Effects of Onpi-To (One of Herb Medicine) on Production of Active Oxygen Species from Neutrophils in Hemodialysis Patients
Hemodialysis patients (HD) were treated with onpi-to (an herb medicine) administration, and the changes in active oxygen production by neutrophils, and serum superoxide dismutase activities and methylguanidine levels were examined throughout the treatment. The active oxygen production by neutrophils...
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| Published in | Japanese Journal of Clinical Chemistry Vol. 24; no. 3; pp. 163 - 169 |
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| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
Japan Society of Clinical Chemistry
1995
一般社団法人 日本臨床化学会 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0370-5633 2187-4077 |
| DOI | 10.14921/jscc1971b.24.3_163 |
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| Abstract | Hemodialysis patients (HD) were treated with onpi-to (an herb medicine) administration, and the changes in active oxygen production by neutrophils, and serum superoxide dismutase activities and methylguanidine levels were examined throughout the treatment. The active oxygen production by neutrophils was measured by a flow-cytometric technique or by a cytochrome c reduction method. The active oxygen production was greater in the neutrophils of the HD patients than in normal subjects with or without phorbol myristate acetate (PMA) stimulation. Superoxide dismutase activities and methylguanidine levels in the serum of HD patients were reduced by the treatment. An in vitro experiment using neutrophils from normal subjects showed that onpi-to suppressed stimulated active oxygen production by phorbol myristate acetate, but not by N formyl-methionyl-leucyl-phenylalanine (fMLP) or opsonized zymosan (OZ). |
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| AbstractList | Hemodialysis patients (HD) were treated with onpi-to (an herb medicine) administration, and the changes in active oxygen production by neutrophils, and serum superoxide dismutase activities and methylguanidine levels were examined throughout the treatment. The active oxygen production by neutrophils was measured by a flow-cytometric technique or by a cytochrome c reduction method. The active oxygen production was greater in the neutrophils of the HD patients than in normal subjects with or without phorbol myristate acetate (PMA) stimulation. Superoxide dismutase activities and methylguanidine levels in the serum of HD patients were reduced by the treatment. An in vitro experiment using neutrophils from normal subjects showed that onpi-to suppressed stimulated active oxygen production by phorbol myristate acetate, but not by N formyl-methionyl-leucyl-phenylalanine (fMLP) or opsonized zymosan (OZ).
腎透析患者 (Hemodialysis patients: HD患者) に対する活性酸素の関与について好中球活性酸素産生能, 血中superoxide dismutase (SOD) 値およびメチルグアニジン値を測定し, 臨床的に腎疾患に用いられる温脾湯 (漢方薬) を投与して, その作用について調べた。好中球の産生する活性酸素量はフローサイトメトリーとチトクロームC還元法で測定した。HD患者は健常人に比して無刺激あるいは, phorbol myristate acetate (PMA) 刺激による活性酸素産生能は両者共に有意に上昇した。HD患者に温脾湯を投与し好中球活性酸素産生能, 血中SOD値およびメチルグアニジン値の変動を調べた。それぞれは, 投与前値に比して有意に低下した。次に好中球活性酸素産生に対する温脾湯の作用についてPMA, N-formyl-methionyl-leucyl-phenyla-anine (fMLP) およびオプソニン化ザイモザン (OZ) を刺激剤としチトクロームC還元法にて検討した。PMA刺激では温脾湯は好中球活性酸素産生能を抑制するが, fMLPおよびOZ刺激では抑制しないことが明らかとなった。 Hemodialysis patients (HD) were treated with onpi-to (an herb medicine) administration, and the changes in active oxygen production by neutrophils, and serum superoxide dismutase activities and methylguanidine levels were examined throughout the treatment. The active oxygen production by neutrophils was measured by a flow-cytometric technique or by a cytochrome c reduction method. The active oxygen production was greater in the neutrophils of the HD patients than in normal subjects with or without phorbol myristate acetate (PMA) stimulation. Superoxide dismutase activities and methylguanidine levels in the serum of HD patients were reduced by the treatment. An in vitro experiment using neutrophils from normal subjects showed that onpi-to suppressed stimulated active oxygen production by phorbol myristate acetate, but not by N formyl-methionyl-leucyl-phenylalanine (fMLP) or opsonized zymosan (OZ). |
