The Graft Infusion Technique (GIT) for Treatment of Peri-Implantitis Defects: Case Series

Peri-implantitis is a site-specific infectious disease that causes an inflammatory process in soft tissues, and bone loss around an osseointegrated implant in function. Several techniques with non-surgical or surgical debridement and decontamination followed by ongoing supportive therapy or regenera...

Full description

Saved in:
Bibliographic Details
Published inJournal of dentistry (Shiraz) Vol. 22; no. 4; pp. 296 - 303
Main Authors Bhatavadekar, Neel B, Gharpure, Amit S
Format Journal Article
LanguageEnglish
Published Iran Shiraz University of Medical Sciences 01.12.2021
Subjects
Online AccessGet full text
ISSN2345-6485
2345-6418
DOI10.30476/DENTJODS.2021.86658.1203

Cover

Abstract Peri-implantitis is a site-specific infectious disease that causes an inflammatory process in soft tissues, and bone loss around an osseointegrated implant in function. Several techniques with non-surgical or surgical debridement and decontamination followed by ongoing supportive therapy or regeneration of the peri-implant bone defects have been proposed in the literature. However, the literature is still unclear on an effective protocol for implant surface decontamination or the appropriate choice of regenerative materials. This case series describes a surgical technique to treat peri-implantitis osseous defects using a mixture of deproteinized bovine bone mineral with 10% porcine collagen (DBBM-C) in a block form, soaked in an appropriate antibiotic. The use of this combination provides advantages such as good graft adaptability along with localized antibiotic release without the use of systemic antibiotics. Thus, this technique might be an effective method to treat amenable peri-implantitis defects. Additionally, the proposed algorithm also allows for customized culture based antibiotic loading. To the best of the authors' knowledge, this is the first case series documenting this technique for peri-implantitis defects. Long-term studies with controlled samples would be necessary for further evaluation.
AbstractList Peri-implantitis is a site-specific infectious disease that causes an inflammatory process in soft tissues, and bone loss around an osseointegrated implant in function. Several techniques with non-surgical or surgical debridement and decontamination followed by ongoing supportive therapy or regeneration of the peri-implant bone defects have been proposed in the literature. However, the literature is still unclear on an effective protocol for implant surface decontamination or the appropriate choice of regenerative materials. This case series describes a surgical technique to treat peri-implantitis osseous defects using a mixture of deproteinized bovine bone mineral with 10% porcine collagen (DBBM-C) in a block form, soaked in an appropriate antibiotic. The use of this combination provides advantages such as good graft adaptability along with localized antibiotic release without the use of systemic antibiotics. Thus, this technique might be an effective method to treat amenable peri-implantitis defects. Additionally, the proposed algorithm also allows for customized culture based antibiotic loading. To the best of the authors' knowledge, this is the first case series documenting this technique for peri-implantitis defects. Long-term studies with controlled samples would be necessary for further evaluation.
Peri-implantitis is a site-specific infectious disease that causes an inflammatory process in soft tissues, and bone loss around an osseointegrated implant in function. Several techniques with non‐surgical or surgical debridement and decontamination followed by ongoing supportive therapy or regeneration of the peri‐implant bone defects have been proposed in the literature. However, the literature is still unclear on an effective protocol for implant surface decontamination or the appropriate choice of regenerative materials. This case series describes a surgical technique to treat peri-implantitis osseous defects using a mixture of deproteinized bovine bone mineral with 10% porcine collagen (DBBM-C) in a block form, soaked in an appropriate antibiotic. The use of this combination provides advantages such as good graft adaptability along with localized antibiotic release without the use of systemic antibiotics. Thus, this technique might be an effective method to treat amenable peri-implantitis defects. Additionally, the proposed algorithm also allows for customized culture based antibiotic loading. To the best of the authors’ knowledge, this is the first case series documenting this technique for peri-implantitis defects. Long-term studies with controlled samples would be necessary for further evaluation.
