Systematic review of the effect of external beam radiation therapy to the breast on axillary recurrence after negative sentinel lymph node biopsy

Background: Axillary recurrence after negative sentinel lymph node biopsy (SLNB) in patients with invasive breast carcinoma remains a concern. Previous investigations to identify prognostic factors for axillary recurrence identified that a disproportionate number of patients with an axillary recurre...

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Published inBritish journal of surgery Vol. 98; no. 3; pp. 326 - 333
Main Authors van Wely, B. J., Teerenstra, S., Schinagl, D. A. X., Aufenacker, T. J., de Wilt, J. H. W., Strobbe, L. J. A.
Format Journal Article
LanguageEnglish
Published Chichester, UK John Wiley & Sons, Ltd 01.03.2011
Wiley
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ISSN0007-1323
1365-2168
1365-2168
DOI10.1002/bjs.7360

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Abstract Background: Axillary recurrence after negative sentinel lymph node biopsy (SLNB) in patients with invasive breast carcinoma remains a concern. Previous investigations to identify prognostic factors for axillary recurrence identified that a disproportionate number of patients with an axillary recurrence after negative SLNB were not treated with external beam radiation therapy (EBRT) of the breast as part of initial treatment. This finding prompted a systematic review to test the hypothesis that EBRT to the breast reduces the risk of axillary recurrence after negative SLNB. Methods: A literature search was performed in PubMed, the Cochrane Library and the Spanish‐language database LILACS to identify articles publishing data regarding follow‐up of sentinel lymph node (SLN)‐negative patients. Reports and articles lacking information on the initial treatment were excluded. Results: Forty‐five articles were accepted for review. A total of 23 357 SLN‐negative patients were identified with median follow‐up ranging from 15 to 102 months. Some 18 878 patients were treated with EBRT to the breast as part of their initial treatment. One hundred and twenty‐seven patients with an axillary recurrence were identified, of whom 73 had EBRT as part of their initial treatment. Meta‐analysis showed that EBRT was associated with a lower rate of axillary recurrence (P < 0·001), but this finding was subject to heterogeneity. Conclusion: This review and meta‐analysis showed that EBRT is associated with a significantly lower axillary recurrence rate after negative SLNB. Copyright © 2010 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd. Decreased axillary recurrence
AbstractList Axillary recurrence after negative sentinel lymph node biopsy (SLNB) in patients with invasive breast carcinoma remains a concern. Previous investigations to identify prognostic factors for axillary recurrence identified that a disproportionate number of patients with an axillary recurrence after negative SLNB were not treated with external beam radiation therapy (EBRT) of the breast as part of initial treatment. This finding prompted a systematic review to test the hypothesis that EBRT to the breast reduces the risk of axillary recurrence after negative SLNB. A literature search was performed in PubMed, the Cochrane Library and the Spanish-language database LILACS to identify articles publishing data regarding follow-up of sentinel lymph node (SLN)-negative patients. Reports and articles lacking information on the initial treatment were excluded. Forty-five articles were accepted for review. A total of 23,357 SLN-negative patients were identified with median follow-up ranging from 15 to 102 months. Some 18,878 patients were treated with EBRT to the breast as part of their initial treatment. One hundred and twenty-seven patients with an axillary recurrence were identified, of whom 73 had EBRT as part of their initial treatment. Meta-analysis showed that EBRT was associated with a lower rate of axillary recurrence (P < 0·001), but this finding was subject to heterogeneity. This review and meta-analysis showed that EBRT is associated with a significantly lower axillary recurrence rate after negative SLNB.
Background: Axillary recurrence after negative sentinel lymph node biopsy (SLNB) in patients with invasive breast carcinoma remains a concern. Previous investigations to identify prognostic factors for axillary recurrence identified that a disproportionate number of patients with an axillary recurrence after negative SLNB were not treated with external beam radiation therapy (EBRT) of the breast as part of initial treatment. This finding prompted a systematic review to test the hypothesis that EBRT to the breast reduces the risk of axillary recurrence after negative SLNB. Methods: A literature search was performed in PubMed, the Cochrane Library and the Spanish‐language database LILACS to identify articles publishing data regarding follow‐up of sentinel lymph node (SLN)‐negative patients. Reports and articles lacking information on the initial treatment were excluded. Results: Forty‐five articles were accepted for review. A total of 23 357 SLN‐negative patients were identified with median follow‐up ranging from 15 to 102 months. Some 18 878 patients were treated with EBRT to the breast as part of their initial treatment. One hundred and twenty‐seven patients with an axillary recurrence were identified, of whom 73 had EBRT as part of their initial treatment. Meta‐analysis showed that EBRT was associated with a lower rate of axillary recurrence (P < 0·001), but this finding was subject to heterogeneity. Conclusion: This review and meta‐analysis showed that EBRT is associated with a significantly lower axillary recurrence rate after negative SLNB. Copyright © 2010 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd. Decreased axillary recurrence
