ラ氏島における糖代謝について
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          | Published in | 日本医科大学雑誌 Vol. 45; no. 6; pp. 367 - 375 | 
|---|---|
| Main Author | |
| Format | Journal Article | 
| Language | Japanese | 
| Published | 
            日本医科大学医学会
    
        01.12.1978
     | 
| Online Access | Get full text | 
| ISSN | 0048-0444 1884-0108  | 
| DOI | 10.1272/jnms1923.45.367 | 
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| Author | 中島, 信治 | 
    
|---|---|
| Author_xml | – sequence: 1 fullname: 中島, 信治 organization: 日本医科大学老人病研究所  | 
    
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| ContentType | Journal Article | 
    
| Copyright | 日本医科大学医学会 | 
    
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| DOI | 10.1272/jnms1923.45.367 | 
    
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| Discipline | Medicine | 
    
| EISSN | 1884-0108 | 
    
| EndPage | 375 | 
    
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| PublicationDateYYYYMMDD | 1978-12-01 | 
    
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| PublicationTitle | 日本医科大学雑誌 | 
    
| PublicationTitleAlternate | 日医大医会誌 | 
    
| PublicationYear | 1978 | 
    
| Publisher | 日本医科大学医学会 | 
    
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| References | 24) Grodsky, G. M.: Insulin and the pancreas, vitamin and hormon. 25, p.37-107, Academic Press, New York, Londen, 1970. 10) Ashcroft, S. J. H., Weerasinger, L. C. C., Bassett, J. M., and Randle, P. J. The pentose cycle and insulin release in mouse pancreatic islets. Biochem. J., 126, 525-532, 1972. 7) 坂本康二: 膵ラ氏島の活動霞位. 糖尿病と代謝, 5, 1-8 1977. 3b) Coore, H. G., and Randle, P. J., Simon, E., Kraicer, P. E., and Shelesnyak, M. C.: Block of insulin secretion from the pancreas by mannohe-Ptulose. Nature (London), 197, 1264-1266, 1963. 9) Ashcroft, S. J. H., Capito, K. and Hedeskov, C. J.: Time course studies of glucose-indused change in glucose-6 phosphate and fructose 1, 6 diphosphate content of mouse and rat pancreatic islets. Diabetologica, 9, 299-302, 1973. 40) Fritz, C. T., Lazarow, A., and Cooperstein, S. J.: Insulin and pancreas. Biol. Bull., 119, 161, 1965. 35) Kissane, J. M., and Brolin, S. E.: Enzymatic activity of pancreatic islets and acini in normal and tolbutamide-treated rats. J. Histochem. Cytochem., 11, 197-201, 196. 3. 26) Randle, P. J., Garland, P. B., Hales, C. N., and Newsholme, E. A.: The glucose fatty acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet, 13, 785-789, 1963. 41) Hellerström, C., Westman, S., Marden, N., and Turner, D.: The structure and metabolism of pancreatic islets. p.315-325, Pergamon Press, Oxford, 1970. 54) Grodsky, G. M.: Insulin and the pancreas. Vitamin and hormon, 25, p.37-101, Academic Press, New York, London, 1970. 13) Akhtar, M. S., Verspohl, E., Hegner, D., and Ammon, H. P. T.: 6-Phosphogluconate/glucose 6-phosphate ratio in rat pancreatic islets during inhibition of insulin release by exogeneous insulin. Diabetes, 26, 857-463, 1977. 23) Weber, G., Convery, H. J. H., La, M., and Stamm, N.B.: Feedback inhibition of key glycolytic enzymes in liver. Action of free fatty acids. Science, 154, 1357-1360, 1966. 44) Bloom, B., and Stetten, D. W.: The fraction of glucose catabolism via the glycolytic pathway. J. Biol. Chem., 212, 555-561, 1955. 11b) Ammon, H. P. T., and Verspohl, E.: Pyridine nucleotides in pancreatic islets during inhibition of insulin release by exogeneous insulin. Endocrinology, 99, 1469-4476, 1976. 5) Lernmark, A., and Winblad, B.: Scanning electron microscopy of surface change on dispersed pancreatic β-cells following stimulation of insulin release. Med. Biol., 55, 141-146, 1977. 31) Grodsky, G. M. Insulin and the pancreas.