Measurement of somatosensory evoked magnetic fields at room temperature using a TMR sensor system

Measurement of somatosensory magnetic evoked fields (SEFs), using a magnetoencephalography (MEG) system with superconducting quantum interference devices (SQUIDs), are one of the most popular diagnostic tools to evaluate and localize brain function in human. However, wall size of liquid helium conta...

Full description

Saved in:
Bibliographic Details
Published inTransactions of Japanese Society for Medical and Biological Engineering Vol. Annual59; no. Proc; pp. 752 - 753
Main Authors Ando, Yasuo, Nakasato, Nobukazu, Fujiwara, Kosuke, Matsuzaki, Hitoshi, Kanno, Akitake, Oogane, mikihiko
Format Journal Article
LanguageJapanese
Published Japanese Society for Medical and Biological Engineering 2021
公益社団法人 日本生体医工学会
Online AccessGet full text
ISSN1347-443X
1881-4379
DOI10.11239/jsmbe.Annual59.752

Cover

Abstract Measurement of somatosensory magnetic evoked fields (SEFs), using a magnetoencephalography (MEG) system with superconducting quantum interference devices (SQUIDs), are one of the most popular diagnostic tools to evaluate and localize brain function in human. However, wall size of liquid helium container for SQUIDs has been constituting a barrier to minimize sensor-source distance, the most important factor for spatial resolution. We recently achieved a success to measure human magneto-cardiogram and spontaneous alpha activity of MEG at room temperature using newly developed tunnel magneto-resistive (TMR) sensors. Here we applied a TMR sensor system to measure SEFs, challenging MEG signals due to their weakness. In a normal volunteer subject, using a standard stimulation protocol of median nerve stimulus, a TMR sensor system combined with magnetic flux concentrators, and a signal averaging technique up to 5,000 times, we successfully demonstrated a clear N20m peak, the first and weakest component of SEFs.
AbstractList Measurement of somatosensory magnetic evoked fields (SEFs), using a magnetoencephalography (MEG) system with superconducting quantum interference devices (SQUIDs), are one of the most popular diagnostic tools to evaluate and localize brain function in human. However, wall size of liquid helium container for SQUIDs has been constituting a barrier to minimize sensor-source distance, the most important factor for spatial resolution. We recently achieved a success to measure human magneto-cardiogram and spontaneous alpha activity of MEG at room temperature using newly developed tunnel magneto-resistive (TMR) sensors. Here we applied a TMR sensor system to measure SEFs, challenging MEG signals due to their weakness. In a normal volunteer subject, using a standard stimulation protocol of median nerve stimulus, a TMR sensor system combined with magnetic flux concentrators, and a signal averaging technique up to 5,000 times, we successfully demonstrated a clear N20m peak, the first and weakest component of SEFs. "【背景】従来の脳磁計は超伝導量子干渉素子（SQUID）を液体ヘリウム容器に格納する必要があり、センサと頭皮との距離が離れる欠点があった。我々は室温で体表に接した生体磁気計測を可能とすべく、トンネル磁気抵抗（TMR）素子を用いたセンサを開発し、すでに健常被験者における心磁図や脳磁図アルファ波の計測に成功している。今回、正中神経刺激による体性感覚誘発磁界の第１波N20mを再現性よく計測できたので報告する。【方法】健常被験者の左手首の正中神経刺激を、通常の臨床検査と同様に、持続時間は0.3 ms、刺激頻度は2.9 Hz、刺激強度は母指外転筋運動閾値の1.5倍で刺激した。磁気シールド室内で、1チャンネルのTMR素子（JST S-イノベプロジェクトで製作）と磁束集束構造を組み合わせた磁気センサを、被験者の右頭頂部に固定し、頭皮に水平な磁界成分を計測した。得られた信号は16ビットでサンプル周波数2,000HzにてA/D変換し、帯域フィルタ5-250Hzで処理後に、波形が明瞭になるまで合計1,000から5,000回の平均加算を行った。【結果】刺激から潜時約20msに頂点をもつ第１波と、その後の第２、第３波が明瞭に記録され、同一被験者でSQUID脳磁計にて測定した波形と同一成分と確認できた。【結語】今回の結果は、TMR脳磁計の実用化に大きく寄与するものと期待される。"
