Structure and anticoagulant activity of sulfated fucans. Comparison between the regular, repetitive, and linear fucans from echinoderms with the more heterogeneous and branched polymers from brown algae - Pereira, M.S. (Universidade Federal do Rio de Janeiro, Brazil.); Mulloy, B; Mourao, P.A.S (The Journal of biological chemistry, 1999)
Keywords: Animals; antagonists & inhibitors; Anticoagulants; Anticoagulants - chemistry; Anticoagulants - isolation & purification; Anticoagulants - pharmacology; ANTITHROMBIN; ARBACIA LIXULA; ASCOPHYLLUM NODOSUM; BLOOD COAGULATION; BLOOD COAGULATION FACTORS; BLOOD PROTEINS; Carbohydrate Sequence; CHEMICAL STRUCTURE; chemistry; Chromatography, Ion Exchange; COAGULACION SANGUINEA; COAGULATION SANGUINE; ECHINODERMATA; Echinodermata - chemistry; ESPECTROSCOPIA RMN; ESTRUCTURA QUIMICA; FACTOR X; FUCUS VESICULOSUS; In Vitro Techniques; isolation & purification; LAMINARIA; LAMINARIA BRASILIENSIS; LUDWIGOTHUREA GRISEA; LYTECHINUS VARIEGATUS; Magnetic Resonance Spectroscopy; MEDICINAL PROPERTIES; Molecular Sequence Data; NMR SPECTROSCOPY; nuclear magnetic resonance spectroscopy; Partial Thromboplastin Time; PHAEOPHYCEAE; Phaeophyceae - chemistry; Phaeophycophyta; Phaeophyta; pharmacology; POLISACARIDOS; POLYHOLOSIDE; Polymers; POLYSACCHARIDES; Polysaccharides - chemistry; Polysaccharides - isolation & purification; Polysaccharides - pharmacology; PROPIEDADES MEDICINALES; PROPRIETE PHARMACOLOGIQUE; PROTEINAS SANGUINEAS; PROTEINE SANGUINE; Sea Cucumbers; Sea Cucumbers - chemistry; Sea Urchins; Sea Urchins - chemistry; SPECTROSCOPIE RMN; STRUCTURE CHIMIQUE; SULFATED POLYSACCHARIDES; THROMBIN; Thrombin - antagonists & inhibitors