“Vitamin and hormones” 25, p.37-107, Academic Press, New York, London, 1970. 56) 中島信治: インスリンAおよびB鎖の生理作用に関する研究. 日本臨床病理学会誌, 24, 155-155, 1976. 8) Hedeskov, C. J., and Capito, K. The pentose cycle and insulin release in isolated mouse pancreatic islets during starvation. Biochem. J. 152, 571-576, 1975. 22) Lauris, V., Cahill, G. F.: Hepatic glucose phosphotransferases variation among species. Diabetes, 15, 475-479, 1966. 48b) Eggleston, L. V., and Krebs, H. A.: Regulation of the pentosecycle. Biochem. J., 138, 425-435, 1. 974. 45) Clock, G. E., and Mclean, P.: Levels of enzymes of the direct oxidative pathway of carbohydrate metabolism in mammalian tissue and tumors. Biochem. J., 56, 171-178, 1954. 47) Lacy, D. P., and Williams, J. R.: Quantitative histochemistry of the islet of Langerhans.(II) Insulin content of dissected β-cells. Diabetes, 11, 101-103, 1962. 12) Snyder, R. T., Kashket, S., and O'sullivan, J. B.: Pentose cycle in isolated islets during glucose stimulated insulin release. Am. J. Physiol., 219, 876-480, 1970. 27) Sugden, M. C., and Ashcroft, S. J. H.: Phosphoenol pyruvate in rat pancreatic islets. A possible intercellular trigger of insulin release?. Diabetolo gica, 13, 481-486, 1977. 34) Smith, J., and Lacy, P. E.: Enzymatic activity of pancreatic islet and acini in glucose-injected and control rabbits. Lab. Invest., 11, 159-166, 1962. 46) Abraham, B., Hirsch, P. E., and Chaikoff, I. L. The quantitative significance of glycolysis and non-glycolysis in glucose utilization by rat mammary gland. J. Biol. Chem., 211, 31-37, 1954. 33) Devis, G., Somers, G., and Malaisse, W. J.: Dynamics of calcium-induced insulin release. Diabetologica, 13, 531-536, 1977. 4) Akerstrom, S., Hellman, B., Lernmark, A., Lindberg, B., Soderberg, M. and Tajedal, I. B.: Effects of dextranlinked chroromercuribenzoicacid on insulin release from microdissected pancreatic islets. Biochem. Biophys. Acta, 451, 96-402, 1976. 28) Krebs. H. A.: The regulation of the release of ketone bodies by the liver. Advances in enzyme regulation 5, p.261, Pergamon Press, Oxford, 1967. 51) Schatz, H., and Pfeiffer, E. F.: Release of immunoreactive and radioactively prelabeled endogenous (pro-) insulin from islets of rat pancreas in the presence of exogenous insulin. J. Endocr., 74, 243-249, 1977. 57) Dixit, P. K. Lazarow, A., : Effect of alloxanon the enzyme activity of microdissected mammalian pancreatic islets. Diabetes, 18, 589-597, 1969. 11a) Matschinsky, F. M., Kauffman, F. C. and Ellermann, E.: Effect of hyperglycemia on the hexose monophosphate shunt in islet of Langerhans. Diabetes, 17, 475-480, 1968. 52) Schauder, P., Schindler, B., Panten, U., Brown, J. C., and French, H.: Insulin release from isolated rat pancreatic islets induced a-Ketoisocaproinic acid, D-glucose or D-glyceraldehyde. Mol. Cell Endocrinol., 1, 115-123, 1977. 38) Lazarus, S. S.: Oxidative pathway in pancreatic, β-cells. Proc. Soc. Exp. Biol., 102, 463-468, 1959. 1) Metz, R.: The effect of blood glucose concentration on insulin out put. Diabetes, 9, 89-93, 1960. 6) Hellman, B., Lernmark, A., and Soderberg, M. On the possible role of thiolgroups in the insulinreleasing action of mercurials organic disulfides, alkylating agents, and sulfonylureas. Endocrinology, 99, 1398-4406, 1977. 55) Milner, R. D. G.: Effect of glucose on tissue culture of human fetal endocrine pancreas. Excerpts Med. Int. Congr. Ser., 408, 143-147, 1977. 14) Rappaport, A. M., Ohira, S., Coddling, J. A., Empey, G., Kalnius, A., Lin, B.J., and Haist, R. E.: Effects on insulin out put and on pancreatic blood flow of exogeneous insulin infusion into an in situ isolated portion of the pancreas. Endocrinology, 91, 168-176, 1972. 