The Fib rinolytic Therapy in Renal Disease
1) Twenty-nine cases of renal diseases were administrated intravenously 30, 000 units/day of urokinase during 2 weeks. Urinary volume, urinary protein, urinary blood cells, blood urea nitrogen, serum creatinine, renal function, FDP in urine and blood, and fibrinogen in plasma before and after urokin...
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| Published in | The Japanese Journal of Nephrology Vol. 22; no. 1; pp. 59 - 79 |
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| Main Authors | , , , , , , , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
Japanese Society of Nephrology
1980
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| ISSN | 0385-2385 1884-0728 |
| DOI | 10.14842/jpnjnephrol1959.22.59 |
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| Abstract | 1) Twenty-nine cases of renal diseases were administrated intravenously 30, 000 units/day of urokinase during 2 weeks. Urinary volume, urinary protein, urinary blood cells, blood urea nitrogen, serum creatinine, renal function, FDP in urine and blood, and fibrinogen in plasma before and after urokinase therapy were observed.2) Twelve cases were effective for urokinase therapy. GFR increased in 7 cases, urinary protein decr-eased in 10 cases and urinary red cells decreased in 5 cases.3) Eight cases in effective cases for urokinase therapy were taken renal biopsy. In these histological findings, 5 cases were proliferative glomerulonephritis, 2 cases were membranoproliferative glomerulon-ephritis and 1 case was membranonephropathy.4) In 2 cases of acute renal failure, after urokinase therapy GFR increased with diuresis. And, in pati-ents with pregnancy kidney, after urokinase therapy urinary protein and urinary blood cells decreased.5) In many cases that were effective for urokinase therapy, FDP in morning urine was positive. How ever, in chronic renal failure in which FDP in urine was posititve, urokinase therapy was non-effective. |
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| AbstractList | 1) Twenty-nine cases of renal diseases were administrated intravenously 30, 000 units/day of urokinase during 2 weeks. Urinary volume, urinary protein, urinary blood cells, blood urea nitrogen, serum creatinine, renal function, FDP in urine and blood, and fibrinogen in plasma before and after urokinase therapy were observed.2) Twelve cases were effective for urokinase therapy. GFR increased in 7 cases, urinary protein decr-eased in 10 cases and urinary red cells decreased in 5 cases.3) Eight cases in effective cases for urokinase therapy were taken renal biopsy. In these histological findings, 5 cases were proliferative glomerulonephritis, 2 cases were membranoproliferative glomerulon-ephritis and 1 case was membranonephropathy.4) In 2 cases of acute renal failure, after urokinase therapy GFR increased with diuresis. And, in pati-ents with pregnancy kidney, after urokinase therapy urinary protein and urinary blood cells decreased.5) In many cases that were effective for urokinase therapy, FDP in morning urine was positive. How ever, in chronic renal failure in which FDP in urine was posititve, urokinase therapy was non-effective. |
