Extracellular vesicles derived from Staphylococcus aureus induce atopic dermatitis-like skin inflammation
To cite this article: Hong S-W, Kim M-R, Lee E-Y, Kim JH, Kim Y-S, Jeon SG, Yang J-M, Lee B-J, Pyun B-Y, Gho YS, Kim Y-K. Extracellular vesicles derived from Staphylococcus aureus induce atopic dermatitis-like skin inflammation. Allergy 2011; 66: 351-359. ABSTRACT: Background: Recently, we found tha...
Saved in:
| Published in | Allergy (Copenhagen) Vol. 66; no. 3; pp. 351 - 359 |
|---|---|
| Main Authors | , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Oxford, UK
Blackwell Publishing Ltd
01.03.2011
Blackwell |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0105-4538 1398-9995 1398-9995 |
| DOI | 10.1111/j.1398-9995.2010.02483.x |
Cover
| Abstract | To cite this article: Hong S-W, Kim M-R, Lee E-Y, Kim JH, Kim Y-S, Jeon SG, Yang J-M, Lee B-J, Pyun B-Y, Gho YS, Kim Y-K. Extracellular vesicles derived from Staphylococcus aureus induce atopic dermatitis-like skin inflammation. Allergy 2011; 66: 351-359. ABSTRACT: Background: Recently, we found that Staphylococcus aureus produces extracellular vesicles (EV) that contain pathogenic proteins. Although S. aureus infection has been linked with atopic dermatitis (AD), the identities of the causative agents from S. aureus are controversial. We evaluated whether S. aureus-derived EV are causally related to the pathogenesis of AD. Methods: Extracellular vesicles were isolated by the ultracentrifugation of S. aureus culture media. The EV were applied three times per week to tape-stripped mouse skin. Inflammation and immune dysfunction were evaluated 48 h after the final application in hairless mice. Extracellular vesicles-specific IgE levels were measured by ELISA in AD patients and healthy subjects. Results: The in vitro application of S. aureus EV increased the production of pro-inflammatory mediators (IL-6, thymic stromal lymphopoietin, macrophage inflammatory protein-1α, and eotaxin) by dermal fibroblasts. The in vivo application of S. aureus EV after tape stripping caused epidermal thickening with infiltration of the dermis by mast cells and eosinophils in mice. These changes were associated with the enhanced cutaneous production of IL-4, IL-5, IFN-γ, and IL-17. Interestingly, the serum levels of S. aureus EV-specific IgE were significantly increased in AD patients relative to healthy subjects. Conclusion: These results indicate that S. aureus EV induce AD-like inflammation in the skin and that S. aureus-derived EV are a novel diagnostic and therapeutic target for the control of AD. |
|---|---|
| AbstractList | Recently, we found that Staphylococcus aureus produces extracellular vesicles (EV) that contain pathogenic proteins. Although S. aureus infection has been linked with atopic dermatitis (AD), the identities of the causative agents from S. aureus are controversial. We evaluated whether S. aureus-derived EV are causally related to the pathogenesis of AD.
Extracellular vesicles were isolated by the ultracentrifugation of S. aureus culture media. The EV were applied three times per week to tape-stripped mouse skin. Inflammation and immune dysfunction were evaluated 48 h after the final application in hairless mice. Extracellular vesicles-specific IgE levels were measured by ELISA in AD patients and healthy subjects.
The in vitro application of S. aureus EV increased the production of pro-inflammatory mediators (IL-6, thymic stromal lymphopoietin, macrophage inflammatory protein-1α, and eotaxin) by dermal fibroblasts. The in vivo application of S. aureus EV after tape stripping caused epidermal thickening with infiltration of the dermis by mast cells and eosinophils in mice. These changes were associated with the enhanced cutaneous production of IL-4, IL-5, IFN-γ, and IL-17. Interestingly, the serum levels of S. aureus EV-specific IgE were significantly increased in AD patients relative to healthy subjects.
