In vivo tumorigenesis by Jaagsiekte sheep retrovirus (JSRV) requires Y590 in Env TM, but not full-length orfX open reading frame
Jaagsiekte retrovirus (JSRV) causes ovine pulmonary adenocarcinoma (OPA), a transmissible lung cancer of sheep. The envelope (Env) glycoprotein protein of JSRV functions as a dominant oncoprotein in vitro and in vivo. An SH2 binding domain (YXXM) in the cytoplasmic tail of the JSRV Env is one of the...
Saved in:
| Published in | Virology (New York, N.Y.) Vol. 367; no. 2; pp. 413 - 421 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
25.10.2007
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 0042-6822 1096-0341 |
| DOI | 10.1016/j.virol.2007.06.004 |
Cover
| Abstract | Jaagsiekte retrovirus (JSRV) causes ovine pulmonary adenocarcinoma (OPA), a transmissible lung cancer of sheep. The envelope (Env) glycoprotein protein of JSRV functions as a dominant oncoprotein
in vitro and
in vivo. An SH2 binding domain (YXXM) in the cytoplasmic tail of the JSRV Env is one of the main determinants of viral transformation at least
in vitro. In these studies, we report the first
in vivo tests of site-specific mutants of JSRV in their natural host, the sheep. We show that,
in vivo, JSRV
21 with the cytoplasmic tail YXXM mutated to DXXM did not cause disease nor detectable infection, indicating that this motif is absolutely required for virus replication and possibly transformation
in vivo. In contrast, mutation of the JSRV open reading frame
orfX, for which no function has yet been attributed, did not alter the disease induced by JSRV
21. |
|---|---|
| AbstractList | Jaagsiekte retrovirus (JSRV) causes ovine pulmonary adenocarcinoma (OPA), a transmissible lung cancer of sheep. The envelope (Env) glycoprotein protein of JSRV functions as a dominant oncoprotein in vitro and in vivo. An SH2 binding domain (YXXM) in the cytoplasmic tail of the JSRV Env is one of the main determinants of viral transformation at least in vitro. In these studies, we report the first in vivo tests of site-specific mutants of JSRV in their natural host, the sheep. We show that, in vivo, JSRV sub(2) sub(1) with the cytoplasmic tail YXXM mutated to DXXM did not cause disease nor detectable infection, indicating that this motif is absolutely required for virus replication and possibly transformation in vivo. In contrast, mutation of the JSRV open reading frame orfX, for which no function has yet been attributed, did not alter the disease induced by JSRV sub(2) sub(1). Jaagsiekte retrovirus (JSRV) causes ovine pulmonary adenocarcinoma (OPA), a transmissible lung cancer of sheep. The envelope (Env) glycoprotein protein of JSRV functions as a dominant oncoprotein in vitro and in vivo. An SH2 binding domain (YXXM) in the cytoplasmic tail of the JSRV Env is one of the main determinants of viral transformation at least in vitro. In these studies, we report the first in vivo tests of site-specific mutants of JSRV in their natural host, the sheep. We show that, in vivo, JSRV(21) with the cytoplasmic tail YXXM mutated to DXXM did not cause disease nor detectable infection, indicating that this motif is absolutely required for virus replication and possibly transformation in vivo. In contrast, mutation of the JSRV open reading frame orfX, for which no function has yet been attributed, did not alter the disease induced by JSRV(21).Jaagsiekte retrovirus (JSRV) causes ovine pulmonary adenocarcinoma (OPA), a transmissible lung cancer of sheep. The envelope (Env) glycoprotein protein of JSRV functions as a dominant oncoprotein in vitro and in vivo. An SH2 binding domain (YXXM) in the cytoplasmic tail of the JSRV Env is one of the main determinants of viral transformation at least in vitro. In these