Probabilistic estimation of respiratory rate using Gaussian processes

• Published in: 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) Vol. 2013; pp. 2902 - 2905
• Main Authors: Pimentel, Marco A. F., Clifton, David A., Clifton, Lei, Tarassenko, Lionel
• Format: Conference Proceeding Journal Article
• Language: English
• Published: United States IEEE 01.01.2013
• Subjects: Adult; Age Factors; Aged; Aged, 80 and over; Algorithms; Biomedical monitoring; Electrocardiography; Electrocardiography - instrumentation; Electrocardiography - methods; Estimation; Female; Gaussian processes; Humans; Male; Middle Aged; Models, Theoretical; Normal Distribution; Probabilistic logic; Probability; Regression Analysis; Reproducibility of Results; Respiration; Respiratory Rate; Signal Processing, Computer-Assisted; Supine Position; Time series analysis; Uncertainty; Young Adult
• ISSN: 1094-687X; 1557-170X
• DOI: 10.1109/EMBC.2013.6610147

The presence of respiratory information within the electrocardiogram (ECG) signal is a well-documented phenomenon. We present a Gaussian process framework for the estimation of respiratory rate from the different sources of modulation in a single-lead ECG. We propose a periodic covariance function to model the frequency- and amplitude-modulation time series derived from the ECG, where the hyperparameters of the process are used to derive the respiratory rate. The approach is evaluated using data taken from 40 healthy subjects each with 2 hours of monitoring, containing ECG and respiration waveforms. Results indicate that the accuracy of our proposed method is comparable with that of existing methods, but with the advantages of a principled probabilistic approach, including the direct quantification of the uncertainty in the estimation.