HISTOPATHOLOGICAL STUDY OF THE MIDDLE EAR MUCOSA IN OTITIS MEDIA WITH EFFUSION IN CHILDREN
Otitis media with effusion (OME) is caused by inflammation of the epipharynx, eustachian tubal dysfunction and discharge into the mastoid cavity. These process is associated with the change in the middle ear mucosa. We performed histopathological study on the middle ear mucosa in OME in children, an...
Saved in:
| Published in | JIBI INKOKA TEMBO Vol. 36; no. 5; pp. 582 - 590 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
Society of Oto-rhino-laryngology Tokyo
1993
耳鼻咽喉科展望会 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0386-9687 1883-6429 |
| DOI | 10.11453/orltokyo1958.36.582 |
Cover
| Abstract | Otitis media with effusion (OME) is caused by inflammation of the epipharynx, eustachian tubal dysfunction and discharge into the mastoid cavity. These process is associated with the change in the middle ear mucosa. We performed histopathological study on the middle ear mucosa in OME in children, and also investigated the relation to the mastoid pneumatization and to adenoids. The subjects consisted of 27 cases or 34 sides of OME in children aged from 4 years to 14 years. Middle ear mucosal samples were taken during adenoidectomy and insertion of middle ear ventilation tube under general anesthesia. Before tube insertion, we did myringotomy and carried out biopsy. We studied the epithelium and the subepithlial layer of the middle ear mucosa and classified them into 4 categories. On the result, severe subepithelial layer changes were observed in 53% of the cases in poorly pneumatized mastoid cell group. On the other hand, these changes were observed in 17% of the cases in the well pneumatized mastoid cell group. Adenoid changes were observed in 71% of cases with OME in children. Adenoid appeared to play an important role in the etigology of OME. |
|---|---|
| AbstractList | Otitis media with effusion (OME) is caused by inflammation of the epipharynx, eustachian tubal dysfunction and discharge into the mastoid cavity. These process is associated with the change in the middle ear mucosa. We performed histopathological study on the middle ear mucosa in OME in children, and also investigated the relation to the mastoid pneumatization and to adenoids. The subjects consisted of 27 cases or 34 sides of OME in children aged from 4 years to 14 years. Middle ear mucosal samples were taken during adenoidectomy and insertion of middle ear ventilation tube under general anesthesia. Before tube insertion, we did myringotomy and carried out biopsy. We studied the epithelium and the subepithlial layer of the middle ear mucosa and classified them into 4 categories. On the result, severe subepithelial layer changes were observed in 53% of the cases in poorly pneumatized mastoid cell group. On the other hand, these changes were observed in 17% of the cases in the well pneumatized mastoid cell group. Adenoid changes were observed in 71% of cases with OME in children. Adenoid appeared to play an important role in the etigology of OME. Otitis media with effusion (OME) is caused by inflammation of the epipharynx, eustachian tubal dysfunction and discharge into the mastoid cavity. These process is associated with the change in the middle ear mucosa. We performed histopathological study on the middle ear mucosa in OME in children, and also investigated the relation to the mastoid