These results indicate that S. aureus EV induce AD-like inflammation in the skin and that S. aureus-derived EV are a novel diagnostic and therapeutic target for the control of AD. To cite this article: Hong S-W, Kim M-R, Lee E-Y, Kim JH, Kim Y-S, Jeon SG, Yang J-M, Lee B-J, Pyun B-Y, Gho YS, Kim Y-K. Extracellular vesicles derived from Staphylococcus aureus induce atopic dermatitis-like skin inflammation. Allergy 2011; 66: 351-359. Background: Recently, we found that Staphylococcus aureus produces extracellular vesicles (EV) that contain pathogenic proteins. Although S. aureus infection has been linked with atopic dermatitis (AD), the identities of the causative agents from S. aureus are controversial. We evaluated whether S. aureus-derived EV are causally related to the pathogenesis of AD. Methods: Extracellular vesicles were isolated by the ultracentrifugation of S. aureus culture media. The EV were applied three times per week to tape-stripped mouse skin. Inflammation and immune dysfunction were evaluated 48h after the final application in hairless mice. Extracellular vesicles-specific IgE levels were measured by ELISA in AD patients and healthy subjects. Results: The in vitro application of S. aureus EV increased the production of pro-inflammatory mediators (IL-6, thymic stromal lymphopoietin, macrophage inflammatory protein-1 alpha , and eotaxin) by dermal fibroblasts. The in vivo application of S. aureus EV after tape stripping caused epidermal thickening with infiltration of the dermis by mast cells and eosinophils in mice. These changes were associated with the enhanced cutaneous production of IL-4, IL-5, IFN- gamma , and IL-17. Interestingly, the serum levels of S. aureus EV-specific IgE were significantly increased in AD patients relative to healthy subjects. Conclusion: These results indicate that S. aureus EV induce AD-like inflammation in the skin and that S. aureus-derived EV are a novel diagnostic and therapeutic target for the control of AD. Background: Recently, we found that Staphylococcus aureus produces extracellular vesicles (EV) that contain pathogenic proteins. Although S. aureus infection has been linked with atopic dermatitis (AD), the identities of the causative agents from S. aureus are controversial. We evaluated whether S. aureus-derived EV are causally related to the pathogenesis of AD. Methods: Extracellular vesicles were isolated by the ultracentrifugation of S. aureus culture media. The EV were applied three times per week to tape-stripped mouse skin. Inflammation and immune dysfunction were evaluated 48h after the final application in hairless mice. Extracellular vesicles-specific IgE levels were measured by ELISA in AD patients and healthy subjects. Results: The in vitro application of S. aureus EV increased the production of pro-inflammatory mediators (IL-6, thymic stromal lymphopoietin, macrophage inflammatory protein-1α, and eotaxin) by dermal fibroblasts. The in vivo application of S. aureus EV after tape stripping caused epidermal thickening with infiltration of the dermis by mast cells and eosinophils in mice. These changes were associated with the enhanced cutaneous production of IL-4, IL-5, IFN-γ, and IL-17. Interestingly, the serum levels of S. aureus EV-specific IgE were significantly increased in AD patients relative to healthy subjects. Conclusion: These results indicate that S. aureus EV induce AD-like inflammation in the skin and that S. aureus-derived EV are a novel diagnostic and therapeutic target for the control of AD. [PUBLICATION ABSTRACT] To cite this article: Hong S‐W, Kim M‐R, Lee E‐Y, Kim JH, Kim Y‐S, Jeon SG, Yang J‐M, Lee B‐J, Pyun B‐Y, Gho YS, Kim Y‐K. Extracellular vesicles derived from Staphylococcus aureus induce atopic dermatitis‐like skin inflammation. Allergy 2011; 66: 351–359. Background: Recently, we found that Staphylococcus aureus produces extracellular vesicles (EV) that contain pathogenic proteins. Although S. aureus infection has been linked with atopic dermatitis (AD), the identities of the causative agents from S. aureus are controversial. We evaluated whether S. aureus‐derived EV are causally related to the pathogenesis of AD. Methods: Extracellular vesicles were isolated by the ultracentrifugation of S. aureus culture media. The EV were applied three