| Author | Takeuchi, Nozomu Kanno, Kazuhisa Tokunaga, Kenji Ninomiya, Hiroyuki Saheki, Shuichi Ishiguro, Isao Shinohara, Rikio Murase, Mitsuharu Mistuma, Tadamichi |
| Author_FL | 菅野 和久 徳永 賢治 佐伯 修一 村瀬 光春 三潴 忠道 篠原 力雄 石黒 伊三雄 二宮 裕幸 武内 望 |
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| Author_xml | – sequence: 1 fullname: Ninomiya, Hiroyuki organization: The First Department of Internal Medicine, School of Medicine, Ehime University – sequence: 1 fullname: Saheki, Shuichi organization: Department of Clinical Laboratory, Ehime University Hospital – sequence: 1 fullname: Shinohara, Rikio organization: Department of Biochemistry, Fujita Health University, School of Hygiene – sequence: 1 fullname: Ishiguro, Isao organization: Department of Biochemistry, Fujita Health University, School of Medicine – sequence: 1 fullname: Tokunaga, Kenji organization: Department of Clinical Laboratory, Ehime University Hospital – sequence: 1 fullname: Takeuchi, Nozomu organization: Department of Clinical Laboratory, Ehime University Hospital – sequence: 1 fullname: Mistuma, Tadamichi organization: Department of Japanese Oriental (Kampo) Medicine, Iizuka Hospital – sequence: 1 fullname: Murase, Mitsuharu organization: Department of Clinical Laboratory, Ehime University Hospital – sequence: 1 fullname: Kanno, Kazuhisa organization: Department of Clinical Laboratory, Ehime University Hospital |
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| References | 18) Blackburn Jr WD, Heck LW, Wallace RW: The bioflavonoid quercetin inhibits neutrophil degranulation, super-oxide production, and the phosphorylation of specific neutrophil proteins, Biochem Biophys Res Commun, 144: 1229-1236, 1987. 5) Ritchey EE, Wallin JD, Shah SV: Chemiluminescence and superoxide anion production by leukocytes from chronic hemodialysis patients, Kidney Int, 19: 349-358, 1981. 15) 増子早苗, 保坂俊太郎, 内田隆志: 医用材料とヒト好中球の接触による活性酸素放出の測定, 人工臓器, 18: 63-66, 1989. 12) Baud L, Pewrez J, Ardaillou R: Dexamethasone and hydrogen peroxide production by mesangial cells during phagocytosis. Am J Physiol, 250: F596-604, 1986. 1) Fillit H, Elison E, Sullivan J: Thiobarbituric acid reactive material in uremic blood, Nephron, 29: 40-43, 1981. 8) 三潴忠道, 横澤隆子, 大浦彦吉, 寺澤掟: 大黄並びに大黄含漢方方剤による慢性腎不全の治療に関する研究 (第2報), 日本腎臓学会誌, 29: 195, 1987. 3) 徳永賢治, 宍野宏治, 村瀬光春, 武内望, 篠原力雄, 石黒伊三雄: 血中および尿中SOD 活性他の臨床的意義, 臨床化学, 16: 129-135, 1987. 6) Lucci L, Cappelli G, Acerbi MA: Oxidative metabolism of polymorphonuclear leukocytes and serum opsonic activity in chronic renal failure, Nephron, 51: 44-50, 1989. 10) 徳永賢治, 土居修, 宍野宏治, 村瀬光春, 武内望, 篠原力雄, 石黒伊三雄: 慢性関節リュウマチにおける関節液, 血清中のSuper-oxide Dismutase活性値, 過酸化脂質値, セルロプラスミン値の検討, 臨床化学, 18: 42-48, 1989. 4) 甲田豊, 鈴木正司, 高橋幸男, 平沢由平: 透析患者の好中球の化学発光動態. 腎とブリーラジカル, p.142-143, 東京医学社, 東京, 1991. 13) Radeke HH, Meier B, Topley N, Flöge J, Habermehl GG, Resch L: Interleukin l-alpha and tumor necrosis factor-alpha induce oxygen radical production in mesangial cells, Kidney Int, 37: 767-775, 1990. 2) Kuroda M, Asaka S, Tofuku Y: Serum antioxidant activity in uremic patients, Nephron, 41: 293-298, 1985. 9) 菅野和久, 徳永賢治, 越智正昭, 宍野宏治, 村瀬光春, 佐伯修一, 武内望, 篠原力雄, 石黒伊三雄: 糖尿病患者における好中球活性酸素産生能について, 臨床化学, 22: 168-172, 1993. 14) Markert M, Heierli C, Kuwahara T, Frei J, Wauters JP: Dialyzed polymorphonuclear neutrophil oxidative metabolism during dialysis: a comparative study with 5 new and reused membranes, Clin Nephrol, 29, 129-136, 1988. 