Lack of association of LINGO1 rs9652490 and rs11856808 SNPs with familial essential tremor

• Published in: European journal of neurology Vol. 18; no. 8; pp. 1085 - 1089
• Main Authors: Lorenzo-Betancor, O., García-Martín, E., Cervantes, S., Agúndez, J. A. G., Jiménez-Jiménez, F. J., Alonso-Navarro, H., Luengo, A., Coria, F., Lorenzo, E., Irigoyen, J., Pastor, P.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.08.2011
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; association study; Case-Control Studies; essential tremor; Essential Tremor - epidemiology; Essential Tremor - genetics; Gene Frequency - genetics; Genetic Predisposition to Disease - genetics; Genetic Testing; genetics; Genotype; Genotyping; Humans; LINGO1; Membrane Proteins - genetics; Middle Aged; Movement disorders; Nerve Tissue Proteins - genetics; Polymorphism, Single Nucleotide - genetics; Risk Factors; Single-nucleotide polymorphism; tremor; Young Adult
• ISSN: 1351-5101; 1468-1331; 1468-1331
• DOI: 10.1111/j.1468-1331.2010.03251.x

Background:  Essential tremor (ET) is a frequent movement disorder with a substantial family aggregation. A genome‐wide association study has recently shown that LINGO1 gene variants are associated with increased risk of ET. Methods:  We intended to replicate these findings by genotyping rs9652490 and rs11856808 in a series of 226 familial ET subjects and 1117 healthy controls from referral movement disorder clinics in Spain. Results:  We were unable to replicate the association between LINGO1 variants and familial ET. Conclusions:  Our results indicate that the LINGO1 variants analyzed are not a major risk factor for developing familial ET in our population, which suggests the existence of other unknown genetic risk factors responsible for familial ET in the Spanish population.