SRC激酶调控肿瘤糖代谢的研究进展
R730; SRC激酶是一种与膜相关的非受体酪氨酸激酶,在细胞生长、分裂、迁移和存活信号通路中发挥着重要作用.此外,它还通过不同机制调节癌细胞中的葡萄糖代谢,如直接调节葡萄糖代谢相关酶和葡萄糖转运体,或间接调节相关信号转导通路等.在这篇综述中,我们阐明了SRC激酶在调控癌细胞葡萄糖代谢中的作用,还讨论了以SRC为靶点的各种抑制剂的研究进展与存在问题,探讨研发更高选择性和更高活性的SRC抑制剂,使靶向SRC成为治疗肿瘤的新希望....
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| Published in | Zhongshan da xue xue bao. Zhongshan daxue xuebao yixue kexue ban = Journal of Sun Yat-sen University. Yi xue ke xue ban Vol. 45; no. 5; pp. 755 - 763 |
|---|---|
| Main Authors | , |
| Format | Journal Article |
| Language | Chinese |
| Published |
兰州大学第二医院泌尿外科//兰州大学第二医院泌尿外科研究所//甘肃省泌尿系统疾病研究重点实验室//甘肃省泌尿系统疾病临床医学中心,甘肃 兰州,730000
01.09.2024
Editorial Office of Journal of Sun Yat-sen University |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1672-3554 |
| DOI | 10.13471/j.cnki.j.sun.yat-sen.univ(med.sci).20240907.003 |
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| Abstract | R730; SRC激酶是一种与膜相关的非受体酪氨酸激酶,在细胞生长、分裂、迁移和存活信号通路中发挥着重要作用.此外,它还通过不同机制调节癌细胞中的葡萄糖代谢,如直接调节葡萄糖代谢相关酶和葡萄糖转运体,或间接调节相关信号转导通路等.在这篇综述中,我们阐明了SRC激酶在调控癌细胞葡萄糖代谢中的作用,还讨论了以SRC为靶点的各种抑制剂的研究进展与存在问题,探讨研发更高选择性和更高活性的SRC抑制剂,使靶向SRC成为治疗肿瘤的新希望. |
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| AbstractList | R730; SRC激酶是一种与膜相关的非受体酪氨酸激酶,在细胞生长、分裂、迁移和存活信号通路中发挥着重要作用.此外,它还通过不同机制调节癌细胞中的葡萄糖代谢,如直接调节葡萄糖代谢相关酶和葡萄糖转运体,或间接调节相关信号转导通路等.在这篇综述中,我们阐明了SRC激酶在调控癌细胞葡萄糖代谢中的作用,还讨论了以SRC为靶点的各种抑制剂的研究进展与存在问题,探讨研发更高选择性和更高活性的SRC抑制剂,使靶向SRC成为治疗肿瘤的新希望. SRC激酶是一种与膜相关的非受体酪氨酸激酶，在细胞生长、分裂、迁移和存活信号通路中发挥着重要作用。此外，它还通过不同机制调节癌细胞中的葡萄糖代谢，如直接调节葡萄糖代谢相关酶和葡萄糖转运体，或间接调节相关信号转导通路等。在这篇综述中，我们阐明了SRC激酶在调控癌细胞葡萄糖代谢中的作用，还讨论了以SRC为靶点的各种抑制剂的研究进展与存在问题，探讨研发更高选择性和更高活性的SRC抑制剂，使靶向SRC成为治疗肿瘤的新希望。 |
| Abstract_FL | SRC kinase is a membrane-associated non-receptor tyrosine kinase that plays an important role in cell growth,division,migration and survival signaling pathways.In addition,it regulates glucose metabolism in cancer cells through different mechanisms,such as direct regulation of glucose metabolism-related enzymes and glucose transporters,or indirect regulation of related signaling pathways.In this review,we elucidate the role of SRC kinase in the regulation of glucose metabolism in cancer cells,and also discuss the research advance of SRC inhibitors,to explore the development of more selective and active SRC inhibitors,so as to make the targeting SRC become a new hope for the treatment of tumors. |
| Author | 龚玉雯 王志平 |
| AuthorAffiliation | 兰州大学第二医院泌尿外科//兰州大学第二医院泌尿外科研究所//甘肃省泌尿系统疾病研究重点实验室//甘肃省泌尿系统疾病临床医学中心,甘肃 兰州,730000 |
| AuthorAffiliation_xml | – name: 兰州大学第二医院泌尿外科//兰州大学第二医院泌尿外科研究所//甘肃省泌尿系统疾病研究重点实验室//甘肃省泌尿系统疾病临床医学中心,甘肃 兰州,730000 |
| Author_FL | WANG Zhiping GONG Yuwen |
| Author_FL_xml | – sequence: 1 fullname: GONG Yuwen – sequence: 2 fullname: WANG Zhiping |
| Author_xml | – sequence: 1 fullname: 龚玉雯 – sequence: 2 fullname: 王志平 |
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| DOI | 10.13471/j.cnki.j.sun.yat-sen.univ(med.sci).20240907.003 |
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| DocumentTitle_FL | Research Progress in Regulation of SRC Kinase on Tumor Glucose Metabolism |
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| Keywords | 抑制剂 targeted therapy inhibitor 肿瘤 靶向治疗 tumor 糖代谢 SRC kinase glucose metabolism SRC激酶 沃伯格效应 Warburg effect |
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| Publisher | 兰州大学第二医院泌尿外科//兰州大学第二医院泌尿外科研究所//甘肃省泌尿系统疾病研究重点实验室//甘肃省泌尿系统疾病临床医学中心,甘肃 兰州,730000 Editorial Office of Journal of Sun Yat-sen University |
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| Snippet | R730; SRC激酶是一种与膜相关的非受体酪氨酸激酶,在细胞生长、分裂、迁移和存活信号通路中发挥着重要作用.此外,它还通过不同机制调节癌细胞中的葡萄糖代谢,如直接调节葡萄糖... SRC激酶是一种与膜相关的非受体酪氨酸激酶，在细胞生长、分裂、迁移和存活信号通路中发挥着重要作用。此外，它还通过不同机制调节癌细胞中的葡萄糖代谢，如直接调节葡萄糖代... |
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| SubjectTerms | SRC激酶 抑制剂 沃伯格效应 糖代谢 肿瘤 靶向治疗 |
| Title | SRC激酶调控肿瘤糖代谢的研究进展 |
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