times per week to tape‐stripped mouse skin. Inflammation and immune dysfunction were evaluated 48 h after the final application in hairless mice. Extracellular vesicles‐specific IgE levels were measured by ELISA in AD patients and healthy subjects. Results: The in vitro application of S. aureus EV increased the production of pro‐inflammatory mediators (IL‐6, thymic stromal lymphopoietin, macrophage inflammatory protein‐1α, and eotaxin) by dermal fibroblasts. The in vivo application of S. aureus EV after tape stripping caused epidermal thickening with infiltration of the dermis by mast cells and eosinophils in mice. These changes were associated with the enhanced cutaneous production of IL‐4, IL‐5, IFN‐γ, and IL‐17. Interestingly, the serum levels of S. aureus EV‐specific IgE were significantly increased in AD patients relative to healthy subjects. Conclusion: These results indicate that S. aureus EV induce AD‐like inflammation in the skin and that S. aureus‐derived EV are a novel diagnostic and therapeutic target for the control of AD. To cite this article: Hong S-W, Kim M-R, Lee E-Y, Kim JH, Kim Y-S, Jeon SG, Yang J-M, Lee B-J, Pyun B-Y, Gho YS, Kim Y-K. Extracellular vesicles derived from Staphylococcus aureus induce atopic dermatitis-like skin inflammation. Allergy 2011; 66: 351-359. ABSTRACT: Background: Recently, we found that Staphylococcus aureus produces extracellular vesicles (EV) that contain pathogenic proteins. Although S. aureus infection has been linked with atopic dermatitis (AD), the identities of the causative agents from S. aureus are controversial. We evaluated whether S. aureus-derived EV are causally related to the pathogenesis of AD. Methods: Extracellular vesicles were isolated by the ultracentrifugation of S. aureus culture media. The EV were applied three times per week to tape-stripped mouse skin. Inflammation and immune dysfunction were evaluated 48 h after the final application in hairless mice. Extracellular vesicles-specific IgE levels were measured by ELISA in AD patients and healthy subjects. Results: The in vitro application of S. aureus EV increased the production of pro-inflammatory mediators (IL-6, thymic stromal lymphopoietin, macrophage inflammatory protein-1α, and eotaxin) by dermal fibroblasts. The in vivo application of S. aureus EV after tape stripping caused epidermal thickening with infiltration of the dermis by mast cells and eosinophils in mice. These changes were associated with the enhanced cutaneous production of IL-4, IL-5, IFN-γ, and IL-17. Interestingly, the serum levels of S. aureus EV-specific IgE were significantly increased in AD patients relative to healthy subjects. Conclusion: These results indicate that S. aureus EV induce AD-like inflammation in the skin and that S. aureus-derived EV are a novel diagnostic and therapeutic target for the control of AD. Recently, we found that Staphylococcus aureus produces extracellular vesicles (EV) that contain pathogenic proteins. Although S. aureus infection has been linked with atopic dermatitis (AD), the identities of the causative agents from S. aureus are controversial. We evaluated whether S. aureus-derived EV are causally related to the pathogenesis of AD.BACKGROUNDRecently, we found that Staphylococcus aureus produces extracellular vesicles (EV) that contain pathogenic proteins. Although S. aureus infection has been linked with atopic dermatitis (AD), the identities of the causative agents from S. aureus are controversial. We evaluated whether S. aureus-derived EV are causally related to the pathogenesis of AD.Extracellular vesicles were isolated by the ultracentrifugation of S. aureus culture media. The EV were applied three times per week to tape-stripped mouse skin. Inflammation and immune dysfunction were evaluated 48 h after the final application in hairless mice. Extracellular vesicles-specific IgE levels were measured by ELISA in AD patients and healthy subjects.METHODSExtracellular vesicles were isolated by the ultracentrifugation of S. aureus culture media. The EV were applied three times per week to tape-stripped mouse skin. Inflammation and immune dysfunction were evaluated 48 h after the final application in hairless mice. Extracellular vesicles-specific IgE levels were measured by ELISA in AD patients and healthy