Ten Cases of Feline Mediastinal Lymphoma
From 2005 November through 2010 July, ten cases of feline mediastinal lymphoma which had been treated according to the University of Wisconsin-Madison chemotherapy protocol for dogs (UW 25) were surveyed retrospectively regarding complete remission rate, survival time, and adverse effects of this co...
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| Published in | Journal of Animal Clinical Medicine Vol. 20; no. 4; pp. 115 - 120 |
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| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
Japanese Society of Clinical Veterinary Medicine
2011
動物臨床医学会 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1344-6991 1881-1574 |
| DOI | 10.11252/dobutsurinshoigaku.20.115 |
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| Abstract | From 2005 November through 2010 July, ten cases of feline mediastinal lymphoma which had been treated according to the University of Wisconsin-Madison chemotherapy protocol for dogs (UW 25) were surveyed retrospectively regarding complete remission rate, survival time, and adverse effects of this compound chemotherapy. The average complete remission rate was 90%. Six cats survived for less than one year, one of which is still alive. Another cat survived for over one year, and is still alive. Yet another cat survived for over two years, and is still alive. The remaining two survived for over three years, and one of them is still alive. In general, side effects were slight, and were cured with symptomatic treatment. This multi-agent protocol, UW 25, proved to be much better than conventional COP protocol in respect of survival time, showing that long-term survival could be achieved with its use. |
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| AbstractList | From 2005 November through 2010 July, ten cases of feline mediastinal lymphoma which had been treated according to the University of Wisconsin-Madison chemotherapy protocol for dogs (UW 25) were surveyed retrospectively regarding complete remission rate, survival time, and adverse effects of this compound chemotherapy. The average complete remission rate was 90%. Six cats survived for less than one year, one of which is still alive. Another cat survived for over one year, and is still alive. Yet another cat survived for over two years, and is still alive. The remaining two survived for over three years, and one of them is still alive. In general, side effects were slight, and were cured with symptomatic treatment. This multi-agent protocol, UW 25, proved to be much better than conventional COP protocol in respect of survival time, showing that long-term survival could be achieved with its use.
2005年11月～2010年7月までに，縦隔型リンパ腫と診断した猫10例に，犬のUniversity of Wisconsin-Madison chemotherapy protocol（UW25）に準じたプロトコールを行い，完全寛解率，生存期間ならびに抗癌剤の副作用について調査した。完全寛解率は90%と非常に高く，生存期間は1年未満が6例（現在生存中1例含む），1年以上2年未満が1例（現在生存中），2年以上3年未満が1例（現在生存中），3年以上が2例（現在生存中1例含む）と長期の生存期間が得られた。副作用の程度は軽度であり対症療法により回復した。このプロトコールでは25週の治療期間中に再発がみられなかった場合，過去のCOP療法の報告と比べ非常に長期の生存期間が得られることが証明された。 From 2005 November through 2010 July, ten cases of feline mediastinal lymphoma which had been treated according to the University of Wisconsin-Madison chemotherapy protocol for dogs (UW 25) were surveyed retrospectively regarding complete remission rate, survival time, and adverse effects of this compound chemotherapy. The average complete remission rate was 90%. Six cats survived for less than one year, one of which is still alive. Another cat survived for over one year, and is still alive. Yet another cat survived for over two years, and is still alive. The remaining two survived for over three years, and one of them is still alive. In general, side effects were slight, and were cured with symptomatic treatment. This multi-agent protocol, UW 25, proved to be much better than conventional COP protocol in respect of survival time, showing that long-term survival could be achieved with its use. |
| Author | MORISHITA, Keitarou SHIMODA, Tetsuya YASUKAWA, Kuniyoshi TABATA, Katsutoshi NAGAYA, Yusuke UENO, Takashi SHOJI, Yuki FUKUI, Kenta |
| Author_FL | 福井 健太 森下 啓太郎 庄司 祐樹 安川 邦美 植野 孝志 下田 哲也 田端 克俊 長屋 有祐 |
