TDP-43 Depletion in Microglia Promotes Amyloid Clearance but Also Induces Synapse Loss - Paolicelli, Rosa C.; Jawaid, Ali; Henstridge, Christopher M.; Valeri, Andrea; Merlini, Mario; Robinson, John L.; Lee, Edward B.; Rose, Jamie; Appel, Stanley; Lee, Virginia M.-Y.; Trojanowski, John Q.; Spires-Jones, Tara; et al. (Neuron (Cambridge, Mass.), 2017)
Keywords: Alzheimer's disease; Amyloid; Amyloid - genetics; Amyloid - metabolism; Amyotrophic Lateral Sclerosis; Amyotrophic Lateral Sclerosis - pathology; Animals; Brain; Brain - metabolism; Brain - pathology; Central nervous system; Clearance; Cognition - physiology; Cognitive ability; Deoxyribonucleic acid; Disease; DNA; DNA-Binding Proteins - genetics; Frontotemporal Lobar Degeneration; Genes; Homeostasis; Life span; Mice, Transgenic; Microglia; Microglia - metabolism; Nervous system; Neurodegeneration; Neurodegenerative diseases; Pathogenesis; Pathology; Peptides; Phagocytes; Phagocytosis; Proteins; Ribonucleic acid; RNA; RNA-binding protein; Rodents; Synapse Loss; Synapses; Synapses - metabolism; Synapses - pathology; Synaptic Pruning; Tardbp; TDP-43; Transgenic animals; β-Amyloid; Alzheimer’s Disease; Amyotrophic Lateral Sclerosis; Synapse Loss; TDP-43; Frontotemporal Lobar Degeneration; Synaptic Pruning; Amyloid; Clearance; Tardbp; Phagocytosis; Microglia