铁死亡参与肝疾病研究进展
R575; 肝脏作为机体新陈代谢的核心器官,深度调节体内各类营养物质的合成及代谢.铁死亡作为一种铁依赖性的脂质过氧化物积累引起的新型细胞程序性死亡方式,参与多种急慢性肝疾病的生理和病理进程.目前认为,在急性肝损伤、代谢相关脂肪性肝病、酒精性肝病、病毒性肝炎、自身免疫性肝炎等大部分肝疾病中,铁死亡可加速疾病进程;而在晚期肝纤维化和肝细胞癌中,铁死亡则延缓疾病进程.因此,靶向调控铁死亡能够有效预防并延缓急慢性肝疾病的发生发展.本文讨论了铁死亡在急性肝损伤、代谢相关脂肪性肝病、酒精性肝病、病毒性肝炎、自身免疫性肝炎、肝纤维化以及肝细胞癌等肝疾病中的最新研究进展,以期为靶向铁死亡防治急慢性肝疾病提供新...
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| Published in | Zhejiang da xue xue bao. Journal of Zhejiang University. Medical sciences. Yi xue ban Vol. 53; no. 6; pp. 747 - 755 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | Chinese |
| Published |
南华大学衡阳医学院药学院,湖南 衡阳 421001%南华大学衡阳医学院公共卫生学院,湖南 衡阳 421001%浙江大学医学院,浙江 杭州 310058%南华大学衡阳医学院公共卫生学院,湖南 衡阳 421001
01.01.2025
浙江大学医学院,浙江 杭州 310058 Zhejiang University Press |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1008-9292 |
| DOI | 10.3724/zdxbyxb-2024-0566 |
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| Abstract | R575; 肝脏作为机体新陈代谢的核心器官,深度调节体内各类营养物质的合成及代谢.铁死亡作为一种铁依赖性的脂质过氧化物积累引起的新型细胞程序性死亡方式,参与多种急慢性肝疾病的生理和病理进程.目前认为,在急性肝损伤、代谢相关脂肪性肝病、酒精性肝病、病毒性肝炎、自身免疫性肝炎等大部分肝疾病中,铁死亡可加速疾病进程;而在晚期肝纤维化和肝细胞癌中,铁死亡则延缓疾病进程.因此,靶向调控铁死亡能够有效预防并延缓急慢性肝疾病的发生发展.本文讨论了铁死亡在急性肝损伤、代谢相关脂肪性肝病、酒精性肝病、病毒性肝炎、自身免疫性肝炎、肝纤维化以及肝细胞癌等肝疾病中的最新研究进展,以期为靶向铁死亡防治急慢性肝疾病提供新的理论依据. |
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| AbstractList | 肝脏作为机体新陈代谢的核心器官，深度调节体内各类营养物质的合成及代谢。铁死亡作为一种铁依赖性的脂质过氧化物积累引起的新型细胞程序性死亡方式，参与多种急慢性肝疾病的生理和病理进程。目前认为，在急性肝损伤、代谢相关脂肪性肝病、酒精性肝病、病毒性肝炎、自身免疫性肝炎等大部分肝疾病中，铁死亡可加速疾病进程；而在晚期肝纤维化和肝细胞癌中，铁死亡则延缓疾病进程。因此，靶向调控铁死亡能够有效预防并延缓急慢性肝疾病的发生发展。本文讨论了铁死亡在急性肝损伤、代谢相关脂肪性肝病、酒精性肝病、病毒性肝炎、自身免疫性肝炎、肝纤维化以及肝细胞癌等肝疾病中的最新研究进展，以期为靶向铁死亡防治急慢性肝疾病提供新的理论依据。 R575; 肝脏作为机体新陈代谢的核心器官,深度调节体内各类营养物质的合成及代谢.铁死亡作为一种铁依赖性的脂质过氧化物积累引起的新型细胞程序性死亡方式,参与多种急慢性肝疾病的生理和病理进程.目前认为,在急性肝损伤、代谢相关脂肪性肝病、酒精性肝病、病毒性肝炎、自身免疫性肝炎等大部分肝疾病中,铁死亡可加速疾病进程;而在晚期肝纤维化和肝细胞癌中,铁死亡则延缓疾病进程.因此,靶向调控铁死亡能够有效预防并延缓急慢性肝疾病的发生发展.本文讨论了铁死亡在急性肝损伤、代谢相关脂肪性肝病、酒精性肝病、病毒性肝炎、自身免疫性肝炎、肝纤维化以及肝细胞癌等肝疾病中的最新研究进展,以期为靶向铁死亡防治急慢性肝疾病提供新的理论依据. |
| Abstract_FL | As the central organ of metabolism,the liver plays a pivotal role in the regulation of the synthesis and metabolism of various nutrients within the body.Ferroptosis,as a newly discovered type of programmed cell death caused by the accumulation of iron-dependent lipid peroxides,is involved in the physiological and pathological processes of a variety of acute and chronic liver diseases.Ferroptosis can accelerate the pathogenetic process of acute liver injury,metabolic associated fatty liver disease,alcoholic liver disease,viral hepatitis,and autoimmune hepatitis;while it can slower disease progression in advanced liver fibrosis and hepatocellular carcinoma.This suggests that targeted regulation of ferroptosis may impact the occurrence and development of various liver diseases.This article reviews the latest research progress of ferroptosis in various liver diseases,including acute liver injury,metabolic associated fatty liver disease,alcoholic liver disease,viral hepatitis,autoimmune hepatitis,liver fibrosis and hepatocellular carcinoma.It aims to provide insights for the prevention and treatment of acute and chronic liver diseases through targeting ferroptosis. |
| Author | 王福俤 吴谦 李欣 陶亮 闵军霞 钟美娟 |
| AuthorAffiliation | 南华大学衡阳医学院药学院,湖南 衡阳 421001%南华大学衡阳医学院公共卫生学院,湖南 衡阳 421001%浙江大学医学院,浙江 杭州 310058%南华大学衡阳医学院公共卫生学院,湖南 衡阳 421001;浙江大学医学院,浙江 杭州 310058 |
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| Author_FL | WANG Fudi WU Qian MIN Junjia LI Xin ZHONG Meijuan TAO Liang |
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| DOI | 10.3724/zdxbyxb-2024-0566 |
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| Keywords | Iron metabolism 肝疾病 Ferroptotic signaling pathway 铁死亡信号通路 Liver disease 铁代谢 Ferroptosis 综述 Review 铁死亡 |
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| Publisher | 南华大学衡阳医学院药学院,湖南 衡阳 421001%南华大学衡阳医学院公共卫生学院,湖南 衡阳 421001%浙江大学医学院,浙江 杭州 310058%南华大学衡阳医学院公共卫生学院,湖南 衡阳 421001 浙江大学医学院,浙江 杭州 310058 Zhejiang University Press |
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| Snippet | R575; 肝脏作为机体新陈代谢的核心器官,深度调节体内各类营养物质的合成及代谢.铁死亡作为一种铁依赖性的脂质过氧化物积累引起的新型细胞程序性死亡方式,参与多种急慢性肝... 肝脏作为机体新陈代谢的核心器官，深度调节体内各类营养物质的合成及代谢。铁死亡作为一种铁依赖性的脂质过氧化物积累引起的新型细胞程序性死亡方式，参与多种急慢性肝疾病... |
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| SubjectTerms | 综述 肝疾病 铁代谢 铁死亡 铁死亡信号通路 |
| Title | 铁死亡参与肝疾病研究进展 |
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