27-hydroxycholesterol impairs placental development via p53/p21/Cdk6 pathway: Implications for nutrient transport and cellular senescence - Chen, Zhaoyang; Cai, Xiaxia; Wei, Yuchen; Zhao, Xiaoyan; Dang, Qinyu; Zhu, Yandi; Gao, Min; Zhang, Yulu; Zhang, Yadi; Yu, Huanling (Biochimica et biophysica acta. General subjects, 2025)
Keywords: 27-hydroxycholesterol; Animals; Biological Transport - drug effects; cell cycle; cell senescence; Cellular senescence; Cellular Senescence - drug effects; Cyclin-Dependent Kinase 6 - genetics; Cyclin-Dependent Kinase 6 - metabolism; Cyclin-Dependent Kinase Inhibitor p21 - genetics; Cyclin-Dependent Kinase Inhibitor p21 - metabolism; Female; Humans; Hydroxycholesterols - pharmacology; hypercholesterolemia; Intrauterine growth restriction; Mice; nutrient transport; Nutrients - metabolism; phenotype; Placenta; Placenta - drug effects; Placenta - metabolism; Placentation - drug effects; Pregnancy; Signal Transduction - drug effects; Syncytiotrophoblast; transcriptome; trophoblast; Trophoblasts - drug effects; Trophoblasts - metabolism; Tumor Suppressor Protein p53 - genetics; Tumor Suppressor Protein p53 - metabolism; Intrauterine growth restriction; Syncytiotrophoblast; Placenta; 27-hydroxycholesterol; Cellular senescence