CEFOPERAZONE (T-1551) IN THE FIELD OF DERMATOLOGY
1) MICs of cefoperazone (CPZ, T-1551), cefazolin, cephalothin and cephaloridine against 32 strains of Staphylococcus aureus isolated from the lesions of skin infection were studied. MIC of CPZ was inferior to cefazolin, cephalothin and cephaloridine. 2) Serum and skin levels of CPZ (20mg/kg im) were...
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| Published in | CHEMOTHERAPY Vol. 28; no. Supplement6; pp. 849 - 852 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
Japanese Society of Chemotherapy
25.10.1980
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| Online Access | Get full text |
| ISSN | 0009-3165 1884-5894 |
| DOI | 10.11250/chemotherapy1953.28.Supplement6_849 |
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| Abstract | 1) MICs of cefoperazone (CPZ, T-1551), cefazolin, cephalothin and cephaloridine against 32 strains of Staphylococcus aureus isolated from the lesions of skin infection were studied. MIC of CPZ was inferior to cefazolin, cephalothin and cephaloridine. 2) Serum and skin levels of CPZ (20mg/kg im) were determined in rats at 1/4, 1/2, 1, 2 and 4 hours. Serum levels were 9.8±3.02, 6.2±2.30, 0.66±0.19μg/ml at 1/4, 1/2 and 1 hour, respectively. The corresponding skin levels were 4.6±1.35, 3.9±1.39, 1.08±0.37μg/g. At 2 and 4 hours those levels were trace (wet skin)(n=4). 3) CPZ was used clinically in 5 cases of skin infection with the following result: excellent in 3 cases, poor in 1 case. In 1 case evaluation was not possible. Any side effects were not observed. |
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| AbstractList | 1) MICs of cefoperazone (CPZ, T-1551), cefazolin, cephalothin and cephaloridine against 32 strains of Staphylococcus aureus isolated from the lesions of skin infection were studied. MIC of CPZ was inferior to cefazolin, cephalothin and cephaloridine. 2) Serum and skin levels of CPZ (20mg/kg im) were determined in rats at 1/4, 1/2, 1, 2 and 4 hours. Serum levels were 9.8±3.02, 6.2±2.30, 0.66±0.19μg/ml at 1/4, 1/2 and 1 hour, respectively. The corresponding skin levels were 4.6±1.35, 3.9±1.39, 1.08±0.37μg/g. At 2 and 4 hours those levels were trace (wet skin)(n=4). 3) CPZ was used clinically in 5 cases of skin infection with the following result: excellent in 3 cases, poor in 1 case. In 1 case evaluation was not possible. Any side effects were not observed. |
| Author | KASHIWA, NAOHIRO YAMAMOTO, YASUO AKIYAMA, HISANORI NOHARA, NOZOMI ARATA, JIRO SUWAKI, MASAO |
| Author_xml | – sequence: 1 fullname: AKIYAMA, HISANORI organization: Department of Dermatology, Okayama University Medical School – sequence: 1 fullname: SUWAKI, MASAO organization: Department of Dermatology, Okayama University Medical School – sequence: 1 fullname: ARATA, JIRO organization: Department of Dermatology, Okayama University Medical School – sequence: 1 fullname: YAMAMOTO, YASUO organization: Department of Dermatology, Okayama University Medical School – sequence: 1 fullname: KASHIWA, NAOHIRO organization: Department of Dermatology, Okayama University Medical School – sequence: 1 fullname: NOHARA, NOZOMI organization: Department of Dermatology, Okayama University Medical School |
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| References | 1) 第27回日本化学療法学会総会, 新薬シンポジウムI, T-1551抄録集, 1979 |
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| Title | CEFOPERAZONE (T-1551) IN THE FIELD OF DERMATOLOGY |
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