft.pub=Japanese+Society+of+Chemotherapy&rft.issn=1340-7007&rft.eissn=1884-5886&rft.volume=44&rft.issue=11&rft.spage=853&rft.epage=857&rft_id=info:doi/10.11250%2Fchemotherapy1995.44.853&rft.externalDocID=article_chemotherapy1995_44_11_44_11_853_article_char_en |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1340-7007&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1340-7007&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1340-7007&client=summon |