| Author_FL_xml | – sequence: 1 fullname: 福井 健太 – sequence: 2 fullname: 安川 邦美 – sequence: 3 fullname: 田端 克俊 – sequence: 4 fullname: 森下 啓太郎 – sequence: 5 fullname: 植野 孝志 – sequence: 6 fullname: 庄司 祐樹 – sequence: 7 fullname: 長屋 有祐 – sequence: 8 fullname: 下田 哲也 |
| Author_xml | – sequence: 1 fullname: MORISHITA, Keitarou organization: Sanyo Animal Medical Center – sequence: 1 fullname: NAGAYA, Yusuke organization: Sanyo Animal Medical Center – sequence: 1 fullname: SHOJI, Yuki organization: Sanyo Animal Medical Center – sequence: 1 fullname: FUKUI, Kenta organization: Sanyo Animal Medical Center – sequence: 1 fullname: TABATA, Katsutoshi organization: Sanyo Animal Medical Center – sequence: 1 fullname: YASUKAWA, Kuniyoshi organization: Sanyo Animal Medical Center – sequence: 1 fullname: UENO, Takashi organization: Sanyo Animal Medical Center – sequence: 1 fullname: SHIMODA, Tetsuya organization: Sanyo Animal Medical Center |
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| References | 13) Cotter.S.M.: Treatment of lymphoma and leukemia with cyclophosphamide, vincristine, and prednisone.II. Treatment of cat. J Am Anim Hosp Assoc, 19, 166-172 (1983 21) Moore AS, Cotter SM, Frimberger AE, Wood CA, Rand WM, L'Heureux DA: A comparison of doxorubicin and COP for maintenance of remission in cats with lymphoma. J Vet Intern Med, 10, 372-375 (1996 2) Gabor LJ, Canfield PJ, Malik R: Immunophenotypic and histological characterization of 109 cases of feline lymphosarcoma. Aust Vet J, 77, 436-441 (1999 22) Hadden AG, Cotter SM, Rand W, Moore AS, Davis RM, Morrissey P: Efficacy and Toxicosis of VELCAP-C Treatment of Lymphoma in Cats. J Vet Intern Med, 22, 153-157 (2008 3) Cockerell GL, Krakowka S, Hoover EA, Olsen RG, Yohn DS: Characterization of feline T-and B-lymphocytes and identification of an experimental induced T-cell neoplasm in the cat. J Natl Cancer Inst, 57, 907-913 (1976 15) Milner RJ, Peyton J, Cooke K, Fox LE, Gallagher A, Gordon P, Hester J: Response rates and survival times for cats with lymphoma treated with the University of Wisconsin-Madison chemotherapy protocol:38 cases (1996-2003). J Am Vet Med Assoc, 227, 1118-1122 (2005 5) Callanan JJ, Jones BA, Irvine J, Willett BJ, McCandish IA, Jarret O: Histologic classification and immunophenotype of lymphosarcomas in cats with naturally and experimentally acquired feline immunodeficiency virus infection. Vet Pathol, 33, 264-272 (1996 7) Hardy WD Jr.: Hematopoietic tumors of cats. J Am Anim Hosp Assoc, 17, 921-940 (1981 11) Louwerens M, London CA, Pedersen NC, Lyons LA: Feline lymphoma in the post-feline leukemia virus era. J Vet Inter Med, 19, 329-335 (2005 4) Hardy WD, Zukerman EE, MacEwen EG, Hayes AA, Essex M: A feline leukemia virus and sarcoma virus-induced tumor-specific antigen. Nature (London), 270, 249-251 (1977 19) Peaston AE, Maddison JE: Efficacy of doxorubicin as an induction agent for cats with lymphoma. Aust Vet J, 77, 442-444 (1999 20) Kristal O, Lana SE, Ogilvie GK, Rand WM, Cotter SM, Moore AS: Single agent chemotherapy with doxorubicin for feline lymphoma a retrospective study of 19 cases (1994-1997). J Vet Intern Med, 15, 125-130 (2001 9) Jeglum KA, Whereat A, Young K: Chemotherapy of lymphoma in 75 cats. J Am Vet Med Assoc, 190, 174-178 (1987 18) Shimoda T: Clinicopathological Findings in 12 Cases of Feline Thymic Lymphoma. J Jpn Vet Med Assoc, 46, 227-230 (1993 12) Simon D, Eberle L, Laacke-Singer, Nolte I: Combination Chemotherapy in Feline Lymphoma: Treatment Outcome, Tolerability, and Duration in 23 Cats. J Vet Intern Med, 22, 394-400 (2008 1) Ettinger SN: Principles of treatment for feline lymphoma. Clin Tech Small Anim Pract, 18, 98-102 (2003 14) Teske E, Straten GV, Noort RV, Rutteman GR: Chemotherapy with Cyclophosphamide, Vincristine, and Prednisolone (COP) in Cats with Malignant Lymphoma: New Results with an Old Protocol. J Vet Intern Med, 16, 179-186 (2002 17) Owen LN ed: TNM Classification of Tumors in Domestic Animals, I st ed, Geneva, World Health Organiation (1980 6) Holmberg CA, Manning JS, Osburn BI: Feline malignant lymphomas comparison of morphologic and immunologic characteristics. Am J Vet Res, 37, 1455-1460 (1976 8) Mooney SC, Hayes AA: Lymphoma in the cat: An approach to diagnosis and management. Semin Vet Med Surg (Small Anim), 1, 51-57 (1986 10) Vail DM, Moore AS, Ogilvie GK, Volk LM: Feline Lymphoma (145 Cases) Proliferation Indices, Cluster of Differentiation 3 Immunoreactivity, and Their Association with Prognosis in 90 Cats. J Vet Intern Med, 12, 349-354 (1998 16) Vail DM: Veterinary Co-operative oncology Group. Blackwell Publishing Ltd, 194-213 (2004 |