| Author | Suzuki, Toyosaka Kishimoto, Thiharu Takayama, Shinithi Yoyoyama, Shoithi Kaburagi, Thuneo Tanaka, Kazunari Tornimoto, Kazuhiko Oguma, Shigeru Haniu, Thunehisa Hatori, Toshio Mithunami, Kenithi |
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| References | 18) Brown, C. B., Wilson, D., Turner, D., Cameron, J. S., Ogg, C. S., Chantler, C. & Gill, D.: Combined immunosupression and anticoagulation in rapidly progressive glomerulonephritis. Lancet, 2:1166-1172,1974. 21) Pirani, R. H., Pollak, V. E., et al.: The renal glomerular lesion of pre-eclampsia ; electron mi-croscopic studies. Am. J. Obstet. Gynecol., 87 1047, 1963. 14) 佐藤昌史,中空博,大藤真:糸球体腎炎,ネフローゼ症候群に於ける線溶療法の研究。第III報線溶療法の適応・開始時期・効果判定について。日腎誌,14:717,1977. 16) Herdmann, R. C., Edson, J. R., Pickering, R. J., Fish, A. J., Marker, S. & Good, R. A.: Anticoagulants in renal disease in children. Am. J. Dis. Child., 119 : 27-35, 1970. 28) 宮村祥二:腎疾患における尿中FDPの臨床的意義第一報:原発性糸球体腎炎における尿中FDPの意義。日腎誌,20:67-77,1968. 5) Humair, L., Kwaan, H. C. & Potter, E. V.: The role of fibrinogen in renal disease. II. Effects of anticoagulants and urokinase on experimental lesion in mice. J. Lab. & Cli. Med., 74 : 74-78,1969. 15) 海津嘉蔵:腎疾患における尿中FDPの臨床的意義。日腎誌,18:371,1976. 4) Kincaid-Smith, P., Layer, M. C., Fairley, K. F., and Mathews, D. C.: Dipyridamole and anticoagulants in renal disease due to glomerular and vascular lesions : a new approach to therapy. Med. J. Aust., 1 :145, 1970. 10) 石川兵衛,林需,本庄昭,浜口尚重,岡林正純,辰巳勝彦,進藤敬久,松島明彦:腎炎の線溶療法にかんする臨床的研究。Urokinaseの効果。日本腎臓学会雑誌,18,5:357-367,1976. 1) Vassalli, P. and McClusky, R. T.: The pathogenic role of fibrin deposition inimmunologically induced glomerulonephriti. Ann. New York Acad. Sci., 116:1052, 1964. 6) Briggs, J. D., Kwaan, H. C. & Potter, E. V. The role of fibrinogen in renal disease. III. Fibrinolytic and anticoagulant treatment of nep-hrotoxic serum nephritis in mice. J. Lab. & Cli. Nled., 74 : 715-724, 1969. 11) 水田耕二,吉田豊茂,中園秀朗:慢性腎炎に対するウロキナーゼの使用経験。新薬と臨床,24,1:161-164,1975. 20) MacDonald, M. K., Clarkson, A. R. & Davison, A. M.: The Role of Coagulation in Renal Disease. "Glomerulonephritis." Kincaid-Smith, Mathew and Becker. (Eds.), Willey comp., 1972. p. 809. 27) Vassalli, P., McClusky, R. T.: The coagulation process and glomerular disease. Amer. J. Med., 39 : 179-183, 1965. 25) Clarkson, A. R., MacDonald, M. K., Petrie, J. J. B., Cash, J. D., Robson, J. S.: Serum and urinary fibrin/fibrinogen degradation products in glomerulonephritis. Brit. Med. J., 21: 447-451, 1971. 3) Kincaid-Smith, P., Saker, B. M. and Fairley, K. F.: Anticoagulants in "irreversible" acute renal failure. Lancet, 2 :1360, 1968. 