Peri-implantitis is a site-specific infectious disease that causes an inflammatory process in soft tissues, and bone loss around an osseointegrated implant in function. Several techniques with non-surgical or surgical debridement and decontamination followed by ongoing supportive therapy or regeneration of the peri-implant bone defects have been proposed in the literature. However, the literature is still unclear on an effective protocol for implant surface decontamination or the appropriate choice of regenerative materials. This case series describes a surgical technique to treat peri-implantitis osseous defects using a mixture of deproteinized bovine bone mineral with 10% porcine collagen (DBBM-C) in a block form, soaked in an appropriate antibiotic. The use of this combination provides advantages such as good graft adaptability along with localized antibiotic release without the use of systemic antibiotics. Thus, this technique might be an effective method to treat amenable peri-implantitis defects. Additionally, the proposed algorithm also allows for customized culture based antibiotic loading. To the best of the authors' knowledge, this is the first case series documenting this technique for peri-implantitis defects. Long-term studies with controlled samples would be necessary for further evaluation.Peri-implantitis is a site-specific infectious disease that causes an inflammatory process in soft tissues, and bone loss around an osseointegrated implant in function. Several techniques with non-surgical or surgical debridement and decontamination followed by ongoing supportive therapy or regeneration of the peri-implant bone defects have been proposed in the literature. However, the literature is still unclear on an effective protocol for implant surface decontamination or the appropriate choice of regenerative materials. This case series describes a surgical technique to treat peri-implantitis osseous defects using a mixture of deproteinized bovine bone mineral with 10% porcine collagen (DBBM-C) in a block form, soaked in an appropriate antibiotic. The use of this combination provides advantages such as good graft adaptability along with localized antibiotic release without the use of systemic antibiotics. Thus, this technique might be an effective method to treat amenable peri-implantitis defects. Additionally, the proposed algorithm also allows for customized culture based antibiotic loading. To the best of the authors' knowledge, this is the first case series documenting this technique for peri-implantitis defects. Long-term studies with controlled samples would be necessary for further evaluation.
Author Bhatavadekar, Neel B
Gharpure, Amit S
AuthorAffiliation 1 Private Practice, Clarus Dental Specialities, Pune, India. Adjunct Faculty, University of North Carolina at Chapel Hill, NC, Adjunct Faculty, University of Texas Health Science Center, Houston, TX, Adjunct Faculty, Bioengineering Department, Rice University, FL
2 Graduate Periodontics, University of Washington School of Dentistry, Seattle, WA
AuthorAffiliation_xml – name: 2 Graduate Periodontics, University of Washington School of Dentistry, Seattle, WA
– name: 1 Private Practice, Clarus Dental Specialities, Pune, India. Adjunct Faculty, University of North Carolina at Chapel Hill, NC, Adjunct Faculty, University of Texas Health Science Center, Houston, TX, Adjunct Faculty, Bioengineering Department, Rice University, FL
Author_xml – sequence: 1
  givenname: Neel B
  surname: Bhatavadekar
  fullname: Bhatavadekar, Neel B
  organization: Private Practice, Clarus Dental Specialities, Pune, India. Adjunct Faculty, University of North Carolina at Chapel Hill, NC, Adjunct Faculty, University of Texas Health Science Center, Houston, TX, Adjunct Faculty, Bioengineering Department, Rice University, FL
– sequence: 2
  givenname: Amit S
  surname: Gharpure
  fullname: Gharpure, Amit S
  organization: Graduate Periodontics, University of Washington School of Dentistry, Seattle, WA
BackLink https://www.ncbi.nlm.nih.gov/pubmed/34904127$$D View this record in MEDLINE/PubMed
BookMark eNpVkU1v1DAQhi1UREvpX0DmVg5Z_BU74YCEdssSVFGkhgMny7HHXVdJvLWzSPx7DC0VncuMZkbPq3nnJTqa4wwIvaFkxYlQ8t3m4mv_5WpzvWKE0VUjZd2sKCP8GTphXNSVFLQ5eqyb-hid5XxLSrQtZ0K9QMdctERQpk7Qj34HeJuMX3A3-0MOccY92N0c7g6Az7dd_xb7mHCfwCwTzAuOHn-DFKpu2o9mXsISMt6AB7vk93htMuDrMob8Cj33Zsxw9pBP0fdPF_36c3V5te3WHy8rR5WSlYOh5aZxnlBgnKl6aGuwTg6NZzXwVllF3MCZZ2A5iAEEt3IwQ-2tAEVqfoq6e66L5lbvU5hM-qWjCfpvI6YbbdIS7AjaC2cAOBDGSyl8W2xgFJRtHW2ZsoX14Z61PwwTOFvuTWZ8An06mcNO38Sf-s8XBJcFcP4ASLEYmBc9hWxhLE5BPGTNJCWkIVzQsvr6f61HkX-_4b8BLwWWQw
ContentType Journal Article
Copyright Copyright: © Journal of Dentistry.
Copyright: © Journal of Dentistry
Copyright_xml – notice: Copyright: © Journal of Dentistry.
