LDLレセプター活性定量化の試み リンパ球PHA反応によるLDLレセプター活性測定法を用いて
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| Published in | 動脈硬化 Vol. 16; no. 5; pp. 689 - 695 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
一般社団法人 日本動脈硬化学会
01.10.1988
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| Online Access | Get full text |
| ISSN | 0386-2682 2185-8284 |
| DOI | 10.5551/jat1973.16.5_689 |
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| Author | 渡辺, 哲彦 梶山, 梧朗 大屋, 敏秀 高田, 耕基 河村, 寛 堀内, 至 |
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| Author_xml | – sequence: 1 fullname: 河村, 寛 organization: 広島大学医学部第一内科 – sequence: 1 fullname: 渡辺, 哲彦 organization: 広島大学医学部第一内科 – sequence: 1 fullname: 高田, 耕基 organization: 広島大学医学部第一内科 – sequence: 1 fullname: 梶山, 梧朗 organization: 広島大学医学部第一内科 – sequence: 1 fullname: 堀内, 至 organization: 広島大学医学部第一内科 – sequence: 1 fullname: 大屋, 敏秀 organization: 広島大学医学部第一内科 |
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| References | 3) Cuthbert, J. A., Eas, C. A., Bilheimer, D. W. and Lipsky, P. E.: Detection of Familial Hypercholesterolemia by Assaying Functional Low-Density-Lipoprotein Receptors on Lymphocytes. N. Engl. J. Med., 314: 879-883 (1986). 6) Cuthbert, J. A. and Lipsky, P. E.: Sterol Metabolism and Lymphocyte Function: Inhibition of Endogenous Sterol Biosynthesis Does not Prevent Mitogen-Induced Human T Lymphocyte Activation. J. Immunol., 124: 2240-2246 (1980). 8) Melzner, I., Hambitzer, R. and Kirkpatrick, C. J.: Cholesterol Synthesis in Cultured Human Peripheral Lymphocytes. Influence of LDL, HDL, Cholesterol/Phosphatidylcholine liposomes and Complete Serum. Biochim. Biophys. Acta, 875: 439-449 (1986). 9) Ho, Y. K., Brown, M. S., Bilheimer, D. W. and Goldstein, J. L.: Regulation of Low Density Lipoprotein Receptor Activity in Freshly Isolated Human Lymphocytes. J. Clin. Invest., 58: 1465-1474 (1976). 10) Bilheimer, D. W., Ho, Y. K., Brown, M. S., Anderson, R. G. W. and Goldstein, J. L.: Genetics of the Low Density Lipoprotein Receptor. J. Clin. Invest., 61: 678-696 (1978). 12) 林洋: リンパ球および単球を用いた, LDL (低比重リポ蛋白) レセプター活性に関する臨床的研究. 特に血漿コレステロール濃度とLDLレセプター活性との相関について. お茶の水医学雑誌, 34: 119-127 (1986). 1) Brown, M. S. and _Goldstein, J. L.: A ReceptorMediated Pathway for Cholesterol Homeostasis. Science, 232: 34-47 (1986). 11) 小泉順二, 道下一郎, 伊藤英章, 酒井泰征, 坂井健志, 吉村陽, 渡辺彰, 若杉隆伸, 馬渕宏, 竹田亮祐: 家族性高コレステロール血症患者における末梢血リンパ球のコレステロール合成とLDLレセプター. 動脈硬化, 11: 1369-1373 (1984). 2) Haba, T., Mabuchi, H., Yoshimura, A., Watanabe, A., Wakasugi, T., Tatami, R., Ueda, .R., Kametani, T., Koizumi, J., Miyamoto, S. and Takeda, R.: Effects of ML-236B (Compactin) on Sterol Synthesis and Low Density Lipoprotein Receptor Activities in Fibroblasts of Patients with Homozygous Familial Hypercholesterolemia. J. Clin. Invest., 67: 1532-1540 (1981). 4) Cuthbert, J. A. and Lipsky, P. E.: Promotion of Human T Lymphocyte Activation and Proliferation by Fatty Acids in Low Density and High Density Lipoproteins. J. Biol. Chem., 261: 3620-3627 (1986). 7) 滝口智夫, 小中義照, 清水史朗, 紺田進, 重原万寿美: Semi-automatic Multiple Sample Harvesterによるヒトリンパ球幼弱化試験. 免疫実験操作法B (日本免疫学会編), pp. 1426-1435, 1974. 5) 垂井清一郎: 総括報告. 原発性高脂血症調査研究班昭和60年度研究報告書, pp. 11-20 (1986). |