Measurement of somatosensory magnetic evoked fields (SEFs), using a magnetoencephalography (MEG) system with superconducting quantum interference devices (SQUIDs), are one of the most popular diagnostic tools to evaluate and localize brain function in human. However, wall size of liquid helium container for SQUIDs has been constituting a barrier to minimize sensor-source distance, the most important factor for spatial resolution. We recently achieved a success to measure human magneto-cardiogram and spontaneous alpha activity of MEG at room temperature using newly developed tunnel magneto-resistive (TMR) sensors. Here we applied a TMR sensor system to measure SEFs, challenging MEG signals due to their weakness. In a normal volunteer subject, using a standard stimulation protocol of median nerve stimulus, a TMR sensor system combined with magnetic flux concentrators, and a signal averaging technique up to 5,000 times, we successfully demonstrated a clear N20m peak, the first and weakest component of SEFs.
Author Kanno, Akitake
Matsuzaki, Hitoshi
Oogane, mikihiko
Ando, Yasuo
Fujiwara, Kosuke
Nakasato, Nobukazu
Author_FL 菅野 彰剛
大兼 幹彦
中里 信和
藤原 耕輔
松﨑 斉
安藤 康夫
Author_FL_xml – sequence: 1
  fullname: 菅野 彰剛
– sequence: 2
  fullname: 大兼 幹彦
– sequence: 3
  fullname: 藤原 耕輔
– sequence: 4
  fullname: 松﨑 斉
– sequence: 5
  fullname: 安藤 康夫
– sequence: 6
  fullname: 中里 信和
Author_xml – sequence: 1
  fullname: Ando, Yasuo
  organization: Department of Applied Physics, Graduate School of Engineering, Tohoku University
– sequence: 1
  fullname: Nakasato, Nobukazu
  organization: Department of Epileptology, Tohoku University Graduate School of Medicine Tohoku University Graduate School of Medicine, Sendai, Japan
– sequence: 1
  fullname: Fujiwara, Kosuke
  organization: Spin Sensing Factory Corp., Sendai, Japan
– sequence: 1
  fullname: Matsuzaki, Hitoshi
  organization: Department of Applied Physics, Graduate School of Engineering, Tohoku University
– sequence: 1
  fullname: Kanno, Akitake
  organization: Department of Epileptology, Tohoku University Graduate School of Medicine Tohoku University Graduate School of Medicine, Sendai, Japan
– sequence: 1
  fullname: Oogane, mikihiko
  organization: Department of Applied Physics, Graduate School of Engineering, Tohoku University
BackLink https://cir.nii.ac.jp/crid/1390571240017336704$$DView record in CiNii
BookMark eNpFkMtOwzAQRS0EEqX0C9h4wTZlHMdxsqwqXlILCBWJXTRJxiUlsSs7RerfEyiPzTykc0dz7xk7ts4SYxcCpkLEMr_ahK6k6czaHbYqn2oVH7GRyDIRJVLnx8MsEx0liXw9ZZMQmhJACACI1YjhkjDsPHVke-4MD67D3gWywfk9pw_3TjXvcG2pbypuGmrrwLHn3rmO99RtyWM_6PkuNHbNka-Wz_wg52EfBuKcnRhsA01--pi93Fyv5nfR4vH2fj5bRJvhlyRKZWxqmSkjDaQgKqixFBoBEEhkWgEZrVKVkdAGFJRQYmqkrKs8FmVpjByzy8Nd2zRF1XxVIXNQWsTJYFhLmWpIBuzhgG1Cj2sqtr7p0O8L9IPBlorvMIvfMIsn76r_bYj2D6ze0Bdk5SemuXjM
ContentType Journal Article
Copyright 2021 Japanese Society for Medical and Biological Engineering
Copyright_xml – notice: 2021 Japanese Society for Medical and Biological Engineering
DBID RYH
DOI 10.11239/jsmbe.Annual59.752
DatabaseName CiNii Complete
DatabaseTitleList