studies, we report the first in vivo tests of site-specific mutants of JSRV in their natural host, the sheep. We show that, in vivo, JSRV(21) with the cytoplasmic tail YXXM mutated to DXXM did not cause disease nor detectable infection, indicating that this motif is absolutely required for virus replication and possibly transformation in vivo. In contrast, mutation of the JSRV open reading frame orfX, for which no function has yet been attributed, did not alter the disease induced by JSRV(21). Abstract Jaagsiekte retrovirus (JSRV) causes ovine pulmonary adenocarcinoma (OPA), a transmissible lung cancer of sheep. The envelope (Env) glycoprotein protein of JSRV functions as a dominant oncoprotein in vitro and in vivo . An SH2 binding domain (YXXM) in the cytoplasmic tail of the JSRV Env is one of the main determinants of viral transformation at least in vitro . In these studies, we report the first in vivo tests of site-specific mutants of JSRV in their natural host, the sheep. We show that, in vivo , JSRV21 with the cytoplasmic tail YXXM mutated to DXXM did not cause disease nor detectable infection, indicating that this motif is absolutely required for virus replication and possibly transformation in vivo . In contrast, mutation of the JSRV open reading frame orfX , for which no function has yet been attributed, did not alter the disease induced by JSRV21. Jaagsiekte retrovirus (JSRV) causes ovine pulmonary adenocarcinoma (OPA), a transmissible lung cancer of sheep. The envelope (Env) glycoprotein protein of JSRV functions as a dominant oncoprotein in vitro and in vivo. An SH2 binding domain (YXXM) in the cytoplasmic tail of the JSRV Env is one of the main determinants of viral transformation at least in vitro. In these studies, we report the first in vivo tests of site-specific mutants of JSRV in their natural host, the sheep. We show that, in vivo, JSRV 21 with the cytoplasmic tail YXXM mutated to DXXM did not cause disease nor detectable infection, indicating that this motif is absolutely required for virus replication and possibly transformation in vivo. In contrast, mutation of the JSRV open reading frame orfX, for which no function has yet been attributed, did not alter the disease induced by JSRV 21. Jaagsiekte retrovirus (JSRV) causes ovine pulmonary adenocarcinoma (OPA), a transmissible lung cancer of sheep. The envelope (Env) glycoprotein protein of JSRV functions as a dominant oncoprotein in vitro and in vivo . An SH2 binding domain (YXXM) in the cytoplasmic tail of the JSRV Env is one of the main determinants of viral transformation at least in vitro . In these studies, we report the first in vivo tests of site-specific mutants of JSRV in their natural host, the sheep. We show that, in vivo , JSRV 21 with the cytoplasmic tail YXXM mutated to DXXM did not cause disease nor detectable infection, indicating that this motif is absolutely required for virus replication and possibly transformation in vivo . In contrast, mutation of the JSRV open reading frame orfX , for which no function has yet been attributed, did not alter the disease induced by JSRV 21 . Jaagsiekte retrovirus (JSRV) causes ovine pulmonary adenocarcinoma (OPA), a transmissible lung cancer of sheep. The envelope (Env) glycoprotein protein of JSRV functions as a dominant oncoprotein in vitro and in vivo. An SH2 binding domain (YXXM) in the cytoplasmic tail of the JSRV Env is one of the main determinants of viral transformation at least in vitro. In these studies, we report the first in vivo tests of site-specific mutants of JSRV in their natural host, the sheep. We show that, in vivo, JSRV(21) with the cytoplasmic tail YXXM mutated to DXXM did not cause disease nor detectable infection, indicating that this motif is absolutely required for virus replication and possibly transformation in vivo. In contrast, mutation of the JSRV open reading frame orfX, for which no function has yet been attributed, did not alter the disease induced by JSRV(21). |