17) Ashmore, J., and Carr, L.: Action of insulin on carbohydrate metabolism. Action of hormones on molecular processes. p.360-381, edd by Litwak, G. and Kritchersky, D., John Wiley and Sons Inc., New York, London, Sydney, 1964. 43) Utter, M. F.:“Carbohydrate metabolism”. Ann. Rev. Biochem., 21, 245-284, 1958. 37) Dixit, p.K., and Lazarow, A. Effect of alloxan on the lactic dehydrogenase (LDH) activity of the microdissected mammalian pancreatic islets. Metabolism, 13, 285-289, 1964. 25) Lacy, P. E.: Quantitative histochemistry of the islets of Langerhans. I. Lactic, malic, glucose-6 phosphate and 6-phosphogluconic dehydrogenase activities of beta cells and acini. Diabetes, 11, 96-100, 1962. 3a) Coore, H. G., and Randle, P. J.: Regulation of insulin secretion studied with pieces of rabbit Pancreas incubated in vitro. Biochem. J., 93, 66-78, 1964. 29) Weber, G., La, M., Convery, H. J. H., and Stamm, N. B.: Regulation of gluconeogenesis and glycolysis: Studies of mechanisms controlling enzyme activity. Adv. Enzyme Regul., 5, 261-302, 1967. 30) Weber, G.: 代謝調節の原理 (勝沼信彦訳)“代謝調節”. 市原明, 勝沼信彦編集, p.1-32, 朝愈書店, 東京, 1968. 48a) Freichs, H., Reich, U., and Creutzfeldt, W.: Insulin. sekretion in Vitro.(I) Herrunung der glukoseinduzierten Insulin Abgabe durch Insulin. Klin. Wochenschr., 43, 136-141, 1965. 36) Dixit, P. K., Lowe, I., and Lazarow, A.: Effect of alloxan on malic dehydrogenase activity of the microdissected mammalian pancreatic islets. Proc. Soc. Exp.Biol. Med., 114, 607-609, 1963. 39) Lambert, A. E., Jeanrenaned, B. A., and Renold, A. E. Organ culture of fetal rat pancreas (II). Insulin release induced by amino acid and organic acid by hormonal peptides, by cation alteration of the medium and by other agents. Biochem. Biophys, Acta, 184, 540-546, 1969. 49) Assal, J. P., Potel. T. N., and Steinke, J.: Tentative mechanism of insulin feedback inhibition on insulin release. Clin. Res., 21, 272-274, (Abstr.) 1973. 53) Argen, A., Andersson, A., and Hellerstrom, C. Effects of D-glyceraldehyde and D-glucose on the insulin release of pancreatic islets isolated from the nowborn rat. FEBS Lett, 7, 185-188, 1976. 32) Webb, J. L.:“Enzyme and metabolic inhibitor”, 3, p.1-36, Academic Press, New York, 1970. 15) Grodsky, G. M., : Insulin and the pancreas.“Vitamin and hormon”, 25, p.37-87, Academic Press, New York, London, 1970. 19) Hellmann, B., Idahl, L. A., Lernmark, A., Sehlin, J., and Taljedahl, I. B. The pancreatic β-cell recognition of insulin secretagognes. Comparisons of glucose with glyceraldehyde isomers and dihydroxyacetone. Arch. Biochem. Biophys., 162, 448-457, 1974. 50) Ammon, H. P. T.: Effect of glucose and methylen blue (M B) on NADP, NADPH and insulin secretion of isolated pancreatic rats islets. Arch. Pharm.(Weinheim, Ger) p.272-273, (Suppl.) 1973. 18) Matschinsky, F. M., and Ellermann, J. E.: Metabolism of glucose in the islets of Langerhans. J. Biol. Chem., 243, 2730-2736, 1968. 20) Ashcroft, S. J. H., and Randle, P. J.: Enzymes of glucose metabolism in normal mouse islets. Biochem. J., 119, 5-15, 1970. 2) Grodsky, G. M. Batts, A. A., Benett, L. L. Vcella, E., Williams, N. B., and Smith, D. F.: Effects of carbohydrates on secretion of insulin from isolated rat pancreas. Am. J. Physiol., 205, 638-644, 1963. 21) Aschroft, S. J. H., Hedeskov, C. J., and Randle, P.J.; Glucose metabolism in mouse pancreatic islets. Biochem. J., 118, 143-154, 1970. 16) Weber, G., Singhal, R., Stamm, N. B., Lea, M. A., and Fisher, E. A.: Advances in enzyme regulation. 4, p.59, Pergamon Press, Oxford 1966. 42) Keen, H., Sells, R., and Jarrett, R. J.: A method for the study of the metabolism of isolated mammalian islets of Langerhans. Diabetologica, 1, 28-33, 1965.  | 
    
