I've got algorithm: predicting tumor and autoimmune peptide targets for [CD8.sup.+] T cells

[CD8.sup.+] T cells play a central role in eradicating intracellular pathogens, but also are important for noninfectious diseases, including cancer and autoimmunity. The ability to clinically manipulate [CD8.sup.+] T cells to target cancer and autoimmune disease is limited by our ignorance of releva...

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Bibliographic Details
Published inThe Journal of clinical investigation Vol. 126; no. 12; pp. 4399 - 4401
Main Authors Dersh, Devin, Yewdell, Jonathan W
Format Journal Article
LanguageEnglish
Published American Society for Clinical Investigation 01.12.2016
Subjects
Algorithms
Analysis
Autoimmunity
Influence
Major histocompatibility complex
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ISSN0021-9738
DOI10.1172/JCI91302

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Summary:[CD8.sup.+] T cells play a central role in eradicating intracellular pathogens, but also are important for noninfectious diseases, including cancer and autoimmunity. The ability to clinically manipulate [CD8.sup.+] T cells to target cancer and autoimmune disease is limited by our ignorance of relevant self-peptide target antigens. In this issue of the JCI, Pearson et al. describe 25,270 MHC class l-associated peptides presented by a wide range of HLA A and B allomorphs expressed by 18 different B cell lines. Via extensive bioinformatic analysis, the authors make surprising conclusions regarding the selective nature of peptide generation at the level of individual gene products and create a predictive algorithm for disease-relevant self-peptides that will be of immediate use for clinical and basic immunological research.
ISSN:0021-9738
DOI:10.1172/JCI91302