| References_xml | – reference: 18) Shimoda T: Clinicopathological Findings in 12 Cases of Feline Thymic Lymphoma. J Jpn Vet Med Assoc, 46, 227-230 (1993) – reference: 20) Kristal O, Lana SE, Ogilvie GK, Rand WM, Cotter SM, Moore AS: Single agent chemotherapy with doxorubicin for feline lymphoma a retrospective study of 19 cases (1994-1997). J Vet Intern Med, 15, 125-130 (2001) – reference: 21) Moore AS, Cotter SM, Frimberger AE, Wood CA, Rand WM, L'Heureux DA: A comparison of doxorubicin and COP for maintenance of remission in cats with lymphoma. J Vet Intern Med, 10, 372-375 (1996) – reference: 7) Hardy WD Jr.: Hematopoietic tumors of cats. J Am Anim Hosp Assoc, 17, 921-940 (1981) – reference: 12) Simon D, Eberle L, Laacke-Singer, Nolte I: Combination Chemotherapy in Feline Lymphoma: Treatment Outcome, Tolerability, and Duration in 23 Cats. J Vet Intern Med, 22, 394-400 (2008) – reference: 15) Milner RJ, Peyton J, Cooke K, Fox LE, Gallagher A, Gordon P, Hester J: Response rates and survival times for cats with lymphoma treated with the University of Wisconsin-Madison chemotherapy protocol:38 cases (1996-2003). J Am Vet Med Assoc, 227, 1118-1122 (2005) – reference: 1) Ettinger SN: Principles of treatment for feline lymphoma. Clin Tech Small Anim Pract, 18, 98-102 (2003) – reference: 5) Callanan JJ, Jones BA, Irvine J, Willett BJ, McCandish IA, Jarret O: Histologic classification and immunophenotype of lymphosarcomas in cats with naturally and experimentally acquired feline immunodeficiency virus infection. Vet Pathol, 33, 264-272 (1996) – reference: 3) Cockerell GL, Krakowka S, Hoover EA, Olsen RG, Yohn DS: Characterization of feline T-and B-lymphocytes and identification of an experimental induced T-cell neoplasm in the cat. J Natl Cancer Inst, 57, 907-913 (1976) – reference: 16) Vail DM: Veterinary Co-operative oncology Group. Blackwell Publishing Ltd, 194-213 (2004) – reference: 11) Louwerens M, London CA, Pedersen NC, Lyons LA: Feline lymphoma in the post-feline leukemia virus era. J Vet Inter Med, 19, 329-335 (2005) – reference: 8) Mooney SC, Hayes AA: Lymphoma in the cat: An approach to diagnosis and management. Semin Vet Med Surg (Small Anim), 1, 51-57 (1986) – reference: 2) Gabor LJ, Canfield PJ, Malik R: Immunophenotypic and histological characterization of 109 cases of feline lymphosarcoma. Aust Vet J, 77, 436-441 (1999) – reference: 14) Teske E, Straten GV, Noort RV, Rutteman GR: Chemotherapy with Cyclophosphamide, Vincristine, and Prednisolone (COP) in Cats with Malignant Lymphoma: New Results with an Old Protocol. J Vet Intern Med, 16, 179-186 (2002) – reference: 9) Jeglum KA, Whereat A, Young K: Chemotherapy of lymphoma in 75 cats. J Am Vet Med Assoc, 190, 174-178 (1987) – reference: 13) Cotter.S.M.: Treatment of lymphoma and leukemia with cyclophosphamide, vincristine, and prednisone.II. Treatment of cat. J Am Anim Hosp Assoc, 19, 166-172 (1983) – reference: 22) Hadden AG, Cotter SM, Rand W, Moore AS, Davis RM, Morrissey P: Efficacy and Toxicosis of VELCAP-C Treatment of Lymphoma in Cats. J Vet Intern Med, 22, 153-157 (2008) – reference: 10) Vail DM, Moore AS, Ogilvie GK, Volk LM: Feline Lymphoma (145 Cases) Proliferation Indices, Cluster of Differentiation 3 Immunoreactivity, and Their Association with Prognosis in 90 Cats. J Vet Intern Med, 12, 349-354 (1998) – reference: 19) Peaston AE, Maddison JE: Efficacy of doxorubicin as an induction agent for cats with lymphoma. Aust Vet J, 77, 442-444 (1999) – reference: 17) Owen LN ed: TNM Classification of Tumors in Domestic Animals, I st ed, Geneva, World Health Organiation (1980) – reference: 4) Hardy WD, Zukerman EE, MacEwen EG, Hayes AA, Essex M: A feline leukemia virus and sarcoma virus-induced tumor-specific antigen. Nature (London), 270, 249-251 (1977) – reference: 6) Holmberg CA, Manning JS, Osburn BI: Feline malignant lymphomas comparison of morphologic and immunologic characteristics. Am J Vet Res, 37, 1455-1460 (1976) |
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| Title | Ten Cases of Feline Mediastinal Lymphoma |
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