髓系细胞触发受体2在阿尔茨海默病中的作用
R518.4; 阿尔茨海默病(AD)是老年性痴呆症中最常见的形式,其发病机制仍不清楚,但β淀粉样蛋白(Aβ)被认为是引起AD发病的重要原因,然而其引发AD的病理机制同样存在多种争议.最近研究显示,髓系细胞触发受体(TREM2)在AD病理进程中扮演重要角色,其不仅可以作为Aβ内化的重要受体,还可能成为生物学诊断标志物和治疗靶点,阐明TREM2的结构和功能,将为AD的防治提供重要的思路.本文将从TREM2的结构、TREM2对小胶质细胞功能的影响、TREM2在AD中的病理学作用以及靶向TREM2治疗AD的现状进行系统性综述,这些总结将为AD的基础研究提供具有价值的参考....
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| Published in | Zhongshan da xue xue bao. Zhongshan daxue xuebao yixue kexue ban = Journal of Sun Yat-sen University. Yi xue ke xue ban Vol. 45; no. 3; pp. 344 - 353 |
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| Main Authors | , |
| Format | Journal Article |
| Language | Chinese |
| Published |
西藏民族大学医学院高原环境脑神经损伤与修复研究实验室,陕西 咸阳,712082
01.05.2024
Editorial Office of Journal of Sun Yat-sen University |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1672-3554 |
| DOI | 10.13471/j.cnki.j.sun.yat-sen.univ(med.sci).20240419.006 |
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| Abstract | R518.4; 阿尔茨海默病(AD)是老年性痴呆症中最常见的形式,其发病机制仍不清楚,但β淀粉样蛋白(Aβ)被认为是引起AD发病的重要原因,然而其引发AD的病理机制同样存在多种争议.最近研究显示,髓系细胞触发受体(TREM2)在AD病理进程中扮演重要角色,其不仅可以作为Aβ内化的重要受体,还可能成为生物学诊断标志物和治疗靶点,阐明TREM2的结构和功能,将为AD的防治提供重要的思路.本文将从TREM2的结构、TREM2对小胶质细胞功能的影响、TREM2在AD中的病理学作用以及靶向TREM2治疗AD的现状进行系统性综述,这些总结将为AD的基础研究提供具有价值的参考. |
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| AbstractList | 阿尔茨海默病（AD）是老年性痴呆症中最常见的形式，其发病机制仍不清楚，但β淀粉样蛋白（Aβ）被认为是引起AD发病的重要原因，然而其引发AD的病理机制同样存在多种争议。最近研究显示，髓系细胞触发受体（TREM2）在AD病理进程中扮演重要角色，其不仅可以作为Aβ内化的重要受体，还可能成为生物学诊断标志物和治疗靶点，阐明TREM2的结构和功能，将为AD的防治提供重要的思路。本文将从TREM2的结构、TREM2对小胶质细胞功能的影响、TREM2在AD中的病理学作用以及靶向TREM2治疗AD的现状进行系统性综述，这些总结将为AD的基础研究提供具有价值的参考。 R518.4; 阿尔茨海默病(AD)是老年性痴呆症中最常见的形式,其发病机制仍不清楚,但β淀粉样蛋白(Aβ)被认为是引起AD发病的重要原因,然而其引发AD的病理机制同样存在多种争议.最近研究显示,髓系细胞触发受体(TREM2)在AD病理进程中扮演重要角色,其不仅可以作为Aβ内化的重要受体,还可能成为生物学诊断标志物和治疗靶点,阐明TREM2的结构和功能,将为AD的防治提供重要的思路.本文将从TREM2的结构、TREM2对小胶质细胞功能的影响、TREM2在AD中的病理学作用以及靶向TREM2治疗AD的现状进行系统性综述,这些总结将为AD的基础研究提供具有价值的参考. |
| Abstract_FL | Alzheimer's disease(AD)is the most common form of senile dementia,and its pathogenesis is still un-clear.While β-amyloid(Aβ)is considered an important cause of AD,the pathological mechanism of Aβ inducing AD is subject to various controversies.Recent studies have shown that the myeloid cell trigger receptor(TREM2)plays an impor-tant role in the pathological process of AD,and it can not only serve as an important receptor for the internalization of Aβ but also become a biological diagnostic biomarker and therapeutic target.Hence,elucidating the structure and function of TREM2 will provide important ideas for the prevention and treatment of AD.This article will provide a systematic review of the structure of TREM2,its impact on microglial cell function,its pathological role in AD,and the current status of target-ed TREM2 therapy for AD.These summaries will provide valuable references for basic research on AD. |
| Author | 石镜明 代玉婷 |
| AuthorAffiliation | 西藏民族大学医学院高原环境脑神经损伤与修复研究实验室,陕西 咸阳,712082 |
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| Author_FL | DAI Yuting SHI Jingming |
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| DocumentTitle_FL | The Role of TREM2 Receptor in Alzheimer's Disease |
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| Keywords | 髓系细胞触发受体 阿尔茨海默病 细胞受体 TREM2 cell receptors Alzheimer's disease microglia β淀粉样蛋白 小胶质细胞 β-amyloid |
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| Title | 髓系细胞触发受体2在阿尔茨海默病中的作用 |
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