DeliveryMethod fulltext_linktorsrc
Discipline Engineering
DocumentTitleAlternate トンネル磁気抵抗素子を用いた室温脳磁計による体性感覚誘発磁界の測定
DocumentTitle_FL トンネル磁気抵抗素子を用いた室温脳磁計による体性感覚誘発磁界の測定
EISSN 1881-4379
EndPage 753
ExternalDocumentID 130008105571
article_jsmbe_Annual59_Proc_Annual59_752_article_char_en
GroupedDBID 2WC
ALMA_UNASSIGNED_HOLDINGS
JSF
OK1
RJT
RYH
ID FETCH-LOGICAL-j1004-632fd385f3f0601c0dab17a00a0e18750ef75658e17f050b0ba6f33dc921bbff3
ISSN 1347-443X
IngestDate Fri Jun 27 00:45:41 EDT 2025
Wed Sep 03 06:31:09 EDT 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue Proc
Language Japanese
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-j1004-632fd385f3f0601c0dab17a00a0e18750ef75658e17f050b0ba6f33dc921bbff3
ORCID 0000-0002-2362-3505
0000-0001-8164-4171
OpenAccessLink https://www.jstage.jst.go.jp/article/jsmbe/Annual59/Proc/Annual59_752/_article/-char/en
PageCount 2
ParticipantIDs nii_cinii_1390571240017336704
jstage_primary_article_jsmbe_Annual59_Proc_Annual59_752_article_char_en
PublicationCentury 2000
PublicationDate 2021
PublicationDateYYYYMMDD 2021-01-01
PublicationDate_xml – year: 2021
  text: 2021
PublicationDecade 2020
PublicationTitle Transactions of Japanese Society for Medical and Biological Engineering
PublicationTitleAlternate Transactions of Japanese Society for Medical and Biological Engineering
PublicationTitle_FL TJSBME
Trans. jpn. Soc. Med. Bio. Eng
生体医工学
Transactions of Japanese Society for Medical and Biological Engineering
PublicationYear 2021
Publisher Japanese Society for Medical and Biological Engineering
公益社団法人 日本生体医工学会
Publisher_xml – name: Japanese Society for Medical and Biological Engineering
– name: 公益社団法人 日本生体医工学会
SSID ssib001100025
ssib002484549
ssib023159591
ssj0069534
ssib020474828
ssib000937326
ssib058494337
ssib002223871
ssib046007037
ssib007484362
Score 2.2507029
Snippet Measurement of somatosensory magnetic evoked fields (SEFs), using a magnetoencephalography (MEG) system with superconducting quantum interference devices...
SourceID nii
jstage
SourceType Publisher
StartPage 752
Title Measurement of somatosensory evoked magnetic fields at room temperature using a TMR sensor system
URI https://www.jstage.jst.go.jp/article/jsmbe/Annual59/Proc/Annual59_752/_article/-char/en
https://cir.nii.ac.jp/crid/1390571240017336704
Volume Annual59
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
ispartofPNX Transactions of Japanese Society for Medical and Biological Engineering, 2021, Vol.Annual59(Proc), pp.752-753
journalDatabaseRights – providerCode: PRVAFT
  databaseName: Open Access Digital Library
  customDbUrl:
  eissn: 1881-4379
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssib007484362
  issn: 1347-443X
  databaseCode: KQ8
  dateStart: 20030101
  isFulltext: true
  titleUrlDefault: http://grweb.coalliance.org/oadl/oadl.html
  providerName: Colorado Alliance of Research Libraries
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwELZKucAB8RQFinzgFmVxYud1rBCwKloQaCv1FtmJ02ajTVCTgNRfy09hJs4mXhWJ1yXKejfRxuOZfDOe-YaQV74fFczTkau0CF2RBxLOvMINw0CJIMmlHuKQq4_h8kycngfnBwc_rKylvlOL7PqXdSX_IlUYA7lilexfSHa6KQzAOcgXjiBhOP6RjFdzgA9BX9sA_GxacExx41x_aypAk1t5UWOhojPkqrVYvIhg2UFOqpFQ2emHgIF01qsvjrl8ZHi2oet67iw-pH-cwmsW21fuJX7u9n0wHG_aXA4fLdbDycLLum6ck6rsZDUtrk_NBdzT2ZZVeVlWzbS4-k35XV5J50PT9pWVrdu1_TVAYGcJdqm9LO0Qhj8HL_7nnxp7zUXkCjG0FIbXmRmLY3CLuelRszPyplvBSD5uljRWYlimOzJMuiMKiAyF8c0XjM-RoHXTbpVeyPGmi-naPeZu3CkExIUsZ-Cf3_YxYoRpA58tAAzo0AbQSOBn7_sieosju_I4Fva-LDLB8pnw0WcCRmaHEsB7kFgEhQK7EbAZkAL6TASfQxRhEpg8jN20jjxd-NSvbz4zoLYN-DBITnGrLksLmK3vk3ujR0VPjHo8IAcb-ZDcteT4iEhLUWhT0D1FoUZR6E5RqFEUKjuKikItRaGDolBJQVGouZwaRXlMzt69Xb9ZumNvEXeDHIluyP0i53FQ8AIZiTKWS-VFkjHJtAc-PNNFBL5OrD2wZQFTTMmw4DzPEt9Tqij4E3JYN7V-SmgS4F5-nETSz0QI6y4Smnky4FkMElL5EXlvZin9aghk0tFgpMOMprulmeKCnD_B_E4_xApMMHhH5BimOc1KPILrBr6WhzngHnKaRkw8-833z8kdVD8TQXxBDrurXh8Dpu7Uy2FZ_gQzesjZ
linkProvider Colorado Alliance of Research Libraries
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Measurement+of+somatosensory+evoked+magnetic+fields+at+room+temperature+using+a+TMR+sensor+system&rft.jtitle=Transactions+of+Japanese+Society+for+Medical+and+Biological+Engineering&rft.au=Kanno+Akitake&rft.au=Oogane+mikihiko&rft.au=Fujiwara+Kosuke&rft.au=Matsuzaki+Hitoshi&rft.date=2021&rft.pub=Japanese+Society+for+Medical+and+Biological+Engineering&rft.issn=1347-443X&rft.eissn=1881-4379&rft.volume=Annual59&rft.issue=Proc&rft.spage=752&rft.epage=753&rft_id=info:doi/10.11239%2Fjsmbe.annual59.752&rft.externalDocID=130008105571
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1347-443X&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1347-443X&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1347-443X&client=summon