血管紧张素-(1-7)对兔急性心肌梗死再灌注微血管 内皮功能和完整性的保护作用

【目的】 探讨血管紧张素-(1-7)[ Ang-(1-7)]对急性心肌梗死再灌注微血管内皮功能和完整性的保护作用?【方法】 30只新西兰雄性大白兔,随机分成①假手术组,②缺血再灌注(I-R)对照组,③Ang-(1-7)治疗组,每组10只?Ang-(1-7)治疗组,经微量泵持续颈静脉给予Ang-(1-7) 3 d,假手术组和I-R对照组经微量泵只给予等量的生理盐水?每组均在3 d预处理后,冠状动脉左前降支结扎2 h,再灌注2 h?测定缺血前?后和再灌注2 h时血中一氧化氮(NO)含量,再灌注2 h时心肌一氧化氮合酶(NOS)活性,血循环内皮细胞(CEC)计数以及光镜下心肌灶性出血发生率的变化,并...

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Published inZhongshan da xue xue bao. Zhongshan daxue xuebao yixue kexue ban = Journal of Sun Yat-sen University. Yi xue ke xue ban Vol. 29
Format Journal Article
LanguageChinese
Published Editorial Office of Journal of Sun Yat-sen University 01.01.2008
Subjects
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ISSN1672-3554
DOI10.3321/j.issn:1672-3554.2008.03.008

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Abstract 【目的】 探讨血管紧张素-(1-7)[ Ang-(1-7)]对急性心肌梗死再灌注微血管内皮功能和完整性的保护作用?【方法】 30只新西兰雄性大白兔,随机分成①假手术组,②缺血再灌注(I-R)对照组,③Ang-(1-7)治疗组,每组10只?Ang-(1-7)治疗组,经微量泵持续颈静脉给予Ang-(1-7) 3 d,假手术组和I-R对照组经微量泵只给予等量的生理盐水?每组均在3 d预处理后,冠状动脉左前降支结扎2 h,再灌注2 h?测定缺血前?后和再灌注2 h时血中一氧化氮(NO)含量,再灌注2 h时心肌一氧化氮合酶(NOS)活性,血循环内皮细胞(CEC)计数以及光镜下心肌灶性出血发生率的变化,并采用氯化三苯四唑(TTC)染色观察心肌梗死范围?【结果】 ①心肌缺血前各组对比,NO在Ang-(1-7)治疗组已显著升高(P < 0.01);心肌缺血后2 h时,NO在Ang-(1-7)治疗组比I-R对照组显著增高(P < 0.01);再灌注2 h后,在Ang-(1-7)治疗组仍比I-R对照组显著增高(P < 0.01)?② 再灌注2 h后,Ang-(1-7)治疗组与I-R对照组相比CEC显著降低(7.8个/mm3对15.8个/mm3,P < 0.05)并与假手术组无显著差异?③在Ang-(1-7)治疗组NOS活性比I-R对照组明显增高(P < 0.05)?④心肌梗死面积在I-R对照组为29%,而Ang-(1-7)治疗组(15%)与之相比则显著降低(P < 0.01)?⑤心肌灶性出血发生率在I-R对照组为65.0%,而Ang-(1-7)治疗组为27.5%,治疗组较I-R对照组显著降低(P < 0.01)?【结论】静脉持续给予Ang-(1-7) 对急性心肌梗死再灌注微血管内皮功能和完整性具有保护作用?
AbstractList 【目的】 探讨血管紧张素-(1-7)[ Ang-(1-7)]对急性心肌梗死再灌注微血管内皮功能和完整性的保护作用?【方法】 30只新西兰雄性大白兔,随机分成①假手术组,②缺血再灌注(I-R)对照组,③Ang-(1-7)治疗组,每组10只?Ang-(1-7)治疗组,经微量泵持续颈静脉给予Ang-(1-7) 3 d,假手术组和I-R对照组经微量泵只给予等量的生理盐水?每组均在3 d预处理后,冠状动脉左前降支结扎2 h,再灌注2 h?测定缺血前?后和再灌注2 h时血中一氧化氮(NO)含量,再灌注2 h时心肌一氧化氮合酶(NOS)活性,血循环内皮细胞(CEC)计数以及光镜下心肌灶性出血发生率的变化,并采用氯化三苯四唑(TTC)染色观察心肌梗死范围?【结果】 ①心肌缺血前各组对比,NO在Ang-(1-7)治疗组已显著升高(P < 0.01);心肌缺血后2 h时,NO在Ang-(1-7)治疗组比I-R对照组显著增高(P < 0.01);再灌注2 h后,在Ang-(1-7)治疗组仍比I-R对照组显著增高(P < 0.01)?② 再灌注2 h后,Ang-(1-7)治疗组与I-R对照组相比CEC显著降低(7.8个/mm3对15.8个/mm3,P < 0.05)并与假手术组无显著差异?③在Ang-(1-7)治疗组NOS活性比I-R对照组明显增高(P < 0.05)?④心肌梗死面积在I-R对照组为29%,而Ang-(1-7)治疗组(15%)与之相比则显著降低(P < 0.01)?⑤心肌灶性出血发生率在I-R对照组为65.0%,而Ang-(1-7)治疗组为27.5%,治疗组较I-R对照组显著降低(P < 0.01)?【结论】静脉持续给予Ang-(1-7) 对急性心肌梗死再灌注微血管内皮功能和完整性具有保护作用?
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Snippet 【目的】 探讨血管紧张素-(1-7)[ Ang-(1-7)]对急性心肌梗死再灌注微血管内皮功能和完整性的保护作用?【方法】 30只新西兰雄性大白兔,随机分成①假手术组,②缺血再灌注(I-R)对照...
SourceID doaj
SourceType Open Website
SubjectTerms 内皮功能
急性心肌梗死
缺血再灌注损伤
血管紧张素-(1-7)
Title 血管紧张素-(1-7)对兔急性心肌梗死再灌注微血管 内皮功能和完整性的保护作用
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Volume 29
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