The Change of Brain Blood Flow When Chewing Chewing-gum Using NIRS
The purpose of this experiment was to clarify the change of brain blood flow when chewing chewing-gum using NIRS (near infrared spectroscopy). Twenty healthy subjects in their twenties were asked to chew chewing-gum on their habitual chewing side and on their non-habitual chewing side for 1 minute r...
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| Published in | Journal of Japanese Society for Mastication Science and Health Promotion Vol. 14; no. 2; pp. 68 - 73 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | English Japanese |
| Published |
Japanese Society for Mastication Science and Health Promotion
2004
特定非営利活動法人 日本咀嚼学会 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0917-8090 1884-4448 |
| DOI | 10.14858/soshaku1991.14.68 |
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| Abstract | The purpose of this experiment was to clarify the change of brain blood flow when chewing chewing-gum using NIRS (near infrared spectroscopy). Twenty healthy subjects in their twenties were asked to chew chewing-gum on their habitual chewing side and on their non-habitual chewing side for 1 minute respectively, and the order was random. The brain blood flow was recorded using NIRS. The measurement was performed about 7 sessions; before chewing (rest), during chewing, and 1, 2, 3, 4, and 5 minutes after chewing. Measuring probe was attached on the skin over the cortical masticatory area. The change in blood flow in the brain caused by chewing was investigated using repeated measures ANOVA. Next the amount of change in blood flow was compared between the habitual side chewing and the non-habitual side chewing using paired t-test. The brain blood flow increased for both habitual and non-habitual chewing sides during mastication and decreased gradually after mastication and returned the condition prior to the mastication (habitual chewing side; F=127.0, non-habitual chewing side; F=92.9, p<0.01). When comparing the session prior to mastication with all the other sessions significant differences were found except with the session 5 minutes after mastication. In 18 out of 20 cases the amount of change in blood flow was larger for the habitual chewing side than for the non-habitual chewing side and a statistically significant difference was found (t = 3.78, p <0.01). From these results it was suggested that mastication activated brain activities and that the habitual chewing side had a stronger effect than the non-habitual chewing side. |
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| AbstractList | The purpose of this experiment was to clarify the change of brain blood flow when chewing chewing-gum using NIRS (near infrared spectroscopy).Twenty healthy subjects in their twenties were asked to chew chewing-gum on their habitual chewing side and on their non-habitual chewing side for 1 minute respectively, and the order was random. The brain blood flow was recorded using NIRS. The measurement was performed about 7 sessions; before chewing (rest), during chewing, and 1, 2, 3, 4, and 5 minutes after chewing. Measuring probe was attached on the skin over the cortical masticatory area. The change in blood flow in the brain caused by chewing was investigated using repeated measures ANOVA. Next the amount of change in blood flow was compared between the habitual side chewing and the non-habitual side chewing using paired t-test.The brain blood flow increased for both habitual and non-habitual chewing sides during mastication and decreased gradually after mastication and returned the condition prior to the mastication (habitual chewing side; F=127.0, non-habitual chewing side; F=92.9, p<0.01). When comparing the session prior to mastication with all the other sessions significant differences were found except with the session 5 minutes after mastication. In 18 out of 20 cases the amount of change in blood flow was larger for the habitual chewing side than for the non-habitual chewing side and a statistically significant difference was found (t = 3.78, p <0.01).From these results it was suggested that mastication activated brain activities and that the habitual chewing side had a stronger effect than the non-habitual chewing side.
