Structure and evolvement of Spirulina platensis Fe-SOD

The Superoxide dismutase (SOD) is a kind of important metal enzyme for protecting organism from toxic oxidation. In this paper, the structure and evolvement of Spirulina platensis Fe-SOD were predicted by the method of bioinformatics. Related to its function, it was showed that: about its structure,...

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Published inZhejiang da xue xue bao. Journal of Zhejiang University. Sciences edition. Li xue ban Vol. 32; no. 4; pp. 442 - 447
Main Authors Lu, Min, Qin, Gui-xiang, Gong, Xing-guo, Guo, Jian-jun, Zhong, Wen-tao
Format Journal Article
LanguageChinese
Published Zhejiang University Press 01.07.2005
Subjects
fe-sod
Spirulina platensis
功能与进化
结构预测
钝顶螺旋藻
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ISSN1008-9497

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Abstract The Superoxide dismutase (SOD) is a kind of important metal enzyme for protecting organism from toxic oxidation. In this paper, the structure and evolvement of Spirulina platensis Fe-SOD were predicted by the method of bioinformatics. Related to its function, it was showed that: about its structure, the midst of the protein sequence (26AA-160AA) was tight and it was the active center of the enzyme, the ends were far from the active center; as to its evolvement, the ends of the protein sequence were more inclined to mutant. According to the Fe-SOD, a hypothesis about the mechanism of this relation was put forward for the first time.
AbstractList The Superoxide dismutase (SOD) is a kind of important metal enzyme for protecting organism from toxic oxidation. In this paper, the structure and evolvement of Spirulina platensis Fe-SOD were predicted by the method of bioinformatics. Related to its function, it was showed that: about its structure, the midst of the protein sequence (26AA-160AA) was tight and it was the active center of the enzyme, the ends were far from the active center; as to its evolvement, the ends of the protein sequence were more inclined to mutant. According to the Fe-SOD, a hypothesis about the mechanism of this relation was put forward for the first time.
超氧化物歧化酶（Superoxide dismutase，SOD）是一类重要的具有抗氧化损伤功能的金属酶.利用生物信息学手段，分析了钝顶螺旋藻(Spirulina platensis)Fe-SOD的结构与进化，结合此蛋白的功能，揭示了两者的内在联系：在结构上，此蛋白的中间区城(26 AA~160 AA）结构紧凑，为酶的活性中心，两端区域离活性中心较远；在进化上，此蛋白两端区域较中间区域更倾向于发生突变.并且通过Fe-SOD，首次对以上三者间特殊关系的形成机制进行了猜想与假设.
Author Qin, Gui-xiang
Lu, Min
Guo, Jian-jun
Gong, Xing-guo
Zhong, Wen-tao
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Snippet The Superoxide dismutase (SOD) is a kind of important metal enzyme for protecting organism from toxic oxidation. In this paper, the structure and evolvement of...
超氧化物歧化酶（Superoxide dismutase，SOD）是一类重要的具有抗氧化损伤功能的金属酶.利用生物信息学手段，分析了钝顶螺旋藻(Spirulina platensis)Fe-SOD的结构与进化，...
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SubjectTerms fe-sod
Spirulina platensis
功能与进化
结构预测
钝顶螺旋藻
Title Structure and evolvement of Spirulina platensis Fe-SOD
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