A mechanism for immediate reduction in mitral regurgitation after Cardiac resynchronization therapy: Insights from mechanical activation strain mapping

• Published in: Journal of the American College of Cardiology Vol. 44; no. 8; pp. 1619 - 1625
• Main Authors: KANZAKI, Hideaki, BAZAZ, Raveen, SCHWARTZMAN, David, DOHI, Kaoru, SADE, L. Elif, GORCSAN, John III
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Science 19.10.2004; Elsevier Limited
• Subjects: Aged; Biological and medical sciences; Biomechanical Phenomena - instrumentation; Blood pressure; Bundle-Branch Block - diagnostic imaging; Bundle-Branch Block - physiopathology; Bundle-Branch Block - therapy; Cardiology; Cardiology. Vascular system; Cardiovascular disease; Classical genetics, quantitative genetics, hybrids; Echocardiography, Doppler; Echocardiography, Doppler, Color - instrumentation; Electrodes, Implanted; Endocardial and cardiac valvular diseases; Female; Fundamental and applied biological sciences. Psychology; Genetics of eukaryotes. Biological and molecular evolution; Heart; Heart failure; Human; Humans; Image Processing, Computer-Assisted - instrumentation; Male; Medical sciences; Microcomputers; Middle Aged; Mitral Valve Insufficiency - diagnostic imaging; Mitral Valve Insufficiency - physiopathology; Mitral Valve Insufficiency - therapy; Mortality; Myocardial Contraction - physiology; Pacemaker, Artificial; Papillary Muscles - physiopathology; Software; Stroke; Stroke Volume - physiology; Studies; Treatment Outcome; Ventricular Function, Left - physiology; Heart; Human; Cardiac resynchronization; Cartography; Mitral valve; Treatment; Cardiac valvular disease; Mitral regurgitation; Instrumentation therapy; Cardiovascular disease
• ISSN: 0735-1097; 1558-3597
• DOI: 10.1016/j.jacc.2004.07.036

We tested the hypothesis that an immediate reduction in mitral regurgitation (MR) after cardiac resynchronization therapy (CRT) results from improved coordinated timing of the papillary muscle insertion sites, using the novel approach of mechanical activation strain mapping. Heart failure patients with left bundle branch block often benefit acutely from CRT; however, the role and mechanism of reduction of MR are unclear. Twenty-six consecutive patients undergoing CRT with at least mild MR were studied (ejection fraction 24 +/- 6%; QRS duration 168 +/- 30 ms). Echocardiographic Doppler and strain imaging was performed immediately before and the day after CRT, as well as in 10 normal control subjects. Mechanical activation sequence maps were constructed using longitudinal strain from 12 basal and mid-LV sites, with color coding of time-to-peak strain. Mitral regurgitation by the volumetric method consistently decreased after CRT: regurgitant volume from 40 +/- 20 ml to 24 +/- 17 ml and regurgitant fraction from 40 +/- 12% to 25 +/- 14% (both: p < 0.001 vs. baseline). Normal controls had uniform segmental time-to-peak strain, with a difference of only 12 +/- 8 ms between all segments. In contrast, CRT patients at baseline had a 106 +/- 74 ms time delay between papillary muscle insertion sites (p < 0.001 vs. normal). This interpapillary muscle time delay shortened after CRT to 39 +/- 43 ms (p < 0.001 vs. baseline) and was significantly correlated with reductions in mitral regurgitant fraction (r = 0.77, p < 0.001). Cardiac resynchronization therapy significantly and immediately reduced MR. Improved coordinated timing of mechanical activation of papillary muscle insertion sites appears to be a mechanistic contributor to immediate MR reduction by CRT.