Methylguanidine and Adequacy of Dialysis

The sensitive method for the quantitative determination of all guanidino compounds in human serum was developed by the adaptation of fluorometric detection and high-pressure liquid chromatographic method. Our new analytical method for guanidino compounds was successfully applied for the evaluation o...

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Published inJinko Zoki Vol. 7; no. 1; pp. 30 - 33
Main Authors YAMAMOTO, Y., MANJI, T., MAEDA, K., SAITO, A., OHTA, K., KOBAYASHI, K.
Format Journal Article
LanguageJapanese
Published JAPANESE SOCIETY FOR ARTIFICIAL ORGANS 1978
一般社団法人 日本人工臓器学会
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ISSN0300-0818
1883-6097
DOI10.11392/jsao1972.7.30

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Abstract The sensitive method for the quantitative determination of all guanidino compounds in human serum was developed by the adaptation of fluorometric detection and high-pressure liquid chromatographic method. Our new analytical method for guanidino compounds was successfully applied for the evaluation of normal and uremic subjects. The cerebrospinal fluid as well as serum levels of methylguanidine, guanidine and guanidinosuccinic acid was found to be significantly elevated in uremic subjects. Methylguanidine was dialyzed more easily through a cuprophane membrane than a acetate membrane. Methylguanidine showed a similar curve of the removal rate during dialysis with creatinine and had the removal rate of 50-60%.
AbstractList The sensitive method for the quantitative determination of all guanidino compounds in human serum was developed by the adaptation of fluorometric detection and high-pressure liquid chromatographic method. Our new analytical method for guanidino compounds was successfully applied for the evaluation of normal and uremic subjects. The cerebrospinal fluid as well as serum levels of methylguanidine, guanidine and guanidinosuccinic acid was found to be significantly elevated in uremic subjects. Methylguanidine was dialyzed more easily through a cuprophane membrane than a acetate membrane. Methylguanidine showed a similar curve of the removal rate during dialysis with creatinine and had the removal rate of 50-60%.
Author MANJI, T.
OHTA, K.
KOBAYASHI, K.
YAMAMOTO, Y.
MAEDA, K.
SAITO, A.
Author_FL 太田 和宏
山本 征夫
前田 憲志
斎藤 明
万治 忠福
小林 快三
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DocumentTitleAlternate メチルグアニジンと適性透析
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References 3) Dobbelstein, H., et al: Klin. Wschr., 49, 348 (1971
6) Yatizidis, H., et al: Nature, 212, 1498 (1966
1) Giovanneti, S., Biagini, M., & Cioni, L.: Experimentia, 15, 341 (1968
5) Jinnai, D., et al: Jap. J. Brain physiol, 106, 3668 (1969
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References_xml – reference: 14) Itarto, H.A., et al: Biochem. Biophys. Ac ta, 130, 538 (1966)
– reference: 11) 小林快三ほか: 日内会誌, 60, 185 (1971)
– reference: 1) Giovanneti, S., Biagini, M., & Cioni, L.: Experimentia, 15, 341 (1968)
– reference: 3) Dobbelstein, H., et al: Klin. Wschr., 49, 348 (1971)
– reference: 13) Matsumoto, M., Kishikawa, H., Mori, A.: Biochem. Med., 16, 1 (1976)
– reference: 9) Mori, A, Hosotani, M., & Tye, L. C., Biochem. Med., 10, 8 (1974)
– reference: 2) Giovanneti, S., et al: Clin. Sci., 36, 445 (1969)
– reference: 5) Jinnai, D., et al: Jap. J. Brain physiol, 106, 3668 (1969)
– reference: 7) Stein, I. M., et al: J. Lab. Clin Med., 77, 1020 (1971)
– reference: 8) Menichini, G. C., et al: Experienta, 27, 1157 (1971)
– reference: 4) Horowitz, H., Stein, I. M., & Cohen, B. D.: Amer. J. Med., 49, 671 (1971)
– reference: 12) 下条文武: 日腎誌, 16, 53 (1974)
– reference: 6) Yatizidis, H., et al: Nature, 212, 1498 (1966)
– reference: 10) Shainkin, R., et al: Clinica Chimica Acta, 60, 45 (1975)
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Title Methylguanidine and Adequacy of Dialysis
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