Simplified Detection System for Neuroreceptor Studies in the Human Brain

A simple, inexpensive dual-detector system has been developed for measurement of positronemitting receptor-binding drugs in the human brain. This high efficiency coincidence counting system requires that only a few hundred microcuries of labeled drug be administered to the subject, thereby allowing...

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Published inThe Journal of nuclear medicine (1978) Vol. 27; no. 2; p. 184
Main Authors Bice, Alden N, Wagner, Henry N., Jr, Frost, J. James, Natarajan, T. K, Lee, Myung C, Wong, Dean F, Dannals, Robert F, Ravert, Hayden T, Wilson, Alan A, Links, Jonathan M
Format Journal Article
LanguageEnglish
Published United States Soc Nuclear Med 01.02.1986
Subjects
Binding, Competitive
Brain - metabolism
Calibration
Carbon Radioisotopes
Electrons
Equipment Design
Fentanyl - analogs & derivatives
Humans
Naloxone - pharmacology
Radioligand Assay - instrumentation
Receptors, Opioid - analysis
Receptors, Opioid - drug effects
Scintillation Counting - instrumentation
Online AccessGet full text
ISSN0161-5505
1535-5667

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Abstract A simple, inexpensive dual-detector system has been developed for measurement of positronemitting receptor-binding drugs in the human brain. This high efficiency coincidence counting system requires that only a few hundred microcuries of labeled drug be administered to the subject, thereby allowing for multiple studies without an excessive radiation dose. Measurement of the binding of [11C]carfentanil, a high affinity synthetic opiate, to opiate receptors in the presence and in the absence of a competitive opiate antagonist indicates the potential utility of this system for estimating different degrees of receptor occupation in the human brain.
AbstractList A simple, inexpensive dual-detector system has been developed for measurement of positronemitting receptor-binding drugs in the human brain. This high efficiency coincidence counting system requires that only a few hundred microcuries of labeled drug be administered to the subject, thereby allowing for multiple studies without an excessive radiation dose. Measurement of the binding of [11C]carfentanil, a high affinity synthetic opiate, to opiate receptors in the presence and in the absence of a competitive opiate antagonist indicates the potential utility of this system for estimating different degrees of receptor occupation in the human brain.A simple, inexpensive dual-detector system has been developed for measurement of positronemitting receptor-binding drugs in the human brain. This high efficiency coincidence counting system requires that only a few hundred microcuries of labeled drug be administered to the subject, thereby allowing for multiple studies without an excessive radiation dose. Measurement of the binding of [11C]carfentanil, a high affinity synthetic opiate, to opiate receptors in the presence and in the absence of a competitive opiate antagonist indicates the potential utility of this system for estimating different degrees of receptor occupation in the human brain.
A simple, inexpensive dual-detector system has been developed for measurement of positronemitting receptor-binding drugs in the human brain. This high efficiency coincidence counting system requires that only a few hundred microcuries of labeled drug be administered to the subject, thereby allowing for multiple studies without an excessive radiation dose. Measurement of the binding of [11C]carfentanil, a high affinity synthetic opiate, to opiate receptors in the presence and in the absence of a competitive opiate antagonist indicates the potential utility of this system for estimating different degrees of receptor occupation in the human brain.
Author Wagner, Henry N., Jr
Natarajan, T. K
Wilson, Alan A
Links, Jonathan M
Wong, Dean F
Bice, Alden N
Dannals, Robert F
Ravert, Hayden T
Lee, Myung C
Frost, J. James
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SubjectTerms Binding, Competitive
Brain - metabolism
Calibration
Carbon Radioisotopes
Electrons
Equipment Design
Fentanyl - analogs & derivatives
Humans
Naloxone - pharmacology
Radioligand Assay - instrumentation
Receptors, Opioid - analysis
Receptors, Opioid - drug effects
Scintillation Counting - instrumentation
Title Simplified Detection System for Neuroreceptor Studies in the Human Brain
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