19) 阿部恒男:血管内凝固。産婦人科の実際,25:669-677,1976. 9) 杉崎徹三,志和池成世,菊地祥治,米倉正博:馬杉腎炎の糸球体内フィブリン沈着に対するUrokinaseの影響。臨床と研究,52,7:2131-2136,1975. 7) 藤岡正彦,土肥和紘,木田寛,中本安,浅野喜博,飯田博行,服部信:馬杉腎炎に対する線溶療法の試み。臨床と研究,54,4:1197-1201,1977. 12) 佐藤昌史,中空博,大藤真他:糸球体腎炎,ネフローゼ症候群に於ける線溶療法の研究。第I報有効症例の検討。Medical Postgraduate,15:55-67,1977. 24) Kincaid-Smith, P., Sake.r, B. M., Fairley, K. F.: Anticoagulants in "irreversible" acute renal failure. Lancet, 2 :1363, 1968. 22) Morris, R. H., Vassalli, P., et al.: The role of coagulation in renal disease, glomerulonephritis. Morphology natural history and treatment. New York : John Wiley & Sons, 1972. Part II of two volumes, P. 809. 23) McClusky, R. T., Vassalli, P., Gallo, G. & Baldwin, D. S.: An immunofluorescent study of pathogenic mechanisms in glomerular diseases. New Eng. J. Med., 274 : 695-701, 1966. 8) 浜口尚重,林需,本庄昭,森田哲生,岡林正純,進藤敬久,石川兵衛:腎炎の線溶療法にかんする実験的研究(第1報)馬杉腎炎の発生過程におよぼすUrokinaseの影響。第19回日本腎臓学会総会予稿集:1976. 13) 佐藤昌史,中空博,大藤真他:糸球体腎炎,ネフローゼ症候群における線溶療法の研究。第II報線溶療法の効果。Medical Postgraduate,15:97-109,1977. 26) Briggs, J. D., Prentice, C. R. M., Hutton, H. M., Kennedy, A. C., McNicol, G. P.: Serum and urine fibrinogen-fibrin-related antigen (F. R. Antigen) levels in renal disease. Brit. Med. J., 4 : 82-85, 1972. 17) Arieff, A. I. & Pinggerna, W. F.: Rapidly progressive glomerulonephritis treated with anticoagulants. Arch. Intern. Med., 129: 77-84, 19 72. 2) Vassalli, P. and McClusky, R. T.: The pathoenic role of the Coagulation process in rabbit Masugi nephritis. Amer. J. Pathol., 45 : 653, 1964. |
| References_xml | – reference: 12) 佐藤昌史,中空博,大藤真他:糸球体腎炎,ネフローゼ症候群に於ける線溶療法の研究。第I報有効症例の検討。Medical Postgraduate,15:55-67,1977. – reference: 20) MacDonald, M. K., Clarkson, A. R. & Davison, A. M.: The Role of Coagulation in Renal Disease. "Glomerulonephritis." Kincaid-Smith, Mathew and Becker. (Eds.), Willey comp., 1972. p. 809. – reference: 10) 石川兵衛,林需,本庄昭,浜口尚重,岡林正純,辰巳勝彦,進藤敬久,松島明彦:腎炎の線溶療法にかんする臨床的研究。Urokinaseの効果。日本腎臓学会雑誌,18,5:357-367,1976. – reference: 8) 浜口尚重,林需,本庄昭,森田哲生,岡林正純,進藤敬久,石川兵衛:腎炎の線溶療法にかんする実験的研究(第1報)馬杉腎炎の発生過程におよぼすUrokinaseの影響。第19回日本腎臓学会総会予稿集:1976. – reference: 14) 佐藤昌史,中空博,大藤真:糸球体腎炎,ネフローゼ症候群に於ける線溶療法の研究。第III報線溶療法の適応・開始時期・効果判定について。日腎誌,14:717,1977. – reference: 15) 海津嘉蔵:腎疾患における尿中FDPの臨床的意義。日腎誌,18:371,1976. – reference: 21) Pirani, R. H., Pollak, V. E., et al.: The renal glomerular lesion of pre-eclampsia ; electron mi-croscopic studies. Am. J. Obstet. Gynecol., 87 1047, 1963. – reference: 22) Morris, R. H., Vassalli, P., et al.: The role of coagulation in renal disease, glomerulonephritis. Morphology natural history and treatment. New York : John Wiley & Sons, 1972. Part II of two volumes, P. 809. – reference: 26) Briggs, J. D., Prentice, C. R. M., Hutton, H. M., Kennedy, A. C., McNicol, G. P.: Serum and urine fibrinogen-fibrin-related antigen (F. R. Antigen) levels in renal disease. Brit. Med. J., 4 : 82-85, 1972. – reference: 4) Kincaid-Smith, P., Layer, M. C., Fairley, K. F., and Mathews, D. C.: Dipyridamole and anticoagulants in renal disease due to glomerular and vascular lesions : a new approach to therapy. Med. J. Aust., 1 :145, 1970. – reference: 13) 佐藤昌史,中空博,大藤真他:糸球体腎炎,ネフローゼ症候群における線溶療法の研究。