pneumatization and to adenoids.The subjects consisted of 27 cases or 34 sides of OME in children aged from 4 years to 14 years. Middle ear mucosal samples were taken during adenoidectomy and insertion of middle ear ventilation tube under general anesthesia. Before tube insertion, we did myringotomy and carried out biopsy. We studied the epithelium and the subepithlial layer of the middle ear mucosa and classified them into 4 categories.On the result, severe subepithelial layer changes were observed in 53% of the cases in poorly pneumatized mastoid cell group. On the other hand, these changes were observed in 17% of the cases in the well pneumatized mastoid cell group.Adenoid changes were observed in 71% of cases with OME in children.Adenoid appeared to play an important role in the etigology of OME. 小児滲出性中耳炎は, 上咽頭の炎症病態, 耳管機能障害及び耳管を介した中耳含気蜂巣への換気排泄障害に起因している。これらの過程には, 中耳粘膜上皮の変性が関与していると考えられる。我々は, 小児滲出性中耳炎の中耳粘膜を病理組織学的に検討し, 乳突蜂巣及びアデノイドとの関連についても検討を行った。対象は4歳から14歳の小児滲出性中耳炎27例34側である。中耳粘膜上皮は, 全身麻酔下にてアデノイド切除術と中耳換気チューブ挿入術を行う際に採取した。チューブ挿入前に光錐部に限定して鼓膜切開を行い, 中耳粘膜を採取した。中耳粘膜の粘膜上皮及び粘膜上皮下層の観察を行い, それぞれ4段階に分類した。結果は, 著明な粘膜上皮下層の変化が乳突蜂巣発育不良例で53%に観察されたのに対して, 発育良好例で粘膜上皮下層に変化が認められた症例は17%であった。アデノイド組織は全体の71%に変化が認められ, 滲出性中耳炎の発症に重要な役割を果していると思われた。 |
| Author | Kikuchi, Yasutaka Esaki, Shiro Moriyama, Hiroshi Kaneko, Yukie Aoki, Kazuhiro |
| Author_FL | 森山 寛 兼子 幸恵 青木 和博 江崎 史朗 菊池 康隆 |
| Author_FL_xml | – sequence: 1 fullname: 兼子 幸恵 – sequence: 2 fullname: 菊池 康隆 – sequence: 3 fullname: 江崎 史朗 – sequence: 4 fullname: 青木 和博 – sequence: 5 fullname: 森山 寛 |
| Author_xml | – sequence: 1 fullname: Kaneko, Yukie organization: Department of Otorhinolaryngol, The Jikei University School of Medicine – sequence: 1 fullname: Kikuchi, Yasutaka organization: Department of Otorhinolaryngol, The Jikei University School of Medicine – sequence: 1 fullname: Esaki, Shiro organization: Department of Otorhinolaryngol, The Jikei University School of Medicine – sequence: 1 fullname: Aoki, Kazuhiro organization: Department of Otorhinolaryngol, The Jikei University School of Medicine – sequence: 1 fullname: Moriyama, Hiroshi organization: Department of Otorhinolaryngol, The Jikei University School of Medicine |
| BackLink | https://cir.nii.ac.jp/crid/1390282679927306368$$DView record in CiNii |
| BookMark | eNpNkEtLw0AAhBdRsNb-Aw978Jq6j-zrGPIwC2kjzQbRS9ikW02tiSS99N_b0iJeZg7zMQNzB667vnMAPGA0x9hn9Kkfdvv-69BjxeSc8jmT5ApMsJTU4z5R12CCqOSe4lLcgtk4tjVCTArFuZiA91QXJn8JTJpn-bMOgwwWpozeYJ5Ak8ZwoaMoi2EcrOCiDPMigHoJc6ONLuAijnQAX7VJYZwkZaHz5SkNU51Fq3h5D242dje62cWnoExiE6beZcjbYoalJxRiiKDa3whVE9_6glOiZLPG3BLh1sjJNWa1YramhDolHBWN8OtaUYFYTegUPJ57u7atmvakmCpEJOFCKSIo4pTLI5aese24tx-u-hnabzscKjvs22bnqv83VpRX7CzHN_-Q5tMOlevoL1yVaDs |
| ContentType | Journal Article |
| Copyright | Oto-rhino-laryngology Tokyo |
| Copyright_xml | – notice: Oto-rhino-laryngology Tokyo |
| DBID | RYH |
| DOI | 10.11453/orltokyo1958.36.582 |
| DatabaseName | CiNii Complete |
| DatabaseTitleList | |
| DeliveryMethod | fulltext_linktorsrc |
| DocumentTitleAlternate | 小児しん出性中耳炎における中耳粘膜の病理組織学的検討 |
| DocumentTitle_FL | 小児しん出性中耳炎における中耳粘膜の病理組織学的検討 |
| EISSN | 1883-6429 |
| EndPage | 590 |
| ExternalDocumentID | 130003794817 article_orltokyo1958_36_5_36_5_582_article_char_en |
| GroupedDBID | ALMA_UNASSIGNED_HOLDINGS JSF RJT OK1 RYH |
| ID | FETCH-LOGICAL-j1518-7905020b4f79b24a4763298cd16a27ed0e8d15b95ab323e97e37c74bb93705b23 |
| ISSN | 0386-9687 |
