Hepatobiliary damage and changes in hepatic gene expression caused by the antitumor drug ecteinascidin-743 (ET-743) in the female rat - DONALD, Sarah; VERSCHOYLE, Richard D; GREAVES, Peter; GESCHER, Andreas J; EDWARDS, Richard; JUDAH, David J; DAVIES, Reginald; RILEY, Joan; DINSDALE, David; LOPEZ LAZARO, Luis; SMITH, Andrew G; GANT, Timothy W (Cancer research (Chicago, Ill.), 2002)
Keywords: Animals; Antineoplastic Agents, Alkylating - toxicity; Bile Duct Diseases - chemically induced; Bile Duct Diseases - metabolism; Bile Duct Diseases - pathology; Bilirubin - blood; Biological and medical sciences; Cell Division - drug effects; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System - metabolism; Dioxoles - toxicity; Drug toxicity and drugs side effects treatment; Female; Gene Expression - drug effects; Isoquinolines - toxicity; Liver - drug effects; Liver - metabolism; Liver - pathology; Liver - physiology; Liver Diseases - blood; Liver Diseases - pathology; Medical sciences; Pharmacology. Drug treatments; Rats; Rats, Wistar; Tetrahydroisoquinolines; Toxicity: digestive system; Marine animal; Antineoplastic agent; Intravenous administration; Rat; Toxicity; Liver; Hepatic disease; Biliary tract disease; Urochordata; Alkaloid; Hepatobiliary; Gene; Female; Isoquinoline derivatives; Rodentia; Animal origin; Prochordata; Hepatobiliary disease; Gene expression; Vertebrata; Chemotherapy; Mammalia; Animal; Digestive diseases; Invertebrata