目的: 本研究の目的は, 近赤外分光装置を用いてチューインガム咀嚼時の脳内血流の変化を明らかにすることである.方法: 20歳代の健常者20名に軟化したチューインガム1枚を1分間咀嚼させたときの両側の脳内血流を記録した.なお, 測定用プローブは, 皮質咀嚼野相当部の皮膚上に設置し, ガム咀嚼は, 主咀嚼側と非主咀嚼側について各1回を被験者ごとにランダムに行った.分析は, はじめに咀嚼前, 咀嚼中, 咀嚼終了1, 2, 3, 4, 5分後の7セッションにおける脳内血流量を測定した.次いで, これらのセッションの脳内血流量について, 経時的変化を調べた後, 脳内血流の変化量について, 主咀嚼側咀嚼時と非主咀嚼側咀嚼時との間で比較した.結果: 脳内血流は, 主咀嚼側咀嚼時, 非主咀嚼側咀嚼時ともに咀嚼中に増加し, 咀嚼後速やかに減少し, 咀嚼前の状態に回復する経時的変化を示した (主咀嚼側;F=127.0, 非主咀嚼側;F=92.9, p<0.01).咀嚼前と他のセッションの比較では, 咀嚼終了5分後を除くすべてのセッションとの間に有意差が認められた.チューインガム咀嚼時の脳内血流の変化量は, 20例中18例において主咀嚼側咀嚼時のほうが非主咀嚼側咀嚼時よりも多く, 両咀嚼側間に有意差が認められた (t=3.78, p<0.01).結論: 咀嚼により, 脳が活性化されること, またそれは主咀嚼側咀嚼時のほうが非主咀嚼側咀嚼時よりも強い可能性が示唆された. The purpose of this experiment was to clarify the change of brain blood flow when chewing chewing-gum using NIRS (near infrared spectroscopy). Twenty healthy subjects in their twenties were asked to chew chewing-gum on their habitual chewing side and on their non-habitual chewing side for 1 minute respectively, and the order was random. The brain blood flow was recorded using NIRS. The measurement was performed about 7 sessions; before chewing (rest), during chewing, and 1, 2, 3, 4, and 5 minutes after chewing. Measuring probe was attached on the skin over the cortical masticatory area. The change in blood flow in the brain caused by chewing was investigated using repeated measures ANOVA. Next the amount of change in blood flow was compared between the habitual side chewing and the non-habitual side chewing using paired t-test. The brain blood flow increased for both habitual and non-habitual chewing sides during mastication and decreased gradually after mastication and returned the condition prior to the mastication (habitual chewing side; F=127.0, non-habitual chewing side; F=92.9, p<0.01). When comparing the session prior to mastication with all the other sessions significant differences were found except with the session 5 minutes after mastication. In 18 out of 20 cases the amount of change in blood flow was larger for the habitual chewing side than for the non-habitual chewing side and a statistically significant difference was found (t = 3.78, p <0.01). From these results it was suggested that mastication activated brain activities and that the habitual chewing side had a stronger effect than the non-habitual chewing side. |
| Author | KOBAYASHI, Yoshinori YOKOYAMA, Masaoki SHIGA, Hiroshi ARAKAWA, Ichiro |
| Author_FL | 志賀 博 横山 正起 小林 義典 荒川 一郎 |
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| Author_xml | – sequence: 1 fullname: YOKOYAMA, Masaoki organization: Department of Partial and Complete Denture, The Nippon Dental University, School of Dentistry at Tokyo – sequence: 1 fullname: KOBAYASHI, Yoshinori organization: Department of Partial and Complete Denture, The Nippon Dental University, School of Dentistry at Tokyo – sequence: 1 fullname: ARAKAWA, Ichiro organization: Department of Partial and Complete Denture, The Nippon Dental University, School of Dentistry at Tokyo – sequence: 1 fullname: SHIGA, Hiroshi organization: Department of Partial and Complete Denture, The Nippon Dental University, School of Dentistry at Tokyo |