| Author | Dagleish, Mark P. Cousens, Chris Fan, Hung Maeda, Naoyoshi Murgia, Claudio Palmarini, Massimo |
| AuthorAffiliation | b University of California Irvine, Irvine, California c Institute of Comparative Medicine, University of Glasgow Veterinary School, Glasgow, UK a Moredun Research Institute, Edinburgh, UK |
| AuthorAffiliation_xml | – name: c Institute of Comparative Medicine, University of Glasgow Veterinary School, Glasgow, UK – name: a Moredun Research Institute, Edinburgh, UK – name: b University of California Irvine, Irvine, California |
| Author_xml | – sequence: 1 givenname: Chris surname: Cousens fullname: Cousens, Chris email: chris.cousens@moredun.ac.uk organization: Moredun Research Institute, Pentlands Science Park, Penicuik, Edinburgh, EH28 0PZ, UK – sequence: 2 givenname: Naoyoshi surname: Maeda fullname: Maeda, Naoyoshi organization: University of California Irvine, Irvine, CA, USA – sequence: 3 givenname: Claudio surname: Murgia fullname: Murgia, Claudio organization: Institute of Comparative Medicine, University of Glasgow Veterinary School, Glasgow, UK – sequence: 4 givenname: Mark P. surname: Dagleish fullname: Dagleish, Mark P. organization: Moredun Research Institute, Pentlands Science Park, Penicuik, Edinburgh, EH28 0PZ, UK – sequence: 5 givenname: Massimo surname: Palmarini fullname: Palmarini, Massimo organization: Institute of Comparative Medicine, University of Glasgow Veterinary School, Glasgow, UK – sequence: 6 givenname: Hung surname: Fan fullname: Fan, Hung organization: University of California Irvine, Irvine, CA, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/17610928$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFUk1v1DAQtVAR3RZ-ARLyCVGpCeN8OF5VIKGqQKsiJFpQOVlOMsl6m9hbO4m0N346Di0FDqgn2-M3783H2yM7xhok5DmDmAHjr9fxpJ3t4gSgiIHHANkjsmCw5BGkGdshixBJIi6SZJfseb-G8C4KeEJ2WcEDLhEL8uPU0ElPlg5jb51u0aDXnpZbeqZU6zVeD0j9CnFDHQ7OBsnR01dnF1--HYTIzagdevo9XwLVhp6YiV5-OqTlOFBjB9qMXRd1aNphRa1rrqjdoAlpqtampY1TPT4ljxvVeXx2d-6Tr-9PLo8_RuefP5wevzuPMMv5EDUCynRZgGI5YCawYIkQucIU6mVWVSpNRVFxVZdLobKalyyFEspcsLLIRZpjuk_e3vJuxrLHukIzONXJjdO9cltplZb__hi9kq2dZAI8F1keCF7eETh7M6IfZK99hV2nDNrRSx5kijTLHgSy0EbOxMz44u-S7mv5vZ0AeHMLwDCYSaOTvtJoKqzD1KtB1lZLBnJ2g1zLX26QsxskcBl2_afn-_yq00ZXqrvGLfq1HZ0JM5dM-kSCvJj9MtsFinBj2VUgOPo_wYPyPwHVMdOP |
| ContentType | Journal Article |
| Copyright | 2007 Elsevier Inc. Elsevier Inc. |
| Copyright_xml | – notice: 2007 Elsevier Inc. – notice: Elsevier Inc. |
| DBID | 6I. AAFTH CGR CUY CVF ECM EIF NPM 7TM 7U9 H94 7X8 5PM |
| DOI | 10.1016/j.virol.2007.06.004 |
| DatabaseName | ScienceDirect Open Access Titles Elsevier:ScienceDirect:Open Access Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Nucleic Acids Abstracts Virology and AIDS Abstracts AIDS and Cancer Research Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) AIDS and Cancer Research Abstracts Virology and AIDS Abstracts Nucleic Acids Abstracts MEDLINE - Academic |
| DatabaseTitleList | AIDS and Cancer Research Abstracts MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology |
| EISSN | 1096-0341 |
| EndPage | 421 |
| ExternalDocumentID | PMC2065845 17610928 S004268220700414X 1_s2_0_S004268220700414X |
| Genre | Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural |
| GrantInformation_xml | – fundername: NCI NIH HHS grantid: R01 CA95706 – fundername: NCI NIH HHS grantid: R01 CA095706 – fundername: NCI NIH HHS grantid: R01 CA082564 – fundername: NCI NIH HHS grantid: R01 CA82564 |