Axillary recurrence after negative sentinel lymph node biopsy (SLNB) in patients with invasive breast carcinoma remains a concern. Previous investigations to identify prognostic factors for axillary recurrence identified that a disproportionate number of patients with an axillary recurrence after negative SLNB were not treated with external beam radiation therapy (EBRT) of the breast as part of initial treatment. This finding prompted a systematic review to test the hypothesis that EBRT to the breast reduces the risk of axillary recurrence after negative SLNB.BACKGROUNDAxillary recurrence after negative sentinel lymph node biopsy (SLNB) in patients with invasive breast carcinoma remains a concern. Previous investigations to identify prognostic factors for axillary recurrence identified that a disproportionate number of patients with an axillary recurrence after negative SLNB were not treated with external beam radiation therapy (EBRT) of the breast as part of initial treatment. This finding prompted a systematic review to test the hypothesis that EBRT to the breast reduces the risk of axillary recurrence after negative SLNB.A literature search was performed in PubMed, the Cochrane Library and the Spanish-language database LILACS to identify articles publishing data regarding follow-up of sentinel lymph node (SLN)-negative patients. Reports and articles lacking information on the initial treatment were excluded.METHODSA literature search was performed in PubMed, the Cochrane Library and the Spanish-language database LILACS to identify articles publishing data regarding follow-up of sentinel lymph node (SLN)-negative patients. Reports and articles lacking information on the initial treatment were excluded.Forty-five articles were accepted for review. A total of 23,357 SLN-negative patients were identified with median follow-up ranging from 15 to 102 months. Some 18,878 patients were treated with EBRT to the breast as part of their initial treatment. One hundred and twenty-seven patients with an axillary recurrence were identified, of whom 73 had EBRT as part of their initial treatment. Meta-analysis showed that EBRT was associated with a lower rate of axillary recurrence (P < 0·001), but this finding was subject to heterogeneity.RESULTSForty-five articles were accepted for review. A total of 23,357 SLN-negative patients were identified with median follow-up ranging from 15 to 102 months. Some 18,878 patients were treated with EBRT to the breast as part of their initial treatment. One hundred and twenty-seven patients with an axillary recurrence were identified, of whom 73 had EBRT as part of their initial treatment. Meta-analysis showed that EBRT was associated with a lower rate of axillary recurrence (P < 0·001), but this finding was subject to heterogeneity.This review and meta-analysis showed that EBRT is associated with a significantly lower axillary recurrence rate after negative SLNB.CONCLUSIONThis review and meta-analysis showed that EBRT is associated with a significantly lower axillary recurrence rate after negative SLNB.
Author Teerenstra, S.
Aufenacker, T. J.
de Wilt, J. H. W.
Schinagl, D. A. X.
van Wely, B. J.
Strobbe, L. J. A.
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Issue 3
Keywords Relapse
Sentinel lymph node
Evidence-based practice
Radiation
Systematic review
Evidence-based medicine
Extracorporeal irradiation
Anatomic pathology
Treatment
Biopsy
Surgery
Breast
Mammary gland
Bibliographic review
Axillary
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Snippet Background: Axillary recurrence after negative sentinel lymph node biopsy (SLNB) in patients with invasive breast carcinoma remains a concern. Previous...
Axillary recurrence after negative sentinel lymph node biopsy (SLNB) in patients with invasive breast carcinoma remains a concern. Previous investigations to...
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SubjectTerms Axilla - pathology
Biological and medical sciences
Breast Neoplasms - pathology
Breast Neoplasms - radiotherapy
Female
General aspects
Humans
Lymphatic Metastasis
Medical sciences
Miscellaneous
Neoplasm Recurrence, Local - pathology
Neoplasm Recurrence, Local - radiotherapy
Public health. Hygiene
Public health. Hygiene-occupational medicine
Sentinel Lymph Node Biopsy - methods
Title Systematic review of the effect of external beam radiation therapy to the breast on axillary recurrence after negative sentinel lymph node biopsy
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https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fbjs.7360
https://www.ncbi.nlm.nih.gov/pubmed/21254004
https://www.proquest.com/docview/846901102
Volume 98
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