Study of antigen presenting cells—Age-Dependent Loss of antigen presenting ability in New Zealand black and white (NZB × NZW) F1 mice and the effect of indomethacin
NZB×NZW F1 hybrid (B/W F1) mice have been extensively investigated as model animals for resembling human systemic lupus erythematosus. Some reports suggested, that the aging of B/W F1 mice provided influences to the immune response and the function of macrophage in B/W F1. In the present investigati...
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| Published in | Ensho Vol. 6; no. 2; pp. 172 - 175 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
The Japanese Society of Inflammation and Regeneration
01.04.1986
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0389-4290 1884-4006 |
| DOI | 10.2492/jsir1981.6.172 |
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| Abstract | NZB×NZW F1 hybrid (B/W F1) mice have been extensively investigated as model animals for resembling human systemic lupus erythematosus. Some reports suggested, that the aging of B/W F1 mice provided influences to the immune response and the function of macrophage in B/W F1. In the present investigation, we studied on antigen presenting ability of SACs (spleen adherent cells), epidermal cells, Kupffer cells, and alveolar macrophages from B/W F1 mice in various ages. Aging of these mice decreased antigen presenting ability on SACs, epidermal cells, and alveolar macrophages, but not Kupffer cells. And the response of antigen presening abilities in both B/W F1 and B6×DBAF1 hybrid (B/D F1) mice were decreased when indomethacin administrated. |
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| AbstractList | NZB×NZW F1 hybrid (B/W F1) mice have been extensively investigated as model animals for resembling human systemic lupus erythematosus. Some reports suggested, that the aging of B/W F1 mice provided influences to the immune response and the function of macrophage in B/W F1. In the present investigation, we studied on antigen presenting ability of SACs (spleen adherent cells), epidermal cells, Kupffer cells, and alveolar macrophages from B/W F1 mice in various ages. Aging of these mice decreased antigen presenting ability on SACs, epidermal cells, and alveolar macrophages, but not Kupffer cells. And the response of antigen presening abilities in both B/W F1 and B6×DBAF1 hybrid (B/D F1) mice were decreased when indomethacin administrated. |
| Author | Katoh, Kiyoshi Nagaoka, Shohei Matsunaga, Keiichiro Igarashi, Toshihisa Kiuchi, Mitsuyo Tani, Kenji Okubo, Takao Narita, Masahiro |
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| References | 6) Leventhal, B.G., Talal, N.: Response of NZB and NZB/NZW spleen cells to mitogenic agents. J. Immunol. 104: 918-923, 1970. 7) Krakauer, R.S., Strober, W., Waldmann, T.A.: Loss of suppressor T cells in the pathogenesis of the autoimmunity of the NZB/NZW mice. Arthritis Rheum. 21: supple 185-189, 1978. 1) Howie, J.N., Helyer, B.J.: : The immunology and pathology of NZB mice. Adv. Immunol.9: 215-219, 1968. 4) Sawada, S., Talal, N.: Characteristics of in vitro production of antibodies to DNA in normal and autoimmune mouse. J. Immunol. 122: 2309-2313, 1979. 15) Walker, W.S.: Macrophage functional heterogeneity. Adv. Exp. Med. Biol. 155: 435-443, 1982. 2) Talal, N., Steinberg, A.D.: The pathogenesis of autoimmunity in New Zealand Black mice. Curr. Top. Microbiol. Immunol. 64: 79-103, 1974. 5) Papoian, R., Pillarisetty, R., Talal, N.: Immunological regulation of spontaneous antibodies to DNA and RNA. II. Sequantial switch from IgM to IgG in NZB/NZW F1 mice. Immunology 32: 75-81, 1977. 8) Allison, A.C. Denman, A.M., Barnes, R.D.: Cooperating and controlling functions of thymusderived lymphocytes in relation to autoimmunity. Lancet 2: 135-140, 1971. 3) Dixon, F.G., Feldman, J.D., Vasquez, J. J.: Expeimental glomerulonephritis. The pathogenesis of a laboratory model resembling the spectrum of human glomerulonephritis. J. Exp. Med. 113: 889-897, 1961. 14) Morgan, A.G., Steward, M.W.: Macrophage clerance function and immune complex disease in New Zealand Black/White Fl hybrid mice. Clin. exp. Immunol. 