Broad-Spectrum Multi-Modality Image Registration: From PET, CT, and MRI to Autoradiography, Microscopy, and Beyond

Image registration and fusion are increasingly important components of both clinical and small-animal imaging and have lead to the development of a variety of pertinent hardware and software tools, including multi-modality, e.g. PET-CT, devices. At the same time, advances in microscopic imaging, inc...

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Bibliographic Details
Published in2006 International Conference of the IEEE Engineering in Medicine and Biology Society Vol. 2006; pp. 1584 - 1588
Main Author Zanzonico, P.B.
Format Conference Proceeding Journal Article
LanguageEnglish
Published United States IEEE 2006
Subjects
Animals
Biomedical imaging
Computed tomography
Diagnostic Imaging - instrumentation
Diagnostic Imaging - methods
Diagnostic Imaging - veterinary
Equipment Design
Equipment Failure Analysis
Hardware
Image Enhancement - instrumentation
Image Enhancement - methods
Image registration
Immune system
In vivo
Magnetic resonance imaging
Mice
Microscopy
Positron emission tomography
Rats
Software tools
Stereotaxic Techniques - instrumentation
Stereotaxic Techniques - veterinary
Subtraction Technique - instrumentation
Subtraction Technique - veterinary
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ISBN9781424400324
1424400325
ISSN1557-170X
DOI10.1109/IEMBS.2006.259650

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Summary:Image registration and fusion are increasingly important components of both clinical and small-animal imaging and have lead to the development of a variety of pertinent hardware and software tools, including multi-modality, e.g. PET-CT, devices. At the same time, advances in microscopic imaging, including phosphor-plate digital autoradiography and immunohistochemistry, now allow ultra-high (sub-100 mum)-resolution molecular characterization of tissue sections. To date, however, in vivo imaging of intact subjects and ex vivo imaging of harvested tissues sections have remained separate and distinct, making it difficult to reliably inter-compare the former and the latter. The Department of Medical Physics and the Radiation Biophysics Laboratory at Memorial Sloan-Kettering Cancer Center, under the direction of Dr. Clifton Ling, has now designed, fabricated, and tested a stereotactic imaging system for so-called "broad-spectrum" image registration, from coarser-resolution in vivo imaging modalities such as PET, CT, and MRI to ultra-high-resolution ex vivo imaging techniques such as histology, autoradiography, and immunohistochemistry
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ISBN:9781424400324
1424400325
ISSN:1557-170X
DOI:10.1109/IEMBS.2006.259650