subjects.The in vitro application of S. aureus EV increased the production of pro-inflammatory mediators (IL-6, thymic stromal lymphopoietin, macrophage inflammatory protein-1α, and eotaxin) by dermal fibroblasts. The in vivo application of S. aureus EV after tape stripping caused epidermal thickening with infiltration of the dermis by mast cells and eosinophils in mice. These changes were associated with the enhanced cutaneous production of IL-4, IL-5, IFN-γ, and IL-17. Interestingly, the serum levels of S. aureus EV-specific IgE were significantly increased in AD patients relative to healthy subjects.RESULTSThe in vitro application of S. aureus EV increased the production of pro-inflammatory mediators (IL-6, thymic stromal lymphopoietin, macrophage inflammatory protein-1α, and eotaxin) by dermal fibroblasts. The in vivo application of S. aureus EV after tape stripping caused epidermal thickening with infiltration of the dermis by mast cells and eosinophils in mice. These changes were associated with the enhanced cutaneous production of IL-4, IL-5, IFN-γ, and IL-17. Interestingly, the serum levels of S. aureus EV-specific IgE were significantly increased in AD patients relative to healthy subjects.These results indicate that S. aureus EV induce AD-like inflammation in the skin and that S. aureus-derived EV are a novel diagnostic and therapeutic target for the control of AD.CONCLUSIONThese results indicate that S. aureus EV induce AD-like inflammation in the skin and that S. aureus-derived EV are a novel diagnostic and therapeutic target for the control of AD. |
| Author | Lee, E.-Y Kim, M.-R Kim, J.H Kim, Y.-K Pyun, B.-Y Lee, B.-J Hong, S.-W Jeon, S.G Yang, J.-M Gho, Y.S Kim, Y.-S |
| Author_xml | – sequence: 1 fullname: Hong, S.-W – sequence: 2 fullname: Kim, M.-R – sequence: 3 fullname: Lee, E.-Y – sequence: 4 fullname: Kim, J.H – sequence: 5 fullname: Kim, Y.-S – sequence: 6 fullname: Jeon, S.G – sequence: 7 fullname: Yang, J.-M – sequence: 8 fullname: Lee, B.-J – sequence: 9 fullname: Pyun, B.-Y – sequence: 10 fullname: Gho, Y.S – sequence: 11 fullname: Kim, Y.-K |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23878441$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/20831718$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFkk1vGyEQhlGVqnHS_oV2VanqaV1YYBcOjRRFSVvJUg9pzgizkOCwiwu7rv3vOxu77selcAAxz3ww856hkz72FqGC4DmB9WE1J1SKUkrJ5xWGV1wxQefbZ2h2NJygGVh4yTgVp-gs5xXGuKkkfoFOKywoaYiYIX-9HZI2NoQx6FRsbPYm2Fy0NvmNbQuXYlfcDnr9sAvRRGPGXOgxWTh8347GFnqIa28mh04PfvC5DP7RFvnR94C4oLvpPfYv0XOnQ7avDuc5uru5_nb1uVx8_fTl6nJROg5_KClrHG4Yr3GzJNZVvGlbjpeyrYwwS820xLVwlhtd121la9NYaQxjDpPKcEfpObrYx12Py862xvbwwaDWyXc67VTUXv1t6f2Duo8bRTGvOOUQ4P0hQIrfR5sH1fk8dUj3No5ZCV43ohGU_Z9kEkbQCALk23_IVRxTD30ACALCxgC9_rPyY8m_pgXAuwOgs9HBJd0bn39zFMpibMr2cc_98MHujnaC1aQetVKTSNQkEjWpRz2pR23V5WIx3cD_zd7f6aj0fYIcd7dAUkwklQQU9RNlxsVu |
| CODEN | LLRGDY |
| ContentType | Journal Article |
| Copyright | 2010 John Wiley & Sons A/S 2015 INIST-CNRS 2010 John Wiley & Sons A/S. Copyright © 2011 John Wiley & Sons A/S |
| Copyright_xml | – notice: 2010 John Wiley & Sons A/S – notice: 2015 INIST-CNRS – notice: 2010 John Wiley & Sons A/S. – notice: Copyright © 2011 John Wiley & Sons A/S |
| DBID | FBQ 24P IQODW CGR CUY CVF ECM EIF NPM 7T5 H94 K9. 7X8 7QL C1K 5PM |
| DOI | 10.1111/j.1398-9995.2010.02483.x |
| DatabaseName | AGRIS Wiley Online Library Open Access Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Immunology Abstracts AIDS and Cancer Research Abstracts ProQuest Health & Medical Complete (Alumni) MEDLINE - Academic Bacteriology Abstracts (Microbiology B) Environmental Sciences and Pollution Management PubMed Central (Full Participant titles) |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) AIDS and Cancer Research Abstracts ProQuest Health & Medical Complete (Alumni) Immunology Abstracts MEDLINE - Academic Bacteriology Abstracts (Microbiology B) Environmental Sciences and Pollution Management |
| DatabaseTitleList | MEDLINE AIDS and Cancer Research Abstracts AIDS and Cancer Research Abstracts MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: 24P name: Wiley Online Library Open Access url: https://authorservices.wiley.com/open-science/open-access/browse-journals.html sourceTypes: Publisher – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 4 dbid: FBQ name: AGRIS url: http://www.fao.org/agris/Centre.asp?Menu_1ID=DB&Menu_2ID=DB1&Language=EN&Content=http://www.fao.org/agris/search?Language=EN sourceTypes: Publisher |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1398-9995 |
