The discovery of benzoxazine sulfonamide inhibitors of NaV1.7: Tools that bridge efficacy and target engagement - La, Daniel S.; Peterson, Emily A.; Bode, Christiane; Boezio, Alessandro A.; Bregman, Howard; Chu-Moyer, Margaret Y.; Coats, James; DiMauro, Erin F.; Dineen, Thomas A.; Du, Bingfan; Gao, Hua; Graceffa, Russell; et al. (Bioorganic & medicinal chemistry letters, 2017)
Keywords: Medicinal chemistry; Nav1.7; Pharmacology; Structure activity relationship; Medicinal chemistry; MPE; LLE; SAR; VSD; HLM; PX; VDW; MW; Pharmacology; CIP; CLu; NaV1.7; RLM; Structure activity relationship; SCN9A; TM; MDCK