| References_xml | – reference: 35) Kissane, J. M., and Brolin, S. E.: Enzymatic activity of pancreatic islets and acini in normal and tolbutamide-treated rats. J. Histochem. Cytochem., 11, 197-201, 196. 3. – reference: 43) Utter, M. F.:“Carbohydrate metabolism”. Ann. Rev. Biochem., 21, 245-284, 1958. – reference: 45) Clock, G. E., and Mclean, P.: Levels of enzymes of the direct oxidative pathway of carbohydrate metabolism in mammalian tissue and tumors. Biochem. J., 56, 171-178, 1954. – reference: 47) Lacy, D. P., and Williams, J. R.: Quantitative histochemistry of the islet of Langerhans.(II) Insulin content of dissected β-cells. Diabetes, 11, 101-103, 1962. – reference: 41) Hellerström, C., Westman, S., Marden, N., and Turner, D.: The structure and metabolism of pancreatic islets. p.315-325, Pergamon Press, Oxford, 1970. – reference: 3a) Coore, H. G., and Randle, P. J.: Regulation of insulin secretion studied with pieces of rabbit Pancreas incubated in vitro. Biochem. J., 93, 66-78, 1964. – reference: 23) Weber, G., Convery, H. J. H., La, M., and Stamm, N.B.: Feedback inhibition of key glycolytic enzymes in liver. Action of free fatty acids. Science, 154, 1357-1360, 1966. – reference: 42) Keen, H., Sells, R., and Jarrett, R. J.: A method for the study of the metabolism of isolated mammalian islets of Langerhans. Diabetologica, 1, 28-33, 1965. – reference: 51) Schatz, H., and Pfeiffer, E. F.: Release of immunoreactive and radioactively prelabeled endogenous (pro-) insulin from islets of rat pancreas in the presence of exogenous insulin. J. Endocr., 74, 243-249, 1977. – reference: 32) Webb, J. L.:“Enzyme and metabolic inhibitor”, 3, p.1-36, Academic Press, New York, 1970. – reference: 16) Weber, G., Singhal, R., Stamm, N. B., Lea, M. A., and Fisher, E. A.: Advances in enzyme regulation. 4, p.59, Pergamon Press, Oxford 1966. – reference: 46) Abraham, B., Hirsch, P. E., and Chaikoff, I. L. The quantitative significance of glycolysis and non-glycolysis in glucose utilization by rat mammary gland. J. Biol. Chem., 211, 31-37, 1954. – reference: 38) Lazarus, S. S.: Oxidative pathway in pancreatic, β-cells. Proc. Soc. Exp. Biol., 102, 463-468, 1959. – reference: 29) Weber, G., La, M., Convery, H. J. H., and Stamm, N. B.: Regulation of gluconeogenesis and glycolysis: Studies of mechanisms controlling enzyme activity. Adv. Enzyme Regul., 5, 261-302, 1967. – reference: 33) Devis, G., Somers, G., and Malaisse, W. J.: Dynamics of calcium-induced insulin release. Diabetologica, 13, 531-536, 1977. – reference: 20) Ashcroft, S. J. H., and Randle, P. J.: Enzymes of glucose metabolism in normal mouse islets. Biochem. J., 119, 5-15, 1970. – reference: 50) Ammon, H. P. T.: Effect of glucose and methylen blue (M B) on NADP, NADPH and insulin secretion of isolated pancreatic rats islets. Arch. Pharm.(Weinheim, Ger) p.272-273, (Suppl.) 1973. – reference: 55) Milner, R. D. G.: Effect of glucose on tissue culture of human fetal endocrine pancreas. Excerpts Med. Int. Congr. Ser., 408, 143-147, 1977. – reference: 22) Lauris, V., Cahill, G. F.: Hepatic glucose phosphotransferases variation among species. Diabetes, 15, 475-479, 1966. – reference: 49) Assal, J. P., Potel. T. N., and Steinke, J.: Tentative mechanism of insulin feedback inhibition on insulin release. Clin. Res., 21, 272-274, (Abstr.) 1973. – reference: 48a) Freichs, H., Reich, U., and Creutzfeldt, W.: Insulin. sekretion in Vitro.