– notice: Copyright: © Journal of Dentistry
DBID NPM
7X8
5PM
DOA
DOI 10.30476/DENTJODS.2021.86658.1203
DatabaseName PubMed
MEDLINE - Academic
PubMed Central (Full Participant titles)
DOAJ Directory of Open Access Journals
DatabaseTitle PubMed
MEDLINE - Academic
DatabaseTitleList PubMed


MEDLINE - Academic
Database_xml – sequence: 1
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Dentistry
EISSN 2345-6418
EndPage 303
ExternalDocumentID oai_doaj_org_article_f4daee3e023f4d4f949021e7c9d1927c
PMC8665436
34904127
Genre Case Reports
GroupedDBID 34H
ADBBV
ADRAZ
ALMA_UNASSIGNED_HOLDINGS
AOIJS
BAWUL
BCNDV
EOJEC
GROUPED_DOAJ
HYE
KQ8
M48
M~E
NPM
OBODZ
PGMZT
RNS
RPM
7X8
5PM
ID FETCH-LOGICAL-d1776-deb93a8df01e23275b95ecd6b8f25e397c70db32f2ec3e4be43c6bab5fc4e7053
IEDL.DBID M48
ISSN 2345-6485
IngestDate Fri Oct 03 12:42:32 EDT 2025
Thu Aug 21 14:13:03 EDT 2025
Thu Oct 02 06:11:53 EDT 2025
Thu Jan 02 22:55:45 EST 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 4
Keywords Deproteinized bovine bone mineral with 10% collagen
Peri-implantitis
Bone Grafting
Radiographs
Dental Implants
Survival
Surgical Procedures
Reconstructive Surgical Procedures
Success
Language English
License Copyright: © Journal of Dentistry.
This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 Unported License, ( http://creativecommons.org/licenses/by/4.0/ ) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-d1776-deb93a8df01e23275b95ecd6b8f25e397c70db32f2ec3e4be43c6bab5fc4e7053
Notes ObjectType-Case Study-2
SourceType-Scholarly Journals-1
ObjectType-Feature-4
content type line 23
ObjectType-Report-1
ObjectType-Article-3
OpenAccessLink https://doaj.org/article/f4daee3e023f4d4f949021e7c9d1927c
PMID 34904127
PQID 2610080341
PQPubID 23479
PageCount 8
ParticipantIDs doaj_primary_oai_doaj_org_article_f4daee3e023f4d4f949021e7c9d1927c
pubmedcentral_primary_oai_pubmedcentral_nih_gov_8665436
proquest_miscellaneous_2610080341
pubmed_primary_34904127
PublicationCentury 2000
PublicationDate 2021-Dec
20211201
2021-12-01
PublicationDateYYYYMMDD 2021-12-01
PublicationDate_xml – month: 12
  year: 2021
  text: 2021-Dec
PublicationDecade 2020
PublicationPlace Iran
PublicationPlace_xml – name: Iran
PublicationTitle Journal of dentistry (Shiraz)
PublicationTitleAlternate J Dent (Shiraz)
PublicationYear 2021
Publisher Shiraz University of Medical Sciences
Publisher_xml – name: Shiraz University of Medical Sciences
SSID ssj0000993247
Score 2.1674736
Snippet Peri-implantitis is a site-specific infectious disease that causes an inflammatory process in soft tissues, and bone loss around an osseointegrated implant in...
SourceID doaj
pubmedcentral
proquest
pubmed
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
StartPage 296
SubjectTerms Case Series
dental implants; bone grafting; peri-implantitis; radiographs; surgical procedures; reconstructive surgical procedures; deproteinized bovine bone mineral with 10% collagen; success; survival
SummonAdditionalLinks – databaseName: DOAJ Directory of Open Access Journals
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1LT9wwELYQh7YXBC0tS6EyEgc4GBLHr_RG2V0eB0AiSPQU-TEWcMiiffz_jpNdtIsq9dJblEjJyN8k843z6RtCDktpQFsRGFJbyUTwgRmrA1Mxi1y7wF2ntrhRlw_i-lE-Lo36Spqwzh64W7jTKIIFKABrCx6KWIoSyxJoXwYkJ9qnr29myqVm6qXjPcgUdDtZTkimhJEfyEFqUTOh1Wl_cFNd3_bvsT_k-UmyfDMnOU-Ds1rj_r-xzfeiyaUqNNwkG3P6SM-6sLfIGjSfycd-kvykqW1fyG_EnV6MbZzSqybO0l4YrRY-rfTo4qo6pshTabUQmNNRpHeYhiz5BNvWYXVC-9CqPH7ScyxyNO2gwWSbPAwH1fklm49PYCHXWrEAriysCTHLAXmTlq6U4INyJnIJyEO8zoIreOTgCxAOROGVs05GL0Djy_mVrDejBnYIzYMRVkkXkNwJrGg2h0x6x8vgCw6Z6ZFfad3q184ho06e1e0JRLKeI1n_C8keOViseo05nn5c2AZGs0mNXV5itlhwe-Rbh8Lbowq8C4ake0Sv4LMSy-qV5vmp9dFOuItC7f6P4L-TTymXOqHLHlmfjmewj3Rl6n60mfkHYt7nYQ
