纳米硒联合聚维酮碘对手术感染杀菌的效果
R63; [目的]负载多功能纳米硒聚维酮碘(PVP-I@Se)消毒剂对金黄色葡萄球菌(SA)、耐甲氧西林金黄色葡萄球菌(MRSA)的杀菌效果,为皮肤手术部位消毒提供实验依据.[方法]实验分为PVP-I组(对照组)与PVP-I@Se组(实验组),两组的碘浓度梯度相同,分别为50、75、100、200和400 μg/mL,实验组硒浓度2 μg/mL,对照组不添加硒,比较两组不同的消毒液对SA、MRSA的消毒效果,检测指标包括最低抑菌浓度(MIC)和最低杀菌浓度(MBC);碘浓度50 μg/mL时的最短杀菌时间;碘浓度200 μg/mL、400 μg/mL时的抑菌圈大小.[结果]对照组对SA、MRS...
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| Published in | Zhongshan da xue xue bao. Zhongshan daxue xuebao yixue kexue ban = Journal of Sun Yat-sen University. Yi xue ke xue ban Vol. 45; no. 2; pp. 206 - 215 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | Chinese |
| Published |
暨南大学附属第六医院眼科,广东 东莞 523000
01.03.2024
暨南大学附属第一医院手术室,广东 广州 510630%暨南大学化学与材料学院,广东 广州 510630%暨南大学附属第一医院眼科,广东 广州 510630%暨南大学附属第一医院眼科,广东 广州 510630 Editorial Office of Journal of Sun Yat-sen University |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1672-3554 |
| DOI | 10.13471/j.cnki.j.sun.yat-sen.univ(med.sci).20240305.001 |
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| Abstract | R63; [目的]负载多功能纳米硒聚维酮碘(PVP-I@Se)消毒剂对金黄色葡萄球菌(SA)、耐甲氧西林金黄色葡萄球菌(MRSA)的杀菌效果,为皮肤手术部位消毒提供实验依据.[方法]实验分为PVP-I组(对照组)与PVP-I@Se组(实验组),两组的碘浓度梯度相同,分别为50、75、100、200和400 μg/mL,实验组硒浓度2 μg/mL,对照组不添加硒,比较两组不同的消毒液对SA、MRSA的消毒效果,检测指标包括最低抑菌浓度(MIC)和最低杀菌浓度(MBC);碘浓度50 μg/mL时的最短杀菌时间;碘浓度200 μg/mL、400 μg/mL时的抑菌圈大小.[结果]对照组对SA、MRSA的MIC均为79.17 μg/mL、实验组分别为54.17和70.83 μg/mL.而对照组对SA、MRSA的MBC分别为129.17和150.00 μg/mL,实验组分别为70.83和87.50 μg/mL.碘浓度50 μg/mL时,对照组对SA、MRSA的最短杀菌时间为130 s、140 s,实验组分别为65 s、75 s.碘浓度200 μg/mL时,对照组对SA、MRSA的抑菌圈直径分别为7.67 mm、8.33 mm,实验组均为9.50 mm.碘浓度400 μg/mL时,对照组对SA、MRSA的抑菌圈直径分别为9.00 mm、9.33 mm,实验组分别为11.67 mm、12.00 mm.[结论]在聚维酮碘浓度为50、75、100、200和400 μg/mL时,分别加入浓度为2 μg/mL的硒,可增强其对SA、MRSA的杀菌效果、缩短作用时间.硒(SeNPs)加入PVP-I对SA、MRSA 的杀菌效果均有增效作用.但增敏效果SA较MRSA显著.MRSA的增效作用对碘浓度(400 μg/mL)需求较高.为临床精准选用消毒剂的浓度和作用时间,降低临床皮肤手术部位感染提供理论依据. |
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| AbstractList | 目的负载多功能纳米硒聚维酮碘（PVP-I@Se）消毒剂对金黄色葡萄球菌（SA）、耐甲氧西林金黄色葡萄球菌（MRSA）的杀菌效果，为皮肤手术部位消毒提供实验依据。方法实验分为PVP-I组（对照组）与PVP-I@Se组（实验组），两组的碘浓度梯度相同，分别为50、75、100、200和400 μg/mL，实验组硒浓度2 μg/mL，对照组不添加硒，比较两组不同的消毒液对SA、MRSA的消毒效果，检测指标包括最低抑菌浓度（MIC）和最低杀菌浓度（MBC）；碘浓度50 μg/mL时的最短杀菌时间；碘浓度200 μg/mL、400 μg/mL时的抑菌圈大小。结果对照组对SA、MRSA的MIC均为79.17 μg/mL、实验组分别为54.17和70.83 μg/mL。而对照组对SA、MRSA的MBC分别为129.17和150.00 μg/mL，实验组分别为70.83和87.50 μg/mL。碘浓度50 μg/mL时，对照组对SA、MRSA的最短杀菌时间为130 s、140 s，实验组分别为65 s、75 s。碘浓度200 μg/mL时，对照组对SA、MRSA的抑菌圈直径分别为7.67 mm、8.33 mm，实验组均为9.50 mm。碘浓度400 μg/mL时，对照组对SA、MRSA的抑菌圈直径分别为9.00 mm、9.33 mm，实验组分别为11.67 mm、12.00 mm。