(I) Herrunung der glukoseinduzierten Insulin Abgabe durch Insulin. Klin. Wochenschr., 43, 136-141, 1965. – reference: 5) Lernmark, A., and Winblad, B.: Scanning electron microscopy of surface change on dispersed pancreatic β-cells following stimulation of insulin release. Med. Biol., 55, 141-146, 1977. – reference: 40) Fritz, C. T., Lazarow, A., and Cooperstein, S. J.: Insulin and pancreas. Biol. Bull., 119, 161, 1965. – reference: 26) Randle, P. J., Garland, P. B., Hales, C. N., and Newsholme, E. A.: The glucose fatty acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet, 13, 785-789, 1963. – reference: 28) Krebs. H. A.: The regulation of the release of ketone bodies by the liver. Advances in enzyme regulation 5, p.261, Pergamon Press, Oxford, 1967. – reference: 15) Grodsky, G. M., : Insulin and the pancreas.“Vitamin and hormon”, 25, p.37-87, Academic Press, New York, London, 1970. – reference: 4) Akerstrom, S., Hellman, B., Lernmark, A., Lindberg, B., Soderberg, M. and Tajedal, I. B.: Effects of dextranlinked chroromercuribenzoicacid on insulin release from microdissected pancreatic islets. Biochem. Biophys. Acta, 451, 96-402, 1976. – reference: 7) 坂本康二: 膵ラ氏島の活動霞位. 糖尿病と代謝, 5, 1-8 1977. – reference: 11b) Ammon, H. P. T., and Verspohl, E.: Pyridine nucleotides in pancreatic islets during inhibition of insulin release by exogeneous insulin. Endocrinology, 99, 1469-4476, 1976. – reference: 12) Snyder, R. T., Kashket, S., and O'sullivan, J. B.: Pentose cycle in isolated islets during glucose stimulated insulin release. Am. J. Physiol., 219, 876-480, 1970. – reference: 53) Argen, A., Andersson, A., and Hellerstrom, C. Effects of D-glyceraldehyde and D-glucose on the insulin release of pancreatic islets isolated from the nowborn rat. FEBS Lett, 7, 185-188, 1976. – reference: 54) Grodsky, G. M.: Insulin and the pancreas. Vitamin and hormon, 25, p.37-101, Academic Press, New York, London, 1970. – reference: 25) Lacy, P. E.: Quantitative histochemistry of the islets of Langerhans. I. Lactic, malic, glucose-6 phosphate and 6-phosphogluconic dehydrogenase activities of beta cells and acini. Diabetes, 11, 96-100, 1962. – reference: 44) Bloom, B., and Stetten, D. W.: The fraction of glucose catabolism via the glycolytic pathway. J. Biol. Chem., 212, 555-561, 1955. – reference: 37) Dixit, p.K., and Lazarow, A. Effect of alloxan on the lactic dehydrogenase (LDH) activity of the microdissected mammalian pancreatic islets. Metabolism, 13, 285-289, 1964. – reference: 2) Grodsky, G. M. Batts, A. A., Benett, L. L. Vcella, E., Williams, N. B., and Smith, D. F.: Effects of carbohydrates on secretion of insulin from isolated rat pancreas. Am. J. Physiol., 205, 638-644, 1963. – reference: 57) Dixit, P. K. Lazarow, A., : Effect of alloxanon the enzyme activity of microdissected mammalian pancreatic islets. Diabetes, 18, 589-597, 1969. – reference: 8) Hedeskov, C. J., and Capito, K. The pentose cycle and insulin release in isolated mouse pancreatic islets during starvation. Biochem. J. 152, 571-576, 1975. – reference: 36) Dixit, P. K., Lowe, I., and Lazarow, A.: Effect of alloxan on malic dehydrogenase activity of the microdissected mammalian pancreatic islets. Proc. Soc. Exp.Biol. Med., 114, 607-609, 1963. – reference: 39) Lambert, A. E., Jeanrenaned, B. A., and Renold, A. E. Organ culture of fetal rat pancreas (II). Insulin release induced by amino acid and organic acid by hormonal peptides, by cation alteration of the medium and by other agents. Biochem. Biophys, Acta, 184, 540-546, 1969. – reference: 6) Hellman, B., Lernmark, A., and Soderberg, M. On the possible role of thiolgroups in the insulinreleasing action of mercurials organic disulfides, alkylating agents, and sulfonylureas. Endocrinology, 99, 1398-4406, 1977. – reference: 14) Rappaport, A. M., Ohira, S., Coddling, J. A., Empey, G., Kalnius, A., Lin, B.J., and Haist, R. E.: Effects on insulin out put and on pancreatic blood flow of exogeneous insulin infusion into an in situ isolated portion of the pancreas. Endocrinology, 91, 168-176, 1972. – reference: 48b) Eggleston, L. V., and Krebs, H. A.: Regulation of the pentosecycle. Biochem. J., 138, 425-435, 1. 