| GroupedDBID | --- --K --M -DZ -~X .1- .55 .FO .GJ .~1 0R~ 123 1B1 1P~ 1RT 1~. 1~5 29Q 3O- 4.4 457 4G. 53G 5RE 5VS 7-5 71M 8P~ 9JM AAAJQ AABNK AAEDT AAEDW AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AARKO AATTM AAXKI AAXUO AAYWO ABBQC ABEFU ABFNM ABFRF ABJNI ABMAC ABMZM ABXDB ACDAQ ACGFO ACGFS ACIEU ACRLP ACRPL ACVFH ADBBV ADCNI ADEZE ADFGL ADMUD ADNMO ADVLN AEBSH AEFWE AEIPS AEKER AENEX AEUPX AEVXI AEXQZ AFFNX AFJKZ AFPUW AFRHN AFTJW AFXIZ AGCQF AGEKW AGHFR AGQPQ AGUBO AGYEJ AHHHB AIEXJ AIGII AIIUN AIKHN AITUG AJRQY AJUYK AKBMS AKRWK AKYEP ALMA_UNASSIGNED_HOLDINGS AMRAJ ANKPU ANZVX APXCP ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC BNPGV CAG CJTIS COF CS3 DM4 DU5 EBS EFBJH EFKBS EJD EO8 EO9 EP2 EP3 F5P FA8 FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA HEJ HMG HMK HMO HVGLF HX~ HZ~ H~9 IHE IXB J1W KOM LG5 LUGTX LZ5 M29 M41 MO0 MVM N9A O-L O9- OAUVE OD- OHT OK1 OO. OZT P-8 P-9 P2P PC. Q38 Q44 R2- ROL RPZ SAE SCC SDF SDG SDP SES SEW SIN SSH SSI SSZ T5K TN5 UAP UQL WH7 WUQ X7M XOL XPP Y6R Z5R ZGI ZKB ZMT ZU3 ~G- ~KM 0SF 6I. AACTN AAFTH ABVKL AFCTW AFKWA AJOXV AMFUW NCXOZ RIG AAIAV ABLVK ABYKQ AFDAS AFMIJ AHPSJ AJBFU EFLBG LCYCR AGRNS CGR CUY CVF ECM EIF NPM 7TM 7U9 ACLOT H94 ~HD 7X8 5PM |
| ID | FETCH-LOGICAL-e456t-f80b3970a150e48e712885ae30d94cca3387c6adb98a4d6b130b0b581b75835e3 |
| IEDL.DBID | AIKHN |
| ISSN | 0042-6822 |
| IngestDate | Thu Aug 21 13:29:31 EDT 2025 Fri Sep 05 10:12:24 EDT 2025 Thu Sep 25 08:35:33 EDT 2025 Mon Jul 21 05:51:51 EDT 2025 Fri Feb 23 02:33:29 EST 2024 Sun Feb 23 10:19:49 EST 2025 Tue Aug 26 17:17:35 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 2 |
| Keywords | OrfX Oncogenesis Jaagsiekte sheep retrovirus Envelope JSRV |
| Language | English |
| License | http://www.elsevier.com/open-access/userlicense/1.0 |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-e456t-f80b3970a150e48e712885ae30d94cca3387c6adb98a4d6b130b0b581b75835e3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| OpenAccessLink | https://www.sciencedirect.com/science/article/pii/S004268220700414X |
| PMID | 17610928 |
| PQID | 19705185 |
| PQPubID | 23462 |
| PageCount | 9 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_2065845 proquest_miscellaneous_68357344 proquest_miscellaneous_19705185 pubmed_primary_17610928 elsevier_sciencedirect_doi_10_1016_j_virol_2007_06_004 elsevier_clinicalkeyesjournals_1_s2_0_S004268220700414X elsevier_clinicalkey_doi_10_1016_j_virol_2007_06_004 |
| PublicationCentury | 2000 |
| PublicationDate | 2007-10-25 |
| PublicationDateYYYYMMDD | 2007-10-25 |
| PublicationDate_xml | – month: 10 year: 2007 text: 2007-10-25 day: 25 |
| PublicationDecade | 2000 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | Virology (New York, N.Y.) |
| PublicationTitleAlternate | Virology |
| PublicationYear | 2007 |
| Publisher | Elsevier Inc |
| Publisher_xml | – name: Elsevier Inc |
| References | Hull, Fan (bib16) 2006; 80 De las Heras, Ortin, Salvatori, Perez de Villareal, Cousens, Miguel Ferrer, Miguel Cebrian, Garcia de Jalon, Gonzalez, Sharp (bib11) 2005; 79 Maeda, Inoshima, Fruman, Brachmann, Fan (bib19) 2003; 77 Cousens, Minguijon, Dalziel, Ortin, Garcia, Park, Gonzalez, Sharp, De las Heras (bib8) 1999; 73 Bai, Bishop, Carlson, DeMartini (bib3) 1999; 258 Danilkovitch-Miagkova, Duh, Kuzmin, Angeloni, Liu, Miller, Lerman (bib10) 2003; 100 Maeda, Fu, Ortin, De las Heras, Fan (bib20) 2005; 79 Hofacre, Fan (bib14) 2004; 78 York, Vigne, Verwoerd, Querat (bib39) 1992; 66 Rai, Duh, Vigdorovich, Danilkovitch-Miagkova, Lerman, Miller (bib31) 2001; 98 Palmarini, Fan (bib23) 2001; 93 Wootton, Halbert, Miller (bib38) 2005; 434 Allen, Sherrill, Crispell, Perrott, Carlson, DeMartini (bib2) 2002; 83 Maeda, Palmarini, Murgia, Fan (bib18) 2001; 98 Palmarini, Sharp, De