Prevalence of Obesity in Rheumatologie Diseases and Its Relationship with Disease Activity/Romatolojik Hastaliklarda Obezite Prevalansi ve Hastalik Aktivitesi ile Iliskisi

• Published in: Bagcilar Medical Bulletin Vol. 7; no. 4; p. 326
• Main Authors: Haliloglu, Sema, Carlioglu, Ayse, Uzkeser, Hulya, Arslan, Abdulmuttalip, Yumusakhuylu, Yasemin
• Format: Journal Article
• Language: English
• Published: Galenos Yayinevi Tic. Ltd 01.12.2022
• Subjects: Fibromyalgia; Health aspects; Inflammation; Medical research; Medicine, Experimental; Obesity; Osteoarthritis; Prevalence studies (Epidemiology); Rheumatoid factor; Scleroderma (Disease); Systemic lupus erythematosus; Systemic scleroderma
• ISSN: 2547-9431; 2547-9431
• DOI: 10.4274/BMB.galenos.2022.202l-11-118

Objective: Obesity Is a common health problem and a complex disease that Is defined as overly fat deposition In adipotic tissue. Studies conducted in our country (Turkey) have reported prevalence of obesity between 12 and 22 percent. Obesity has been shown to be associated with several rheumatic diseases and inflammation. The aim of this study is to assess the prevalence of obesity in rheumatologic diseases, and possible relationships between disease activity and accompanying obesity. Method: A total of 1064 newly patients diagnosed with osteoarthritis (OA), rheumatoid arthritis (RA), ankylosing spondylitis (AS), systemic lupus erythematosus (SLE), fibromyalgia (FM), gout, Behget's disease (BD), vasculitis, polymyalgia rheumatica (PMR), Sjogren's syndrome (SS), Familial Mediterranean fever, polymyositis, and systemic sclerosis (SSc) were included in the study. Age, gender, disease activity scores, and laboratory and clinical findings were all recorded. Results: Obesity incidences were found to be 4.5% in RA, 3.2% in SLE, 1.6% in AS, 40.1% in OA, 11.2% in FM, 19.7% in gout, 1.8% in BD, 15% in vasculitis, 13.7% in PMR, 8% in SS, and 8.3% in SSc. Obesity and OA were revealed to have a statistically significant association. Disease activity scores were statistically significantly higher in obese FM patients compared to non-obese patients (p<0.001). We found a low rate of obesity in inflammatory rheumatic diseases, and we could not find a relationship between obesity and disease activity. Conclusion: While recent studies have associated obesity with inflammation, interestingly, in our study, obesity was found to be related to OA and FM, but was not associated with inflammatory rheumatic diseases. The relationship with OA may be explained by mechanical factors, but more comprehensive studies are needed on the relationship with obesity and inflammatory rheumatic diseases. Keywords: Ankylosing spondylitis, disease activity, obesity, osteoarthritis, rheumatoid arthritis, rheumatological diseases Amac: Obezite adipoz dokuda fazla yag depolanmasi olarak tanimlanan kompleks bir hastalik ve genel saglik sorunudur. Ulkemizde yapilan arastirmalarda obezite prevelansi %12-22 olarak bildirilmistir. Obezitenin cesitli romatizmal hastaliklar ve enflamasyonla iliskisi gosterilmistir. Bu calismanin amaci romatolojik hastaliklarda obezite prevelansini ve hastalik aktivitesi ile iliskisini arastirmaktir. Yontem: Calismaya yeni osteoartrit (OA), romatoid artrit (RA), ankilozan spondilit (AS), sistemik lupus eeritamatosus (SLE), fibromiyalji (FM), gut, Behcet hastaligi (BH), vaskulit, polimiyalji romatika (PMR), Sjogren sendromu (SS), Ailevi Akdeniz atesi, polimiyozit ve sistemik skleroz (SSc) tanisi almis 1064 romatoloji hastasi dahil edilmistir. Hastalarin yas, cinsiyet, hastalik aktivite skorlari, laboratuvar ve klinik bulgulari kaydedilmistir. Bulgular: Obezite insidanslari RA'da %4,5, SLE'de %3,2, AS'de %1,6, OA'de %40,1, FM'de %11,2, gutta %19,7, BH'de %1,8, vaskulitte %15, PMR'de %13,7, SS'de %8, ve SSc'de %8,3 olarak tespit edildi. Obezite ve OA arasinda istatistiksel olarak kuvvetli iliski saptandi. Hastalik aktivite skorlari ise obez FM hastalarinda obez olmayanlara gore istatistiksel olarak anlamli duzeyde yuksek bulundu (p<0,001). Enflamatuvar romatizmal hastaliklarda obezite orani dusuk bulunurken, obezite ile hastalik aktivitesi arasinda bir iliski bulunmadi. Sonuc: Yapilan son calismalarda obezite ve enflamasyon arasinda iliski gosterilse de bizim calismamizda ilginc olarak obezitenin OA ve FM hastalariyla iliskisi ortaya konmus ancak enflamatuvar romatizmal hastaliklar ile arasinda iliski gosterilememistir. OA ve obezite arasindaki iliski mekanik faktorlerle aciklanabilir, ancak FM ve diger enflamatuvar romatizmal hastaliklar ve obezite iliskisini aciklayabilmek icin daha kapsamli ileri calismalara ihtiyac duyulmaktadir. Anahtar kelimeler: Ankilozan spondilit, hastalik aktivitesi, obezite, osteoartrit, romatoid artrit, romatizmal hastaliklar