974. – reference: 1) Metz, R.: The effect of blood glucose concentration on insulin out put. Diabetes, 9, 89-93, 1960. – reference: 21) Aschroft, S. J. H., Hedeskov, C. J., and Randle, P.J.; Glucose metabolism in mouse pancreatic islets. Biochem. J., 118, 143-154, 1970. – reference: 18) Matschinsky, F. M., and Ellermann, J. E.: Metabolism of glucose in the islets of Langerhans. J. Biol. Chem., 243, 2730-2736, 1968. – reference: 13) Akhtar, M. S., Verspohl, E., Hegner, D., and Ammon, H. P. T.: 6-Phosphogluconate/glucose 6-phosphate ratio in rat pancreatic islets during inhibition of insulin release by exogeneous insulin. Diabetes, 26, 857-463, 1977. – reference: 30) Weber, G.: 代謝調節の原理 (勝沼信彦訳)“代謝調節”. 市原明, 勝沼信彦編集, p.1-32, 朝愈書店, 東京, 1968. – reference: 9) Ashcroft, S. J. H., Capito, K. and Hedeskov, C. J.: Time course studies of glucose-indused change in glucose-6 phosphate and fructose 1, 6 diphosphate content of mouse and rat pancreatic islets. Diabetologica, 9, 299-302, 1973. – reference: 11a) Matschinsky, F. M., Kauffman, F. C. and Ellermann, E.: Effect of hyperglycemia on the hexose monophosphate shunt in islet of Langerhans. Diabetes, 17, 475-480, 1968. – reference: 34) Smith, J., and Lacy, P. E.: Enzymatic activity of pancreatic islet and acini in glucose-injected and control rabbits. Lab. Invest., 11, 159-166, 1962. – reference: 3b) Coore, H. G., and Randle, P. J., Simon, E., Kraicer, P. E., and Shelesnyak, M. C.: Block of insulin secretion from the pancreas by mannohe-Ptulose. Nature (London), 197, 1264-1266, 1963. – reference: 19) Hellmann, B., Idahl, L. A., Lernmark, A., Sehlin, J., and Taljedahl, I. B. The pancreatic β-cell recognition of insulin secretagognes. Comparisons of glucose with glyceraldehyde isomers and dihydroxyacetone. Arch. Biochem. Biophys., 162, 448-457, 1974. – reference: 56) 中島信治: インスリンAおよびB鎖の生理作用に関する研究. 日本臨床病理学会誌, 24, 155-155, 1976. – reference: 10) Ashcroft, S. J. H., Weerasinger, L. C. C., Bassett, J. M., and Randle, P. J. The pentose cycle and insulin release in mouse pancreatic islets. Biochem. J., 126, 525-532, 1972. – reference: 52) Schauder, P., Schindler, B., Panten, U., Brown, J. C., and French, H.: Insulin release from isolated rat pancreatic islets induced a-Ketoisocaproinic acid, D-glucose or D-glyceraldehyde. Mol. Cell Endocrinol., 1, 115-123, 1977. – reference: 31) Grodsky, G. M. Insulin and the pancreas.“Vitamin and hormones” 25, p.37-107, Academic Press, New York, London, 1970. – reference: 24) Grodsky, G. M.: Insulin and the pancreas, vitamin and hormon. 25, p.37-107, Academic Press, New York, Londen, 1970. – reference: 27) Sugden, M. C., and Ashcroft, S. J. H.: Phosphoenol pyruvate in rat pancreatic islets. A possible intercellular trigger of insulin release?. Diabetolo gica, 13, 481-486, 1977. – reference: 17) Ashmore, J., and Carr, L.: Action of insulin on carbohydrate metabolism. Action of hormones on molecular processes. p.360-381, edd by Litwak, G. and Kritchersky, D., John Wiley and Sons Inc., New York, London, Sydney, 1964.  | 
    
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| Title | ラ氏島における糖代謝について | 
    
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