结论在聚维酮碘浓度为50、75、100、200和400 μg/mL时，分别加入浓度为2 μg/mL的硒，可增强其对SA、MRSA的杀菌效果、缩短作用时间。硒（SeNPs）加入PVP-I对SA、MRSA 的杀菌效果均有增效作用。但增敏效果SA较MRSA显著。MRSA的增效作用对碘浓度（400 μg/mL）需求较高。为临床精准选用消毒剂的浓度和作用时间，降低临床皮肤手术部位感染提供理论依据。 R63; [目的]负载多功能纳米硒聚维酮碘(PVP-I@Se)消毒剂对金黄色葡萄球菌(SA)、耐甲氧西林金黄色葡萄球菌(MRSA)的杀菌效果,为皮肤手术部位消毒提供实验依据.[方法]实验分为PVP-I组(对照组)与PVP-I@Se组(实验组),两组的碘浓度梯度相同,分别为50、75、100、200和400 μg/mL,实验组硒浓度2 μg/mL,对照组不添加硒,比较两组不同的消毒液对SA、MRSA的消毒效果,检测指标包括最低抑菌浓度(MIC)和最低杀菌浓度(MBC);碘浓度50 μg/mL时的最短杀菌时间;碘浓度200 μg/mL、400 μg/mL时的抑菌圈大小.[结果]对照组对SA、MRSA的MIC均为79.17 μg/mL、实验组分别为54.17和70.83 μg/mL.而对照组对SA、MRSA的MBC分别为129.17和150.00 μg/mL,实验组分别为70.83和87.50 μg/mL.碘浓度50 μg/mL时,对照组对SA、MRSA的最短杀菌时间为130 s、140 s,实验组分别为65 s、75 s.碘浓度200 μg/mL时,对照组对SA、MRSA的抑菌圈直径分别为7.67 mm、8.33 mm,实验组均为9.50 mm.碘浓度400 μg/mL时,对照组对SA、MRSA的抑菌圈直径分别为9.00 mm、9.33 mm,实验组分别为11.67 mm、12.00 mm.[结论]在聚维酮碘浓度为50、75、100、200和400 μg/mL时,分别加入浓度为2 μg/mL的硒,可增强其对SA、MRSA的杀菌效果、缩短作用时间.硒(SeNPs)加入PVP-I对SA、MRSA 的杀菌效果均有增效作用.但增敏效果SA较MRSA显著.MRSA的增效作用对碘浓度(400 μg/mL)需求较高.为临床精准选用消毒剂的浓度和作用时间,降低临床皮肤手术部位感染提供理论依据. |
| Abstract_FL | [Objective]To investigate the bactericidal effect of loaded multifunctional povidoneiodine-nanometer sele-nium(PVP-I@Se)disinfectant on Staphylococcus aureus(SA)and methicillin-resistant Staphylococcus aureus(MRSA),and to provide an experimental basis for the reduction of surgical site infection(SSI).[Methods]The control group was the povidone iodine(PVP-I)group with different concentrations of iodine(50,75,100,200 and 400 μg/mL).The PVP-I@Se group(experimental group)was the PVP-I group further supplemented with 2 μg/mL Selenium nanoparticles(SeNPs).Then we compared the bactericidal effect of the two groups of disinfectant solutions on SA and MRSA by examin-ing the minimum inhibitory concentration(MIC),minimum bactericidal concentration(MBC),the shortest sterilization time at a concentration of 50 μg/mL iodine and the inhibition zone diameters at concentrations of 200 μg/mL and 400 μg/mL iodine.[Results]MIC values of PVP-I against SA and MRSA were both 79.17 μg/mL,and those of PVP-I@Se were 54.17 and 70.83 μg/mL,respectively.MBC values of PVP-I against SA and MRSA were 129.17 and 150.00 μg/mL,re-spectively,and those of PVP-I@Se were 70.83 and 87.50 μg/mL,respectively.At a concentration of 50 μg/mL iodine,the shortest sterilization time of PVP-I for SA and MRSA was 130 s and 140 s,respectively,and that of PVP-I@Se was 65 s and 75 s,respectively.At a concentration of 200 μg/ml iodine,the inhibition zone diameters of PVP-I for SA and MRSA were 7.67 mm and 8.33 mm,and those of PVP-I@Se were both 9.50 mm.At a concentration of 400 μg/mL iodine,the in-hibition zone diameters of PVP-I for SA and MRSA were 9.00 mm and 9.33 mm,and those of PVP-I@Se were 11.67 mm and 12.00 mm,respectively.