| EndPage | 359 |
| ExternalDocumentID | PMC3052535 2254312091 20831718 23878441 ALL2483 US201301939145 |
| Genre | article Research Support, Non-U.S. Gov't Journal Article |
| GroupedDBID | .3N .GA .GJ .Y3 05W 0R~ 10A 1OB 1OC 23M 24P 2WC 31~ 33P 36B 3SF 4.4 50Y 50Z 51W 51X 52M 52N 52O 52P 52R 52S 52T 52U 52V 52W 52X 53G 5GY 5HH 5LA 5RE 5VS 66C 702 7PT 8-0 8-1 8-3 8-4 8-5 8F7 8UM 930 A01 A03 AAESR AAEVG AAHHS AAKAS AANLZ AAONW AASGY AAVGM AAXRX AAZKR ABCQN ABCUV ABEML ABHUG ABJNI ABLJU ABOCM ABPTK ABPVW ABQWH ABXGK ACAHQ ACBWZ ACCFJ ACCZN ACGFS ACGOF ACMXC ACPOU ACPRK ACSCC ACXBN ACXME ACXQS ADAWD ADBBV ADBTR ADDAD ADEOM ADIZJ ADKYN ADMGS ADOZA ADXAS ADZCM ADZMN AEEZP AEIGN AEIMD AENEX AEQDE AEUQT AEUYR AFBPY AFEBI AFFNX AFFPM AFGKR AFPWT AFRAH AFVGU AFZJQ AGJLS AHMBA AIACR AIURR AIWBW AJBDE ALAGY ALMA_UNASSIGNED_HOLDINGS ALUQN AMBMR AMYDB AOETA ATUGU AZBYB AZFZN AZVAB BAFTC BAWUL BDRZF BFHJK BHBCM BMXJE BROTX BRXPI BY8 C45 CAG COF CS3 D-6 D-7 D-E D-F DC6 DCZOG DIK DPXWK DR2 DRFUL DRMAN DRSTM E3Z EBS EJD EMOBN ESX EX3 F00 F01 F04 F5P FBQ FEDTE FUBAC FZ0 G-S G.N GODZA H.X HF~ HVGLF HZI HZ~ IHE IX1 J0M K48 KBYEO LATKE LC2 LC3 LEEKS LH4 LITHE LOXES LP6 LP7 LUTES LW6 LYRES MEWTI MK4 MRFUL MRMAN MRSTM MSFUL MSMAN MSSTM MXFUL MXMAN MXSTM N04 N05 N9A NF~ O66 O9- OK1 OVD P2P P2W P2X P2Z P4B P4D P6G PALCI PQQKQ Q.N Q11 QB0 R.K RIWAO RJQFR ROL RX1 SAMSI SUPJJ TEORI TR2 UB1 V9Y W8V W99 WBKPD WHWMO WIH WIJ WIK WOHZO WOW WQJ WRC WUP WVDHM WXI WXSBR XG1 Y6R ZGI ZXP ZZTAW ~IA ~KM ~WT AAHQN AAIPD AAMMB AAMNL AANHP AAYCA ACRPL ACYXJ ADNMO AEFGJ AEYWJ AFWVQ AGHNM AGQPQ AGXDD AGYGG AHBTC AHEFC AIDQK AIDYY AITYG ALVPJ HGLYW OIG WIN IQODW CGR CUY CVF ECM EIF NPM 7T5 H94 K9. 7X8 7QL C1K 5PM |
| ID | FETCH-LOGICAL-f5483-347f0745607b1ef257dd50b9d2c8cba4a9068fe5ca66d2e6c7e9cc44f012c5f33 |
| IEDL.DBID | DR2 |
| ISSN | 0105-4538 1398-9995 |
| IngestDate | Thu Aug 21 17:48:54 EDT 2025 Fri Jul 11 04:45:48 EDT 2025 Fri Jul 11 06:51:57 EDT 2025 Sat Jul 26 02:28:15 EDT 2025 Mon Jul 21 06:05:45 EDT 2025 Mon Jul 21 09:13:20 EDT 2025 Wed Aug 20 07:27:04 EDT 2025 Wed Dec 27 19:14:39 EST 2023 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 3 |
| Keywords | Vesicle Allergy Immunopathology Skin disease extracellular vesicles Dermatology Inflammation Extracellular Atopy Immunology Atopic dermatitis Bacteria Micrococcales Micrococcaceae Skin Staphylococcus aureus skin inflammation |
| Language | English |
| License | CC BY 4.0 2010 John Wiley & Sons A/S. Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-f5483-347f0745607b1ef257dd50b9d2c8cba4a9068fe5ca66d2e6c7e9cc44f012c5f33 |
| Notes | http://dx.doi.org/10.1111/j.1398-9995.2010.02483.x Edited by: Thomas Bieber Re‐use of this article is permitted in accordance with the Terms and Conditions set out at http://wileyonlinelibrary.com/onlineopen#OnlineOpen_Terms . ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 ObjectType-Article-2 ObjectType-Feature-1 Re-use of this article is permitted in accordance with the Terms and Conditions set out at http://wileyonlinelibrary.com/onlineopen#OnlineOpen_Terms. |
| OpenAccessLink | https://proxy.k.utb.cz/login?url=https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fj.1398-9995.2010.02483.x |
| PMID | 20831718 |
| PQID | 848565650 |
| PQPubID | 34098 |
| PageCount | 9 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_3052535 proquest_miscellaneous_856787834 proquest_miscellaneous_849010781 proquest_journals_848565650 pubmed_primary_20831718 pascalfrancis_primary_23878441 wiley_primary_10_1111_j_1398_9995_2010_02483_x_ALL2483 fao_agris_US201301939145 |
| PublicationCentury | 2000 |
| PublicationDate | March 2011 |
| PublicationDateYYYYMMDD | 2011-03-01 |
| PublicationDate_xml | – month: 03 year: 2011 text: March 2011 |
| PublicationDecade | 2010 |
| PublicationPlace | Oxford, UK |
| PublicationPlace_xml | – name: Oxford, UK – name: Oxford – name: Denmark – name: Zurich |
| PublicationTitle | Allergy (Copenhagen) |
| PublicationTitleAlternate | Allergy |
| PublicationYear | 2011 |
| Publisher | Blackwell Publishing Ltd Blackwell |