第II報線溶療法の効果。Medical Postgraduate,15:97-109,1977. – reference: 5) Humair, L., Kwaan, H. C. & Potter, E. V.: The role of fibrinogen in renal disease. II. Effects of anticoagulants and urokinase on experimental lesion in mice. J. Lab. & Cli. Med., 74 : 74-78,1969. – reference: 6) Briggs, J. D., Kwaan, H. C. & Potter, E. V. The role of fibrinogen in renal disease. III. Fibrinolytic and anticoagulant treatment of nep-hrotoxic serum nephritis in mice. J. Lab. & Cli. Nled., 74 : 715-724, 1969. – reference: 24) Kincaid-Smith, P., Sake.r, B. M., Fairley, K. F.: Anticoagulants in "irreversible" acute renal failure. Lancet, 2 :1363, 1968. – reference: 17) Arieff, A. I. & Pinggerna, W. F.: Rapidly progressive glomerulonephritis treated with anticoagulants. Arch. Intern. Med., 129: 77-84, 19 72. – reference: 25) Clarkson, A. R., MacDonald, M. K., Petrie, J. J. B., Cash, J. D., Robson, J. S.: Serum and urinary fibrin/fibrinogen degradation products in glomerulonephritis. Brit. Med. J., 21: 447-451, 1971. – reference: 2) Vassalli, P. and McClusky, R. T.: The pathoenic role of the Coagulation process in rabbit Masugi nephritis. Amer. J. Pathol., 45 : 653, 1964. – reference: 16) Herdmann, R. C., Edson, J. R., Pickering, R. J., Fish, A. J., Marker, S. & Good, R. A.: Anticoagulants in renal disease in children. Am. J. Dis. Child., 119 : 27-35, 1970. – reference: 18) Brown, C. B., Wilson, D., Turner, D., Cameron, J. S., Ogg, C. S., Chantler, C. & Gill, D.: Combined immunosupression and anticoagulation in rapidly progressive glomerulonephritis. Lancet, 2:1166-1172,1974. – reference: 27) Vassalli, P., McClusky, R. T.: The coagulation process and glomerular disease. Amer. J. Med., 39 : 179-183, 1965. – reference: 23) McClusky, R. T., Vassalli, P., Gallo, G. & Baldwin, D. S.: An immunofluorescent study of pathogenic mechanisms in glomerular diseases. New Eng. J. Med., 274 : 695-701, 1966. – reference: 7) 藤岡正彦,土肥和紘,木田寛,中本安,浅野喜博,飯田博行,服部信:馬杉腎炎に対する線溶療法の試み。臨床と研究,54,4:1197-1201,1977. – reference: 19) 阿部恒男:血管内凝固。産婦人科の実際,25:669-677,1976. – reference: 28) 宮村祥二:腎疾患における尿中FDPの臨床的意義第一報:原発性糸球体腎炎における尿中FDPの意義。日腎誌,20:67-77,1968. – reference: 1) Vassalli, P. and McClusky, R. T.: The pathogenic role of fibrin deposition inimmunologically induced glomerulonephriti. Ann. New York Acad. Sci., 116:1052, 1964. – reference: 11) 水田耕二,吉田豊茂,中園秀朗:慢性腎炎に対するウロキナーゼの使用経験。新薬と臨床,24,1:161-164,1975. – reference: 3) Kincaid-Smith, P., Saker, B. M. and Fairley, K. F.: Anticoagulants in "irreversible" acute renal failure. Lancet, 2 :1360, 1968. – reference: 9) 杉崎徹三,志和池成世,菊地祥治,米倉正博:馬杉腎炎の糸球体内フィブリン沈着に対するUrokinaseの影響。臨床と研究,52,7:2131-2136,1975. |
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