17) Erben-Russ M, Bors W, Saran M: Reactions of linoleic acid peroxyl radicals with phenolic antioxidants, Int J Radiat Biol, 52: 393-412, 1987. 7) Yokozawa T, Zheng PD, Mo ZL, Oura H: The effect of extracts obtained from rhubarb in rats with chronic renal failure, Chem Pharm Bull, 34: 4718-4723, 1986. 11) Yokozawa T, Oura H, Ienaga K, Nakamura K: Comparison of renal effects of creatinine, creatol and methylguanidine in rats with adenine-induced chronic renal failure, Nephron, 64: 424-428, 1993. 16) 坂本まさ子, 青柳一正, 永瀬宗重, 成田光陽, 東條静夫: Guanidine産生におよぼす活性酸素の影響について, 日本腎臓学会誌, 19: 1355-1364, 1987. |
| References_xml | – reference: 1) Fillit H, Elison E, Sullivan J: Thiobarbituric acid reactive material in uremic blood, Nephron, 29: 40-43, 1981. – reference: 18) Blackburn Jr WD, Heck LW, Wallace RW: The bioflavonoid quercetin inhibits neutrophil degranulation, super-oxide production, and the phosphorylation of specific neutrophil proteins, Biochem Biophys Res Commun, 144: 1229-1236, 1987. – reference: 12) Baud L, Pewrez J, Ardaillou R: Dexamethasone and hydrogen peroxide production by mesangial cells during phagocytosis. Am J Physiol, 250: F596-604, 1986. – reference: 17) Erben-Russ M, Bors W, Saran M: Reactions of linoleic acid peroxyl radicals with phenolic antioxidants, Int J Radiat Biol, 52: 393-412, 1987. – reference: 10) 徳永賢治, 土居修, 宍野宏治, 村瀬光春, 武内望, 篠原力雄, 石黒伊三雄: 慢性関節リュウマチにおける関節液, 血清中のSuper-oxide Dismutase活性値, 過酸化脂質値, セルロプラスミン値の検討, 臨床化学, 18: 42-48, 1989. – reference: 2) Kuroda M, Asaka S, Tofuku Y: Serum antioxidant activity in uremic patients, Nephron, 41: 293-298, 1985. – reference: 14) Markert M, Heierli C, Kuwahara T, Frei J, Wauters JP: Dialyzed polymorphonuclear neutrophil oxidative metabolism during dialysis: a comparative study with 5 new and reused membranes, Clin Nephrol, 29, 129-136, 1988. – reference: 11) Yokozawa T, Oura H, Ienaga K, Nakamura K: Comparison of renal effects of creatinine, creatol and methylguanidine in rats with adenine-induced chronic renal failure, Nephron, 64: 424-428, 1993. – reference: 15) 増子早苗, 保坂俊太郎, 内田隆志: 医用材料とヒト好中球の接触による活性酸素放出の測定, 人工臓器, 18: 63-66, 1989. – reference: 9) 菅野和久, 徳永賢治, 越智正昭, 宍野宏治, 村瀬光春, 佐伯修一, 武内望, 篠原力雄, 石黒伊三雄: 糖尿病患者における好中球活性酸素産生能について, 臨床化学, 22: 168-172, 1993. – reference: 13) Radeke HH, Meier B, Topley N, Flöge J, Habermehl GG, Resch L: Interleukin l-alpha and tumor necrosis factor-alpha induce oxygen radical production in mesangial cells, Kidney Int, 37: 767-775, 1990. – reference: 4) 甲田豊, 鈴木正司, 高橋幸男, 平沢由平: 透析患者の好中球の化学発光動態. 腎とブリーラジカル, p.142-143, 東京医学社, 東京, 1991. – reference: 16) 坂本まさ子, 青柳一正, 永瀬宗重, 成田光陽, 東條静夫: Guanidine産生におよぼす活性酸素の影響について, 日本腎臓学会誌, 19: 1355-1364, 1987. – reference: 8) 三潴忠道, 横澤隆子, 大浦彦吉, 寺澤掟: 大黄並びに大黄含漢方方剤による慢性腎不全の治療に関する研究 (第2報), 日本腎臓学会誌, 29: 195, 1987. – reference: 3) 徳永賢治, 宍野宏治, 村瀬光春, 武内望, 篠原力雄, 石黒伊三雄: 血中および尿中SOD 活性他の臨床的意義, 臨床化学, 16: 129-135, 1987. – reference: 5) Ritchey EE, Wallin JD, Shah SV: Chemiluminescence and superoxide anion production by leukocytes from chronic hemodialysis patients, Kidney Int, 19: 349-358, 1981. – reference: 7) Yokozawa T, Zheng PD, Mo ZL, Oura H: The effect of extracts obtained from rhubarb in rats with chronic renal failure, Chem Pharm Bull, 34: 4718-4723, 1986. – reference: 6) Lucci L, Cappelli G, Acerbi MA: Oxidative metabolism of polymorphonuclear leukocytes and serum opsonic activity in chronic renal failure, Nephron, 51: 44-50, 1989. |
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| SubjectTerms | active oxygen productivity flow cytometry methylguanidine onpi-to SOD superoxide dismutase フローサイトメトリー メチルグアニジン 活性酸素産生能 温脾湯 |
| Title | Effects of Onpi-To (One of Herb Medicine) on Production of Active Oxygen Species from Neutrophils in Hemodialysis Patients |
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