Frequency Selective Control of an Ensemble Using RF Pulses Designed via the TOPS Algorithm in NMR Spectroscopy

NMR spectroscopy is all about manipulating the nuclear spin of an atom, and we use radio frequency (RF) pulses for this. This paper introduces the TOPS algorithm, which focuses on phase manipulation in RF pulse design. It addresses the requirement for selective excitation/inversion in MRI and protei...

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Bibliographic Details
Published in2023 Ninth Indian Control Conference (ICC) pp. 85 - 89
Main Authors Jacob, Justin, Khaneja, Navin
Format Conference Proceeding
LanguageEnglish
Published IEEE 18.12.2023
Subjects
Bilinear control
Bloch equation
Broadband excitation
Broadband inversion
Chemical shift
Composite pulse
Magnetic resonance imaging
Nuclear magnetic resonance
Phase modulation
Proteins
Radio frequency
Resonant frequency
Scalar triple product
Similarity transformation
Spectroscopy
Water
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DOI10.1109/ICC61519.2023.10442936

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Summary:NMR spectroscopy is all about manipulating the nuclear spin of an atom, and we use radio frequency (RF) pulses for this. This paper introduces the TOPS algorithm, which focuses on phase manipulation in RF pulse design. It addresses the requirement for selective excitation/inversion in MRI and protein resonance experiments and demonstrates the application of the TOPS-2 algorithm in designing phase-modulated frequency selective pulses. The paper presents the algorithm for designing pulses using the TOPS approach to achieve specific objectives such as selective inversion and excitation. Experimental validation of the selective pulse sequence is performed using a sample consisting of 0.5 % H 2 O in 99.5% D 2 O.
DOI:10.1109/ICC61519.2023.10442936