| References_xml | – reference: 3) Cuthbert, J. A., Eas, C. A., Bilheimer, D. W. and Lipsky, P. E.: Detection of Familial Hypercholesterolemia by Assaying Functional Low-Density-Lipoprotein Receptors on Lymphocytes. N. Engl. J. Med., 314: 879-883 (1986). – reference: 9) Ho, Y. K., Brown, M. S., Bilheimer, D. W. and Goldstein, J. L.: Regulation of Low Density Lipoprotein Receptor Activity in Freshly Isolated Human Lymphocytes. J. Clin. Invest., 58: 1465-1474 (1976). – reference: 7) 滝口智夫, 小中義照, 清水史朗, 紺田進, 重原万寿美: Semi-automatic Multiple Sample Harvesterによるヒトリンパ球幼弱化試験. 免疫実験操作法B (日本免疫学会編), pp. 1426-1435, 1974. – reference: 1) Brown, M. S. and _Goldstein, J. L.: A ReceptorMediated Pathway for Cholesterol Homeostasis. Science, 232: 34-47 (1986). – reference: 2) Haba, T., Mabuchi, H., Yoshimura, A., Watanabe, A., Wakasugi, T., Tatami, R., Ueda, .R., Kametani, T., Koizumi, J., Miyamoto, S. and Takeda, R.: Effects of ML-236B (Compactin) on Sterol Synthesis and Low Density Lipoprotein Receptor Activities in Fibroblasts of Patients with Homozygous Familial Hypercholesterolemia. J. Clin. Invest., 67: 1532-1540 (1981). – reference: 4) Cuthbert, J. A. and Lipsky, P. E.: Promotion of Human T Lymphocyte Activation and Proliferation by Fatty Acids in Low Density and High Density Lipoproteins. J. Biol. Chem., 261: 3620-3627 (1986). – reference: 5) 垂井清一郎: 総括報告. 原発性高脂血症調査研究班昭和60年度研究報告書, pp. 11-20 (1986). – reference: 10) Bilheimer, D. W., Ho, Y. K., Brown, M. S., Anderson, R. G. W. and Goldstein, J. L.: Genetics of the Low Density Lipoprotein Receptor. J. Clin. Invest., 61: 678-696 (1978). – reference: 11) 小泉順二, 道下一郎, 伊藤英章, 酒井泰征, 坂井健志, 吉村陽, 渡辺彰, 若杉隆伸, 馬渕宏, 竹田亮祐: 家族性高コレステロール血症患者における末梢血リンパ球のコレステロール合成とLDLレセプター. 動脈硬化, 11: 1369-1373 (1984). – reference: 6) Cuthbert, J. A. and Lipsky, P. E.: Sterol Metabolism and Lymphocyte Function: Inhibition of Endogenous Sterol Biosynthesis Does not Prevent Mitogen-Induced Human T Lymphocyte Activation. J. Immunol., 124: 2240-2246 (1980). – reference: 12) 林洋: リンパ球および単球を用いた, LDL (低比重リポ蛋白) レセプター活性に関する臨床的研究. 特に血漿コレステロール濃度とLDLレセプター活性との相関について. お茶の水医学雑誌, 34: 119-127 (1986). – reference: 8) Melzner, I., Hambitzer, R. and Kirkpatrick, C. J.: Cholesterol Synthesis in Cultured Human Peripheral Lymphocytes. Influence of LDL, HDL, Cholesterol/Phosphatidylcholine liposomes and Complete Serum. Biochim. Biophys. Acta, 875: 439-449 (1986). |
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| Subtitle | リンパ球PHA反応によるLDLレセプター活性測定法を用いて |
| Title | LDLレセプター活性定量化の試み |
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