| IngestDate | Thu Jun 26 23:48:44 EDT 2025 Wed Sep 03 06:22:12 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | false |
| IsScholarly | true |
| Issue | 5 |
| Language | Japanese |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-j1518-7905020b4f79b24a4763298cd16a27ed0e8d15b95ab323e97e37c74bb93705b23 |
| OpenAccessLink | https://www.jstage.jst.go.jp/article/orltokyo1958/36/5/36_5_582/_article/-char/en |
| PageCount | 9 |
| ParticipantIDs | nii_cinii_1390282679927306368 jstage_primary_article_orltokyo1958_36_5_36_5_582_article_char_en |
| PublicationCentury | 1900 |
| PublicationDate | 1993 |
| PublicationDateYYYYMMDD | 1993-01-01 |
| PublicationDate_xml | – year: 1993 text: 1993 |
| PublicationDecade | 1990 |
| PublicationTitle | JIBI INKOKA TEMBO |
| PublicationTitleAlternate | O.R.L.Tokyo |
| PublicationTitle_FL | OTO-RHINO-LARYNGOLOGY, TOKYO 耳鼻咽喉科展望 ＯＲＬ， Ｔｏｋｙｏ O.R.L.Tokyo OTO-RHINO-LARYNGOLOGY,TOKYO 耳展 |
| PublicationYear | 1993 |
| Publisher | Society of Oto-rhino-laryngology Tokyo 耳鼻咽喉科展望会 |
| Publisher_xml | – name: Society of Oto-rhino-laryngology Tokyo – name: 耳鼻咽喉科展望会 |
| References | 1) 森川清見: 滲出性中耳炎における細菌学的検討. 耳展28 (補5): 431-459, 1985. 12) 兼子幸恵, 鴻信義, 森川清見, 他: 小児滲出性中耳炎におけるアデノイドの要因. Otol Jpn 1: 39-43, 1991. 2) Hjort SC, Adersen LP, Tos M, et al: Nasopharyngeal bacteriology and secretory otiits media in young children. Acta Otolaryngol (stockh) 105: 126-131, 1988. 11) 青木和博, 江崎史朗, 菊池康隆, 他: アデノイド肥大と小児滲出性中耳炎との関係. Otol Jpn 1: 25-28, 1991. 4) Lim DJ and Paparella, MM: Ultrastructure of the eustachian tube and middle ear mucosa in the guinea pigs. Acta Otolaryngol 63: 425, 1967. 5) Kawabata I and Paparella MM: Ultrastructure of normal human middle ear mucosa. Preliminary report. Ann Otol Rhinol Laryngol 78: 125, 1969. 7) Shimada T and Lim DJ: Distribution of ciliated cells in the human middle ear-SEM, TEM, and light microscopic observation. Ann Otol Rhinol Laryngol 81: 203-211, 1972. 3) 青木和博, 江崎史朗, 森川清見, 他: 小児滲出性中耳炎に対する治療と乳突蜂巣発育度日耳鼻92: 893-898, 1989. 9) Tos M: Pathogenesis and pathology of chronic secretory otitis media. Ann Otol Rhinol Laryngol89 [Suppl] 68: 91-96, 1980. 10) 青木和博, 江崎史朗, 本多芳男: 中耳病態の側頭骨含気蜂巣に及ぼす影響. 耳展25: 249-254, 1982. 6) Hentzer E: Ultrastructure of the normal mucosa in human middle ear, mastoid cavities, and eustachian tube. Ann Otol Rhinol Laryngol 79: 1143, 1970. 8) 高坂知節, 朴沢孝治: 中耳・耳管粘膜-正常と病態河本和友編: 滲出性中耳炎. 医学教育出版, 東京, 1985, 67-82. |
| References_xml | – reference: 9) Tos M: Pathogenesis and pathology of chronic secretory otitis media. Ann Otol Rhinol Laryngol89 [Suppl] 68: 91-96, 1980. – reference: 5) Kawabata I and Paparella MM: Ultrastructure of normal human middle ear mucosa. Preliminary report. Ann Otol Rhinol Laryngol 78: 125, 1969. – reference: 10) 青木和博, 江崎史朗, 本多芳男: 中耳病態の側頭骨含気蜂巣に及ぼす影響. 耳展25: 249-254, 1982. – reference: 11) 青木和博, 江崎史朗, 菊池康隆, 他: アデノイド肥大と小児滲出性中耳炎との関係. Otol Jpn 1: 25-28, 1991. – reference: 1) 森川清見: 滲出性中耳炎における細菌学的検討. 耳展28 (補5): 431-459, 1985. – reference: 12) 兼子幸恵, 鴻信義, 森川清見, 他: 小児滲出性中耳炎におけるアデノイドの要因. Otol Jpn 1: 39-43, 1991. – reference: 3) 青木和博, 江崎史朗, 森川清見, 他: 小児滲出性中耳炎に対する治療と乳突蜂巣発育度日耳鼻92: 893-898, 1989. – reference: 8) 高坂知節, 朴沢孝治: 中耳・耳管粘膜-正常と病態河本和友編: 滲出性中耳炎. 医学教育出版, 東京, 1985, 67-82. – reference: 7) Shimada T and Lim DJ: Distribution of ciliated cells in the human middle ear-SEM, TEM, and light microscopic observation. Ann Otol Rhinol Laryngol 81: 203-211, 1972. – reference: 6) Hentzer E: Ultrastructure of the normal mucosa in human middle ear, mastoid cavities, and eustachian tube. Ann Otol Rhinol Laryngol 79: 1143, 1970. – reference: 2) Hjort SC, Adersen LP, Tos M, et al: Nasopharyngeal bacteriology and secretory otiits media in young children. Acta Otolaryngol (stockh) 105: 126-131, 1988. – reference: 4) Lim DJ and Paparella, MM: Ultrastructure of the eustachian tube and middle ear mucosa in the guinea pigs. Acta Otolaryngol 63: 425, 1967. |