26: 133-136, 1976. 13) Kassan, S.S. Chused, M.W.: Impairment of primary in vitro response of New Zealand mouse spleen cells to a thymic dependent antigen. Cell Immunol. 30: 135-146, 1977. 9) Chused, T.A., Steinberg, A.D., Parker, L.M.: Enhanced antibody response of mice to polyinosinic-polycytidylic acid by antithymocyte serum and its age dependent loss of NZB/NZW mice. J. Immunol. 111: 52-57, 1973. 11) Cohen, P.L.: Functional abscense of a B cell subpopulation in aging New Zealand mice. Clin, exp. Immunol. 40: 365-372, 1980. 17) Makinodan, T., Kay, M.M.: Age influence on the immune system. Adv. Immunol. 29: 287-330, 1980. 10) Ranney, D.F., Steinberg, A.D.: Differences in the age dependent release of a low molecular weight suppressor (LMWS) and stimulators by normal and NZB/W lymphoid organs. J. Immunol. 117: 1219-1225, 1976. 12) 加藤清: マウスの尾を用い表皮細胞の採取法. 免役実験操作法 9: 2685-2690, 1980. 16) McCombs, C., Hom. J., Talal, N., Mishell, R. I.: Functional defliciency of splenic adherent cells in New Zealand Black mice. J. Immunol. 115: 1695-1699, 1975. |
| References_xml | – reference: 8) Allison, A.C. Denman, A.M., Barnes, R.D.: Cooperating and controlling functions of thymusderived lymphocytes in relation to autoimmunity. Lancet 2: 135-140, 1971. – reference: 5) Papoian, R., Pillarisetty, R., Talal, N.: Immunological regulation of spontaneous antibodies to DNA and RNA. II. Sequantial switch from IgM to IgG in NZB/NZW F1 mice. Immunology 32: 75-81, 1977. – reference: 17) Makinodan, T., Kay, M.M.: Age influence on the immune system. Adv. Immunol. 29: 287-330, 1980. – reference: 4) Sawada, S., Talal, N.: Characteristics of in vitro production of antibodies to DNA in normal and autoimmune mouse. J. Immunol. 122: 2309-2313, 1979. – reference: 10) Ranney, D.F., Steinberg, A.D.: Differences in the age dependent release of a low molecular weight suppressor (LMWS) and stimulators by normal and NZB/W lymphoid organs. J. Immunol. 117: 1219-1225, 1976. – reference: 15) Walker, W.S.: Macrophage functional heterogeneity. Adv. Exp. Med. Biol. 155: 435-443, 1982. – reference: 6) Leventhal, B.G., Talal, N.: Response of NZB and NZB/NZW spleen cells to mitogenic agents. J. Immunol. 104: 918-923, 1970. – reference: 1) Howie, J.N., Helyer, B.J.: : The immunology and pathology of NZB mice. Adv. Immunol.9: 215-219, 1968. – reference: 2) Talal, N., Steinberg, A.D.: The pathogenesis of autoimmunity in New Zealand Black mice. Curr. Top. Microbiol. Immunol. 64: 79-103, 1974. – reference: 11) Cohen, P.L.: Functional abscense of a B cell subpopulation in aging New Zealand mice. Clin, exp. Immunol. 40: 365-372, 1980. – reference: 14) Morgan, A.G., Steward, M.W.: Macrophage clerance function and immune complex disease in New Zealand Black/White Fl hybrid mice. Clin. exp. Immunol. 26: 133-136, 1976. – reference: 9) Chused, T.A., Steinberg, A.D., Parker, L.M.: Enhanced antibody response of mice to polyinosinic-polycytidylic acid by antithymocyte serum and its age dependent loss of NZB/NZW mice. J. Immunol. 111: 52-57, 1973. – reference: 7) Krakauer, R.S., Strober, W., Waldmann, T.A.: Loss of suppressor T cells in the pathogenesis of the autoimmunity of the NZB/NZW mice. Arthritis Rheum. 21: supple 185-189, 1978. – reference: 13) Kassan, S.S. Chused, M.W.: Impairment of primary in vitro response of New Zealand mouse spleen cells to a thymic dependent antigen. Cell Immunol. 30: 135-146, 1977. – reference: 12) 加藤清: マウスの尾を用い表皮細胞の採取法. 免役実験操作法 9: 2685-2690, 1980. – reference: 3) Dixon, F.G., Feldman, J.D., Vasquez, J. J.: Expeimental glomerulonephritis. The pathogenesis of a laboratory model resembling the spectrum of human glomerulonephritis. J. Exp. Med. 113: 889-897, 1961. – reference: 16) McCombs, C., Hom. J., Talal, N., Mishell, R. I.: Functional defliciency of splenic adherent cells in New Zealand Black mice. J. Immunol. 115: 1695-1699, 1975. |
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| Title | Study of antigen presenting cells—Age-Dependent Loss of antigen presenting ability in New Zealand black and white (NZB × NZW) F1 mice and the effect of indomethacin |
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