Rare Pediatric Non-Hodgkin Lymphomas: A Report From Children's Oncology Group Study ANHL 04B1

• Published in: Pediatric blood & cancer Vol. 63; no. 5; pp. 794 - 800
• Main Authors: O'Suoji, Chibuzo, Welch, Jennifer J. G., Perkins, Sherrie L., Smith, Lynette M., Weitzman, Sheila, Simko, Stephen J., Galardy, Paul J., Bollard, Catherine M., Gross, Thomas G., Termuhlen, Amanda M.
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.05.2016; Wiley Subscription Services, Inc
• Subjects: Adolescent; Child; Child, Preschool; Children & youth; cutaneous lymphoma; Female; follicular lymphoma; Hematology; Humans; Infant; Lymphoma; Lymphoma, Non-Hodgkin - pathology; Male; Non-Hodgkin lymphoma; Oncology; Pediatrics; Rare Diseases - pathology; Registries; Skin Neoplasms - pathology; T cell receptors; Tissue Banks; Non-Hodgkin lymphoma; follicular lymphoma; cutaneous lymphoma
• ISSN: 1545-5009; 1545-5017
• DOI: 10.1002/pbc.25881

Background Non‐Hodgkin lymphoma (NHL) is a relatively common malignancy in pediatric patients; however, a small subgroup have unusual lymphoma subtypes for the pediatric population. Procedure The Children's Oncology Group Rare and Cutaneous NHL registry's (protocol ANHL 04B1) main objectives were to determine the pathologic, biologic, and clinical features of rare and cutaneous pediatric NHL and establish a bank of centrally reviewed tissue specimens. We report the clinical data, treatment data, and outcome for rare pediatric NHL. Results In 101 lymphomas, there is a 97.8% concordance between the reviewing study pathologists and an 87.6% concordance between the central and institutional pathology review. Samples in the specimen bank include primary tumor tissue that is snap frozen, in paraffin blocks, or H&E‐stained and unstained paraffin slides as well as blood, serum, and bone marrow. This descriptive analysis shows that children with pediatric follicular lymphoma, mucosa‐associated lymphoid tissue, nodal marginal zone lymphoma, primary cutaneous, primary central nervous system lymphoma, and subcutaneous panniculitis‐like T‐cell lymphomas have 100% survival at a median of 2 years from enrollment. There are early deaths, mostly from progressive disease, in subjects with peripheral T‐cell (not otherwise specified), NKT, and hepatosplenic T‐cell lymphomas. Conclusions This registry provides high‐quality biologic specimens with clinical data to investigators working on the biology of these unusual pediatric diseases.