FRAIL衰弱量表及衰弱指数与老年维持性血液透析患者不良结局的相关性
目的 探讨FRAIL衰弱量表及衰弱指数(fragile index,FI)与老年维持性血液透析(maintenance hemodialysis,MHD)患者不良结局的相关性.方法 选取 2020年 6月至 2022年 12月在解放军第九六〇医院行MHD治疗的老年患者 116例,并按终点事件将其分为存活组(n=89)和死亡组(n=27).收集患者临床信息,并采用FRAIL衰弱量表和FI评估患者的衰弱状态,多因素Cox回归分析FRAIL衰弱量表和FI与不良结局的相关性,受试者工作特征(receiver operator characteristic,ROC)曲线评价FRAIL衰弱量表和FI对不良...
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| Published in | Linchuang Shenzangbing Zazhi Vol. 24; no. 11; pp. 894 - 898 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | Chinese |
| Published |
解放军第九六〇医院肾脏病科,济南 250031
2024
Editorial Department of Journal of Clinical Nephrology |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1671-2390 |
| DOI | 10.3969/j.issn.1671-2390.2024.11.003 |
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| Abstract | 目的 探讨FRAIL衰弱量表及衰弱指数(fragile index,FI)与老年维持性血液透析(maintenance hemodialysis,MHD)患者不良结局的相关性.方法 选取 2020年 6月至 2022年 12月在解放军第九六〇医院行MHD治疗的老年患者 116例,并按终点事件将其分为存活组(n=89)和死亡组(n=27).收集患者临床信息,并采用FRAIL衰弱量表和FI评估患者的衰弱状态,多因素Cox回归分析FRAIL衰弱量表和FI与不良结局的相关性,受试者工作特征(receiver operator characteristic,ROC)曲线评价FRAIL衰弱量表和FI对不良结局的预测价值.结果 死亡组FRAIL衰弱量表和FI评估的衰弱比例均高于存活组(P=0.001);多因素Cox回归分析显示,调整年龄、性别、体重指数、糖尿病、高血压、原发病、Charlson合并症指数、连续肾脏替代治疗及血管通路后,FRAIL衰弱量表和 FI(衰弱)的 HR值及 95%CI分别为 18.552(2.249～153.018)和 7.367(1.864～29.115).ROC曲线分析结果显示FRAIL衰弱量表和FI预测不良结局的曲线下面积分别为0.792和0.711,且FRAIL衰弱量表明显高于FI的(Z=2.135,P=0.033).结论 FRAIL衰弱量表和FI均与老年MHD患者不良结局有较强的相关性,且均能很好的预测不良结局,其中FRAIL预测能力更优. |
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| AbstractList | 目的 探讨FRAIL衰弱量表及衰弱指数(fragile index,FI)与老年维持性血液透析(maintenance hemodialysis,MHD)患者不良结局的相关性.方法 选取 2020年 6月至 2022年 12月在解放军第九六〇医院行MHD治疗的老年患者 116例,并按终点事件将其分为存活组(n=89)和死亡组(n=27).收集患者临床信息,并采用FRAIL衰弱量表和FI评估患者的衰弱状态,多因素Cox回归分析FRAIL衰弱量表和FI与不良结局的相关性,受试者工作特征(receiver operator characteristic,ROC)曲线评价FRAIL衰弱量表和FI对不良结局的预测价值.结果 死亡组FRAIL衰弱量表和FI评估的衰弱比例均高于存活组(P=0.001);多因素Cox回归分析显示,调整年龄、性别、体重指数、糖尿病、高血压、原发病、Charlson合并症指数、连续肾脏替代治疗及血管通路后,FRAIL衰弱量表和 FI(衰弱)的 HR值及 95%CI分别为 18.552(2.249～153.018)和 7.367(1.864～29.115).ROC曲线分析结果显示FRAIL衰弱量表和FI预测不良结局的曲线下面积分别为0.792和0.711,且FRAIL衰弱量表明显高于FI的(Z=2.135,P=0.033).结论 FRAIL衰弱量表和FI均与老年MHD患者不良结局有较强的相关性,且均能很好的预测不良结局,其中FRAIL预测能力更优. |
| Abstract_FL | Objective To explore the FRAIL scale and fragile index(FI)and adverse outcomes of elderly maintenance hemodialysis(MHD)patients.Methods From June 2020 to December 2022,116 elderly patients on MHD were selected and assigned into two groups of survival(n=27)and mortali-ty(n=89)according to the endpoint events.Clinical profiles were recorded.FRAIL scale and FI were uti-lized for assessing the frailty status.The correlation between FRAIL scale and FI and adverse outcomes was examined by multivariate COX regression.The predictive value of FRAIL scale and FI for adverse outcomes was evaluated by receiver operating characteristic(ROC)curve.Results The proportion of frailty assessed by FRAIL scale and FI was higher in mortality group than that in survival group(P=0.001).Multivariate Cox regression analysis indicated that,after adjusting for age,gender,body mass in-dex(BMI),diabetes mellitus,high blood pressure,primary disease,Charlson comorbidity index(CCI),continuous renal replacement therapy(CRRT)and vascular access,hazard ratio(HR)and 95%confi-dence interval(95%CI)of FRAIL and FI were 18.552(2.249-153.018)and 7.367(1.864-29.115),respec-tively.ROC analysis showed that the area under the curve of FRAIL scale and FI for predicting adverse outcomes was 0.792 and 0.711,respectively,and the area under the curve of FRAIL scale was significant-ly higher than that of FI(Z=2.135,P=0.033).Conclusion With a strong correlation with adverse out-comes in elderly MHD patients,both FRAIL scale and FI may well predict adverse outcomes and FRAIL offers a better predictive capability. |
| Author | 王素霞 高利群 靳芳 |
| AuthorAffiliation | 解放军第九六〇医院肾脏病科,济南 250031 |
| AuthorAffiliation_xml | – name: 解放军第九六〇医院肾脏病科,济南 250031 |
| Author_FL | Wang Su-xia Gao Li-qun Jin Fang |
| Author_FL_xml | – sequence: 1 fullname: Jin Fang – sequence: 2 fullname: Gao Li-qun – sequence: 3 fullname: Wang Su-xia |
| Author_xml | – sequence: 1 fullname: 靳芳 – sequence: 2 fullname: 高利群 – sequence: 3 fullname: 王素霞 |
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| Keywords | Maintenance hemodialysis 老年维持性血液透析 Death FRAIL衰弱量表 死亡 衰弱指数 Fragile index FRAIL scale |
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