| Publisher_xml | – name: Blackwell Publishing Ltd – name: Blackwell |
| References | 2007; 17 2010; 48 2004; 113 2010 2002; 147 2000; 55 2007; 152 2004; 46 2007; 120 2009; 123 2009; 9 2010; 130 2007; 7 2008; 128 2009; 161 2001; 56 2006; 118 2010; 5 2009; 125 2010; 74 1996; 97 2006; 155 11551248 - Allergy. 2001 Sep;56(9):841-9 19962742 - J Allergy Clin Immunol. 2010 Jan;125(1):146-52.e1-2 17540632 - Eur J Dermatol. 2007 Jul-Aug;17(4):267-83 16815171 - J Allergy Clin Immunol. 2006 Jul;118(1):287-90 10858986 - Allergy. 2000 Jun;55(6):551-5 20596087 - J Invest Dermatol. 2010 Nov;130(11):2621-8 8626983 - J Allergy Clin Immunol. 1996 May;97(5):1064-70 19403473 - Pediatrics. 2009 May;123(5):e808-14 20519475 - J Clin Microbiol. 2010 Aug;48(8):2724-8 20197500 - Microbiol Mol Biol Rev. 2010 Mar;74(1):81-94 15151553 - Pediatr Int. 2004 Jun;46(3):337-41 19438853 - Br J Dermatol. 2009 Aug;161(2):300-5 19812593 - J Invest Dermatol. 2010 Feb;130(2):614-7 14991059 - J Clin Invest. 2004 Mar;113(5):651-7 16965415 - Br J Dermatol. 2006 Oct;155(4):680-7 17787032 - Proteomics. 2007 Sep;7(17):3143-53 19834908 - Proteomics. 2009 Dec;9(24):5425-36 12100185 - Br J Dermatol. 2002 Jul;147(1):55-61 17666213 - J Allergy Clin Immunol. 2007 Aug;120(2):238-44; quiz 245-6 19056110 - J Allergy Clin Immunol. 2009 Jan;123(1):59-66.e4 17122896 - Arch Virol. 2007;152(3):543-52 18432274 - J Invest Dermatol. 2008 Nov;128(11):2625-30 20596524 - PLoS One. 2010;5(6):e11334 |
| References_xml | – volume: 7 start-page: 3143 year: 2007 end-page: 3153 article-title: Global proteomic profiling of native outer membrane vesicles derived from Escherichia coli publication-title: Proteomics – volume: 97 start-page: 1064 year: 1996 end-page: 1070 article-title: Induction of atopic dermatitis by inhalation of house dust mite publication-title: J Allergy Clin Immunol – volume: 155 start-page: 680 year: 2006 end-page: 687 article-title: Skin colonization by in patients with eczema and atopic dermatitis and relevant combined topical therapy: a double‐blind multicentre randomized controlled trial publication-title: Br J Dermatol – volume: 74 start-page: 81 year: 2010 end-page: 94 article-title: Virulence and immunomodulatory roles of bacterial outer membrane vesicles publication-title: Microbiol Mol Biol Rev – volume: 161 start-page: 300 year: 2009 end-page: 305 article-title: Isolation of alpha‐toxin‐producing from the skin of highly sensitized adult patients with severe atopic dermatitis publication-title: Br J Dermatol – volume: 130 start-page: 614 year: 2010 end-page: 617 article-title: extracellular protease causes epidermal barrier dysfunction publication-title: J Invest Dermatol – volume: 125 start-page: 146 year: 2009 end-page: 152 article-title: Infected atopic dermatitis lesions contain pharmacologic amounts of lipoteichoic acid publication-title: J Allergy Clin Immunol – volume: 123 start-page: e808 year: 2009 end-page: e814 article-title: Treatment of colonization in atopic dermatitis decreases disease severity publication-title: Pediatrics – volume: 46 start-page: 337 year: 2004 end-page: 341 article-title: Staphylococcal enterotoxin‐specific IgE antibodies in atopic dermatitis publication-title: Pediatr Int – volume: 5 start-page: e11334 year: 2010 article-title: Outer membrane vesicles derived from induce systemic inflammatory response syndrome publication-title: PLoS ONE – volume: 55 start-page: 551 year: 2000 end-page: 555 article-title: Severe atopic dermatitis is associated with sensitization to staphylococcal enterotoxin B (SEB) publication-title: Allergy – volume: 9 start-page: 5425 year: 2009 end-page: 5436 article-title: Gram‐positive bacteria produce membrane vesicles: proteomics‐based characterization of ‐derived membrane vesicles publication-title: Proteomics – volume: 128 start-page: 2625 year: 2008 end-page: 2630 article-title: Possible pathogenic role of Th17 cells for atopic dermatitis publication-title: J Invest Dermatol – volume: 123 start-page: 59 year: 2009 end-page: 66 article-title: IL‐17 in atopic eczema: linking allergen‐specific adaptive and microbial‐triggered innate immune response publication-title: J Allergy Clin Immunol – year: 2010 article-title: Interleukin‐17A promotes IgE production in human B cells publication-title: J Invest Dermatol – volume: 152 start-page: 543 year: 2007 end-page: 552 article-title: Primary mouse dermal fibroblast cell cultures as an model system for the differential pathogenicity of cross‐species herpesvirus papio 2 infections publication-title: Arch Virol – volume: 147 start-page: 55 year: 2002 end-page: 61 article-title: : colonizing features and influence of an antibacterial treatment in adults with atopic dermatitis publication-title: Br J Dermatol – volume: 118 start-page: 287 year: 2006 end-page: 290 article-title: Immunopathology of atopic dermatitis publication-title: J Allergy Clin Immunol – volume: 56 start-page: 841 year: 2001 end-page: 849 article-title: Epidemiology, clinical features, and immunology of the “intrinsic” (non‐IgE‐mediated) type of atopic dermatitis (constitutional dermatitis) publication-title: Allergy – volume: 120 start-page: 238 year: 2007 end-page: 244 article-title: Thymic stromal lymphopoietin and OX40 ligand pathway in the initiation of dendritic cell‐mediated allergic inflammation publication-title: J Allergy Clin Immunol – volume: 113 start-page: 651 year: 2004 end-page: 657 article-title: New insights into atopic dermatitis publication-title: J Clin Invest – volume: 17 start-page: 267 year: 2007 end-page: 283 article-title: Getting more and more complex: the pathophysiology of atopic eczema publication-title: Eur J Dermatol – volume: 48 start-page: 2724 year: 2010 end-page: 2728 article-title: Ecological temporal stability of nasal carriage publication-title: J Clin Microbiol – reference: 18432274 - J Invest Dermatol. 2008 Nov;128(11):2625-30 – reference: 19962742 - J Allergy Clin Immunol. 2010 Jan;125(1):146-52.e1-2 – reference: 16965415 - Br J Dermatol. 2006 Oct;155(4):680-7 – reference: 19812593 - J Invest Dermatol. 2010 Feb;130(2):614-7 – reference: 16815171 - J Allergy Clin Immunol. 2006 Jul;118(1):287-90 – reference: 10858986 - Allergy. 2000 Jun;55(6):551-5 – reference: 11551248 - Allergy. 2001 Sep;56(9):841-9 – reference: 12100185 - Br J Dermatol. 2002 Jul;147(1):55-61 – reference: 19834908 - Proteomics. 2009 Dec;9(24):5425-36 – reference: 17540632 - Eur J Dermatol. 2007 Jul-Aug;17(4):267-83 – reference: 19438853 - Br J Dermatol. 2009 Aug;161(2):300-5 – reference: 20197500 - Microbiol Mol Biol Rev. 2010 Mar;74(1):81-94 – reference: 17666213 - J Allergy Clin Immunol. 2007 Aug;120(2):238-44; quiz 245-6 – reference: 20596087 - J Invest Dermatol. 2010 Nov;130(11):2621-8 – reference: 20596524 - PLoS One. 2010;5(6):e11334 – reference: 19403473 - Pediatrics. 2009 May;123(5):e808-14 – reference: 15151553 - Pediatr Int. 2004 Jun;46(3):337-41 – reference: 19056110 - J Allergy Clin Immunol. 2009 Jan;123(1):59-66.e4 – reference: 17122896 - Arch Virol. 2007;152(3):543-52 – reference: 8626983 - J Allergy Clin Immunol. 1996 May;97(5):1064-70 – reference: 17787032 - Proteomics. 2007 Sep;7(17):3143-53 – reference: 20519475 - J Clin Microbiol. 2010 Aug;48(8):2724-8 – reference: 14991059 - J Clin Invest. 2004 Mar;113(5):651-7 |
| SSID | ssj0007290 |
| Score | 2.4484227 |
| Snippet | To cite this article: Hong S-W, Kim M-R, Lee E-Y, Kim JH, Kim Y-S, Jeon SG, Yang J-M, Lee B-J, Pyun B-Y, Gho YS, Kim Y-K. Extracellular vesicles derived from... To cite this article: Hong S‐W, Kim M‐R, Lee E‐Y, Kim JH, Kim Y‐S, Jeon SG, Yang J‐M, Lee B‐J, Pyun B‐Y, Gho YS, Kim Y‐K. Extracellular vesicles derived from... Recently, we found that Staphylococcus aureus produces extracellular vesicles (EV) that contain pathogenic proteins. Although S. aureus infection has been... Background: Recently, we found that Staphylococcus aureus produces extracellular vesicles (EV) that contain pathogenic proteins. Although S. aureus infection... |
| SourceID | pubmedcentral proquest pubmed pascalfrancis wiley fao |
| SourceType | Open Access Repository Aggregation Database Index Database Publisher |
| StartPage | 351 |