las Heras, Fan (bib25) 1999; 73 Palmarini, Maeda, Murgia, De-Fraja, Hofacre, Fan (bib28) 2001; 75 Chow, Alberti, Mura, Pretto, Murcia, Albritton, Palmarini (bib7) 2003; 77 Cousens, C., Graham, M., Sales, J., Dagleish, M., in press. Evaluation of the efficacy of clinical diagnosis of ovine pulmonary adenocarcinoma (Jaagsiekte). Vet.Record. Gonzalez, Garcia-Goti, Cousens, Dewar, Cortabarria, Extramiana, Ortin, De las Heras, Sharp (bib13) 2001; 82 Blot, Lopez-Verges, Breton, Pique, Berlioz-Torrent, Grange (bib4) 2006; 3 Palmarini, Hallwirth, York, Murgia, De Oliveira, Spencer, Fan (bib27) 2000; 74 Summers, Norval, De las Heras, Gonzalez, Sharp, Woods (bib37) 2005; 106 Caporale, Centorame, Giovannini, Sacchini, Di Ventura, De las Heras, Palmarini (bib5) 2005; 338 Holland, Palmarini, Garcia-Goti, Gonzalez, McKendrick, De las Heras, Sharp (bib15) 1999; 73 Mornex, Thivolet, De las Heras, Leroux (bib22) 2003; 275 Russell, Burch (bib33) 1959 Summers, Neill, Dewar, Gonzalez, van de Molen, Norval, Sharp (bib36) 2002; 83 Perk, Hod (bib30) 1982; 69 Flecknell (bib12) 2002; 19 Palmarini, Holland, Cousens, Dalziel, Sharp (bib24) 1996; 77 Zavala, Pretto, Chow, Jones, Alberti, Grego, De las Heras, Palmarini (bib40) 2003; 312 Liu, Miller (bib17) 2005; 79 Rosati, Pittau, Alberti, Pozzi, York, Sharp, Palmarini (bib32) 2000; 66 Palmarini, Sharp, Lee, Fan (bib26) 1999; 73 Martin, Scott, Sharp, Angus, Norval (bib21) 1976; 264 Alberti, Murgia, Liu, Mura, Cousens, Sharp, Miller, Palmarini (bib1) 2002; 76 Palmarini, Murgia, Fan (bib29) 2002; 294 Suau, Cottin, Archer, Croze, Chastang, Cordier, Thivolet-Bejui, Mornex, Leroux (bib35) 2006; 27 Caporale, Cousens, Centorame, Pinoni, De las Heras, Palmarini (bib6) 2006; 80 Salvatori, Gonzalez, Dewar, Cousens, De las Heras, Dalziel, Sharp (bib34) 2004; 85 |
| References_xml | – volume: 275 start-page: 225 year: 2003 end-page: 248 ident: bib22 article-title: Pathology of human bronchioloalveolar carcinoma and its relationship to the ovine disease publication-title: Curr. Top. Microbiol. Immunol. – volume: 77 start-page: 6341 year: 2003 end-page: 6350 ident: bib7 article-title: Transformation of rodent fibroblasts by the jaagsiekte sheep retrovirus envelope is receptor independent and does not require the surface domain publication-title: J. Virol. – volume: 79 start-page: 927 year: 2005 end-page: 933 ident: bib17 article-title: Transformation of Madin–Darby canine kidney epithelial cells by sheep retrovirus envelope proteins publication-title: J. Virol. – year: 1959 ident: bib33 article-title: The Principles of Humane Experimental Technique – volume: 73 start-page: 4004 year: 1999 end-page: 4008 ident: bib15 article-title: Jaagsiekte retrovirus is widely distributed both in T and B lymphocytes and in mononuclear phagocytes of sheep with naturally and experimentally acquired pulmonary adenomatosis publication-title: J. Virol. – volume: 73 start-page: 3986 year: 1999 end-page: 3993 ident: bib8 article-title: Complete sequence of enzootic nasal tumor virus, a retrovirus associated with transmissible intranasal tumors of sheep publication-title: J. Virol. – volume: 66 start-page: 4930 year: 1992 end-page: 4939 ident: bib39 article-title: Nucleotide sequence of the jaagsiekte retrovirus, an exogenous and endogenous type D and B retrovirus of sheep and goats publication-title: J. Virol. – volume: 106 start-page: 285 year: 2005 end-page: 294 ident: bib37 article-title: An influx of macrophages is the predominant local immune response in ovine pulmonary adenocarcinoma publication-title: Vet. Immunol. Immunopathol. – volume: 77 start-page: 9951 year: 2003 end-page: 9959 ident: bib19 article-title: Transformation of mouse fibroblasts by Jaagsiekte sheep retrovirus