[Conclusions]PVP-I with different concentrations of 50,75,100,200 and 400 μg/mL io-dine supplemented with 2 μg/mL SeNPs have better and faster bactericidal effect on SA and MRSA.When combined with SeNPs,PVP-I can enhance the bactericidal activity against SA and MRSA,but with better sensitizing effect on SA than MRSA and higher demand of iodine concentration(400 μg/mL)for sensitizing effect on MRSA.This study provides a theo-retical basis for selecting optimal concentration and action time of the disinfectant,thus reducing SSI. |
| Author | 侯利环 钟敬祥 余广超 何晓娟 陈金莺 罗学仕 |
| AuthorAffiliation | 暨南大学附属第一医院手术室,广东 广州 510630%暨南大学化学与材料学院,广东 广州 510630%暨南大学附属第一医院眼科,广东 广州 510630%暨南大学附属第一医院眼科,广东 广州 510630;暨南大学附属第六医院眼科,广东 东莞 523000 |
| AuthorAffiliation_xml | – name: 暨南大学附属第一医院手术室,广东 广州 510630%暨南大学化学与材料学院,广东 广州 510630%暨南大学附属第一医院眼科,广东 广州 510630%暨南大学附属第一医院眼科,广东 广州 510630;暨南大学附属第六医院眼科,广东 东莞 523000 |
| Author_FL | CHEN Jinying LUO Xueshi HOU Lihuan YU Guangchao ZHONG Jingxiang HE Xiaojuan |
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| DocumentTitle_FL | Bactericidal Effect of Selenium Nanoparticles Combined with Povidone-iodine on Pathogenic Bacteria in Surgical Site Infection |
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| Keywords | povidone iodine(PVP-I) 聚维酮碘 bactericidal effect 金黄色葡萄球菌 耐甲氧西林金黄色葡萄球菌 staphylococcus aureus(SA) 纳米硒 selenium nanoparticles(SeNPs) 杀菌效果 methicillin resistant staphylococcus aureus(MRSA) |
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| Publisher | 暨南大学附属第六医院眼科,广东 东莞 523000 暨南大学附属第一医院手术室,广东 广州 510630%暨南大学化学与材料学院,广东 广州 510630%暨南大学附属第一医院眼科,广东 广州 510630%暨南大学附属第一医院眼科,广东 广州 510630 Editorial Office of Journal of Sun Yat-sen University |
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| Snippet | R63; [目的]负载多功能纳米硒聚维酮碘(PVP-I@Se)消毒剂对金黄色葡萄球菌(SA)、耐甲氧西林金黄色葡萄球菌(MRSA)的杀菌效果,为皮肤手术部位消毒提供实验依据.[方法]实验分... 目的负载多功能纳米硒聚维酮碘（PVP-I@Se）消毒剂对金黄色葡萄球菌（SA）、耐甲氧西林金黄色葡萄球菌（MRSA）的杀菌效果，为皮肤手术部位消毒提供实验依据。方法实验分... |
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| SubjectTerms | 杀菌效果 纳米硒 耐甲氧西林金黄色葡萄球菌 聚维酮碘 金黄色葡萄球菌 |
| Title | 纳米硒联合聚维酮碘对手术感染杀菌的效果 |
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