  priority: 102
  providerName: Directory of Open Access Journals
Title The Graft Infusion Technique (GIT) for Treatment of Peri-Implantitis Defects: Case Series
URI https://www.ncbi.nlm.nih.gov/pubmed/34904127
https://www.proquest.com/docview/2610080341
https://pubmed.ncbi.nlm.nih.gov/PMC8665436
https://doaj.org/article/f4daee3e023f4d4f949021e7c9d1927c
Volume 22
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
journalDatabaseRights – providerCode: PRVAFT
  databaseName: Open Access Digital Library
  customDbUrl:
  eissn: 2345-6418
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0000993247
  issn: 2345-6485
  databaseCode: KQ8
  dateStart: 20130101
  isFulltext: true
  titleUrlDefault: http://grweb.coalliance.org/oadl/oadl.html
  providerName: Colorado Alliance of Research Libraries
– providerCode: PRVAON
  databaseName: DOAJ Directory of Open Access Journals
  customDbUrl:
  eissn: 2345-6418
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0000993247
  issn: 2345-6485
  databaseCode: DOA
  dateStart: 19990101
  isFulltext: true
  titleUrlDefault: https://www.doaj.org/
  providerName: Directory of Open Access Journals
– providerCode: PRVAQN
  databaseName: PubMed Central
  customDbUrl:
  eissn: 2345-6418
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0000993247
  issn: 2345-6485
  databaseCode: RPM
  dateStart: 20130101
  isFulltext: true
  titleUrlDefault: https://www.ncbi.nlm.nih.gov/pmc/
  providerName: National Library of Medicine
– providerCode: PRVFZP
  databaseName: Scholars Portal Journals: Open Access
  customDbUrl:
  eissn: 2345-6418
  dateEnd: 20250630
  omitProxy: true
  ssIdentifier: ssj0000993247
  issn: 2345-6485
  databaseCode: M48
  dateStart: 20130301
  isFulltext: true
  titleUrlDefault: http://journals.scholarsportal.info
  providerName: Scholars Portal
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1ba9RAFB5qBfVFvLtWyxRE9GHWZK6JIKLdXsEqmIX6FOZyxraUbLsXqP_eM0lWXCnoW0ggM5wL5zszh-8j5GWpCjBWBobQVjEZfGCFNYHpmEVuXOCum7Y40vtjeXisjtfI8kC_N-Ds2tYu6UmNp-fDq8ufHzDh36eOM5NGvx3tHFWHX0bfsN3j-TAxuBXDnGfi1cUlS_pS6R62F9u4QW5iDSuTyMPnvhE463ASIgvTKtFJxbQs1C2y9c8FeqL_69Dp30OWf1St3Xvkbg836ccuPu6TNWgekNujNCKUVN4eku8YJ3RvauOcHjRxkc7OaLXkdaWv9w6qNxRxLa2WA-l0EulXDFuWeIVty8g6oyNop0Le0W0sijSduMHsERnv7lTb-6yXW2AhN0azAK4UtggxywFxllGuVOCDdkXkChC3eJMFJ3jk4AVIB1J47axT0UswmMyPyXozaeApoXkopNXKBQSDEiugzSFT3vEyeMEhKwbkU7JbfdExatSJ47p9MZn-qPuUqaMMFkAAogp8lLGUJVofjC8DwlLjB2RrafUacyJddNgGJotZjV1hQsJYoAfkSeeF30sJ_AtuyQyIWfHPyl5WvzSnJy3vdvK7FPrZf6y7Qe6kUOnmXp6T9fl0AS8QvczdZtv1b7bh9wvM9u3r
linkProvider Scholars Portal
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+Graft+Infusion+Technique+%28GIT%29+for+Treatment+of+Peri-Implantitis+Defects%3A+Case+Series&rft.jtitle=Journal+of+dentistry+%28Shiraz%29&rft.au=Bhatavadekar%2C+Neel+B&rft.au=Gharpure%2C+Amit+S&rft.date=2021-12-01&rft.issn=2345-6485&rft.volume=22&rft.issue=4&rft.spage=296&rft_id=info:doi/10.30476%2FDENTJODS.2021.86658.1203&rft.externalDBID=NO_FULL_TEXT
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2345-6485&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2345-6485&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2345-6485&client=summon