Efficacy and Safety of Antioxidant Treatment With α-Lipoic Acid Over 4 Years in Diabetic Polyneuropathy: The NATHAN 1 trial - Ziegler, Dan; Low, Phillip A; Litchy, William J; Boulton, Andrew J.M; Vinik, Aaron I; Freeman, Roy; Samigullin, Rustem; Tritschler, Hans; Munzel, Ullrich; Maus, Joachim; Schütte, Klemens; Dyck, Peter J (Diabetes care, 2011)
Keywords: Adolescent; Adult; adverse effects; Antioxidants; Antioxidants - adverse effects; Antioxidants - therapeutic use; Biological and medical sciences; Diabetes; Diabetes. Impaired glucose tolerance; Diabetic Neuropathies; Diabetic Neuropathies - drug therapy; Diabetic Neuropathies - pathology; Diabetics; Diet therapy; drug therapy; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Female; Humans; lipoic acid; Male; Medical sciences; Metabolic diseases; Middle Aged; Miscellaneous; nerve tissue; oral administration; Original Research; pathology; patients; peripheral nervous system diseases; Polyneuropathies; Public health. Hygiene; Public health. Hygiene-occupational medicine; therapeutic use; Thioctic Acid; Thioctic Acid - adverse effects; Thioctic Acid - therapeutic use; Treatment Outcome; Young Adult; Serbia; Germany; Endocrinopathy; Human; Lipoic acid; Nervous system diseases; Trial; Nutrition; Toxicity; Diabetes mellitus; Treatment efficiency; Metabolic diseases; Antioxidant; Polyneuropathy; Treatment; Clinical trial; Peripheral nerve disease; Safety; Endocrinology