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| References | 栃倉純, 志賀博, 小林義典 (2000) 主咀嚼側咀嚼時と非主咀嚼側咀嚼時との間の機能的差異, グミゼリー咀嚼時の運動機能, 咀嚼筋筋活動, ならびに咀嚼能率. 日咀嚼誌9: 57-64 Momose T, Nishikawa J, Watanabe T, Sasaki Y, Senda M, Kubota K, Sato Y, Funakoshi M, Minakuchi S (1997) Effect of mastication on regional cerebral blood flow in humans examined by positronemission tomography with 150-labelled water and magnetic resonance imaging. Arch Oral Biol 42: 57 -61 A1-Rawi PG, Smielewski P, Kirkpatrick PJ (2001) Evaluation of a near-infrared spectrometer (NIRO 300) for the detection of intracranial oxygenation changes in the adult head. Stroke 32: 2492-2500 江依法, 長崎幸雄 (2000) fMRIを用いた人脳の咀嚼 機能に関する基礎的検討. 岐阜大医紀48: 10-17 酒谷薫 (2002) 基礎編. 臨床医のための近赤外分光法 (片山容一, 酒谷薫編), 1-9, 新興医学出版社, 東京 安河内正文, BaeSang Yong, 小関迫 (1997) 無酸素性運動時及び回復時の局所脳内酸素血行動態. TherapeuticResearch 18: 2340-2345 Hock C, Villringer K, Muller-Spahn F, Wenzel R, Heekeren H, Schuh-Hofer S, Hofmann M, Minoshima S, Schwaiger M, Dirnagl U, Villringer A (1997) Decrease in parietal cerebral hemoglobin oxygenation during performance of a verbal fluency task in patients with Alzheimer's disease monitored by means of near-infrared spectroscopy (NIRS)-correlation with simultaneous rCBF-PET measurements. Brain Res 755: 293-303 仁村秀由喜, 小林義典 (1990) 咀嚼運動における主咀嚼側咀嚼時と非主咀嚼側咀嚼時との差異.補綴誌34: 1127-1139 |
| References_xml | – reference: Hock C, Villringer K, Muller-Spahn F, Wenzel R, Heekeren H, Schuh-Hofer S, Hofmann M, Minoshima S, Schwaiger M, Dirnagl U, Villringer A (1997) Decrease in parietal cerebral hemoglobin oxygenation during performance of a verbal fluency task in patients with Alzheimer's disease monitored by means of near-infrared spectroscopy (NIRS)-correlation with simultaneous rCBF-PET measurements. Brain Res 755: 293-303 – reference: Momose T, Nishikawa J, Watanabe T, Sasaki Y, Senda M, Kubota K, Sato Y, Funakoshi M, Minakuchi S (1997) Effect of mastication on regional cerebral blood flow in humans examined by positronemission tomography with 150-labelled water and magnetic resonance imaging. Arch Oral Biol 42: 57 -61 – reference: 安河内正文, BaeSang Yong, 小関迫 (1997) 無酸素性運動時及び回復時の局所脳内酸素血行動態. TherapeuticResearch 18: 2340-2345 – reference: A1-Rawi PG, Smielewski P, Kirkpatrick PJ (2001) Evaluation of a near-infrared spectrometer (NIRO 300) for the detection of intracranial oxygenation changes in the adult head. Stroke 32: 2492-2500 – reference: 仁村秀由喜, 小林義典 (1990) 咀嚼運動における主咀嚼側咀嚼時と非主咀嚼側咀嚼時との差異.補綴誌34: 1127-1139 – reference: 酒谷薫 (2002) 基礎編. 臨床医のための近赤外分光法 (片山容一, 酒谷薫編), 1-9, 新興医学出版社, 東京 – reference: 栃倉純, 志賀博, 小林義典 (2000) 主咀嚼側咀嚼時と非主咀嚼側咀嚼時との間の機能的差異, グミゼリー咀嚼時の運動機能, 咀嚼筋筋活動, ならびに咀嚼能率. 日咀嚼誌9: 57-64 – reference: 江依法, 長崎幸雄 (2000) fMRIを用いた人脳の咀嚼 機能に関する基礎的検討. 岐阜大医紀48: 10-17 |
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| SubjectTerms | Brain blood flow Habitual chewing side Mastication NIRS Non-habitual chewing side |
| Title | The Change of Brain Blood Flow When Chewing Chewing-gum Using NIRS |
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