Spirocyclic Oxetanes: Synthesis and Properties

Wurmlöcher im chemischen Raum: Spirocyclische Oxetane werden als Analoga von Morpholin und als topologische Gegenstücke entsprechender Carbonylverbindungen beschrieben. Solche Oxetane sind vielversprechend bezüglich ihrer physikochemischen Eigenschaften und der Leichtigkeit, mit der sie in Molekülst...

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Published inAngewandte Chemie Vol. 120; no. 24; pp. 4588 - 4591
Main Authors Wuitschik, Georg, Rogers-Evans, Mark, Buckl, Andreas, Bernasconi, Maurizio, Märki, Moritz, Godel, Thierry, Fischer, Holger, Wagner, Björn, Parrilla, Isabelle, Schuler, Franz, Schneider, Josef, Alker, André, Schweizer, W. Bernd, Müller, Klaus, Carreira, Erick M.
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 02.06.2008
WILEY‐VCH Verlag
Subjects
Online AccessGet full text
ISSN0044-8249
1521-3757
DOI10.1002/ange.200800450

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Abstract Wurmlöcher im chemischen Raum: Spirocyclische Oxetane werden als Analoga von Morpholin und als topologische Gegenstücke entsprechender Carbonylverbindungen beschrieben. Solche Oxetane sind vielversprechend bezüglich ihrer physikochemischen Eigenschaften und der Leichtigkeit, mit der sie in Molekülstrukturen eingebaut werden können. Die gesammelten Daten präsentieren die Oxetan‐Gruppe einerseits als hydrophile Entsprechung einer geminalen Dimethyleinheit und andererseits als lipophile Entsprechung einer Carbonylgruppe.
AbstractList Wurmlöcher im chemischen Raum: Spirocyclische Oxetane werden als Analoga von Morpholin und als topologische Gegenstücke entsprechender Carbonylverbindungen beschrieben. Solche Oxetane sind vielversprechend bezüglich ihrer physikochemischen Eigenschaften und der Leichtigkeit, mit der sie in Molekülstrukturen eingebaut werden können. Die gesammelten Daten präsentieren die Oxetan‐Gruppe einerseits als hydrophile Entsprechung einer geminalen Dimethyleinheit und andererseits als lipophile Entsprechung einer Carbonylgruppe.
Author Märki, Moritz
Bernasconi, Maurizio
Godel, Thierry
Carreira, Erick M.
Parrilla, Isabelle
Buckl, Andreas
Wagner, Björn
Müller, Klaus
Fischer, Holger
Alker, André
Schweizer, W. Bernd
Schuler, Franz
Rogers-Evans, Mark
Wuitschik, Georg
Schneider, Josef
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  surname: Rogers-Evans
  fullname: Rogers-Evans, Mark
  email: mark.rogers-evans@roche.com
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  surname: Schneider
  fullname: Schneider, Josef
  organization: F. Hoffmann-La Roche AG, Pharmaceuticals Division, 4070 Basel, Switzerland, Fax: (+41) 61-688-6965
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  givenname: André
  surname: Alker
  fullname: Alker, André
  organization: F. Hoffmann-La Roche AG, Pharmaceuticals Division, 4070 Basel, Switzerland, Fax: (+41) 61-688-6965
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  surname: Schweizer
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  organization: Laboratorium für Organische Chemie, ETH Zürich, Switzerland
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  givenname: Klaus
  surname: Müller
  fullname: Müller, Klaus
  email: klaus.mueller@roche.com
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  givenname: Erick M.
  surname: Carreira
  fullname: Carreira, Erick M.
  email: carreira@org.chem.ethz.ch
  organization: Laboratorium für Organische Chemie, ETH Hönggerberg, HCI H335, 8093 Zürich, Switzerland, Fax: (+41) 44-632-1328
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F. Hoffmann-La Roche AG
We thank F. Hoffmann-La Roche AG for support of this research. We are indebted to Frank Senner and Pia Warga for their great dedication in measuring the physicochemical data described herein.
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We thank F. Hoffmann‐La Roche AG for support of this research. We are indebted to Frank Senner and Pia Warga for their great dedication in measuring the physicochemical data described herein.
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SubjectTerms Carbonylverbindungen
Heterocyclen
Morpholin
Oxetane
Spiroverbindungen
Title Spirocyclic Oxetanes: Synthesis and Properties
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