Gene-environment interaction and obesity

The epidemic of obesity has become a major public health problem. Common-form obesity is underpinned by both environmental and genetic factors. Epidemiological studies have documented that increased intakes of energy and reduced consumption of high-fiber foods, as well as sedentary lifestyle, were a...

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Published in	Nutrition reviews Vol. 66; no. 12; pp. 684 - 694
Main Authors	Lu, Qi, Cho, Young Ae
Format	Journal Article
Language	English
Published	Malden, USA Blackwell Publishing Inc 01.12.2008 Wiley Oxford University Press
Subjects	administration & dosage Biological and medical sciences Clinical trials diet therapy dietary fiber Dietary Fiber - administration & dosage disease control disease incidence disease prevention energy intake Energy Intake - physiology Environment epidemiological studies Epidemiology etiology Exercise Exercise - physiology food choices food intake gene genes Genetic Predisposition to Disease genetics Genomics genotype-environment interaction human health Humans interaction Life Style lifestyle literature reviews Medical sciences melanocyte-stimulating hormone Metabolic diseases nutritional intervention Obesity Obesity - epidemiology Obesity - etiology Obesity - genetics Obesity - prevention & control physical activity physiology prevention & control psychosocial factors Public health Risk Factors Sieges Studies Human Obesity Gene Gene interaction Nutrition disorder Risk factor interaction Environment Review Nutritional status Feeding Life style
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ISSN	0029-6643 1753-4887 1753-4887
DOI	10.1111/j.1753-4887.2008.00128.x

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Abstract	The epidemic of obesity has become a major public health problem. Common-form obesity is underpinned by both environmental and genetic factors. Epidemiological studies have documented that increased intakes of energy and reduced consumption of high-fiber foods, as well as sedentary lifestyle, were among the major driving forces for the epidemic of obesity. Recent genome-wide association studies have identified several genes convincingly related to obesity risk, including the fat mass and obesity associated gene and the melanocortin-4 receptor gene. Testing gene-environment interaction is a relatively new field. This article reviews recent advances in identifying the genetic and environmental risk factors (lifestyle and diet) for obesity. The evidence for gene-environment interaction, especially from observational studies and randomized intervention trials, is examined specifically. Knowledge about the interplay between genetic and environmental components may facilitate the choice of more effective and specific measures for obesity prevention based on the personalized genetic make-up.
AbstractList	The epidemic of obesity has become a major public health problem. Common-form obesity is underpinned by both environmental and genetic factors. Epidemiological studies have documented that increased intakes of energy and reduced consumption of high-fiber foods, as well as sedentary lifestyle, were among the major driving forces for the epidemic of obesity. Recent genome-wide association studies have identified several genes convincingly related to obesity risk, including the fat mass and obesity associated gene and the melanocortin-4 receptor gene. Testing gene-environment interaction is a relatively new field. This article reviews recent advances in identifying the genetic and environmental risk factors (lifestyle and diet) for obesity. The evidence for gene-environment interaction, especially from observational studies and randomized intervention trials, is examined specifically. Knowledge about the interplay between genetic and environmental components may facilitate the choice of more effective and specific measures for obesity prevention based on the personalized genetic make-up. The epidemic of obesity has become a major public health problem. Common-form obesity is underpinned by both environmental and genetic factors. Epidemiological studies have documented that increased intakes of energy and reduced consumption of high-fiber foods, as well as sedentary lifestyle, were among the major driving forces for the epidemic of obesity. Recent genome-wide association studies have identified several genes convincingly related to obesity risk, including the fat mass and obesity associated gene and the melanocortin-4 receptor gene. Testing gene-environment interaction is a relatively new field. This article reviews recent advances in identifying the genetic and environmental risk factors (lifestyle and diet) for obesity. The evidence for gene-environment interaction, especially from observational studies and randomized intervention trials, is examined specifically. Knowledge about the interplay between genetic and environmental components may facilitate the choice of more effective and specific measures for obesity prevention based on the personalized genetic make-up.The epidemic of obesity has become a major public health problem. Common-form obesity is underpinned by both environmental and genetic factors. Epidemiological studies have documented that increased intakes of energy and reduced consumption of high-fiber foods, as well as sedentary lifestyle, were among the major driving forces for the epidemic of obesity. Recent genome-wide association studies have identified several genes convincingly related to obesity risk, including the fat mass and obesity associated gene and the melanocortin-4 receptor gene. Testing gene-environment interaction is a relatively new field. This article reviews recent advances in identifying the genetic and environmental risk factors (lifestyle and diet) for obesity. The evidence for gene-environment interaction, especially from observational studies and randomized intervention trials, is examined specifically. Knowledge about the interplay between genetic and environmental components may facilitate the choice of more effective and specific measures for obesity prevention based on the personalized genetic make-up. The epidemic of obesity has become a major public health problem. Common-form obesity is underpinned by both environmental and genetic factors. Epidemiological studies have documented that increased intakes of energy and reduced consumption of high-fiber foods, as well as sedentary lifestyle, were among the major driving forces for the epidemic of obesity. Recent genome-wide association studies have identified several genes convincingly related to obesity risk, including the fat mass and obesity associated gene and the melanocortin-4 receptor gene. Testing gene-environment interaction is a relatively new field. This article reviews recent advances in identifying the genetic and environmental risk factors (lifestyle and diet) for obesity. The evidence for gene-environment interaction, especially from observational studies and randomized intervention trials, is examined specifically. Knowledge about the interplay between genetic and environmental components may facilitate the choice of more effective and specific measures for obesity prevention based on the personalized genetic makeup. [PUBLICATION ABSTRACT]
Author	Qi, Lu Cho, Young Ae
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Snippet	The epidemic of obesity has become a major public health problem. Common-form obesity is underpinned by both environmental and genetic factors. Epidemiological... The epidemic of obesity has become a major public health problem. Common‐form obesity is underpinned by both environmental and genetic factors. Epidemiological...
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SubjectTerms	administration & dosage Biological and medical sciences Clinical trials diet therapy dietary fiber Dietary Fiber - administration & dosage disease control disease incidence disease prevention energy intake Energy Intake - physiology Environment epidemiological studies Epidemiology etiology Exercise Exercise - physiology food choices food intake gene genes Genetic Predisposition to Disease genetics Genomics genotype-environment interaction human health Humans interaction Life Style lifestyle literature reviews Medical sciences melanocyte-stimulating hormone Metabolic diseases nutritional intervention Obesity Obesity - epidemiology Obesity - etiology Obesity - genetics Obesity - prevention & control physical activity physiology prevention & control psychosocial factors Public health Risk Factors Sieges Studies
Title	Gene-environment interaction and obesity
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