envelope does not require phosphatidylinositol 3-kinase publication-title: J. Virol. – volume: 80 start-page: 8069 year: 2006 end-page: 8080 ident: bib16 article-title: Mutational analysis of the cytoplasmic tail of jaagsiekte sheep retrovirus envelope protein publication-title: J. Virol. – volume: 98 start-page: 4449 year: 2001 end-page: 4454 ident: bib18 article-title: Direct transformation of rodent fibroblasts by jaagsiekte sheep retrovirus DNA publication-title: Proc. Natl. Acad. Sci. U. S. A. – volume: 73 start-page: 6964 year: 1999 end-page: 6972 ident: bib25 article-title: Jaagsiekte sheep retrovirus is necessary and sufficient to induce a contagious lung cancer in sheep publication-title: J. Virol. – volume: 85 start-page: 3319 year: 2004 end-page: 3324 ident: bib34 article-title: Successful induction of ovine pulmonary adenocarcinoma in lambs of different ages and detection of viraemia during the preclinical period publication-title: J. Gen. Virol. – volume: 27 start-page: 1175 year: 2006 end-page: 1182 ident: bib35 article-title: Telomerase activation in a model of lung adenocarcinoma publication-title: Eur. Respir. J. – volume: 69 start-page: 747 year: 1982 end-page: 749 ident: bib30 article-title: Sheep lung carcinoma: an endemic analogue of a sporadic human neoplasm publication-title: J. Natl. Cancer Inst. – volume: 3 start-page: 62 year: 2006 ident: bib4 article-title: The conserved dileucine- and tyrosine-based motifs in MLV and MPMV envelope glycoproteins are both important to regulate a common Env intracellular trafficking publication-title: Retrovirology – reference: Cousens, C., Graham, M., Sales, J., Dagleish, M., in press. Evaluation of the efficacy of clinical diagnosis of ovine pulmonary adenocarcinoma (Jaagsiekte). Vet.Record. – volume: 78 start-page: 10479 year: 2004 end-page: 10489 ident: bib14 article-title: Multiple domains of the Jaagsiekte sheep retrovirus envelope protein are required for transformation of rodent fibroblasts publication-title: J. Virol. – volume: 79 start-page: 4440 year: 2005 end-page: 4450 ident: bib20 article-title: Roles of the Ras-MEK-mitogen-activated protein kinase and phosphatidylinositol 3-kinase-Akt-mTOR pathways in Jaagsiekte sheep retrovirus-induced transformation of rodent fibroblast and epithelial cell lines publication-title: J. Virol. – volume: 73 start-page: 10070 year: 1999 end-page: 10078 ident: bib26 article-title: In vitro infection of ovine cell lines by Jaagsiekte sheep retrovirus publication-title: J. Virol. – volume: 258 start-page: 333 year: 1999 end-page: 343 ident: bib3 article-title: Sequence comparison of JSRV with endogenous proviruses: envelope genotypes and a novel ORF with similarity to a G-protein-coupled receptor publication-title: Virology – volume: 98 start-page: 4443 year: 2001 end-page: 4448 ident: bib31 article-title: Candidate tumor suppressor HYAL2 is a glycosylphosphatidylinositol (GPI)-anchored cell-surface receptor for jaagsiekte sheep retrovirus, the envelope protein of which mediates oncogenic transformation publication-title: Proc. Natl. Acad. Sci. U. S. A. – volume: 19 start-page: 73 year: 2002 end-page: 78 ident: bib12 article-title: Replacement, reduction and refinement publication-title: ALTEX – volume: 338 start-page: 144 year: 2005 end-page: 153 ident: bib5 article-title: Infection of lung epithelial cells and induction of pulmonary adenocarcinoma is not the most common outcome of naturally occurring JSRV infection during the commercial lifespan of sheep publication-title: Virology – volume: 264 start-page: 183 year: 1976 end-page: 185 ident: bib21 article-title: Experimental production of sheep pulmonary adenomatosis (Jaagsiekte) publication-title: Nature – volume: 83 