Portal hypertensive gastropathy: from clinical and pathophysiological points of view

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Published inJapanese Journal of Portal Hypertension Vol. 16; no. 1; pp. 58 - 68
Main Authors Nishizaki, Y, Motegi, S, Shiozawa, H, Watanabe, N, Mine, T
Format Journal Article
LanguageJapanese
Published The Japan Society for Portal Hypertension 2010
日本門脈圧亢進症学会
Online AccessGet full text
ISSN1344-8447
2186-6376
DOI10.11423/jsph.16.58

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Author Nishizaki, Y
Motegi, S
Mine, T
Watanabe, N
Shiozawa, H
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63) Panes J, Bordas JM, Pique JM, et al: Effects of propranolol on gastric mucosal perfusion in cirrhotic patients with portal hypertensive gastropathy. Hepatology 1993; 17: 213-218
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5) Teres J, Bordas M, Bru C, et al: Upper gastrointestinal bleeding in cirrhosis: clinical and Endoscopic correlations. Gut 1976; 17: 37-40
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2) McCormack TT, Simms J, Eyre-Brook I, et al: Gastric lesion in portal hypertension. Inflammatory gastritis or congestive gastropathy? Gut 1985; 26: 1226-1232
29) Bahnacy A, Kupcsulik P, Eles ZS, et al: Helicobacter pylori and congestive gastropathy. Z Gastroenterol 1997; 35: 109-121
68) Helton WS, Maves R, Wicks K, et al: Transjugular intrahepatic portasystemic shunt vs surgical shunt in good-risk cirrhotic patients: a case-control comparison. Arch Surg 2001; 136: 17-20
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27) Foster PN, Wyatt JI, Bullimore DW, et al: Gastric mucosa in patients with portal hypertension: prevalence of capillary dilatation and Campylobacter pylori. J Clin Pathol 1989; 42: 919-921
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25) 西崎泰弘，板倉　勝，茂出木成幸，他：門脈圧亢進症性胃症の内視鏡所見と背景肝疾患の進展度に関する臨床的検討．日消誌 2001; 98: A196
53) 織田正也，西崎泰弘，東　俊文，他：肝硬変における出血性胃粘膜病変の発生機構─微小循環障害の観点から．消化器血流の研究 6，消化器血流研究会編，メディカルトリビューン，東京，1990, 55-76
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References_xml – reference: 3) Ripoll C, Garcia-Tsao G: Treatment of gastropathy and gastric antral vascular ectasia in patients with portal hypertension. Curr Treat Options Gastroenterol 2007; 10: 483-494
– reference: 72) Kouroumalis EA, Koutroubakis IE, Manousos ON: Somatostatin for acute severe bleeding from portal hypertensive gastropathy. Eur J Gastroenterol Hepatol 1998; 10: 509-512
– reference: 17) 西崎泰弘，渡辺勲史，中野敦史，他：胃潰瘍からの吐血を契機に発見されたDiffuse antral vascular ectasiaの一例．Gastroenterological endoscopy 1997; 39: 1230-1238
– reference: 48) Chan CC, Wang SS, Lee FY, et al: Endothelin-1 induces vasoconstriction on poeral-systemic collaterals of portalhypertensive rats. Hepatology 2001; 33: 816-820
– reference: 70) Panes J, Pique JM, Bordas JM, et al: Reduction of gastric hyperemia by glypressin and vasopressin administration in cirrhotic patients with portal hypertensive gastropathy. Hepatology 1994; 19: 55-60
– reference: 68) Helton WS, Maves R, Wicks K, et al: Transjugular intrahepatic portasystemic shunt vs surgical shunt in good-risk cirrhotic patients: a case-control comparison. Arch Surg 2001; 136: 17-20
– reference: 43) Withrington PG, De Nucci G, Vane JR: Endithelin-1 causes vasoconstriction and vasodilatation in the blood perfused liver of the dog. J Cardiovasc Parmacol 1989; 12: S209-210
– reference: 45) Gondou K, Ueno T, Sakamoto M, et al: The endothelin-1 binding site in rat liver tissue: light- and electron- microscopic autoradiographic studies. Gastroenterology 1993; 104: 1745-1749
– reference: 31) 北野善郎，卜部　健，金子周一：門脈圧亢進症性胃症におけるH. pylori感染．消化器科 1998; 26: 636-641
– reference: 14) 豊永　純，谷川久一：門脈圧亢進症(肝硬変)における胃病変─胃壁の微小循環．食道，胃静脈瘤の病態と治療，青木春夫編，医学書院，東京，1996, 122-127
– reference: 51) Nakamura M, Oda M, Nishizaki Y, et al: Histochemical chalacterizations of gastric erosion formed in chronic CCl4-treated rats. J. Gastroenterol. Hepatol 1989; 4: 123-125
– reference: 64) 北野善郎，ト部　健，小浦隆義：経頚静脈的肝内門脈大循環短絡術によるportal hypertensive gastropathyの変化．Gastroenterl Endosc 1995; 37: 720-726
– reference: 6) Salfeh IJ, Tarnawski A, Malki A, et al: Portal hypertension and gastric mucosal injury in rats. Gastroenterology 1983; 84: 987-993
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– reference: 61) Cales P, Braillon A, Girod C, et al: Acute effect of propranolol on splanchnic circulation in normal and portal hypertensive rats. J Hepatol 1985; 1: 349-357