| SubjectTerms | Adolescent Allergic diseases Animals Antibodies, Bacterial - blood Atopic dermatitis Biological and medical sciences Child Cytokines - immunology Dermatitis Dermatitis, Atopic - immunology Dermatitis, Atopic - microbiology Dermatitis, Atopic - pathology Dermatology Dermis Disease Models, Animal Enzyme-linked immunosorbent assay eotaxin Epidermis - immunology Exosomes - immunology extracellular vesicles Fibroblasts Fibroblasts - metabolism Fundamental and applied biological sciences. Psychology Fundamental immunology gamma -Interferon Hairless Humans Hypersensitivity Immunoglobulin E Immunoglobulin E - blood Immunopathology Infection Inflammation Interleukin 17 Interleukin 4 Interleukin 5 Interleukin 6 Leukocytes (eosinophilic) Macrophages Mast cells Media (culture) Medical sciences Mice Original Pathogenesis Rodents Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Serum levels Skin Skin allergic diseases. Stinging insect allergies skin inflammation Staphylococcus aureus Staphylococcus aureus - immunology Staphylococcus infections Thymic stromal lymphopoietin Time Factors Ultracentrifugation Vesicles |
| Title | Extracellular vesicles derived from Staphylococcus aureus induce atopic dermatitis-like skin inflammation |
| URI | https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fj.1398-9995.2010.02483.x https://www.ncbi.nlm.nih.gov/pubmed/20831718 https://www.proquest.com/docview/848565650 https://www.proquest.com/docview/849010781 https://www.proquest.com/docview/856787834 https://pubmed.ncbi.nlm.nih.gov/PMC3052535 |
| Volume | 66 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3LbtQwFLWgC8QGyrNpy8gLthlN4keSZQWtKtQiBIzUneUnREFJ1Uyqqqt-Qr-RL-HeJJ02ULFArCZSrjOJfa59bB_fS8hb6QqGZ87jXOQy5lqL2GC4u4XFPZ7MSenxNPLxR3m45B9OxMmof8KzMEN8iPWCG3pG31-jg2vTTp2cFeCsRSFGhVbKczZHPpkwiWH033--jSSVjcstQCdiDk4-FfXc-yAYbYJuUCypW6ivMCS6uI-J_imovEt0-5Hq4Cmpbr5xEKhU825l5vbyt_CP_6cSNsmTkdDSvQGBz8gDXz8nj47HLfsXpNq_gJfF_QEUvNJz3_ZCPOoA-ufeUTzfQoHyQnPDuNpY27VUd2cefsraAfCoXjWnpcUCPbsu259X1z_KytO2KmswCgDq4QDmS7I82P_67jAeMzzEAWZKLGY8C8BhgHVlJvEBug_nxMIULrW5NZrrYiHz4IXVUrrUS5v5wlrOAwyrVgTGXpGNuqn9FqGpYyaRVjInGYdJpEkZGItghHQy5ToiW9CaSn-DvlMtv6S4YwvktUi4iMhs0sTqdAj0oYDOZDnwxYjs3LS5Gl28VTnPkQyLRUTo-i74Jlaorn3ToQmKX7I8-YuJALaAyU4i8nrA0O2_YxI4oA4RySboWhtgZPDpnbr83kcIZ5idkMGHyR486xJ3ZnwAG4WwUQgb1cNGXai9oyO82v7Xgjvk8bDojiK9XbKxOuv8G2BtKzMjD1P-adZ75S8kODhC |
| linkProvider | Wiley-Blackwell |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9NAEB6hIgEX3rSmUPbA1VHifdg-VqhVgKQHaKTeVut9gJXKruq4qjjxE_iN_BJmbDdtoOKAOMWSZx1795vdb3deAG-VyznFnMeZzFQsjJFxQenuxpZsPKlTylM08vxITRfiw4k8GcoBUSxMnx9ifeBGmtHN16TgdCC9qeU8R23Nczm4aCUi4yMklHc7cx0xpE_XuaTS4cAFCUUsUM033XpufRKuN8HU5C5pGuyx0Je6uI2L_ulSeZPqdmvV4SM4vfrK3kVlOWpXxch--y0B5H_qhsfwcOC0bL8H4RO446uncG8-WO2fwfLgEt-WTATk88oufNP54jGH6L_wjlGIC0PWiyOOS2ttbdsw0557_Ckrh9hjZlWflZYadAS7bH5-_3FaLj1rlmWFQgFx3cdgPofF4cHxu2k8FHmIA26WeMxFGpDGIPFKi4kPOIM4J8dF7hKb2cIIk49VFry0RimXeGVTn1srRMCV1crA-QvYqurK7wBLHC8myiruFBe4jywSjsIyFFI5lQgTwQ4OpzZfcPrUi88JGW2Rv-YTISPY2xhjfdbn-tDIaNIMKWMEu1eDrgctb3QmMuLDchwBW99F9aQONZWvWxIh_5c0m_xFRCJhoHonEWz3ILr-d6oDh-whgnQDXmsBSg6-eacqv3ZJwjkVKOT4YapDz7rFjU0fwkYTbDTBRnew0Zd6fzajq5f_2vAN3J8ez2d69v7o4y486M_gyWfvFWytzlv_GkncqtjrlPMXPE07iQ |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9NAEB6hVqq4IMqrprTsgatR4n14faygUYG0qgSRelut9wFWkBPVTdUjP4HfyC9hxnZNLSoOnBLJs4m8-83ON7vzAHijfMEp5zzVUqtUWCvTksrdTRzd8eReqUDZyKdn6mQhPl7Iiz7-iXJhuvoQw4EbaUa7X5OCr30cKzkvUFmLQvYRWpnQ_C3yyW2BMCS0Z-J82JXz_rwF-UQqUMvHUT33_hKam2hXFC1pG5yw2HW6uI-K_h1ReZfptqZq9hge9RyTHXWg2IUHoX4CO6f9LfpTWB7f4HA6sqcYVHYdmjY2jnlE43XwjFJOGLJQXAE0dSvnNg2zm8uAH-jBIxYYeurrytGAlvBWza8fP79Xy8CaZVWjUEScdTmRz2AxO_7y7iTtmy6kEZ0XnnKRR6QVSITychoiarT3clIWPnPalVbYYqJ0DNJZpXwWlMtD4ZwQES2dk5Hz57BVr-qwByzzvJwqp7hXXKBfV2YchWUspfIqEzaBPZxfY7_idmYWnzO6REU-WUyFTOBwNOlm3dXeMMgwco0ULoH921UwvdY1RgtN_FROEmDDU1QXmlBbh9WGRCgeJdfTf4hINODUfySBF92q_vl36suG1jyBfLTegwAV6x4_qatvbdFuTg0DOb6YapExjLjjhCEIDYHQEAhNC0JzY47mc_r28n8Hvoad8_czM_9w9mkfHnZH4hRC9wq2ri434QA51VV52CrLb-KZFyU |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Extracellular+vesicles+derived+from+Staphylococcus+aureus+induce+atopic+dermatitis-like+skin+inflammation&rft.jtitle=Allergy+%28Copenhagen%29&rft.au=Hong%2C+S-W&rft.au=Kim%2C+M-R&rft.au=Lee%2C+E-Y&rft.au=Kim%2C+J+H&rft.date=2011-03-01&rft.pub=Blackwell+Publishing+Ltd&rft.issn=0105-4538&rft.eissn=1398-9995&rft.volume=66&rft.issue=3&rft.spage=351&rft.epage=359&rft_id=info:doi/10.1111%2Fj.1398-9995.2010.02483.x&rft_id=info%3Apmid%2F20831718&rft.externalDocID=PMC3052535 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0105-4538&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0105-4538&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0105-4538&client=summon |