| SSID | ssib005879667 ssib005902162 ssib005879668 ssib058493089 ssib029852170 ssj0066717 ssib007484760 ssib002004161 |
| Score | 1.4010836 |
| Snippet | Otitis media with effusion (OME) is caused by inflammation of the epipharynx, eustachian tubal dysfunction and discharge into the mastoid cavity. These process... |
| SourceID | nii jstage |
| SourceType | Publisher |
| StartPage | 582 |
| SubjectTerms | histopathological study middle ear mucosa otitis media with effusion |
| Title | HISTOPATHOLOGICAL STUDY OF THE MIDDLE EAR MUCOSA IN OTITIS MEDIA WITH EFFUSION IN CHILDREN |
| URI | https://www.jstage.jst.go.jp/article/orltokyo1958/36/5/36_5_582/_article/-char/en https://cir.nii.ac.jp/crid/1390282679927306368 |
| Volume | 36 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| ispartofPNX | JIBI INKOKA TEMBO, 1993/10/15, Vol.36(5), pp.582-590 |
| journalDatabaseRights | – providerCode: PRVAFT databaseName: Open Access Digital Library customDbUrl: eissn: 1883-6429 dateEnd: 99991231 omitProxy: true ssIdentifier: ssib007484760 issn: 0386-9687 databaseCode: KQ8 dateStart: 19580101 isFulltext: true titleUrlDefault: http://grweb.coalliance.org/oadl/oadl.html providerName: Colorado Alliance of Research Libraries |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Bb5swFLbS7rLLtGmb1m2dfNgNkSUYAz7ShAqWJmwNkdpdkAlmJZlgSsmh_V37gXvGhNC1h3XaxUpsMOG9L8_fs_zeQ-gjz5I0S-U_jXOhmybjupMNhA5LseE4KSyZdTmf6czyF-bnC3rR6_3qnFraVkl_eftgXMm_aBX6QK8ySvYRmm0nhQ74DPqFFjQM7V_p2A_mUfjFjfy2pIEkeJe7kzzTYDw-8zTPPdemi1E4d7VgpoVREAXzOq0j2IQg8jWgqgtpUuXoyA_Oxufe7A5nDU4CGJuEE1eLvOlJ2BppXoh1vdV6uV3nLUIm-VpWWKn7-fW24uvW9HvXXJXJnl_lm7IFW6k6J_x22_anTWge2e9BNgdMgd6GValvrvKi1MExvym-q0RSUbm-KTuWjTiWzqxmpRXK8joO0cEZYl3TrHKjNBCkHTtLVcWiZsmmquLo_dXArGt6lJsflfwBMq9On1j99uY7ebYbLcbdq2NixVQ1cFO8u0QGxAH-DtATwwZ-I48CfO04bTKHWSdamDo2-JT2H987SdQY8KxO0kaZ3dXeO60Gc4Bi7a0qMEZGBrJGgOIbMHVdV7oVahMgKl_-0wOvDlRrBY6HzChxUOR5h01Fz9Gzxg3CrnrVF6i34i_Rt3t4xjWecXiKAc9Y4RkDnrHCMw5mWOEZ13jGEs94h2c5usPzK7Q49aKRrzcT6yvgoI4u88aBJBMzs1limBwkQkASy3RoccMW6UCAIaEJozwhBhHMFsRe2maSAN0e0MQgr9FhURbiDcJkKEB8zKRDDoI1KTM4NSxiDYUljCwlR8hVAol_qgQv8eOhcISOQZbxMpctOFVyJ8OyGQPnAHwAy3n7H57xDj1Vp23l_t97dFhttuIYGHGVfKgB-Bseu55i |
| linkProvider | Colorado Alliance of Research Libraries |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=HISTOPATHOLOGICAL+STUDY+OF+THE+MIDDLE+EAR+MUCOSA+IN+OTITIS+MEDIA+WITH+EFFUSION+IN+CHILDREN&rft.jtitle=JIBI+INKOKA+TEMBO&rft.au=Kaneko%2C+Yukie&rft.au=Kikuchi%2C+Yasutaka&rft.au=Esaki%2C+Shiro&rft.au=Aoki%2C+Kazuhiro&rft.date=1993&rft.pub=Society+of+Oto-rhino-laryngology+Tokyo&rft.issn=0386-9687&rft.eissn=1883-6429&rft.volume=36&rft.issue=5&rft.spage=582&rft.epage=590&rft_id=info:doi/10.11453%2Forltokyo1958.36.582&rft.externalDocID=article_orltokyo1958_36_5_36_5_582_article_char_en |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0386-9687&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0386-9687&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0386-9687&client=summon |