– reference: 5) Teres J, Bordas M, Bru C, et al: Upper gastrointestinal bleeding in cirrhosis: clinical and Endoscopic correlations. Gut 1976; 17: 37-40
– reference: 22) Iwao T, Toyonaga A, Oho K, et al: Portal hypertensive gastropathy develops less in cirrhotic patients with fundal varices. J Hepatol 1997; 26: 1235-1241
– reference: 52) Nishizaki Y, Oda M, Azuma T, et al: Pathogenesis of gastric mucosal microcirculatory disturbances in experimental liver cirhosis. in Microcirculation Annual 1990, ed by Tsuchiya M, Asano M, Shozawa T, Nihon-Igakukan, Tokyo, 1990, 97-98
– reference: 24) 西崎泰弘，加持順一郎，塩澤宏和，他：慢性肝障害の進展と門脈圧亢進症性胃症の関連について─内視鏡所見と発生部位に関する検討．日門亢会誌 2002; 8: 57
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– reference: 9) 土屋雅春，織田正也，中村正彦，他：胃潰瘍と自律神経．胃 潰瘍と防御因子．松尾　裕，土屋雅春監修．メデイカルリサーチセンター，東京，1986, 27-51
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– reference: 20) D'Amico G, Montalbane L, Traina M, et al: Natural history of congestive gastropathy in cirrhosis. Gastroenterology 1990; 99: 1558-1564
– reference: 36) Nomura H, Miyake K, Hirakata R, et al: Rebamipide prevents occurrence of gastric lesions following transcatheter arterial embolization in the hepatic artery. J Gastroenterol Hepatol 1999; 14: 495-499
– reference: 39) Sarin SK, Sreenivas DV, Lahoti D, et al: Factors influencing development of portal hypertensive gastropathy in patients with portal hypertension. Gastroenterology 1992; 102: 994-999
– reference: 46) Ohara N, Futagawa S, Watanabe S: Clinical investigation of endothelin-1 and nitric oxide in patients with portal hypertension focusing on plasma levels and immunohistological staining of liver tissue. Hepatol Res 2001; 21: 40-54
– reference: 53) 織田正也，西崎泰弘，東　俊文，他：肝硬変における出血性胃粘膜病変の発生機構─微小循環障害の観点から．消化器血流の研究 6，消化器血流研究会編，メディカルトリビューン，東京，1990, 55-76
– reference: 8) Taor RE, Fox B, Ware J, et al: Gastritis-gastroendoscopic and microscopic. Endoscopy 1975; 7: 209-215
– reference: 10) Sarin SK, Mirsa SP, Singal A, et al: Evaluation of the incidence and significance of the `mosaic pattern' in patients with cirrhosis, noncirrhotic portal fibrosis, and extrahepatic obstruction. Am J Gastroenterol 1988; 83: 1235-1239
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– reference: 44) Takashimizu S, Watanabe N, Nishizaki Y, et al: mechanism of hepatic microcirculatory disturbances induced by acute ethanol administration in rats. With special reference to alterations of sinusoidal endothelial fenestrae. Alcohol Clin Exp Res 1999; 23: s39-46
– reference: 25) 西崎泰弘，板倉　勝，茂出木成幸，他：門脈圧亢進症性胃症の内視鏡所見と背景肝疾患の進展度に関する臨床的検討．日消誌 2001; 98: A196
– reference: 60) Lebrec D, Nouel O, Corbic M, et al: The role of propranolol in congestive gastropathy of portal hypertension. Hepatology 1987; 7: 437-441
– reference: 65) Maezawa S, Homma H, Ohta H, et al: Effect of transjuglar intrahepatic portosystemic shunt formation on portal hypertensive gastropathy and gastric circulation. Am J Gastroenterol 2001; 96: 1155-1159
– reference: 30) Bhargava N, Venkateswaran S, Ramakrishna BS, et al: Colonization by Helicobacter pylori and its relationship to histological changes in the gastric mucosa in portal hypertension. J Gastroenterol Hepatol 1994; 9: 507-511
– reference: 1) 小原勝敏：門脈圧亢進症性胃腸症．Gastroenterological Endoscopy 2007; 49: 305-313
– reference: 2) McCormack TT, Simms J, Eyre-Brook I, et al: Gastric lesion in portal hypertension. Inflammatory gastritis or congestive gastropathy? Gut 1985; 26: 1226-1232
– reference: 69) Shaldon S, Sherlock S: The use of vasopressin (`pitressin') in the control of bleeding from oesophageal varices. Lancet 1960; 2: 222-225
– reference: 56) Nishizaki Y, Guth PH, Kaunitz JD: Impairment of the gastric hyperemic response to luminal acid in cirrhotic rats. Am J Physiol 1996; 270: G71-78
– reference: 15) 門脈圧亢進症学会編：門脈圧亢進症取り扱い規約．金原出版，東京，2004
– reference: 35) Yoshikawa I, murata I, nakano S, et al: Effects of endoscopic variceal ligation on portal hypertensive gastropathy and gastric mucosal blood flow. Am J Gastroenterol 1998; 93: 71-74
– reference: 37) Ohta M, Hashizume M, Higashi H, et al: Portal and gastric mucosal hemodynamics in cirrhotic patients with portal hypertensive gastropathy. Hepatology 1994; 20: 1432-1436
– reference: 32) Iwao T, Toyonaga A, Sumino M, et al: Portal hypertensive gastropathy in patients with cirrhosis. Gastroenterology 1992; 102: 2060-2065
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