CLINICAL INVESTIGATION OF 92 CASES WITH PURPURA NEPHRITIS (HENOCH-SCHÖNLEIN) WHICH PASSED OVER 5 YEARS AFTER ONSET OF DISEASE

• Published in: Japanese Journal of National Medical Services Vol. 44; no. 6; pp. 615 - 619
• Main Authors: YOSHIDA, Yasuhiro, STUDY GROUP ON TREATMENT AND MANAGEMENT OF CHILDHO, YAKABE, Shigeru, TAKEO, Sadanori, MAEKAWA, Soichiro, IKEJIRI, Koji
• Format: Journal Article
• Language: Japanese
• Published: Japanese Society of National Medical Services 1990; 一般社団法人 国立医療学会
• Subjects: long-term prognosis; purpura nephritis; 紫斑病性腎炎; 長期予後
• ISSN: 0021-1699; 1884-8729
• DOI: 10.11261/iryo1946.44.615

Approximately 6% of dialysis cases of patients under 18 years of age in Japan, resulted from Henoch-Schönlein purpura nephritis. We conducted a research on cases of Henoch-Schönlein purpura nephritis, from 15 medical centers, with a total of 92 patients, mean age at onset 8.0±2.7 (years). The prognosis was classified into the following groups; 1st group-cured, 2nd group-improved, 3rd group-unchanged, 4th group-worse. 71.6% of the patients belonged to the 1st and 2nd groups, with a favorable prognosis. 6.5% including 3.2% dialysed patients, had a poor prognosis. With respect to the degree of hematuria, proteinuria and prognosis there was no recognized correlation in each group. The findings of renal biopsy indicated a favorable prognosis in II of the ISKDC (International Study of Kidney Disease in Children) classification. On the other hand, cases with a poor prognosis were distributed in 111 a of the above classification. No significant difference was recognized for prognosis by use or non-use of steroids. At present repeated biopsy as well as clinical findings is considered to be important, for determination of long-term prognosis of purpura nephritis.