start-page: 1753 year: 2002 end-page: 1757 ident: bib36 article-title: Systemic immune responses following infection with Jaagsiekte sheep retrovirus and in the terminal stages of ovine pulmonary adenocarcinoma publication-title: J. Gen. Virol. – volume: 66 start-page: 109 year: 2000 end-page: 116 ident: bib32 article-title: An accessory open reading frame (orf-x) of jaagsiekte sheep retrovirus is conserved between different virus isolates publication-title: Virus Res. – volume: 79 start-page: 259 year: 2005 end-page: 264 ident: bib11 article-title: A PCR technique for the detection of Jaagsiekte sheep retrovirus in the blood suitable for the screening of ovine pulmonary adenocarcinoma in field conditions publication-title: Res.Vet. Sci. – volume: 294 start-page: 180 year: 2002 end-page: 188 ident: bib29 article-title: Spliced and prematurely polyadenylated Jaagsiekte sheep retrovirus-specific RNAs from infected or transfected cells publication-title: Virology – volume: 76 start-page: 5387 year: 2002 end-page: 5394 ident: bib1 article-title: Envelope-induced cell transformation by ovine betaretroviruses publication-title: J. Virol. – volume: 74 start-page: 8065 year: 2000 end-page: 8076 ident: bib27 article-title: Molecular cloning and functional analysis of three type D endogenous retroviruses of sheep reveal a different cell tropism from that of the highly related exogenous jaagsiekte sheep retrovirus publication-title: J. Virol. – volume: 77 start-page: 2991 year: 1996 end-page: 2998 ident: bib24 article-title: Jaagsiekte retrovirus establishes a disseminated infection of the lymphoid tissues of sheep affected by pulmonary adenomatosis publication-title: J. Gen. Virol. – volume: 80 start-page: 8030 year: 2006 end-page: 8037 ident: bib6 article-title: Expression of the jaagsiekte sheep retrovirus envelope glycoprotein is sufficient to induce lung tumors in sheep publication-title: J. Virol. – volume: 93 start-page: 1603 year: 2001 end-page: 1614 ident: bib23 article-title: Retrovirus-induced ovine pulmonary adenocarcinoma, an animal model for lung cancer publication-title: J. Natl. Cancer Inst. – volume: 434 start-page: 904 year: 2005 end-page: 907 ident: bib38 article-title: Sheep retrovirus structural protein induces lung tumours publication-title: Nature – volume: 100 start-page: 4580 year: 2003 end-page: 4585 ident: bib10 article-title: Hyaluronidase 2 negatively regulates RON receptor tyrosine kinase and mediates transformation of epithelial cells by jaagsiekte sheep retrovirus publication-title: Proc. Natl. Acad. Sci. U. S. A. – volume: 312 start-page: 95 year: 2003 end-page: 105 ident: bib40 article-title: Relevance of Akt phosphorylation in cell transformation induced by Jaagsiekte sheep retrovirus publication-title: Virology – volume: 83 start-page: 2733 year: 2002 end-page: 2742 ident: bib2 article-title: The jaagsiekte sheep retrovirus envelope gene induces transformation of the avian fibroblast cell line DF-1 but does not require a conserved SH2 binding domain publication-title: J. Gen.Virol. – volume: 82 start-page: 1355 year: 2001 end-page: 1358 ident: bib13 article-title: Jaagsiekte sheep retrovirus can be detected in the peripheral blood during the pre-clinical period of sheep pulmonary adenomatosis publication-title: J. Gen. Virol. – volume: 75 start-page: 11002 year: 2001 end-page: 11009 ident: bib28 article-title: A phosphatidylinositol 3-kinase docking site in the cytoplasmic tail of the Jaagsiekte sheep retrovirus transmembrane protein is essential for envelope-induced transformation of NIH 3T3 cells publication-title: J. Virol. |
| SSID | ssj0004770 |
| Score | 2.0559654 |
| Snippet | Jaagsiekte retrovirus (JSRV) causes ovine pulmonary adenocarcinoma (OPA), a transmissible lung cancer of sheep. The envelope (Env) glycoprotein protein of JSRV... Abstract Jaagsiekte retrovirus (JSRV) causes ovine pulmonary adenocarcinoma (OPA), a transmissible lung cancer of sheep. The envelope (Env) glycoprotein... |
| SourceID | pubmedcentral proquest pubmed elsevier |
| SourceType | Open Access Repository Aggregation Database Index Database Publisher |
| StartPage | 413 |
| SubjectTerms | Amino Acid Sequence Animals Carcinogenicity Tests Cell Line Cell Transformation, Viral - physiology Cytoplasm - chemistry Envelope Infectious Disease Jaagsiekte sheep retrovirus Jaagsiekte sheep retrovirus - chemistry Jaagsiekte sheep retrovirus - genetics Jaagsiekte sheep retrovirus - physiology JSRV Membrane Proteins - chemistry Membrane Proteins - metabolism Oncogenesis Open Reading Frames OrfX Sheep Viral Envelope Proteins - chemistry Viral Envelope Proteins - physiology |
| Title | In vivo tumorigenesis by Jaagsiekte sheep retrovirus (JSRV) requires Y590 in Env TM, but not full-length orfX open reading frame |
| URI | https://www.clinicalkey.com/#!/content/1-s2.0-S004268220700414X https://www.clinicalkey.es/playcontent/1-s2.0-S004268220700414X https://dx.doi.org/10.1016/j.virol.2007.06.004 https://www.ncbi.nlm.nih.gov/pubmed/17610928 https://www.proquest.com/docview/19705185 https://www.proquest.com/docview/68357344 https://pubmed.ncbi.nlm.nih.gov/PMC2065845 |
| Volume | 367 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Jb9QwFLbaqZC4IHaGpbwDB5AIzWLHybFUrWYGtQdoUThZfonDhCUZTTIj9YL46TxnGRgKQuIYx44T-_l9n523MPaMUIjnaF2U4xAdzjPtxK6vHak9xFRIxNbr_fQsnFzwWSKSHXY0-MJYs8pe93c6vdXWfclBP5oHi6KwPr6ELoRvro3Q7vFkl-35hPbRiO0dTt9Mzn66R0q58USxDYbgQ62Zl_Um-9KHMrT_JfgWKl1lnb8bT_6CRic32Y2eRsJh96a32I4pb7NrXWLJyzvs-7SEdbGuoFl9tamvrEIrasBLmGn9sS7M58ZAPTdmAUvT2FOF5aqG57N3b9-_oBJrHWxq-CBiF4oSjss1nJ--BFw1UFYN2CN7x2ZgaeZQLfMEbAouataa40Nuzb3usouT4_OjidPnWnAMUajGySMXiZq4mgii4ZGRhFuR0CZws5jTLNNOVqahzjCONM9CJOhDFwWRXtpwBMIE99iorErzgEGAyH3a2mVZ7vPMxRhJDsI0SnPaK6YCx4wPA6wG909SWIp0uBpszj6pdl5skkypWss7PmbyT81M3S-6Wnmq9pWrrgjGmIWblluy9e8unw7zr2jV2V8pujTVirqioRJEdf5eI6RRkQGnZ9zv5EUtuvAhypM2xL0f0QdtSdKmgo34vX2nLOZt5G-_JYzi4f9-0CN2vT2bJuz1xWM2apYr84RIVYP7bPfVN2-_Xzp0NU1e_wAgFyQ7 |
| linkProvider | Elsevier |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lj9MwELaWRQguiDfltT5wAIlo3cSOkyOsdtWW7R6gi8LJshOHhkdSNUmlvfHTmXGSQlkQEtfEjuPxeOYbex6EPActxHODIcpxaDzOM-3FzNee1GNjUiGNcVHv87Nwcs5niUj2yNEQC4Nulb3s72S6k9b9k8OemoerosAYX9AuoN8YZmgf8-QKuQpogCFrT5M3P4MjpdzGoWDzIfWQc_LCWLKvfSJDvJXgOzrpMub83XXyF110covc7EEkfd39522yZ8s75FpXVvLiLvk-Lemm2FS0ab9h4SsUZ0VNzQWdaf2pLuyXxtJ6ae2Krm2DZwrrtqYvZu_ffXgJT9A32Nb0o4gZLUp6XG7oYv6KmrahZdVQPLD3sP5Ks6TVOk8oFuCCbs4Zn-bo7HWPnJ8cL44mXl9pwbNAssbLI2YAmDAN8NDyyErQWpHQNmBZzGGNwY6VaagzE0eaZ6EBxWeYEQB5wdwIhA3uk_2yKu1DQgNjuA-GXZblPs-YiQ1wQZhGaQ6WYirMiPCBwGoI_gRxpUCCq8Hj7LNy64IlMqVyfnd8ROSfutm633K1GqvaV0xdYosRCbc9dzjr30MeDOuvYM_hRYoubdXCUEAqAUDn7y1CoIoMOHzjQccvatUlD1FjiQnu_QgmtMNJ2waY73v3TVksXd5v38FF8eh_J3RArk8W81N1Oj17-5jccKfUoIV98YTsN-vWPgV41Zhnbvv8AOFcJA8 |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=In+vivo+tumorigenesis+by+Jaagsiekte+sheep+retrovirus+%28JSRV%29+requires+Y590+in+Env+TM%2C+but+not+full+length+orfX+open+reading+frame&rft.jtitle=Virology+%28New+York%2C+N.Y.%29&rft.au=Cousens%2C+Chris&rft.au=Maeda%2C+Naoyoshi&rft.au=Murgia%2C+Claudio&rft.au=Dagleish%2C+Mark+P.&rft.date=2007-10-25&rft.issn=0042-6822&rft.eissn=1096-0341&rft.volume=367&rft.issue=2&rft.spage=413&rft.epage=421&rft_id=info:doi/10.1016%2Fj.virol.2007.06.004&rft_id=info%3Apmid%2F17610928&rft.externalDocID=PMC2065845 |
| thumbnail_m | http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=https%3A%2F%2Fcdn.clinicalkey.com%2Fck-thumbnails%2F00426822%2FS0042682207X08407%2Fcov150h.gif |